تالیفات

 

METHOTREXATE FOR OCULAR LESIONS OF BEHCET'S DISEASE. COHORT STUDY ON 262 PATIENTS.

Authers: F. Davatchi, F. Shahram, H. Chams. M. Akbarian, A. Nadji. F. Gharibdoost, C. Chams. A. Jamshidi, S. Soroosh

Abstract: INTRODUCTION: Ocular lesions of Behcet's Disease (BD) progress usually toward severe loss of vision or blindness, if not aggressively treated. Cytotoxic drugs are the main therapeutic arsenals used for it: Low dose methotrexate (MTX) by its safety and its efficacy is one of the best therapeutic choices. MATERIALS &METHODS: MTX was used as 7.5 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. Upon the suppression of the inflammatory reaction, prednisolone ... سال انتشار: 1998
 

Pulse Cyclophosphamide for ocular Manifestations of Behcet's Disease. Cohort study on 283 patients.

Authers: F. Davatchi, F. Shahram, H. Chams, M. Akbarian, A. Nadji, F. Gharibdoost , A. Jamshidi

Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) usually progress toward severe loss of vision or blindness, if not aggressively treated. The aim of this study is to evaluate the efficacy of Pulse Cyclophosphamide (PCP) in a cohort study. Methods: This study includes all patients treated with PCP from 1986 to 1998, for active PU and or RV. PCP was administered as Ig cvclophosphamide/m2/body surface, once per month. Prednisolone was given ... سال انتشار: 1998
 

The comparison of Clinical Manifestations between Scleroderma and overlap Syndrome (Polymyositis with Scleroderma).

Authers: F. Gharibdoost, A. Nadji, M. Akbarian, F. Shahram, A. Jamshidi, F. Davatchi

Abstract: The objective of this study was to compare the clinical manifestations of scleroderma(Scl) and overlap syndrome(Scl/PM). Seventy four patients with thirty five months symptoms duration of scleroderma (sixty five women, nine men) and fifteen with thirty two months symptoms duration of overlap (nine women , six men) were studied over a period of 8 years. The mean age at the disease onset was 31.8 years in Scl and 31.6 years ... سال انتشار: 1998
 

Vascular Involvement In Behcet’s Disease: Report Of 323 Cases.

Authers: A. Nadji, F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A. Jamshidi

Abstract: Introduction: Vascular involvement, as a hallmark of Behcet’s disease (BD), involves arteries and veins of all size and may be a poor prognostic sign. Like the other manifestations of the disease, its prevalence varies widely according to the reports from different parts of the world (7.7 to 60%). The difference may be due to ethic variation or environmental factors. The aim of this study is to find the characteristics of ... سال انتشار: 1998
 

Vasculitis in Ocular Lesions Of Behcet’s Disease, Impact on Outcome.

Authers: H. Chams, F. Shahram, F. Davatchi, A. Nadji, M. Akbarian, C. Chams

Abstract: Introduction: Ocular lesions are the leading cause of morbidity in Behcet’s disease (BD). Many factors contribute to the loss of vision in BD, as uveitis, retinal vasculitis, and their secondary complications such as cataract, hemorrhage, vessel necrosis, neovascularization, optic atrophy, etc. The purpose of this study was to determine the impact of retinal vasculitis on the evaluation of ocular Behcet’s (OB) and its outcome after an early or late treatment. Materials & ... سال انتشار: 1998
 

BEHCET'S DISEASE – ANALYSIS OF 3443 CASES.

Authers: F. Davatchi; F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, C. Chams, H. Chams, A. Jamshidi

Abstract: Behcet's Disease (BD) is classified among the Vasculitides. It is characterized by mucocutaneous and ophthalmologic manifestations and seen mostly in the Northern Hemisphere and in countries along the silk road. The characteristics of BD are presented here in a nation wide analysis of 3443 patients in Iran over a 21 year period. There was a slight male preponderance M.F ratio 1.4:1 (53.3% male/46.7% female). The mean age of onset was ... سال انتشار: 1997
 

Outcome of Patients With Ocular Lesions of Behcet's Disease (BD) Non Responding to Classical Treatments.

Authers: F. Davatchi, F. Shahram, F. Gharibdoost, M. Akbarian, A. Nadji, H. Chams, C. Chams

Abstract: Introduction: We reported last year, during the ACR annual meeting, the result of different treatment modalities for ocular lesions of BD in 856 patients. We showed that pulse cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), oral cyclophosphamide (OCP), weakly methotrexate (MTX), chloambucil (CHL), and cyclosparine A (CYA) had all the same efficacy. The percentage of the eyes aggravated (visual acuity) despite the treatment was: For PCP: 21%, LDP: 22%, OCP: ... سال انتشار: 1997
 

Polymyositis in Iran, analysis of 124 patients.

Authers: A. Jamshidi, A. Nadji, F. Gharibdoost, M. Akbarian, F. Shahram, F. Davatchi

Abstract: AIM: The aim of this study was to assess the demography of Polymyositis in Iran. Methods: In the past 20 years, we had seen 124 patients in Rheumatology Research Center. All patients were classified by the American College of Rheumatology classification criteria. Ninety five items were checked for every patient. All patients were followed regularly and the data were updated at each visit. Results: Seventy one patients were female. The female to ... سال انتشار: 1997
 

Polymyositis in Iranian children, analysis of 47 cases.

Authers: F. Gharibdoost, A. Nadji, M. Akbarian, F. Shahram, A.R. Jamshidi, N. Shafaie, F. Davatchi

Abstract: Aim: The aim of this study was to assess the demography of polymyositis in Iranian children. Methods: 47 children classified by the ACR Criteria as having polymyositis were studied. 95 items were checked for every patient. They were followed regularly and the data were updated at each visit. Results: Thirty patients were female (64%). The acute presentation of the disease was seen in 10%. The manifestations at the onset of ... سال انتشار: 1997
 

SCLERODERMA IN IRAN, ANALYSIS OF 350 PATIENTS.

Authers: F. Gharibdoost, M. Akbarian; F. Shahram, A. Nadji, A. Jamshidi, R. Nadjafizadeh, F Davatchi

Abstract: Aim: The aim of this study was to determine the clinical and the laboratory features of scleroderma in Iranian patients. Methods: This is a prospective study done on 350 patients from 1975 to 1995. The diagnosis of scleroderma was based on the clinical and the skin biopsy. One hundred clinical and laboratory data were completed for every patients . Results: The mean age was 29.7 years with a standard deviation (SD) of ... سال انتشار: 1997
 

Scleroderma in Iranian children.

Authers: N. Shafaie, F. Gharibdoost, M. Akbarian, F. Shahram, A. Nadji, A.R. Jamshidi, F. Davatchi

Abstract: Scleroderma may occur in childhood with different characteristics. The present study shows the picture of scleroderma in Iranian children and compares the characteristics in children and adults. Methods: 56 scleroderma patients under 16 were compared with 217 adult scleroderma seen since 1975. Data were compared with Chi square test. Results: Girls were 44 (79%) and boys 12. The initial presentation was: Raynaud's phenomenon 68%, skin edema 27%, limb skin sclerosis 66%, ... سال انتشار: 1997
 

SLE IN IRAN, ANALYSIS OF 1310 CASES.

Authers: M. Akbarian, F. Shahram, F. Gharibdoost, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Aim: The aim of this study was to assess the demography of SLE in Iran. Methods: In the past 20 years, each patient referred to the Lupus Unit had a computerized form with 266 items. All patients were followed regularly and the data were updated at each visit. Results: We have seen 1310 SLE patients with the following characteristics: The mean age was 24 years, females 89.5%, males 10.5 %, fever 58%, ... سال انتشار: 1997
 

CLINICAL AND LABORATORY MANIFESTATIONS OF THROMBOCYTOPENIA IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Authers: I. Salehi., M. Akbarian., F. Shahram., F.Gharibdoost., A. Nadji., A. Jamshidi, F. Davatchi

Abstract: In systemic lupus eryThematosus (SLE) various antibodies are produced against cells including platelets and result in thrombocytopenia. !n the literature, the incidence of thrombocytopenia varied from 7% to 52%, in seven series of SLE patients with a mean cumulative percentage of 14.5% (1-5 ). SLE patients referred to the Lupus Unit of the Rheumatology Research Center. Tehran University for Medical Sciences. (Shariati Hospital) during the period of 1975 to 1977 ... سال انتشار: 1997
 

THE 1996 SURVEY OF BEHCET'S DISEASE IN IRAN, STUDY OF 3153 CASES.

Authers: F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A. Nadji, A. Jamshidi, H. Chams

Abstract: Behcet's disease (BD) is not ran in Iran. The annual incidence is around 345 patients for a population of 60 millions. The male/female ratio is 1. 13. The mean age at the onset of the disease is 26.2+9.7 years (CI at 95%=0 .4). The prevalence of clinical signs were as follow: Mucous membrane lesions 96%+0.7 (oral aphthosis 95.7%, genital aphthosis 64%); skin lesions 74%±I.5 (pseudofolliculitis 66%, erythema nodosum 23%): ocular ... سال انتشار: 1996
 

APLAR validation of Behcet’s disease (BD) diagnosis criteria, Iran experience.

Authers: F. Davatchi, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, C. Chams, H. Chams

Abstract: Considering that the majority of BD patients are from APLAR (Asia and Pacific League of Associations for Rheumatology) countries any diagnosis criteria for BD must have an adequate accuracy in these countries. The APLAR subcommittee for Behcet's Disease has set a prospective study to assess the accuracy of the existing diagnosis criteria. China, Iran, Japan, and Korea, the major countries with BD are participating to this study. The data from ... سال انتشار: 1996
 

Audiovestibular involvement in Behcet’s Disease (in patients with disease duration of more than 5 years).

Authers: F. Shahram, F. Sabeti, F. Davatchi, M. Khalessi, M. Akbarian, N. Shariati

Abstract: Introduction: We have previously shown that audio vestibular involvement is not frequent in early Behcet's disease (BD) at the time of diagnosis. This study was designed to clarify ­the frequency of audio vestibular involvement in patients with more chronic disease. Materials 8 Methods: We studied 60 BD patients with a disease duration of at least 5 years Patients were compared in a prospective study, to 28 controls (age and sex ... سال انتشار: 1996
 

Clinical Features of Behcet’s Disease in Children: A Collaborative Study of 86 cases.

Authers: I. Kone’-Paut, S. Yurdakul, S. Bahabri, N. Shafae, S. Ozen, H. Ozdogan, JL. Bernard

Abstract: We collected retrospectively clinical informations about a large series of 86 patients up to 16y of age, from 4 countries: Turquey (43), France (22), Saudi Arabia (11). Iran (10). All cases were first reviewed then 53 of them were selected according to the criteria of the International study group for BD. Statistical analysis: X2 square test and two tailed Fisher exact test. Descriptive data: males 45, females 41, sex ratio ... سال انتشار: 1996
 

Behcet’s disease and pregnancy.

Authers: A. Nadji, F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A.R. Jamshidi

Abstract: Introduction: Behcet's disease (BD) is a multisystem disorder with potential ability to influence pregnancy outcome. Changes in the BD may also occur during pregnancy. This study was designed to find the effect of pregnancy on BD and the outcome of pregnancy. Materials & Methods: We analyzed 59 pregnancies in 54 women with BD. The disease activity during pregnancy and in the 6 month period both before pregnancy and after delivery were ... سال انتشار: 1996
 

Outcome analysis of ocular lesions in Behcet’s disease with six different therapeutic methods.

Authers: F. Davatchi, F. Shahram, F. Gharibdoost, M. Akbarian, A. Nadji, H. Chams, C. Chams

Abstract: Introduction: Ocular lesions are the major cause of morbidity in Behcet's Disease. If not treated, they usually progress toward severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic arsenal used for this condition. Materials & Methods: in an open, non randomized control study. Pulse Cyclophosphamida (PCP), low dose pulse cyclophosphamide (LDP), oral cyclophosphamide (OCP). weakly methotrexate (MTX), chlorambucil (CHL), and cyclosporine A (CYA) were used in a standard ... سال انتشار: 1996
 

Behcet’s disease treatment.

Authers: C. Chams-Davatchi, F. Davatchi, F. Shahram

Abstract: There is not yet an effective treatment for all lesions of Behcet's disease and for all patients with Behcet's disease. The highest morbidity is from the ocular lesions. The mortality, although rare, is due to neurological and pulmonary involvement. Thrombosis of the large veins and arteries, also rare, may lead to morbidity and mortality. In daily practice, the best treatment for muco cutaneous lesions is colchicine. Thalidomide may be efficient ... سال انتشار: 1996
 

Proposed ocular Behcet therapeutic scoring and activity/chronicity ratio.

Authers: H. Chams, F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A. Nadji, S. Chams

Abstract: The aim of this study is to propose a scoring system to determine the activity of the eyes, and to evaluate our medications in the treatment of ocular inflammation and vasculitis in Behect's disease (BD). Eleven activity and 5 chronicity (constant) parameters are scored from zero to 4 to consider the condition of each eye in Oculo-Behcet's disease. Both parameters are considered in our therapeutic scoring. The activity variables are: Episcleritis and/or ... سال انتشار: 1996
 

Cyclosporine in severe Ocular Lesions of Behcet’s Disease.

Authers: F. Shahram, F. Davatchi, H. Chams, M. Akbarian

Abstract: Introduction: There are several reports of good effects of Cyclosporine A (CsA) in the treatment of Behcet's disease (BD). We studied the long term effect of CsA in prospective open clinical trial on posterior uveitis (PU) and retinal vasculitis (RV) of BD. Materials & Methods: Twenty three patients with PU and/or RV diagnosed as BD (according to the Iran and to the Japan criteria) were selected. Initially CsA 5 mg/Kg/day orally ... سال انتشار: 1996
 

Cyclosporine in the treatment of severe ocular lesions of Behcet’s disease.

Authers: F. Gharibdoost, F. Shahram, F. Davatchi, H. Chams, M. Akbarian, A. Nadji

Abstract: Introduction: there are several reports of good effects of Cyclosporine A (Cs A) in the treatment of Behcet's disease (BD). We studied the long term effect, of A Cs A in a prospective open clinical trial on posterior uveitis (PU) and retinal vasculitis (RV) of BD. Materials & Methods: Twenty three patients with PU and / or RV diagnose as BD (according to the Iran and to the Japan criteria) ... سال انتشار: 1996
 

The Accuracy of IBDDAM in the Treatment Evaluation of Behcet’s Disease.

Authers: A.R. Jamshidi, F. Shahram, F. Davatchi, M. Akbarian, F. Gharibdoost, A. Nadji

Abstract: Introduction: Behcet's disease (BD) is characterized by recurrent attacks followed by remissions, making difficult the assessment of a given treatment. The aim of this study was to compare the Iran Behcet's Disease Dynamic Activity Measure (IBDDAM) with the physician's global assessment (PGA) in evaluating the treatment result. Materials & Methods: Ninety-six patients with BD were followed prospectively, regardless of their treatment modality. The range of follow up was 3 to 62 ... سال انتشار: 1996
 

Iran’s Aspect of Behcet’s Disease in Children, the 1996 Survey.

Authers: N. Shafaie, F. Shahram, A. Nadji, F. Davatchi, M. Akbarian, F. Gharibdoost, A.R. Jamshidi

Abstract: Introduction: There is considerable controversy in the characteristics of Behect's disease (BD) in children. The aim of this study is to show Iran's view m juvenile BD. Materials & Methods: Different manifestations of the disease were determined in the BD patients under the age of 16. They were compared with the adult patients by chi square test. Results: We had 102 children with BD. The male/female ratio was 1.04. Oral aphthosis (64%) ... سال انتشار: 1996
 

Effects of Suppressive Therapy with Levothyroxine on Bone Density.

Authers: B. Larijanie, F. Gharibdoost, M. Pajoohi, M. Bastanhagh, A. Sajadi, M. Shirzad, F. Davatchi

Abstract: Increased thyroid hormones level is associated with diminished bone density. It has been clarified that thyroid hormones by sirculating bone resorption lead to decrease in bone density. Thyroid hormone in many cases as in Non - Toxic Grotre & in supplement therapy in hypothyroidism is used as a drug & it is possible that suppressive therapy with T4 causes subclinical - hyperthyroidism. Studies done in west has shown different results ... سال انتشار: 1996
 

Outcome measurement of ocular lesions in Behcet’s disease.

Authers: F. Davatchi, S. Soroosh, F. Shahram, H. Chams, M. Akbarian, F. Gharibdoost, A. Nadji, C. Shams

Abstract: The outcome of ocular manifestations of Behcet’s Disease remains uncertain and unpredictable despite cytotxic drugs. One of our recent studies, presented to the 1995 Korean Rheumatology Annual Meeting, showed that one third of patients were None Responders, regardless of what treatment used. This study was designed to search for factors predicting the final outcome at the beginning of the treatment. Patients having more than one year of treatment were selected ... سال انتشار: 1996
 

Overview Of Pathogenesis & Management Of Behcet’s Disease.

Authers: F. Davatchi

Abstract: Genetic Background: Behcet’s Disease (BD) is known t0 be associated with the HLA-B5 gene. The association is with the B51subtype, the B*5101allele. The tryptophan amino acid in position 167 and histidine in position 171 seems to determine the susceptibility of B51 for BD. However all persons with B51 do not have BD and all BD patients do not have B51. Some particularity in the TNFβ gene region in BD patients ... سال انتشار: 1996
 

IN TIME VARIATION OF PATHERGY PHENOMENON IN BEHCET'S DISEASE.

Authers: C. Chams, F. Davatchi, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, A.R. Jamshidi

Abstract: The pathergy phenomenon (PP) is one of the hallmarks of Behcet's Disease (BD). It has been reported to be positive from 17.5% to 83% of cases in different studies. PP is used as a diagnosis criterion in the Dilsen criteria, the Japan criteria, the International criteria, and the Iran criteria. It is therefore important to know wether PP is a fix manifestation of the disease or a cyclic manifestation ... سال انتشار: 1996