تالیفات

 

Long-Term Follow up of Type IV SLE Nephritis (without renal failure) Treated by Pulse Cyclophosphamide.

Authers: F. Davatchi, M. Akbarian, F. Shahram, F. Gharibdoost, C. Chams

Abstract: Results of PCP are well known in lupus nephritis. We present here it’s outcome in patients with WHO type IV lupus nephritis, treated before the occurrence of renal failure. Patients having a follow up of more than 36 months were selected for this study. 29 patients fulfilled the selection criteria. Proteinuria, hematuria, leucocyturia, cast, BUN, creatinine and blood pressure were measured before PCP and after each one. The first and ... سال انتشار: 1993
 

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) IN CHILDREN, ANALYSIS OF 220 IRANIAN CASES.

Authers: N. Shafaie, M. Akbarian, F. Shahram, F. Gharibdooost; A. Nadji, F. Davatchi

Abstract: Systemic Lupus Erythematosus is not rare in Iran. We have seen 220 cases in children in a population of 893 SLE in the past 16 years. In this study we show the features of SLE in children. The female to male ratio was 86/14. Fever was present in 72% of the patients, weight loss in 40%, malar rash in 72.5%, photosensitivity in 54%, mucosal lesion in 48%, discoid rash in ... سال انتشار: 1993
 

SALMONELLA INFECTION IN SYSTEMIC LUPUS ERYTHEMAT0SUS.

Authers: F. Shahram, M. Akbarian, F. Gharibdoost, and F. Davatchi

Abstract: Systemic Lupus Erythematosus (SLE) is a known underlying disease predisposing to salmonellosis. We report here 39 cases of salmonellosis in 30 patients in a population of 897 patients with SLE, during a 17 years period. All were women with a mean age of 25.7 years. Eighty percent were taking prednisolone and 26% cytotoxics at the onset of the infection. Renal involvement was present in 77% (type IV WHO in 65% ... سال انتشار: 1993
 

Relationship of pathergy phenomenon and Behcet's disease (BD) manifestations.

Authers: P. Mansoori, C. Chams, F. Davatchi, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, H. Chams

Abstract: In a study on 391 cases of BD presented to the EULAR Congress in 1987 we demonstrated that the following symp­toms were seen more frequently in patients with positive pathergy phenomenon: oral aphthosis as the initial manifes­tation of the disease, genital ulcerations, pseudofolliculitis, and arthralgia. The following symptoms, on the contrary were seen less frequently: oral aphthosis, ankylosing spon­dylitis. It was interesting to look after those findings, 6 years later, in ... سال انتشار: 1993
 

Prospective study on Neuro-Behcet.

Authers: H. Sikaroodi, F. Shahram, M. Akbarian, F. Davatchi

Abstract: Behcet Disease (BD) is known to involve nervous system. In order to evaluate the prevalence of neurological complications as early manifestations of BD, and to determine their value as indicators of the disease, we conducted a prospective study on 261 consecutive patients reffered to our BD clinic (100 control subjects and 161 BD patients), including a Questionaire about neurological symptoms, complete physical (neruological) examination, and paraclinicalstudies, No definite (significant) difference ... سال انتشار: 1993
 

Low dose pulse cyclophosphamide (LDP) in ophthalmological lesions of Behget's disease.

Authers: F. Shahram, F. Davatchi, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Pulse cyclophosphamide (PCP) is the most effective and the least toxic treatment in posterior uveitis (pU) and/or re­tinal vasculitis (RV) of Behcet's disease (BD). Conventional doses (1 g/m2) may be associated with minor side effects such as hair loss, nausea and vomiting. To find whether lower doses, such as those already employed in Lupus nephritis should be useful, we administered IVLDP (0.5 g/m2/month) plus prednisolone (0.5 mg/kg/day) to 40 BD ... سال انتشار: 1993
 

Accuracy of existing diagnosis criteria for Behcet's disease (BD).

Authers: F. Davatchi, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, C. Chams, H. Chams, P. Mansoori, N. Shafai

Abstract: There are 5 major sets of diagnosis criteria for BD: Mason & Barnes, O'Duffy, Dilsen, Japan revised criteria, and the International criteria (the latest one). To evaluate their accu­racy we analysed their sensitivity and specificity in 2069 BD and 1519 control patients. The accuracy was calculated by the sum of BD patients fulfilling the criteria and the control patients correctly classified as non BD, divided by the sum of the ... سال انتشار: 1993
 

A SURVEY OF ANTIBODIES FOR THE EXTRACTABLE NUCLEAR ANTIGENS AND THEIR ROLE IN THE CLINICAL DIAGNOSIS AND PROGNOSIS OF SLE.

Authers: S. R. Tehrani & T. Mousavi, M. Akbarian

Abstract: Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-DNA; anti-Sm (Smith's antigen); and, other extractable nuclear antigens. The tests employed were microhemagglutination, counter immuno­electerphoresis, and radio immunoassay (RIA). The comparison between the two techniques for detectiong anti-DNA titers showed a significant correlation between them. There was also a significant positive correlation between the presence of anti-DNA and lupus nephritis ... سال انتشار: 1993
 

Comparing 3 methods of cytotoxic therapy in ophthalmologic lesions of Behcet's disease.

Authers: F. Shahram, F. Davatchi, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: It is accepted today that cytotoxic drugs are the only re­mittent agents in posterior uveitis (PU) and retinal vasculitis (RV) of Behcet's disease (BD). The important question is which cytotoxic is the most effective and the least harmful. We compare here the results of 3 efficient methods of cyto­toxic therapy with the same mean follow-up time of 12 months: I.V. Pulse Cyclophosphamide (PCP) in 121 patients, weekly low dose Methotrexate ... سال انتشار: 1993
 

Classification tree for the diagnosis of Behcet's disease (BD).

Authers: F. Davatchi, F. Shahram, M. Akbarian, F. Gharibdoost, C. Chams, H. Chams, P. Mansoori, A. Nadji

Abstract: The diagnosis method by Classification And Regression Tree (CART) is gaining more importance every year, spe­cially in Rheumatology by the efforts of the American Col­lege of Rheumatology. The classification tree not only pro­vides an accurate tool for diagnosis, it gives a better insight of the manifestations of the disease and the value of different criteria for the diagnosis. In this study we analyzed 1992 Behcet's patients (BP) and 1506 control ... سال انتشار: 1993
 

OPHTHALMOLOGIC SIDE EFFECTS OF CHLOROQUINE, ANALYSIS IN 1598 PATIENTS WITH RHEUMATlC DISEASES.

Authers: F. Gharibdoost, F. Davatchi, F. Shahram, H. Chams, M. Akbarian, A. Salimzadeh

Abstract: Antimalarials are among the most important disease modifying drugs used in Rheumatology. The major problem with them is their effects on eyes. We have done a retrospective study on 1598 patients with RA and SLE using Chloroquine for 1 month to 16 years (Mean 41 months). Eye problems was detected in 330 patients (20.6%). We found corneal deposition in 205 (13%) that was graded as severe (11%), moderate (12%) and ... سال انتشار: 1993
 

CHILBLAIN LUPUS ERYTHEMATOSUS IN A MONOLYGOTE TWIN.

Authers: C. Chams, M. Akbarian, P. Mansoori, F. Shahram, and F. Davatchi

Abstract: CHILBLAIN LUPUS ERYTHEMATOSUS IN A MONOLYGOTE TWIN.#C. Chams, M. Akbarian, P. Mansoori, F. Shahram, and F. Davatchi#Revista Espanola de Reumatologia, 1993; 20 (Suppl 1): p. 358 #Chilblain lupus erythematosus or lupus pernio was described by HUTCHINSON in 1888. Even actually it is difficult to put this entity in a well defined nosologic place as systemic lupus erythematosus. We report here the case of a twin monozygote brothers of 11 years old, ... سال انتشار: 1993
 

Behcet's disease in children.

Authers: N Shafai, F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A. Nadji

Abstract: Behcet's disease (BD) is not rare in children, and it's clini­cal picture differs from that in adults. We studied 66 patients in whom the disease was diagnosed under the age 16 from a population of 2068 BD patients. Comparison of the results with the adults by the student paired t test showed: although the most frequent initial manifestation of BD in children was oral aphthosis (54.5%), it was less frequent ... سال انتشار: 1993
 

Clinical manifestations of Behcet's disease in Iran. Analysis of 2068 cases.

Authers: F. Gharibdoost, F. Davatchi, F. Shahram, M. Akbarian, C. Chams, H. Chams, P. Mansoori, A. Nadji

Abstract: The annual incidence of Behcet's Disease (BD) is as high as 300 patients per year. The mean age at the onset of the first symptom is 26.7 years (SD = 9.7). The sex distribution is 54% male and 46% female. The initial manifestation was mainly oral aphthosis (73%), uveitis (13%), genital ulcerations ­(11%), arthritis (9%), and skin manifestations (9%). Clinical manifestations were as fallow: mucous mem­brane manifestations were seen in 95.5% ... سال انتشار: 1993
 

Audio vestibular involvement in Behcet's disease (BD).

Authers: N. Shariati, M. Khalesi, F. Shahram, M. Akbarian, F. Sabeti, F. Davatchi

Abstract: There is only three reports on the frequency of audio ves­tibular involvement in BD in the literature. In these studies, done in small population of BD patients, the frequency of auditory involvement were reported as high as 60%, and the vestibular involvement between 25 to 37%. We studied pros­pectively the audio vestibular involvement in 80 patients with BD, and compared them with 102 controls (CG) includ­ing hospital staffs, patients with ... سال انتشار: 1993
 

SYSTEMIC LUPUS ERYTHEMATOSUS AND INFECTION, ANALYSIS OF 893 SLE PATIENTS IN IRAN.

Authers: M. Akbarian, F. Shahram, F. Gharibdoost, A. Nadji, N. Shafaie, and F. Davatchi

Abstract: An increased rate of infection among SLE patients has long been reported from western countries. In a retrospective study in 893 patients, we analyzed 203 cases who had one or more episodes of infection between 1974 and 1992. Among them 181 were females and 22 were males (89% female) . The diagnosis of infection was established by both clinical and laboratory findings. Almost more than half of the infections were ... سال انتشار: 1993