تالیفات

 

Analysis Of Microsatellite Polymorphism Around The HLA-B Locus In Iranian Patients With Behcet's Disease.

Authers: N. Mizuki, K. Yabuki, M. Ota, Y. Katsuyama, H. Ando, E. Nomura, K. Funakoshi, F. Davatchi, H. Chams, B. Nikbin, A.A. Ghaderi, S. Ohno, H. Inoko H

Abstract: We have previously suggested that in a Japanese population the susceptible locus for Behcet's disease (BD) is HLA-B51 itself. To confirm this finding in another population, we performed HLA class I typing using the PCR-SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA-B gene using automated sequencer and subsequent automated fragment detection by fluorescent-based technology with the DNA samples of 84 Iranian patients with BD ... سال انتشار: 2002
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

EVALUATION OF SERUM ALPHA-1-ANTITRYPSIN LEVELS IN 62 PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DISEASE IN TEHRAN.

Authers: K. Bamdad Mehrbany, M. Akbarian, A. Abdoly Fard

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune and chronic inflammatory disease. It is believed that the attachment of autoantibodies to autoantigens leads to inflammation and kidney disorders. Alpha- 1-antitrypsin is an acute phase protein that neu­tralizes the deleterious effects of the proteolytic enzymes. The level of alpha-1-antitrypsin raises in inflammation. This enzyme is produced from those inflammatory cells (neutrophils) infiltrating to the involved sites. The goals of this study were ... سال انتشار: 2002
 

ASSOCIATION OF HLA-B51 WITH CLINICAL EXPRESSION OF BEHCET’S DISEASE, ANALYSIS OF 201 IRANIAN PATIENTS.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, F. Gharibdoost, C. Chams

Abstract: Introduction: Despite the strong association between HLA-B51 and Behcet’s disease (BD), the clinical significance of this genetic marker has not been fully elucidated. The aim of this study was to find out the association of HLA-B51 with various manifestations of BD, and to compare it to those of HLA-B5. Patients & methods: All newly diagnosed BD patients in a 9-month period from April 2001 to January 2002 were studied. They ... سال انتشار: 2002
 

HLA-B51 FREQUENCY IN IRANIAN PATIENTS WITH BEHCET’S DISEASE.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, M. Akbarian, C. Chams

Abstract: Introduction: HLA-B51, a split antigen of HLA-B5, has generally been associated with Behcet’s disease (BD) in different countries notably those along the Silk route. The aim of this study was to determine the frequency of HLA-B51 in Iranian patients with BD, and to compare it with the control patients. Patients & methods: In a prospective study, 599 consecutive new patients referred to the BD clinic, in a 9-month period from ... سال انتشار: 2002
 

CHRONOLOGY OF CLINICAL MANIFESTATIONS IN BEHCET’S DISEASE, ANALYSIS OF 3542 CASES.

Authers: F. Shahram, K. Assadi, F. Davatchi, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian

Abstract: Introduction: Manifestations of Behcet’s disease (BD) appear one after another during the course of the disease. Some involvements such as mucous lesions seem to appear early, and others such as gastrointestinal (GI) and neurological (CNS) involvement many years later. This study was planned to find out the chronology of different manifestations of BD. Patients & methods: In a retrospective study, files of all BD patients diagnosed since 1989 were reviewed ... سال انتشار: 2002
 

AZATHIOPRINE AND LOW DOSE PULSE CYCLOPHOSPHAMIDE IN SEVERE OCULAR LESIONS OF BEHCET’S DISEASE, A PRELIMINARY REPORT.

Authers: F. Shahram, F. Davatchi, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Combination of cytotoxic drugs was suggested to decrease the rate of non-responders in severe ocular lesions of Behcet’s disease (BD). We present here our preliminary data with low dose pulse Cyclophosphamide (LDP) and Azathioprine (AZA) in the treatment of posterior uveitis (PU) and/or retinal vasculitis (RV) of BD. Patients & methods: Twelve BD patients with PU and RV were selected. They all received LDP as 0.5 g/m2 body surface/month ... سال انتشار: 2002
 

TONSILLECTOMY AND BEHCET’S DISEASE.

Authers: M. Jalessi, F. Shahram, A. Safavi, F. Davatchi, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost.

Abstract: Introduction: Increasing development of some diseases such as Behcet’s disease (BD) was reported after tonsillectomy. This study was designed to find the association between tonsillectomy/adenoidectomy (T/A) and subsequent development of BD. Patients & methods: In a prospective control study, 128 patients with BD and 139 controls from the orthopedic clinic (age and sex matched) were studied regarding previous T/A. A complete ENT clinical examination was performed for all of them. ... سال انتشار: 2002
 

URINE ABNORMALITIES IN BEHCET’S DISEASE, STUDY OF 4704 CASES.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost, C. Chams.

Abstract: Introduction: Despite the multisystem nature of Behcet’s disease (BD), renal involvement is rare in this disease. The aim of this study was to find the prevalence and characteristics of urine abnormalities and renal involvement of BD in Iran. Patients & methods: In a cohort of 4704 patients with BD, urinalysis was performed to screen patients with urine abnormalities. Different manifestations of the disease, including 100 clinical and paraclinical parameters, were ... سال انتشار: 2002
 

Vascular involvement in Behcet’s disease.

Authers: F. Shahram

Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet’s disease (BD). Like the other manifestations of the disease, its prevalence varies widely due to ethnic variation or environmental factors. The aim of this study is to find the characteristics of Vasculo-Behcet in Iran. Materials & Methods: In a cohort of 4769 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared ... سال انتشار: 2002
 

BEHCET’S DISEASE. ANALYSIS OF 4660 CASES.

Authers: F. Davatchi, C. Chams, F. Shahram, F. H. Chams, A. Nadji, M. Akbarian, F. Gharibdoost

Abstract: Behcet’s Disease (BD) is a multisystemic disease with a peculiar distribution in the world. The disease is specially seen in the countries bordering the ancient SILK ROAD specially Japan, China, Korea, Iran, and Turkey. The majority of reports on BD are on hospital based patients. Others are either local based patients or epidemilogical studies on a small area. The only two nationwide analysis of BD is from Japan and ... سال انتشار: 2002
 

COMPARATIVE ANALYSIS OF BEHCET’S DISEASE IN APLAR REGION.

Authers: F. Davatchi.

Abstract: INTRODUCTION: Behcet’s Disease (BD) is classified among vasculitides, but its clinical picture is very distinctive and can be easily differentiated from the others. BD was originally seen along the Silk Road, but due to immigrations it is now seen everywhere in the world. There are many reports on clinical manifestations of BD from different parts of the world. The majority are case series except two nationwide surveys, one from Iran1, ... سال انتشار: 2002
 

THE COMPARISON OF ANKYLOSING SPONDYLITIS IN BEHCET'S DISEASE AND NORMAL POPULATION: A CONTROL STUDY.

Authers: A. Nadji, F. Davatchi, F. Shahram, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: We previously reported that ankylosing spondylitis (AS) was associated with Behcet's disease (BD) in Iranian patients. This study was designed to evaluate the features of AS in BD (ASBD) and compare them with the AS in normal population (ASN). Materials and Methods: Among 4700 BD patients, 73 ASBD were found and were compared with a cohort of 180 ASN. Seventy out of 73 ASBD met the European Spondyloarthropathy Study Group ... سال انتشار: 2002
 

COMPARISON OF ORAL APHTHAE IN BEHCET DISEASE AND IDIOPATHIC RECURRENT APHTHOUS STOMATITIS.

Authers: C. Chams-Davatchi, M. Shizarpour, F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi

Abstract: Background: The purpose of this study was to evaluate the difference between oral aphthae in Behcet’s Disease (BD) and recurrent aphthous stomatitis (RAS). Methods: In a prospective study 56 cases of BD and 133 RAS were evaluated consecutively. Sex, age of onset, frequency of aphthous lesions, their duration and their mean number at each attack, pathergy test, HLA-B5, HLA-B51 and HLA-B27 were evaluated in both groups. Comparison was made by Student ... سال انتشار: 2002
 

EVALUATION OF THE MORTALITY IN SLE, ANALYSIS OF 165 PATIENTS.

Authers: A. Hadjiabbassi, M. Akbarian, S. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A.R. Jamshidi, F. Davatchi

Abstract: Objective: SLE is an autoimmune disease. The mortality rate and causes are different in the various countries. The present study is done to find out the causes of mortality in the SLE patients in Iran. Methods: This study was retrospective according to medical records of patients who were referred to Rheumatology polyclinic, admitted in Rheumatology ward, ICU, Gynecology and Nephrology wards of Shariati hospital during 10 years, from 1991-2001. Results: Of 2021 ... سال انتشار: 2002
 

EXTENSIVE PYODERMA GANGRENOSUM LIKE LESION IN TWO CASES OF BEHCET’S DISEASE, RESPONDING ONLY TO CYCLOSPORIN.

Authers: C. Chams-Davatchi, M. Shizarpour, F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi

Abstract: Introduction: Pyoderma gangrenosum (PG) like lesion is a Behcet’s disease (BD) skin lesion, which is seen very exceptionally. We report here 2 cases with unusual severe and extensive skin lesions, having an intensive hypersensitivity to needle injection, inducing new lesions. Cases report: The first case is a 42 years old man with a history of 5 years recurrent bipolar aphthosis, skin pustulosis, ocular lesions, and articular involvement. After ... سال انتشار: 2002
 

THE INFLUENCE OF THE DELAY IN AGGRESSIVE TREATMENT ON THE VISON AND ITS OUTCOME IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The natural course of eye lesions is well known, leading to sever loss of vision or blindness. The cumulative nature of eye lesions during successive attacks, leads to gradual loss of visual acuity (VA). The aim of this study was to evaluate the effect of the delay in aggressive treatment on the VA and its long-term outcome. Materials and Methods: All Behcet’s patients of the treatment registry (1009 ... سال انتشار: 2002
 

TREATMENT OF OCCULAR MANIFESTATIONS OF BEHCET’S DISEASE.

Authers: F. Davatchi

Abstract: Ocular manifestations like other manifestations of Behcet’s Disease (BD) progress by repetitive attacks followed by remission. However, the remission is much slower in posterior uveitis, and practically absent in retinal vasculitis. Usually the healing process do not complete before the next attack. Therefore, lesions will accumulate during successive attacks and lead to severe loss of vision or blindness. An inflammatory index and visual acuity has to be calculated for each ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

HIGH DOSE METHOTREXATE FOR OCULAR LESIONS OF BEHCET’S DISEASE. PRELIMINARY SHORT-TERM RESULTS ON 23 PATIENTS.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Jamshidi, A. Nadji, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: methotrexate in weekly low dose pulse of 7.5 mg has long proved its efficacy in the treatment of ocular lesions. During the 1998 ACR congress where we presented our data on 262 patients it was suggested the high dose of 15 mg. This is the short-term result of that study. Materials and Methods: MTX was used as 15 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. The visual ... سال انتشار: 2002
 

JOINT HYPER-MOBILITY (JHM) IN IRANIAN STUDENTS.

Authers: A. Jamshidi, F. Gharibdoost, M. Akbarian, F. Shahram, A. Nadji, F. Davatchi.

Abstract: Objectives: Joint Hyper-Mobility is an important and occult joint involvement in normal population. We studied to determine the prevalence and features of JHM in Iranian students. Methods: A group of Iranian primary to high school students in Tehran was considered in the figure of a cross sectional-descriptive study. Though validated Carter-Wilkinson & Beighton criteria 997 students from five geographical regions were screened. Sampling method was Randomized - multi process. We had ... سال انتشار: 2002
 

LATE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS IN IRAN.

Authers: M. Akbarian, M. Valizadeh, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objectives: The aim of this study is to analyze the clinical features, laboratory findings and type of treatments in late onset SLE (after 50 years) in Iranian patients and compare them with the early onset. Methods: Records of 1419 SLE patients who attended our lupus unit, between 1975 and 1999 were reviewed. Nineteen Patients with late onset disease were identified. For comparison, 47 patients with disease onset before the age of ... سال انتشار: 2002
 

TREATMENT OF OCULAR MANIFESTATIONS OF BEHCET’S DISEASE.

Authers: F. Davatchi

Abstract: INTRODUCTION : Ocular manifestations are one of the main features of Behcet’s Disease. They occur in more than half the patients. In our series they were seen in 58% of cases1. The natural course of Ocular manifestations, like other manifestations of Behcet's Disease, is a progression by repetitive attacks followed by remission. However, on the contrary of other lesions (muco-cutaneous) the remission is much slower in posterior uveitis, and practically absent ... سال انتشار: 2002
 

MUCO CUTANEOUS LESIONS OF BEHCET'S DISEASE.

Authers: C. Chams-Davatchi

Abstract: Muco-cutaneous lesions are the most important signs in the diagnostic criteria of Behcet’s Disease (BD), but they are not specific and can be seen in other disease too. Mucous Membrane Lesions: 1- Recurrent oral aphthosis is the most frequent lesion of BD (96.1%0.6). It was divided in major, minor, and herpetiforme aphtosis. There are also Punctiform, Miliaria, and giant aphthosis. The shape and the size of aphthae can vary ... سال انتشار: 2002
 

MUCO-CUTANEOUS LESIONS OF BEHÇET’S DISEASE, 10 YEARS EXPIRIENCE ON 4605 PATIENTS.

Authers: C. ChamsDavatchi, F. Davatchi, F. Shahram, A. Nadji, H. Chams, A. Jamshidi

Abstract: Background: Our purpose was to show different aspects of the muco-cutaneous lesions of Behcet’s disease (BD). Although they are not specific, they constitute the major symptoms in all sets of diagnosis criteria for BD. Methods: Description of muco-cutaneous lesions seen during 12 years follow up in 4605 patients. Results: 1- Mucous-membrane lesions: Recurrent oral aphthosis (OA) is the most important and frequent lesion of BD. It resembles the other OA of other ... سال انتشار: 2002
 

ORIGIN AND OUTCOME OF MACULAR EDEMA IN OCULAR-BEHCET.

Authers: H. Chams, A. Lashei, A. Sadeghi-Tari, F. Davatchi, F. Shahram. C. Chams

Abstract: The chronic macular edema, frequent in ocular Behcet's disease, is a treat to the visual outcome of the patients. We have investigated the origin, risk-factors and the outcome of macular edema in patents under immunosuppressors and corticosteroid therapy. This is a retrospective, case series study. In 1999,seventeen patients of the Behcet's clinic of Shariati hospital of Tehran who had macular edema were consecutively selected and included in the study. They were ... سال انتشار: 2002
 

The Impact of the Treatment Delay on the Outcome of Vision in Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ... سال انتشار: 2002
 

THE INFLUENCE OF PATHERGY TEST ON THE ACCURACY OF DIFFERENT DIAGNOSIS CRITERIA FOR BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ... سال انتشار: 2002
 

RHEUMATIC DISEASES IN A SINGLE FAMILY SET UP; "REPORT OF SIMILAR CASES IN FOUR FAMILIES".

Authers: N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Background: The gene effect in pathogenesis of Rheumatic Diseases is well known, but the exact mode of transmission is not clear. In this report we present similar diseases occurred in two generations and in siblings. Methods: We overviewed the medical charts of second member of the family, according to the family history of the index patient. Results: Family I: Discoid Lupus was diagnosed in an eight years old girl whose father had ... سال انتشار: 2002