تالیفات

 

ORIGIN AND OUTCOME OF MACULAR EDEMA IN OCULAR-BEHCET.

Authers: H. Chams, A. Lashei, A. Sadeghi-Tari, F. Davatchi, F. Shahram. C. Chams

Abstract: The chronic macular edema, frequent in ocular Behcet's disease, is a treat to the visual outcome of the patients. We have investigated the origin, risk-factors and the outcome of macular edema in patents under immunosuppressors and corticosteroid therapy. This is a retrospective, case series study. In 1999,seventeen patients of the Behcet's clinic of Shariati hospital of Tehran who had macular edema were consecutively selected and included in the study. They were ... سال انتشار: 2002
 

The Impact of the Treatment Delay on the Outcome of Vision in Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ... سال انتشار: 2002
 

THE INFLUENCE OF PATHERGY TEST ON THE ACCURACY OF DIFFERENT DIAGNOSIS CRITERIA FOR BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ... سال انتشار: 2002
 

RHEUMATIC DISEASES IN A SINGLE FAMILY SET UP; "REPORT OF SIMILAR CASES IN FOUR FAMILIES".

Authers: N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Background: The gene effect in pathogenesis of Rheumatic Diseases is well known, but the exact mode of transmission is not clear. In this report we present similar diseases occurred in two generations and in siblings. Methods: We overviewed the medical charts of second member of the family, according to the family history of the index patient. Results: Family I: Discoid Lupus was diagnosed in an eight years old girl whose father had ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

THE ORAL AND RADIOLOGICAL MANIFESTATIONS OF SYSTEMIC SCLEROSIS IN IRANIAN PATIENTS.

Authers: F. Gharibdoost, R. Nadjafizadeh, M. Akbarian, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi.

Abstract: Objective: Oral involvement is one of the most important manifestations in systemic sclerosis. We studied clinical and radiological presentations of patients with systemic sclerosis in IRAN. Methods: This study is a prospective case series on forty patients with systemic sclerosis (29 limited & 11 diffuse form) according to ACR (American College of Rheumatology) criteria, referred to Rheumatology Research Center from 2000-2001. For every patient, 41 data surveyed. Results: The mean age of ... سال انتشار: 2002
 

Clinical Manifestattion Of Behcet’s Disease.

Authers: A. Jamshidi, F. Shahram, A. Nadji, H. Chams, M. Akbarian, F. Gharibdoost, C. Chams, F. Davatchi

Abstract: Objectives: Behcet's disease (BD) is a multi-system disease. We present here the various clinical aspects of BD based on the data of 4586 Iranian patients. The male to female ratio was 1.17/l. The mean age at the onset of the disease was 26 yr (SD:9.6, CI:0.3). The mean disease duration was 9 yr (SD:7), and the mean follow up time was 3 yr (SD:3.8). As the first manifestation of the ... سال انتشار: 2001
 

THE EFFECT OF COMBINED DRUG TREATMENT USING CHLOROQUINE AND METHOTREXATE ON THE STATUS OF ANTIOXIDANT CAPACITY OF PLASMA IN RHEUMATOID ARTHRITIS.

Authers: S. Sorooh. P. Pasalar, M. Samini, H. Tootoonchi, A. Nadimifarokh

Abstract: Introduction: Oxygen free radicals that are generated mainly through the phagocytic activity of the polymorphonuclear leucocytea have been implicated as mediators of tissue damage in patients with rheumatoid arthritis (RA). Accordingly low levels of antioxidants, which increase free radical activity, are clearly associated with an increased risk of RA. Methods: Of 24 patients who entered the study 14 patients were excluded because they failed regular follow up. The analysis was ... سال انتشار: 2001
 

EXPERIENCE IN IRAN WITH SPECIAL REFERENCE TO BEHCETS DISEASE (BD).

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Pattern of Rheumatic Diseases in Iran: They have the same frequency and the same pattern as in Western countries. A study from 1993 demonstrated a prevalence of 32.6% among adults (31.4% in the USA, Cunningham 1984). Inflammatory disorders counted for 11% of all rheumatic diseases. The ratio of RA to AS was 8/1 (7/1 in USA), and SLE to Scleroderma 3.5/1 (3.6/1 in USA). Psoriatic arthritis and Reiter's syndrome were ... سال انتشار: 2001
 

THE ACCURACY OF IBDDAM (IRAN BEHCET'S DISEASE DYNAMIC ACTIVITY MEASURE) IN THE TREATMENT EVALUATION OF BEHCET'S DISEASE.

Authers: A. Jamshidi, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, C. Chams, F. Davatchi

Abstract: Introduction: Behcet's Disease (BD) is characterized by recurrent attacks and remissions, making difficult the assessment of the treatment's result. Moreover, the remission period between the attacks is not the same and may vary from one attack to another. The attack periods are not always the same and may vary in severity, or extent of organ involvement. Iran Behcet's Disease Dynamic Activity Measure (IBDDAM) takes in account all of these parameters ... سال انتشار: 2001
 

Immunopathogenesis Of Behcet's Disease.

Authers: F. Shahram, F. Davatchi.

Abstract: Objectives: The etiology and pathogenesis of Behcet's disease (BD) are still unknown. It seems that in a special genetic background exogenous or endogenous antigen(s) acts as trigger in up regulating and presenting the pathogenic epitope. The immune system reacts in an abnormal way, by inducing a cascade of cytokines and chemokines to stimulate innate immune responses, leading to the lesions of the disease. Genetic background: The major susceptibility gene is the ... سال انتشار: 2001
 

­LARGE VESSEL MANIFESTATIONS OF BEHCET’S DISEASE,REPORT OF 377 CASES.

Authers: F. Shahram, A. Nadji, M. Akbarian, A. Jamshidi, F. Gharibdoost, F. Davatchi

Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET'S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ... سال انتشار: 2001
 

Cardiac Involvement in Behcet's Disease, A Case Control Study.

Authers: F. Shahram, M. Eslami, B. Shakoori, M. Haydari, A. Nadj, A. Jamshidi, F. Davatchi

Abstract: Background: Cardiac involvement is not a common feature of Behcet's disease (BD), but may be a sign for poor prognosis. There are only few case reports in the literature and the prevalence of cardiac involvement in BD is not exactly known. Our study was designed to find the prevalence and characteristics of cardiac involvement in Iranian patients with BD. Methods: All new cases referred to Behcet's clinic ... سال انتشار: 2001
 

Ocular Lesions Of Behcet's Disease.

Authers: H. Chams, F. Shahram, A. Jamshidi, A. Nadji, F. Davatchi

Abstract: Objectives: The ocular manifestations of Behcet's disease (BD) are very frequent involving approximately 60% of BD patients. These lesions consist mainly of uveitis (anterior, posterior, or panuveitis that are present in almost all the BD patients with ocular involvement) and necrotizing vasculitis of the retina. In a randomized survey carried on 1812 patients with Ocular-Behcet the prevalence of different ocular signs were as follow: Hypopion 8.7%, glaucoma 8.5%, cataract 70%, ... سال انتشار: 2001
 

SACROILIITIS IN BEHCET'S DISEASE, A RADIOLOGIC STUDY.

Authers: A. Nadji, F. Shahram, M. Shabani, A. Jamshidi, L. Shenavar, F. Davatchi

Abstract: Introduction: The association of Behcet's disease (BD) and ankylosing spondylitis (AS) is still a controversial subject. As the presence of sacroiliac joint (SIJ) involvement is an essential criterion in the diagnosis of AS, we decided to determine the prevalence of SIJ involvement in BD and compare it with control group. Materials & Methods: We selected randomly 199 BD patients and 168 non-­BD cases (CG), in a 12 month period (between April ... سال انتشار: 2001
 

The Study Of Osteoporotic Femoral Neck Fractures In The Hospitals Of Tehran In 1380.

Authers: F. Gharibdoust, H. Golshahi, R. Kiani, A. Mohammadi Rad, S. Nafei

Abstract: AIM and BACKGROUND: Osteoporosis is a health growing problem among senile .About 25 millions of people in the USA are suffering from osteoporosis who are dominantly women .The probability of women to men ratio is 5 to 1. There are more than 1.5 millions bone fractures because of osteoporosis that 300000 of them are at hip, 200000 at wrist and 500000 at vertebrae column. Hip fracture has the highest mortality ... سال انتشار: 2001
 

Treatment of Ocular Lesions of Behcet’s Disease.

Authers: F. Davatchi, F. Shahram, H. Shams, A. Jamshidi

Abstract: Purpose: Cytotoxic drugs are the main therapeutic agents. A comparative study of 8 different therapeutic methods in 1220 cases is presented here. Materials & Methods: In an open, non-randomized control study, Pulse Cyclophosphamide (PCP), low dose PCP (LDP), oral cyclophosphamide ( OCP), weakly methotrexate ( MTX), chlorambucil ( CHL), cyclosporine A ( CYA), azathioprine (AZA), and combination therapy with LDP and MTX (COM) were used. Mean Duration: Ocular manifestations in months. FU: ... سال انتشار: 2001
 

Is acne vulgaris seen more often in Behcet Disease than in the normal population?

Authers: C. Chams-Davatchi, F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi,

Abstract: Background: In the literature, some of the skin pustular lesions of BD resembling the pustular lesion of acne vulgaris (AV) was called acneiform lesion of BD. It was suggested that AV was seen more often in BD than in normal population. AV is a common and very frequent skin lesion. The lesions are polymorphic, and are non­inflamed (closed or open comedones) or inflamed (papules, pustules, nodules). Objectives: To find if ... سال انتشار: 2000
 

Behcet's Disease and Malignancy, Report of 10 cases.

Authers: F. Shahram, S. Daneshmandi, N. Bayan, A. Nadji, M. Akbarian, F. Davatchi

Abstract: Introduction: Despite the well-established association of malignancy and autoimmune diseases, malignancy seems to be infrequent in Behcet's Disease (BD). The evidence for neoplasm in BD is derived primarily from case reports (only 19 cases in the literature). This study was designed to find the occurrence of malignant disorders in a large group of patients with BD, and their characteristics. Patients & Methods: We reviewed the medical records of all patients with ... سال انتشار: 2000
 

Behcet's Disease in Afghan immigrants of Iran; Report of 12 cases.

Authers: F. Shahram. F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Behcet's Disease (BD) is mainly seen in the countries along the Silk Rout. Among Asian countries, there is no data from Afghanistan on the clinical features of BD. Near 2 million Afghan immigrants live in Iran. This is a report on the clinical features of the disease in them with a comparison to the Iranian patients. Patients & Methods: All Afghan patients with BD referred to our BD unit ... سال انتشار: 2000
 

Intermediate Term Results Of Combination Therapy With Low Dose Pulse Cyclophosphamide And Methotrexate In Ocular Lesions Of Behcet’s Disease.

Authers: F. Shahram, H. Chams, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian

Abstract: Introduction: In a preliminary report to the 8th International Congress on Behcet’s Disease (BD) in 1998, we showed the efficacy of combination therapy with low dose pulse Cyclophosphamide (LDP) and Methotrexate (MTX) in posterior uveitis (PU) and retinal vasculitis (RV) of BD. We present here our experience with more patients and a longer follow up. Patients & Methods: BD Patients who were on the association of LDP and MTX due ... سال انتشار: 2000
 

Cardiac involvement in Scleroderma (SCL).

Authers: H. Abbasi, F. Gharibdoost, Sh. Shirvani, F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, M. Akbarian.

Abstract: Purpose: Cardiac involvement is not a common feature of the scleroderma, but may be important. The aim of this study was to find the frequency and the characteristics of cardiac involvement in sclroderma. Methods: Our cases were selected consecutively from 1997 to 1999, according to the American College of Rheumatology criteria. A complete cardiac examination (clinical, electrocardiography, chest X-ray, echocardiography, exercise test) was performed for all patients. These data were ... سال انتشار: 2000
 

OUTCOME MEASUREMENT OF TYPE IV SYSTEMIC LUPUS NEPHRITIS BY CLASSIFICATION AND REGRATION TREE (CART).

Authers: S. Soroosh, M. Akbarian, F. Davatchi, F. Shahram, A. Nadji, F. Gharibdoost, A. Jamshidi

Abstract: The prognosis of Systemic Lupus Erythematosus depends partly on renal involvement. Lupus nephritis has evolved from a frequently terminal process such as type IV lupus nephritis according to WHO classification to one in which a fairly normal quality of life and good outcome are possible. The aim of this study was to try to predict the short-term outcome of type IV lupus nephritis by looking at the disease variables before ... سال انتشار: 2000
 

Classification of muco-cutaneous lesions of Behcet's Disease.

Authers: C. Chams-Davatchi, F. Davatchi, F. Shahram, A. Nadji, H. Chams, A. Jamshidi

Abstract: Introduction: The diagnosis of Behcet's Disease (BD) is based on clinical criteria. Muco-cutaneous symptoms are the most important among them. Materials and Methods: From 1992 to 1999 we screened systematically all patients attending the Behcet's Disease Research Unit for muco cutaneous lesions. Only recurrent lesions were taken in consideration. Results: Mucous-membrane lesions: 1- Oral aphthosis was seen in 96.1%+ 0.6 of patients. The separation in major and minor aphthosis has no interest. ... سال انتشار: 2000
 

CLASSIFICATION TREE AS PREDICTOR OF TYPE IV WHO KIDNEY INVOLVEMENT, USING CLINICAL AND LABORATORY TESTS, IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).

Authers: A. Hadjabbassi. M. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Purpose: To use clinical and laboratory tests instead of kidney biopsy for the diagnosis of type IV WHO renal involvement in SLE. Methods: Patients with SLE were divided in two groups according to their kidney biopsy: type IV WHO (110 patients) and other forms (98 patients). Each group was further divided in two groups: the learning sample and the validation ample. The classification and regression tree method was used for the ... سال انتشار: 2000
 

On going epidemiological survey on Behcet's Disease in Iran; Tendency toward milder forms of the disease.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Iran is among the countries with high prevalence of Behcet's Disease (BD). The epidemiological survey on different aspects of the disease has been continuously carrying out since 1975 in our center. The aim of this study was to find if the characteristics of the disease are changing through the time. Patients & Methods: In a cohort of 4130 patients with BD, registered at our BD unit during the past 25 ... سال انتشار: 2000
 

Intermediate term results of combination therapy with low dose pulse Cyclophosphamide and Methotrexate in ocular lesions of Behcet's Disease.

Authers: F. Shahram. H. Chains, F. Davatchi, A. Nadji, A. lamshidi, M. Akbarian

Abstract: Introduction: In a preliminary report to the 8'" International Congress on Behcet's Disease (BD) in 1998, we showed the efficacy of combination therapy with low dose pulse Cyclophosphamide (LDP) and Methotrexate (MTX) in posterior uveitis (PU) and retinal vasculitis (RV) of BD. We present here our experience with more patients and a longer follow up. Patients & Methods: BD Patients who were on the association of LDP and MTX due to ... سال انتشار: 2000
 

Pulse Cyclophosphamide for Ocular Lesions of Behcet's Disease: double blind crossover study.

Authers: F. Davatchi, H. Chams, F. Shahram, M. Akbarian

Abstract: Introduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are thought to be effective, but no control study has yet been done to show their efficacy. This study was designed to evaluate the short-term efficacy of pulse cyclophosphamide (PCP) in a randomized double blind control study. Materials & methods: PCP was used as lg per square meter of body ... سال انتشار: 2000