تالیفات

 

Random Forests Analysis: A modern statistical method for screening in high-dimensional studies and its application in a population-based genetic association study

Authers: Sahar Noori, Keramat Nourijelyani, Kazem Mohammad, Mohammad Hossein Niknam, Mahdi Mahmoudi, Laris Andonian, Arash Akaberi

Abstract: Technology advances in this century, especially, in molecular generics yields high volume, high dimensional data. This creates many unprecedented challenges for statisticians who are responsible for analysis of such data. Although logistic regression method is quite popular in association analysis in medical researches but it has some serious limitations in handling high dimensional data. In present study, our goal is introduce a modern model-free statistical method called random forest that we believe is able to overcome difficulties ... سال انتشار: 2011
 

Osteoarthritis of the knees in the COPCORD world

Authers: Syed A. HAQ, Fereydoun DAVATCHI

Abstract: This paper examines and summarizes data on knee osteoarthritis (AO) in Community Oriented Program For Control Of Rheumatic Disorders (COPCORD) publications. A literature search was made through PubMed, Google, Proceedings of Asia-Pacific League of Associations for Rheumatology (APLAR) congresses, and Abstracts from APLAR congresses. Data were compiled to examine the prevalence of knee OA and knee pain, sex ratio, urban/rural differences and other risk factors. Data on knee pain and OA were available in ... سال انتشار: 2011
 

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Mandana MOHYEDDIN, Farhad SHAHRAM1, Behrooz NIKBIN

Abstract: Background: Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells (MSCs) due to their multi-lineage potential, immunosuppressive activities, limited immunogenicity and relative ease of growth in culture, have attracted attentions for clinical use. Aim: The aim of ... سال انتشار: 2011
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2011
 

Diagnosis/Classification Criteria for Behcet’s Disease

Authers: Fereydoun Davatchi

Abstract: Historical Background. The ISG criteria for Behcet’s, created in 1990, have excellent specificity, but lack sensitivity. The International Criteria for Behcet’s Disease (ICBD) was created in 2006, as replacement to ISG. The aim of this study was to compare their performance. ISG and ICBD Criteria. For ISG oral aphthosis is mandatory. The presence of any two of the following (genital aphthosis, skin lesions, eye lesions, and positive pathergy test) will diagnose/classify the patient ... سال انتشار: 2011
 

Clinical and preclinical manifestation of systemic lupus erythmatous

Authers: M. Ebrahimpur Fini, MD, T. Faezi, MD, M. Akbarian, MD, M. Akhlaghi, MD, M. Kheiyrandish, MD, A. Shahali, MD, F. Gharibdoust, MD, F. Shahram, MD, A.H. Naji, MD, A.R. Jamshidi, MD, F. Davachi, MD

Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male ... سال انتشار: 2011
 

Study of the correlation of serum selenium level with Behcet’s disease

Authers: Kamal ESALATMANESH, Ahmadreza JAMSHIDI, Farhad SHAHRAM, Fereydun DAVATCHI, Seyed Ali MASOUD, Zahra SOLEIMANI, Mansour SALESI, Iman GHAFFARPASAND

Abstract: Selenium, like other trace elements and antioxidant enzymes, is known as an antioxidant and immunomodulator trace element. Due to recent evidence for selenium deficiency in Behcet’s syndrome, this study is to evaluate the correlation of serum selenium level with Behcet’s disease (BD). Materials: This case–control study was conducted on 46 BD patients and 46 healthy controls in a rheumatology research centre. The case and control groups were both age- and race-matched. Serum selenium level ... سال انتشار: 2011
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI, Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2011
 

Investigation of bacterial and viral agents and immune status in Behcet’s disease patients from Iran

Authers: Eveline U. IRSCHICK, Sebastian PHILIPP, Farhad SHAHRAM, Michael SCHIRMER, Massih SEDIGH, Naghmeh ZIAEE, Christoph GASSNER, Harald SCHENNACH, Martina MEYER, Clara LARCHER, Manfred HEROLD, Dieter SCHOENITZER, Dietmar FUCHS, Michael SCHOENBAUER, Matthias MAASS, Hartwig P. HUEMER, Fereydoun DAVATCHI

Abstract: Behc¸et’s disease (BD) is an autoimmune disorder associated with HLA-B51 positivity. Serologic/genomic findings have suggested microbes as possible causative agents and the geographical distribution suggests environmental influences. Methods: We performed comparative analyses of 40 patients with BD or related symptoms not fulfilling BD criteria. Patients originating from different regions of Iran were tested by molecular/serological methods for human herpes viruses and parvovirus B19, two Chlamydiae species, as well as Coxiella, Listeria, Yersinia, Leptospira and Mycobacterium paratuberculosis. ... سال انتشار: 2011
 

Evaluation of the Iranian versions of the bath ankylosing spondylitis disease activity index (BASDAI), the bath ankylosing spondylitis functional index (BASFI) and the patient acceptable symptom state (PASS) in patients with ankylosing spondylitis

Authers: Katayoon Bidad, Sasan Fallahi, Mahdi Mahmoudi, Ahmadreza Jamshidi, Elham Farhadi, Alipasha Meysamie, Mohammad Hossein Nicknam

Abstract: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) are widely used instruments in assessment of patients suffering from ankylosing spondylitis (AS). The Patient Acceptable Symptom State (PASS) is regarded as a target for patients’ well-being. The aim of this study was to translate and adapt BASDAI, BASFI and PASS into the Iranian official language, Farsi, and evaluate their reliability and validity. Ninety patients with AS were included in this study. The ... سال انتشار: 2011
 

Association of mitochondrial polymorphism m.709G>A with Behçet’s disease

Authers: Joana M Xavier, Niloofar Mojarad Shafiee, Fahmida Ghaderi

Abstract: The involvement of nuclear genes in Behçet’s disease (BD) risk has been investigated, but the role of the mitochondrial DNA (mtDNA) has been completely neglected. Mitochondria are the main intracellular source of reactive oxygen species produced during normal aerobic metabolism via the electron transport chain and since mitochondrial dysfunction may underlie a multitude of clinical features in multifactorial and multisystemic diseases such as BD, we assessed whether mtDNA single nucleotide polymorphisms (SNPs) and haplogroups confer susceptibility to BD. A total ... سال انتشار: 2011
 

Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis

Authers: M. Mahmoudi, A.A. Amirzargar, A.R. Jamshidi, E. Farhadi, S. Noori, M. Avraee, B. Nazari, M.H. Nicknam

Abstract: Objective. Ankylosing spondylitis (AS) is one of the mostcommoncauses of inflammatory arthritis, with an estimated prevalence of 0.1-0.9%. Genetic factors have been strongly implicated in its aetiology, and heritability as assessed by twin studies has been estimated to be>90%. HLA- B27 is almost essential for inheritance of AS; it is not merely sufficient for explaining the pattern of familial recurrence of the disease. This study’s purpose is to investigate the association of ankylosing spondylitis ... سال انتشار: 2011
 

The Effects of Multidisciplinary Educational Program on Quality of Life and Disability of Patients with Chronic Low Back Pain: A Clinical Trial with 3, 6, 12 and 18 Months Follow ups

Authers: Sedigheh Sadat Tavafian MD, Ahmad Reza Jamshidi MD, Kazem Mohammad PhD

Abstract: Chronic low back pain is one of the most health problems worldwide. This study aimed to examine the effects of a designed multidisciplinary program on quality of life and disability among chronic low back pain patients up to 18 months. Methods: This study followed the participants in previous randomized controlled trial up to 18 months. Therefore, data at 18- month follow up, were collected through SF-36, Ronald –Morris Disability Questionnaire, and Quebec low back pain ... سال انتشار: 2011
 

Validation of the International Criteria for Behc¸et’s disease (ICBD) in Iran

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Nasim NADERI, Massoomeh AKHLAGHI, Tahereh FAEZI, Alireza FARIDAR

Abstract: To evaluate the performance of the new International Criteria for Behc¸et’s Disease (ICBD) in Iran. The ICBD was created in 2006 to replace the International Study Group (ISG) criteria (created in 1990). In this study, 14 existing diagnosis/classification criteria (Curth, Hewitt, Mason and Barnes, Japan original, Hubault and Hamza, O’Duffy, Cheng and Zhang, Dilsen, Japan revised, International Study Group, Iran traditional, Iran Classification Tree, revised Dilsen, Korea), were evaluated and compared to ICBD by ... سال انتشار: 2010
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

Systemic lupus erythematosus in Iran: a study of 2280 patients over 33 years

Authers: Mahmood AKBARIAN, Seyedeh Tahereh FAEZI, Farhad GHARIBDOOST, Farhad SHAHRAM, Abdolhadi NADJI, Ahmad Reza JAMSHIDI, Maasoumeh AKHLAGHI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Fereydoun DAVATCHI

Abstract: Systemic lupus erythematosus (SLE) as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. The aim of this study was to show the manifestations of SLE in Iranian patients. Methods: The study was on manifestations of SLE according to the database of the Rheumatology Research Center (RRC), Tehran, Iran, on registered patients during the period of 1976 to ... سال انتشار: 2010
 

Seroprevalence of Acanthamoeba Antibodies in Rheumatoid Arthritis Patients by IFAT, Tehran, Iran 2007

Authers: M Eftekhar, *A Athari, A Haghighi, N Mosaffa, F Shahram, A Abadi

Abstract: This preliminary study was conducted to discriminate the prevalence of Acanthamoeba antibodies in rheumatoid arthritis (RA) patients and healthy controls to analyze the correlation between these two groups. Methods: From October 2006 to August 2007 a total of 121 serum samples from RA patients attending the Rheumatolgy Department at Shariati Hospital in Tehran were obtained and stored at -20°C until using by indirect fluorescent-antibody test (IFAT). RA was diagnosed according to the American Collage of Rheumatology ... سال انتشار: 2010
 

Plasma Homocysteine Level in Patients with Behcet’s Disease with or without Thrombosis

Authers:

Abstract: To nd the possible role of plasma homocysteine level as a contributing factor in venous and arterial thrombosis in patients with Behcet’s disease (BD). Methods: In a case control study, two groups of BD patients were included: 47 with thrombosis and 49 without thrombosis. All patients fullled the International Study Group Criteria for BD and the conrming diagnostic procedures for vascular thrombosis were either Doppler sonography or angiography. Forty-nine controls were selected by consecutive ... سال انتشار: 2010
 

Plasma Homocysteine Level in Patients with Behcet’s Disease with or without Thrombosis

Authers: Farhad Shahram MD, Alireza Faridar MD1, Mohammad Ghaffari Hamedani MD, Abdolhadi Nadji MD1, Nassim Naderi MD, Niloofar Mojarad Shaee BS, Johannes J. Rasker MD, Fereydoun Davatchi MD

Abstract: Aim: To nd the possible role of plasma homocysteine level as a contributing factor in venous and arterial thrombosis in patients with Behcet’s disease (BD). Methods: In a case control study, two groups of BD patients were included: 47 with thrombosis and 49 without thrombosis. All patients fullled the International Study Group Criteria for BD and the conrming diagnostic procedures for vascular thrombosis were either Doppler sonography or angiography. Forty-nine controls were selected by ... سال انتشار: 2010
 

Pimecrolimus versus Placebo in Genital Aphthous Ulcers of Behcet’s Disease, Randomized Double-Blind Controlled Trial

Authers: Cheyda Chams-Davatchi, Behrooz Barikbin, Farhad Shahram, Abdolhadi Nadji, Maryam Moghaddassi, Maryam Yousefi, Fereydoun Davatchi

Abstract: genital aphthous ulcers of Behcet’s Disease (BD) are painful and usually resistant to local treatments. Pimecrolimus is an ascomycin macrolactam, used in inflammatory skin diseases. Objective: to find if Pimecrolimus could accelerate the healing of BD genital aphthous ulcers. Methods: Ninety patients with genital aphthous ulcers were enrolled. Only patients treated with colchicine alone were selected. All patients signed a written consent form. Patients were randomly assigned to pimecrolimus or placebo cream, applied twice daily for one week. ... سال انتشار: 2010
 

Effect of early treatment in polymyositis and dermatomyositis

Authers: Peyman Naji, Farhad Shahram, Abdolhadi Nadji, Fereydoun Davatchi

Abstract: Idiopathic inflammatory myopathies, dermatomyositis (DM) and polymyositis (PM) are rare but are potentially treatable. Aim: To compare the effect of early and late treatment in patients with PM and DM. Materials and Methods: The study included all the adult patients with definite diagnosis of PM or DM treated for at least 12 months. The patients were divided into two groups: Early Group - treatment within three months and Late Group - treatment after three months. ... سال انتشار: 2010
 

Mesenchymal Stem Cell Therapy for Knee Osteoarthritis. Preliminary Report of Four Patients

Authers: Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Mandana Mohyeddin, Farhad Shahram*, , Behrooz Nikbin

Abstract: Osteoarthritis is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells due to their multi-lineage potential, immunosuppressive activities, limited immunogenicity, and relative ease of growth in culture have attracted attentions for clinical use. The aim of this study was to look ... سال انتشار: 2010
 

Development of a Questionnaire for Identification of the Risk Factors for Osteoarthritis of the Knees, in developing countries. A pilot study in Iran and Bangladesh. An ILAR- COPCORD phase III study

Authers: Syed Atiqul Haq, Fereydoun Davatchi, Saeideh Dahaghin, Nazrul Islam, Aniruddha Ghose, Arvind Chopra, Zeng Quing Yu, I Dans, Johannes J. Rasker, John Darmawan

Abstract: Knee osteoarthritis (OA) is one of the most prevalent rheumatic disorders in Asia- Pacific. Identification of modifiable risk factors is important for development of strategies for primary and secondary prevention of knee OA. Objective: Developing a core questionnaire for identification of risk factors of knee OA at community level. Methods: Steps performed: 1) item generation from literature, existing knee OA questionnaires and patient focus group discussions. 2) Development of a preliminary APLAR-COPCORD English questionnaire. 3) Translation into ... سال انتشار: 2010
 

Detection of bone erosion in early rheumatoid arthritis: ultrasonography and conventional radiography versus non-contrast magnetic resonance imaging

Authers: Maryam Rahmani, Hosein Chegini, Seyed Reza Najafizadeh, Mohammad Azimi, Peiman Habibollahi, Madjid Shakiba

Abstract: Nowadays, there is a trend toward early diagnosis and treatment of rheumatoid arthritis (RA) especially in patients with early signs of bone erosion which can be detected by magnetic resonance imaging (MRI). The aim of following study is to compare the sensitivity and specificity of ultrasonography (US) and conventional radiography (CR) compared to MRI for early detection of bone erosion in RA patients. In 12 patients with RA diagnosis, 120 first to fifth metacarpophalangeal joints and 96 second ... سال انتشار: 2010
 

Bone density in patients with chondromalacia patella

Authers: Iraj Salehi, Shabnam Khazaeli, Parta Hatami, Mahdi Malekpour

Abstract: Chondromalacia of the patella is the most common cause of anterior knee pain in young women. The etiology of the disease is not well-understood but the initial lesion is a disorganization of collagenous structures. Since the disease is proposed to be due to generalized constitutional disturbance, we postulated that bony structures could also be involved. To investigate this hypothesis we measured the bone density of 286 patients with the diagnosis of chondromalacia of the patella during a 4-year ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

Rituximab in intractable ocular lesions of Behcet’s disease; randomized single-blind control study (pilot study)

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Mozhgan REZAIPOOR, Bahar SADEGHI-ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Massoomeh AKHLAGHI, Tahereh FAEZI, Nasim NADERI

Abstract: Ocular lesions, the main morbidity of Behcet’s disease (BD), are the most difficult to treat. The aim of this study was to evaluate the efficacy of rituximab. Methods: Inclusion criteria were retinal vasculitis and edema, resistant to cytotoxic drugs. Twenty patients were randomized to a rituximab group (RG) or cytotoxic combination therapy group (CCTG). Rituximab was given in two 1000-mg courses (15-day interval). Subjects received methotrexate (15 mg/weekly) with prednisolone (0.5 mg/kg per day). The ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

How to deal with Behcet’s disease in daily practice

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Massoomeh AKHLAGHI, Tahereh FAEZI, SADEGHI ABDOLLAHI

Abstract: Introduction: Behcet’s Disease (BD) is classified as a vasculitis, and progresses via attacks and remissions. BD is mainly seen around the Silk Road. The picture varies in different reports. For clinical descriptions, the data from the international cohort of patients (27 countries), will be used. Clinical manifestations: Mucous membrane manifestations were oral aphthosis seen in 98.1%, and genital aphthosis in 76.9% of patients. Skin manifestations were seen in 71.9% (pseudofolliculitis in 53.6% and erythema nodosum ... سال انتشار: 2010
 

Risk Factors of Blindness in Behcet’s Disease

Authers: Hormoz Chams, MD1, Fereydoun Davatchi, Amir Hossein Mahmoudi, Farhad Shahram, Cheyda Chams, Saeideh Dahaghein

Abstract: Purpose: To investigate long-term ocular manifestations of ocular Behcet’s disease (BD), and the causes for blindness Methods: In August 2008, at Shariati hospital of Tehran (Behcet unit) all files of the ocular BD patients from 1976 to 2008 who were legally blind (Visual acuity=20/200 or less) at least in one eye at the last visit and had at least three years of follow-up were reviewed and the desired informations were extracted. ... سال انتشار: 2010