Publications

 

Anxiety and depression in rheumatoid arthritis: an epidemiologic survey and investigation of clinical correlates in Iranian population

Authers: Ahmad‑Reza Jamshidi1 · Arash Tehrani Banihashemi1, 2 · Pedram Paragomi1 · Maryam Hasanzadeh1 · Mozhgan Barghamdi1 · Shima Ghoroghi1

Abstract: Psychiatric disorders occur in a considerable proportion of patients with rheumatoid arthritis (RA). This study was conducted in order to evaluate the prevalence of anxiety and depression in Iranian RA patients. In the cross sectional study, 414 RA patients were enrolled prospectively during a period of 6 months from RA clinic of Rheumatology Research Center. Beck’s and Cattell’s inventories were applied to investigate depression and anxiety in RA patients. RA activity was measured by Disease Activity Score and patients’ ... Publish year: 2016
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... Publish year: 2016
 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... Publish year: 2016
 

Adult Behcet’s disease in Iran: analysis of 6075 patients

Authers: Fereydoun DAVATCHI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Bahar SADEGHI ABDOLLAHI, Farimah ASHOFTEH, Zahra GHODSI, Negin MOHTASHAM and Farhad SHAHRAM

Abstract: This is an analysis of adult Behcet’s disease (BD) in Iran, from the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%). Patients: Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet’s Disease (ICBD). Adult BDs were patients who had their first ... Publish year: 2016
 

A RARE CYCLOPHOSPHAMIDE -ASSOCIATED LIVER TOXICITY IN A PATIENT WITH PAN-LIKE VASCULITIS: A CASE REPORT AND LITERATURE REVIEW

Authers: MAHMOOD AKBARYAN1, ZAHRA SOLTANI2

Abstract: Cyclophosphamide is an alkylating agent belongs to oxazaphosphorines. It can be prescribed both oral and intravenous and also in a wide ranges of dosage. However various reported side effects of the drug are the main reason to restrict the uses. Cyclophosphamide can be metabolized in the liver mostly by cytochrome p450 enzymes into to form 4-hydroxycyclophosphamide that has the chemotherapeutic characteristic. By metabolizing the parent molecule cytotoxic molecules can be derived such as acrolein which is ... Publish year: 2016
 

A Multidisciplinary Work-Related Low Back Pain Predictor Questionnaire: Psychometric Evaluation of Iranian Patient-Care Workers

Authers: Shojaei Sarallah1, Tavafian Sedigheh Sadat1, Ahmad Reza Jamshidi2, Wagner Joan3

Abstract: Study Design: Psychometric evaluation design. Purpose: Psychometric evaluation of a multidisciplinary work-related low back pain predictor questionnaire (MWRLBPPQ) of Iranians patient-care workers based on the social cognitive theory. Overview of Literature: Healthcare is one of the professions in which work-related musculoskeletal disorders are prevalent. The chronic low back pain experienced by patient caregivers can negatively impact their professional performance, and patient handling in a hospital is the main cause of low back ... Publish year: 2016
 

25 Years Old Women With Inflammatory Low Back Pain

Authers: Zahra Soltani and Fereydoun Davatchi

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological type of malignant lymphomas (approximately 30% of cases). DLBCL is highly curable through chemotherapy. Rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy as the most frequent of care for first - DLBCL therapy, improves long-term survival of patients effectively. Case report: A young female (25 years old) complained about pain in her right back for two years. She was suffering from backache with ... Publish year: 2016
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... Publish year: 2016
 

WHO-ILAR COPCORD study (stage 1, urban study) in Sanandaj, Iran

Authers: Nasrin Moghimi & Fereydoun Davatchi & Ezat Rahimi & Afshin Saidi & Naser Rashadmanesh & Solmaz Moghimi & Hoshyar Ghafori & Peiman Zandi & Negin Ahmadi & Hamed Ghafori & Mohsen Moghimi & Marjan hajiheshmati

Abstract: This study aims to conduct an urban Community Oriented Program for Control Of Rheumatic Diseases (COPCORD) study in Sanandaj (Kurdistan, Iran). Sanandaj with a population of 311,446 (2006 census), Caucasian of Kurdish subgroup, was selected as the field. Sanandaj was divided into 100 clusters and subjects were randomly selected from them (50 subjects from each cluster). The COPCORD study started on July 2011 and ended on June 2012. Of the households, 1,631 was visited and 5,830 persons were interviewed. ... Publish year: 2015
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... Publish year: 2015
 

Nicolau Syndrome in 29 Months Boy: Another Report of Iran

Authers: Mojtaba Fazel1, Parvin Akbar Asbagh2, Azadeh Afshin3*, Mamak Shariat4, Mahmoud Fazel5, Massumeh Akhlaghi5

Abstract: Nicolau syndrome (NS) is a very rare complication of intramuscular injections that leads to some degree of necrosis in skin, subcutaneous fat and muscles. The type of injected Drugs and wrong injection methods are the main factors for this iatrogenic syndrome. Here we report a 29 months boy, one of the Iranian children affected NS following the wrong intramuscular injection of Benzathine Penicillin. But he came back home without any major complication because of ... Publish year: 2015
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

Authers: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI2

Abstract: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... Publish year: 2015
 

HerbalmedicineIMODsuppressesLPS-inducedproductionofproinflammatorycytokinesinhumandendriticcells

Authers: Saeedeh Mirzaee1†, AgataDrewniak1†, RaminSarrami-Forooshani1, TanjaM.Kaptein1, FarhadGharibdoost2 and TeunisB.H.Geijtenbeek1*

Abstract: Traditional medicines thatstimulateormodulatetheimmunesystemcanbeusedasinnovativeapproachestotreatimmunologicaldiseases.TheherbalmedicineIMODhasbeenshowntostronglymodulateimmuneresponsesinseveralanimalstudiesaswellasinclinicaltrials.However,littleisknownaboutthemechanismsofIMODtomodulateimmunity.HerewehaveinvestigatedwhetherIMODmodulatestheimmunologicalfunctionofhumandendriticcells(DCs).IMODalonedidnotinduceDCmaturationnorproductionofcytokines.Notably,IMODdecreasedtheproductionofpro-inflammatorycytokinesIL-6,IL-12p70,andTNFαbyLPS-activatedDCsatbothmRNAandproteinlevelsinadosedependentmanner.Incontrast,treatmentwithIMODdidnotaffectLPSinduced-productionoftheanti-inflammatorycytokineIL-10.Furthermore,IMODinhibitedTcellactivation/proliferationbyLPS-treatedDCsandskewedT-cellsresponsestowardtheThelpertype2polarization.ThesedatastronglyindicatethatIMODhasapotentimmunomodulatoryabilitythataffectsTLRsignalingandtherebymodulatesDCfunction.InsightintotheimmunomodulatoryeffectofherbalmedicineIMODmayprovideinnovativestrategiestoaffecttheimmunesystemandtohelpcombatvarousdiseases. Keywords:IMOD,immune-modulation,LPS,pro-inflammatorycytokines,dendriticcells Publish year: 2015
 

Gender differences in Iranian patients with ankylosing spondylitis

Authers: Abtin Shahlaee & Mahdi Mahmoudi & Mohammad Hossein Nicknam & Elham Farhadi & Sasan Fallahi & Ahmad Reza Jamshidi

Abstract: Abstract Inequalities in features and severity of ankylosing spondylitis (AS) have been noticed between men and women, suggesting a possible influence of gender on disease phenotypes. Comparing disease features and characterization of gender differences in clinical features and medications could help elucidate the potential influence of gender on the severity of AS in patients. This study aims to assess the influence of gender on disease patterns in Iranian patients with AS. Three hundred and twenty patients diagnosed with ... Publish year: 2015
 

ملاس يگدنز كبس ذاختا رد روحم يروئت يشزومآ همانرب ريثأتينيلاب ييامزآراك هعلاطم كي :وناز زورترآ هب نايلاتبم رد

Authers: 217-209 :1393 زییاپ ،3 هرامش ،32 هرود ،ناريا يملاسا يروهمج يكشزپ ماظن نامزاس يملع هلجم

Abstract: یتلکسا ینلاضع متسیس هدننک ناوتان تلالاتخا نیرتلوادتم زا وناز یگدییاس :هنیمز ملاس يگدنز كبس ذاحتا .دوش یم لاتبم دارفا یمسج ییاناوتان و درد بجوم هک تسا نيرت مهم وناز زورترا يتظفاحم ياهراتفر هب نا�سر بيسآ ياهراتفر رييغت هلزنم هب يشزومآ همانرب ريثأت يسررب هعلاطم نيا زا فده .تسا لكشم نيا زا يريگ�شيپ هار.تسا وناز زورترآ هب نايلاتبم رد ملاس يگدنز كبس ذاختا رد روحم يروئت لاتبم ناراميب زا رفن 168 ... Publish year: 2015
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

Authers: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

Abstract: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... Publish year: 2015
 

c-Abl silencing reduced the inhibitory effects of TGF-b1 on apoptosis in systemic sclerosis dermal fibroblasts

Authers: Elham Karimizadeh1 • Farhad Gharibdoost2 • Nasrin Motamed1 • Saeideh Jafarinejad-Farsangi1 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

Abstract: It is generally accepted that the apoptosis of myofibroblasts is a crucial event in the normal wound healing. Delay in myofibroblasts apoptosis results in fibrotic diseases such as systemic sclerosis (SSc). Transforming growth factor-b1 (TGF-b1) is an important cytokine to induce fibroblasts differentiation into myofibroblasts. Cellular Abelson (c-Abl) is known as a TGF-b1- modulating molecule in fibrosis. The role of c-Abl, TGFb1, and their interaction in SSc myofibroblasts apoptosis has not yet been fully explored. The aim of this ... Publish year: 2015
 

Vitamin D deficiency in patients with Behcet’s disease

Authers: Seyedeh Tahereh Faezi*, Narges Ansari, Pedram Paragomi, Maassoumeh Akhlaghi, Majid Ghanavat and Fereydoun Davatchi

Abstract: Background: Behcet’s disease is an autoimmune, recurrent and multisystem disease. Vitamin D has immunomodulator role in immune system. So that vitamin D deficiency was reported in some autoimmune diseases. Behcet’s disease as a Silk Road disease is common in Iran. The aim of this study was to detect the serum level of 25(OH) vitamin D in Behcet’s patients and control group. Methods: In this case–control study, 112 Behcet’s patients as cases group and 112 ... Publish year: 2014
 

Treatment of low back pain: randomized clinical trial comparing a multidisciplinary group-based rehabilitation program with oral drug treatment up to 12 months

Authers: Sedigheh Sadat TAVAFIAN, 1 Ahmad Reza JAMSHIDI2 and Kazem MOHAMMAD3

Abstract: Background: This study aimed to examine the effects of a multidisciplinary treatment program on health-related quality of life of Iranian patients living with chronic low back, at 12 months follow-up. Methods: This study is an extended follow-up of an original randomized, controlled trial with registration number NCT00600197. In the present study 87 patients in an intervention group and 91 patients in a control group were assessed at 12 months follow-up. The intervention was a ... Publish year: 2014
 

The relationship between plasma homocysteine level and HLA-B51 in patients with Behcet’s disease: a case-control study

Authers: Soraya SHADMANFAR, 1, 2 Farhad SHAHRAM, 2 Abdolhadi NADJI, 2 Maassoumeh AKHLAGHI, 2 Seyedeh T. FAEZI, 2 Bahar SADEGHI-ABDOLLAHI, 2 Alireza FARIDAR, 2 Nima MADANCHI3 and Fereydoun DAVATCHI2

Abstract: Background: Various coagulation disorders have been reported to explain hypercoagulability state in Behcet’s disease (BD). A possible negative association between human leukocyte antigen (HLA)-B51 and increased homocysteine level has been suggested in a previous report from Iranian patients with BD. The aim of this study was to find any possible relationship between plasma homocysteine levels and HLA-B51. Methods: In a case-control study, BD patients (fulfilling the new International Criteria for BD) and controls (who had ... Publish year: 2014
 

Spectrum of Mutations of Familial Mediterranean Fever Gene in Iranian Population

Authers: Tayebeh Sabokbar1, 2, Ali Malayeri2, Cyrus Azimi2, Seyyed Reza Raeeskarami3, 4, Vahid Ziaee3, 4, Yahya Aghighi3, 4, Abbas Shakoori2, 5

Abstract: Familial Mediterranean fever is a genetic disease that is caused by the MEFV gene. Our study was based on clinical manifestations of recurrent attacks of fever and inflammation and distribution of MEFV mutations in an Iranian patient using a comprehensive mutation detection method. Methods: Eighty-five clinically diagnosed FMF patients from university hospitals who were referred to the Department of Genetics for molecular diagnosis of FMF. Results: Mutations in one allele and in both ... Publish year: 2014
 

Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients

Authers: Masoumeh Kheirandish , Seyedeh Tahereh Faezi , Pedram Paragomi , Maassoumeh Akhlaghi , Farhad Gharibdoost , Ashraf Shahali , Mahboubeh Ebrahimpour Fini, and Mahmood Akbarian

Abstract: Objectives . We aimed to evaluate the prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE) and explore their association with demographic and clinical features. Methods. In this cross-sectional study, 166 SLE patients in rheumatology center of Shariati hospital, Tehran University of Medical Sciences were enrolled. SLE disease activity index (SLEDAI) and Beck and Cattell inventories for evaluation of depression and anxiety were completed for each patient. Results. The mean age of patients was ... Publish year: 2014
 

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

Authers: Mina Doudkani-Fard1, Vahid Ziaee2, Mohamad-Hassan Moradinejad3 Mojtaba Sedaghat4, Mohammad-Taghi Haghi-Ashtiani5, Zahra Ahmadinejad6

Abstract: Background: Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis (RA). Evaluation of ... Publish year: 2014
 

Relationship between bone density and abdominal visceral fat in premenopausal overweight and obese Iranian women aged 30–50 years

Authers: Ahmad SALIMZADEH, 1 Maryam ABOLHASANI, 2, 3 Moslem SEDAGHATTALAB4 and Maryam MOGHADASI1

Abstract: Aim: The presence of a direct relationship between body mass index (BMI) and bone mineral density (BMD) is frequently reported. However, data on the relationship between visceral fat and bone density varies, with positive, negative or no relationship having been reported. This study aims to examine the relationship between abdominal visceral fat and BMD. Methods: A cross sectional study was carried out on 95 premenopausal, overweight and obese women aged 30– 50 years referred to ... Publish year: 2014
 

RAC1 single nucleotide polymor-phisms in Crohn’s disease

Authers: Mohammad TaheraNasser Ebrahimi DaryaniaMona HedayatbMohammad EslamianaElham Farhadic, dMahdi MahmoudieSamira ShirzadfMohammd Kazem Nouri TaromlouaMeghedi ChaharmahaligMohammad Hossein NicknamcMohammad BashashatihNima

Abstract: diseaseRac1 is a regulator for cellular motility, proliferation andtransformation. A recent showed that mutations of RAC1gene are associated with higher risk of inflammatory boweldisease (IBD). These mutations increase the expression ofRac1 protein and intriguingly, loss of Rac1 expression resultsin protection from colitis [1,2].Thus we conducted a case-control study on 67 patientswith Crohn’s disease (CD) and 78 healthy individuals toidentify whether there is any association between CD andsingle nucleotide polymorphisms (SNPs) ... Publish year: 2014
 

Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study

Authers: Arash TEHRANI-BANIHASHEMI, 1, 2 Fereydoun DAVATCHI, 1 Ahmad-Reza JAMSHIDI, 1 Tahereh FAEZI, 1 Pedram PARAGOMI1 and Mozhgan BARGHAMDI

Abstract: Aim: To estimate the prevalence of osteoarthritis (OA) of different joints in rural areas of Iran. Methods: From five villages of Tuyserkan County, 1565 individuals were randomly selected and were interviewed to complete the Community Oriented Programme for Control of the Rheumatic Diseases (COPCORD) Core Questionnaire. Among these cases 1192 cases with rheumatic complaints were examined by a rheumatologist and laboratory and radiology tests were performed if necessary for the diagnosis. Definition of OA ... Publish year: 2014
 

Evaluating the reliability of Persian version of ankylosing spondylitis quality of life (ASQoL) questionnaire and related clinical and demographic parameters in patients with ankylosing spondylitis

Authers:

Abstract: nkylosing spondylitis quality of life (ASQoL) is an instrument for assessing quality of life (QoL). The aims of this study were to assess the reliability of Persian version of ASQoL questionnaire and evaluation of QoL status and related factors in ankylosing spondylitis (AS). One hundred and sixty-three Iranian patients with AS who fulfilled modified New York criteria were enrolled. Patients were evaluated using questionnaires including demographic and clinical variables, Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index ... Publish year: 2013
 

Osteoporosis in Patients with Pemphigus Vulgaris before Steroid Therapy

Authers: S. Zahra Ghodsi1, 2, Farhad Shahram2, Maryam Daneshpazhooh1, Azam Saadatfar1, and Cheyda Chams-Davatchi1,

Abstract: Pemphigus Vulgaris (PV) is often complicated by osteoporosis. Although corticosteroid therapy undoubtedly plays a causative role, inflammation associated with PV may also contribute to osteoporosis. This study was designed to determine the prevalence of osteoporosis in patients with PV before corticosteroid therapy and to compare these findings with those reported previously in healthy volunteers. Newly diagnosed patients with PV who had not received systemic corticosteroids were enrolled. Bone mineral density (BMD) was measured both in ... Publish year: 2014
 

Polymorphism of killer cell immunoglobulin-like receptors (KIR) and their HLA ligands in Graves’ disease

Authers: Romina Dastmalchi • Ali Farazmand • Sina Noshad • Mohamad Mozafari • Mahdi Mahmoudi • Alireza Esteghamati • Aliakbar Amirzargar

Abstract: Killer immunoglobulin-like receptors (KIR) play a pivotal role in commencement of both innate and adaptive immunity. Dysregulation of KIRs is associated with an increased risk of autoimmune disorders. This study was designed to assess whether polymorphisms in KIR gene family and their respective HLA class I ligands confer protection or susceptibly to Graves’ disease (GD). Eighty patients with confirmed GD (cases) and 176 healthy unrelated subjects (controls) were recruited. Using a polymerase chain reaction sequence-specific primer directed method (PCR-SSP), presence ... Publish year: 2014
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... Publish year: 2014