Immunogenetic basis of resistance to ocular involvement in Behcet's Disease (BD).

Authers: B. Nikbin, F. Khossravi, F. Davatchi, H. Chams, C. Chams

Abstract: In a separate report we demonstrated that B5 cluster antigens acts as a leading factor for ocular injuries. The question is why in some patients, these antigens does not produce the same lesions. This may be due to a genetic factor(s) which determine resistance to ocular lesions. Two HLA antigens attracted our attention as possible factors. One from the class I (CW4), and the other from the class II (DQW1). DQW1 ... Publish year: 1988

HLA-B5 cluster in non ocular type of Behcet's Disease (BD).

Authers: F. Khossravi, A. Sarafnejad, B. Nikbin, M. Akbarian, F. Shahram, M. R. Hatef

Abstract: We have reported a 100% association of ocular type of BD with B5 cluster antigens. The HLA results of non ocular type shows respectively 30% and 40% of association with B5 and B5 cluster antigens. These results indicate that B5 cluster antigens are decreased in non ocular patients compared to 62% of normal population. Considering the etiologic fraction for B5 cluster in ocular type patients which was at its maximum ... Publish year: 1988

HLA-B5 in Behcet's Disease, relationship to symptoms, analysis of 543 cases.

Authers: M. Akbarian, F. Davatchi, B. Nikbin, H. Chams, C. Chams, M.R. Hatef, F. Shahram, Z. Aalami-Harandi, P. Mansoori

Abstract: Behcet's Disease (BD) has been found to be related to the first class HLA antigens, the B5. In Iran, B5 is present in 64% of BD patients versus 34% in normal population. The relative risk is 3.33. Uveitis has been demonstrated to be related to the presence of B5. in our study the posterior uveitis was present in 59% of patients with B5 versus 48% without it (p Publish year: 1988

Pathergy test in Behcet's Disease, relationship to disease symptoms: computer analysis of 391 cases.

Authers: C. Chams-Davatch, F. Davatchi

Abstract: Patients were divided in 2 groups of positive and negative pathergy test. 57 parameters including symptoms and paraclinical tests were analyzed seperately in the 2 groups and then compared to each other by the chi sqaure test (the fourfold table method). The following symptoms were seen more frequently in patients with a positive pathergy test: oral aphthosis in the beginning of the disease (p Publish year: 1986

Lesions cutaneo-muqueuse de la maladie de Behcet.

Authers: C. Chams, F. Davatchi, H. Chams, M. Akbarian

Abstract: 40 cas de maladie de Behcet ont ete etudies entre 1977 et 1985. Il s'agissait 1 hommes (62 %) et de 129 femmes (38 %). La moyenne d'age est de 25.5 ecart type de 9.1. 334 cas avaient des Iesions muqueuses (98 %). L'aphtose de etait presente dans 333 cas (97 %), I'aphtose genitale dans 245 cas (72%). ~f~es-avatent des lesions cutanees (74 %). Les pseudo-folliculites etaient !ntes dans 257 ... Publish year: 1986

The diagnostic value of skin hyper reactivity in Behcet's Disease

Authers: C. Chams, F. Davatchi, F. Baygan, H. Chams, M. Akbarian

Abstract: The skin hyper reactivity (SHR) as detected by the pathergy test is a common feature of Behcet's Disease (BD) in Middle East Countries and in Japan, but not in Western Countries. Yazici et al showed it's sensitivity and it's specificity. As the SHR in pathergy test is revealed by a pseudo follicu­litis, it may have the same significance as the spontaneous pseudo folliculitis (PF) of BD. Thus if a patient ... Publish year: 1985

Difference in male and female Behcet's Disease.

Authers: F. Davatchi, F. Baygan, H. Chams, C. Chams, M. Akbarian

Abstract: In 225 patients with definit Behcet's Disease I5 clinical and 5 paraclinical parameters (CBC,ESR, urinalysis,B5,Pathergy test) were statistically analyzed. The chi-square test (X2) was used for the analysis of difference and P values smaller than 0.05 were accepted as a significative difference between male and female patients. Ophthalmologic manifestations were more frequent in males (80%) than females (63%),X2=7.91,0.01> P> 0.001.The difference concern specially the uveitis (73% males,55% females,X2=7.65,0.01>P>0.001). In osteoarticular ... Publish year: 1985

Evaluation of the 1982 American Rheumatism Association revised criteria for the classification of systemic lupus erythematosus.

Authers: F. Davatchi, C. Chams, M. Akbarian

Abstract: The sensitivity of the 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) was 90% according to Cohen et al (1), who assembled those criteria. This high degree of sensitivity was not found by other investigators (2-6). The1982 revised criteria proposed by Tan et al (7) showed a 96% sensitivity among their patients. In a recent work, Levin et al (8) compared the 1971 and the 1982 American Rheumatism ... Publish year: 1985

Behcet's Disease: review of 100 cases. Report of juvenile, Familial, and unilateral forms.

Authers: H. Chams, F. Davatchi, F. Baygan, C. Chams, M. Contractor

Abstract: In this case study 100 patients with confirmed Behcet's disease have been in reviewed. The following manifestations were observed: buccal aphthous ulcerations 98 per cent, genital ulcerations 63 per cent, positive Behcetine test in 81 per cent, ocular involvement 80 per cent, positive HLA-B5 74 per cent, skin lesions 68 per cent, articular manifestations 63 per cent, digestive problems 21 per cent, thrombophlabitis­ of the extremities 17 per cent, neurologic ... Publish year: 1984

Systemic lupus erythematosus in Iran, analysis of 156 cases.

Authers: F. Davatchi, C. Chams, H. Atarian, F. Bayegan, M. Akbarian

Abstract: From 1975 to 1982, 156 patients with systemic lupus erythematosus were seen. 90 % were women, 69 % were aged between 10 to 30 years. 63 % had a deterioration of their general condition. Skin disorders was found in 92 % with 78 % of facial erythema, 46 % photosensitivity, 56 % Alopecia, 9 % Raynauds phenomenon and 19 % oral lesions. Osteoarticular changes were detected in 84 % renal ... Publish year: 1983

Levamisol in the treatment of Behcet's Disease

Authers: F. Davatchi, F. Baygan, H. Chams, C. Chams, M. Contractor

Abstract: 35 patients with the “complet form“ of Behcet’s disease, according to the criteria of Behcet’s Disease Research Committee of Japan were selected for study. The choice of complet forms make possible to have a more homogenous group of patients to evaluate the effect of levamisole on the major symptoms of the disease. The patients were treated with levamisole at least for 3 to 6 months, they had no cytotoxic ... Publish year: 1983


Authers: F. Davatchi

Abstract: INTROUCTION: Ophthalmologic manifestations are the major cause of morbidity in Behcet's Disease. If not treated, they usually progress toward sever loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents. MATERIALS & METHOD: In an open, non randomized, control study, Pulse Cyclophosphamide (PCP), low dose pulse cyclophos­phamide (LDP), weakly methotrexate (MTX), chlorambucil (CHL), oral cyclophosphamide (OCP), and cyclosporine A (CYA) were used in a standard protocol for 778 ... Publish year: 1981

Histocompatibility antigens (HLA) in rheumatic diseases in Iran

Authers: F. Davatchi،B. Nikbin

Abstract: One hundred and sixty-six patients with different forms of rheumatic diseases were tissue typed for 26 antigens of the A and B locus of the HLA system, using a modified KN cytotoxicity test. Among 25 patients with confirmed ankylosing spondylitis, 23 had HLA B27 (92 per cent), compared to 2.5 per cent in the normal controls. This confirms the strong association of HLA B27 with ankylosing spondylitis. Eight patients had ... Publish year: 1977