تالیفات

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran  

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran

مولف: Shima Hadifara, b, 1, Leila Shamkhalia, b, 1, Mansour Kargarpour Kamakolia, b, Shayan Mostafaeic, d, Sharareh Khanipoura, Noormohamad Mansoorie, Abolfazl Fateha, b, Seyed Davar Siadata, b, Farzam Vaziria, b, ⁎

خلاصه: Objectives: Evaluation of the genetic diversity of Mycobacterium tuberculosis (M.tb) and determining if the association between a specific genotype and the site of infection is crucial. Accordingly, the current study aimed at comparing predominant M.tb genotypes in pulmonary (PTB) and extrapulmonary tuberculosis (EPTB) isolates circulating in the capital of Iran. Methods: The genetic diversity of culture-confirmed PTB and EPTB isolates were evaluated by Spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive-unit–variable-number tandem-repeat) typing methods. Genotyping data were analyzed ... سال انتشار: 2019
The effects of team-based learning on learning outcomes in a course of rheumatology  

The effects of team-based learning on learning outcomes in a course of rheumatology

مولف: SEYEDEH TAHEREH FAEZI1, KAMRAN MORADI1, 2, ALI GHAFAR RAHIMI AMIN3, MASSOOMEH AKHLAGHI1, FATEMEH KESHMIRI4*

خلاصه: Introduction: We evaluated the effects of implementing Team- Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n=84) participating in a course of ... سال انتشار: 2018
Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients  

Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients

مولف: Zafari P.1, 2, Mostafaei Sh.3, Iranshahi N.1, 2, Jalili S.4, Taghadosi M., PhD5

خلاصه: Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of vitamin D plasma level with Foxp3 gene expression in the patients with RA. Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of ... سال انتشار: 2018
Relapsing Polychondritis and Hematuria: A Case Report  

Relapsing Polychondritis and Hematuria: A Case Report

مولف: Mojtaba Fazel1, Zeinab Kavyani2, Masoome Sadat Sadeghzadeh1, Maassoumeh Akhlaghi3

خلاصه: Relapsing polychondritis (RP) is very rare inflammatory disorder characterized by episodic, progressive, and destructive courses affecting cartilages. Renal involvement also is very rare presenting sign in these patients. It has seldom been described in children. We describe an 11-yearold girl with RP and complaint of frequent episodes of hematuria, and dysuria with fever and periorbital edema that auricular cartilage involvement appeared after renal involvement. Renal involvement in the setting of RP is سال انتشار: 2018
Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis  

Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis

مولف: Mohsen Moghoofei1 | Seyed Hamidreza Monavari2 | Shayan Mostafaei3, 4 | Shima Hadifar5, 6 | Amir Ghasemi7 | Farhad Babaei1 | Hoda Kavosi4 | Ahmad Tavakoli2 | Davod Javanmard2 | Maryam Esghaei2 | Nilofar Khodabandehlou8

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle- East’ and ‘Meta-analysis’. The ... سال انتشار: 2018
Paediatric Behçet’s disease in Iran: report of 204 cases  

Paediatric Behçet’s disease in Iran: report of 204 cases

مولف: F. Shahram1, A. Nadji1, M. Akhlaghi1, S.T. Faezi1, C. Chams-Davatchi1, 2, H. Shams1, 3, S. Z. Ghodsi1, 2, F. Davatchi1

خلاصه: ABSTRACT Objectives. This study proposed to report the characteristics of paediatric Behçet’s disease (PED-BD) in a cohort of patients from Iran’s registry and compare them with different reports throughout the world. Methods. From a cohort of 7504 Iranian patients with Behçet’s disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. سال انتشار: 2018
microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients  

microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

مولف: Mohsen Moghoofei1, Farah Bokharaei-Salim1, 2, Maryam Esghaei1, Hossein Keyvani1, Maryam Honardoost3, Shayan Mostafaei4, 5, Amir Ghasemi6, Ahmad Tavakoli1, Davod Javanmard1, Farhad Babaei7, Saba Garshasbi2 & Seyed Hamidreza Monavari*,

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with ... سال انتشار: 2018
Influence of HLA-B27 Subtypes on Ankylosing Spondylitis Phenotype: Comment on the Article by Akassou et al  

Influence of HLA-B27 Subtypes on Ankylosing Spondylitis Phenotype: Comment on the Article by Akassou et al

مولف: Sasan Fallahi1, 2

خلاصه: To the Editor I read the interesting review of Akassou and Bakri about the influence of HLA-B27 on ankylosing spondylitis (AS) phenotype which has been recently published in Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders.1 They concluded in the last row of Table 2, “Fallahi et al found lower markers of activity, better functional status, better quality of life and better spinal and hip mobility in patients with B*2704 and B*2707 compared with patients with B*2705 and B*2702 ... سال انتشار: 2018
Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer  

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2018
 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Curcumin reduces the expression of interleukin 1b and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease

مولف: Mohammad Taghi Palizgira, Maryam Akhtaria, b, Mahdi Mahmoudia , Shayan Mostafaeia, Alireza Rezaiemaneshc and Farhad Shahrama

خلاصه: Objective: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. Methods: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for ... سال انتشار: 2018
 

Cochlea CT radiomics predicts chemoradiotherapy induced sensorineural hearing loss in head and neck cancer patients: A machine learning and multi-variable modelling study

مولف: Hamid Abdollahia, Shayan Mostafaeib, Susan Cheraghic, d, Isaac Shirie, f, Seied Rabi Mahdavia, d, ⁎, Anoshirvan Kazemnejadb, ⁎

خلاصه: Objectives: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. Material and methods: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection ... سال انتشار: 2018
Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors  

Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors

مولف: Maryam Akhtari1 & Seyed Jalal Zargar1 & Mahdi Mahmoudi2 & Mahdi Vojdanian2 & Alireza Rezaeimanesh3 & Ahmadreza Jamshidi2

خلاصه: Macrophages play an important role in the ankylosing spondylitis (AS) auto-inflammatory responses and fibrocartilage destruction. Adenosine is a key modulator of inflammatory conditions. The various effects of adenosine are mediated by its interaction with adenosine receptors (AR). In this study, we investigated the mRNA expression ofA1, A2A, A2B, andA3 adenosine receptors, ectonucleoside triphosphate diphosphohydrolase-1 (CD39), and ecto-5′-nucleotidase (CD73) in the monocyte-derived macrophages from AS patients in comparison to healthy controls. We also explored the ... سال انتشار: 2018
Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients  

Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients

مولف: Parisa Zafari, Kheirollah Yari, Shayan Mostafaei, Nasrin Iranshahi, Shirin Assar, Adel Fekri & Mahdi Taghadosi

خلاصه: The control of auto-reactive cells is defective in rheumatoid arthritis (RA). Regulatory T (Treg) cells which play a key role in the modulation of immune responses have an impaired function in RA. Foxp3 is a master regulator of Treg cells which its expression is سال انتشار: 2018
 

Worldwide prevalence of viral infection in AECOPD patients: A metaanalysis

مولف: Habib Jafarinejada, Mohsen Moghoofeib, Shayan Mostafaeic, Jafar Salimiand, Sadegh Azimzadeh Jamalkandid, ∗, Ali Ahmadia, ∗∗

خلاصه: Background and objective: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. Methods: PubMed database was systematically searched for population-based prevalence studies (1930–2017). Fixed and random effects models were used for estimation of summary effect-sizes. ... سال انتشار: 2017
 

Treatment of low back pain: First extended follow up of an original trial (NCT00600197) comparing a multidisciplinary group-based rehabilitation program with oral drug treatment alone up to 24 months

مولف: Sedigheh Sadat TAVAFIAN, 1 Ahmad Reza JAMSHIDI2 and Barbara SHAY

خلاصه: multidisciplinary rehabilitation program which was continued by monthly motivational consultation. Data on measures of Short Form 36 (SF-36), Quebec Disability Scale (QDS) and Ronald Morris Disability (RDQ) were collected at 12-, 18- and 24-month follow-ups and analyzed through repeated measures analysis of variance. Results: The patients who responded (n = 165) and who did not respond (n = 32) to the questionnaires were the same in terms of all baseline data except for physical ... سال انتشار: 2017
 

The association of pathergy reaction and active clinical presentations of Behçet’s disease

مولف: Shirin Assar1, Bahar Sadeghi2, Fereydoun Davatchi2, Seyyedeh Zahra Ghodsi2, Abdolhadi Nadji2, Farhad Shahram2, Farimah Ashofte2, Seyyedeh Roghieh Larimi2, Masoud Sadeghi3

خلاصه: Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet’s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR. Materials and methods: This was ... سال انتشار: 2017
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

مولف: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI

خلاصه: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2017
 

Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients

مولف: J Karami1, M Mahmoudi2, A Amirzargar1, M Gharshasbi3, A Jamshidi2, S Aslani1, 2 and MH Nicknam1

خلاصه: Methylation of DNA is one of the important regulatory mechanisms of gene transcription. B-cell chronic lymphocytic leukemia/ lymphoma 11B (BCL11B) plays a key role in the development, proliferation, differentiation, and survival of T cells. The aim of this study was to evaluate promoter methylation of BCL11B gene and its mRNA level in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis (AS) patients in relation to healthy controls and evaluate their correlation with diseases ... سال انتشار: 2017
 

Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

مولف: Raheleh ASSARI, 1, 2 Yahya AGHIGHI, 3 Vahid ZIAEE, 1, 2 Maryam SADR, 4 Farzaneh RAHMANI, 5 Arezou REZAEI, 5 Zeinab SADR, 4 Mohammad Hassan MORADINEJAD, 2 Seyed Reza RAEESKARAMI6 and Nima REZAEI

خلاصه: Aim: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-a polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. Methods: Fifty-five patients with KD who were randomly selected from referrals to the main pediatric hospital were enrolled in this ... سال انتشار: 2017
 

Prevalence of respiratory viruses in Iranian patients with idiopathic pulmonary fibrosis

مولف: Hossein Keyvani, 1 Mohsen Moghoofei, 2 Farah Bokharaei-Salim, 1, 3 Shayan Mostafaei, 4 Seyed-Ali Javad Mousavi, 5 Seyed Hamidreza Monavari1 and Maryam Esghaei1, *

خلاصه: Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal ... سال انتشار: 2017
 

Prevalence of Influenza A Infection in the Middle-East: A Systematic Review and Meta-analysis

مولف: Mohsen Moghoofei1, Seyed Hamidreza Monavari2, Shayan Mostafaei3, 4, Shima Hadifar5, 6, Amir Ghasemi7, Farhad Babaei1, Hoda Kavosi5, Ahmad Tavakoli2 , Davod Javanmard2, Maryam Esghaei2*, Nilofar Khodabandehlou8*

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were “Influenza”, “Subtype”, “Seroprevalence”, “Incidence”, “Seroepidemiology”, “H1N1”, “H3N2”, “H5N1”, “H9N2”, “Middle-East”, and “Metaanalysis”. The reported ... سال انتشار: 2017