تالیفات

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran  

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran

مولف: Shima Hadifara, b, 1, Leila Shamkhalia, b, 1, Mansour Kargarpour Kamakolia, b, Shayan Mostafaeic, d, Sharareh Khanipoura, Noormohamad Mansoorie, Abolfazl Fateha, b, Seyed Davar Siadata, b, Farzam Vaziria, b, ⁎

خلاصه: Objectives: Evaluation of the genetic diversity of Mycobacterium tuberculosis (M.tb) and determining if the association between a specific genotype and the site of infection is crucial. Accordingly, the current study aimed at comparing predominant M.tb genotypes in pulmonary (PTB) and extrapulmonary tuberculosis (EPTB) isolates circulating in the capital of Iran. Methods: The genetic diversity of culture-confirmed PTB and EPTB isolates were evaluated by Spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive-unit–variable-number tandem-repeat) typing methods. Genotyping data were analyzed ... سال انتشار: 2019
Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
Paediatric Behçet’s disease in Iran: report of 204 cases  

Paediatric Behçet’s disease in Iran: report of 204 cases

مولف: F. Shahram1, A. Nadji1, M. Akhlaghi1, S.T. Faezi1, C. Chams-Davatchi1, 2, H. Shams1, 3, S. Z. Ghodsi1, 2, F. Davatchi1

خلاصه: ABSTRACT Objectives. This study proposed to report the characteristics of paediatric Behçet’s disease (PED-BD) in a cohort of patients from Iran’s registry and compare them with different reports throughout the world. Methods. From a cohort of 7504 Iranian patients with Behçet’s disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. سال انتشار: 2018
Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer  

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2018
 

Curcumin reduces the expression of interleukin 1b and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease

مولف: Mohammad Taghi Palizgira, Maryam Akhtaria, b, Mahdi Mahmoudia , Shayan Mostafaeia, Alireza Rezaiemaneshc and Farhad Shahrama

خلاصه: Objective: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. Methods: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for ... سال انتشار: 2018
 

Cochlea CT radiomics predicts chemoradiotherapy induced sensorineural hearing loss in head and neck cancer patients: A machine learning and multi-variable modelling study

مولف: Hamid Abdollahia, Shayan Mostafaeib, Susan Cheraghic, d, Isaac Shirie, f, Seied Rabi Mahdavia, d, ⁎, Anoshirvan Kazemnejadb, ⁎

خلاصه: Objectives: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. Material and methods: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection ... سال انتشار: 2018
 

Worldwide prevalence of viral infection in AECOPD patients: A metaanalysis

مولف: Habib Jafarinejada, Mohsen Moghoofeib, Shayan Mostafaeic, Jafar Salimiand, Sadegh Azimzadeh Jamalkandid, ∗, Ali Ahmadia, ∗∗

خلاصه: Background and objective: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. Methods: PubMed database was systematically searched for population-based prevalence studies (1930–2017). Fixed and random effects models were used for estimation of summary effect-sizes. ... سال انتشار: 2017
 

The association of pathergy reaction and active clinical presentations of Behçet’s disease

مولف: Shirin Assar1, Bahar Sadeghi2, Fereydoun Davatchi2, Seyyedeh Zahra Ghodsi2, Abdolhadi Nadji2, Farhad Shahram2, Farimah Ashofte2, Seyyedeh Roghieh Larimi2, Masoud Sadeghi3

خلاصه: Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet’s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR. Materials and methods: This was ... سال انتشار: 2017
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

مولف: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI

خلاصه: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2017
 

Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients

مولف: J Karami1, M Mahmoudi2, A Amirzargar1, M Gharshasbi3, A Jamshidi2, S Aslani1, 2 and MH Nicknam1

خلاصه: Methylation of DNA is one of the important regulatory mechanisms of gene transcription. B-cell chronic lymphocytic leukemia/ lymphoma 11B (BCL11B) plays a key role in the development, proliferation, differentiation, and survival of T cells. The aim of this study was to evaluate promoter methylation of BCL11B gene and its mRNA level in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis (AS) patients in relation to healthy controls and evaluate their correlation with diseases ... سال انتشار: 2017
 

New insights toward the pathogenesis of ankylosing ; genetic variations and epigenetic modifications

مولف: Mahdi Mahmoudi, Saeed Aslani, Mohammad Hossein Nicknam, Jafar Karami & Ahmad Reza Jamshidi

خلاصه: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2017
 

Molecular investigation of virulence factors of Brucella melitensis and Brucella abortus strains isolated from clinical and non-clinical samples

مولف: Reza Mirnejad a, Faramarz Masjedian Jazi b, Shayan Mostafaei c, d, Mansour Sedighi

خلاصه: Brucella is zoonotic pathogen that induces abortion and sterility in domestic mammals and chronic infections in humans called Malta fever. It is a facultative intracellular potential pathogen with high infectivity. The virulence of Brucella is dependent upon its potential virulence factors such as enzymes and cell envelope associated virulence genes. The aim of this study was to investigate the Brucella virulence factors among strains isolated from humans and animals in different parts of Iran. ... سال انتشار: 2017
 

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2017
 

High-dose intravenous steroid pulse therapy in ocular involvement of Behcet’s disease: a pilot double-blind control study

مولف: Mastaneh MOHAMMADI, 1 Farhad SHAHRAM, 1 Hormoz SHAMS, 1, 2 Massoomeh AKHLAGHI, 1 Farimah ASHOFTEH1 and Fereydoun DAVATCHI1

خلاصه: Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet’s disease (BD). Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index ... سال انتشار: 2017
 

Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property

مولف: Keywords: Anemia; Inflammation; Interleukin; Mannuronic acid; M2000; Rheumatoid arthritis; Therapy

خلاصه: Copyright© Autumn 2017, Iran J Allergy Asthma Immunol. All rights reserved. 433 Published by Tehran University of Medical Sciences (http://ijaai.tums.ac.ir) ORIGINAL ARTICLE Iran J Allergy Asthma Immunol October 2017; 16(5): 433-442. Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property Hossein Ahmadi1, Ahmad Reza Jamshidi2, Mahdi Mahmoudi2, Farhad Gharibdoost2, Mahdi Vojdanian2, Mohammad Javad Fattahi1,3, Noushin Rastkari4, Zahra Aghazadeh1, and Abbas Mirshafiey1 1 Department of Immunology, School of ... سال انتشار: 2017
Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus  

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

Authers: Mohammad Sahebalzamani1, PhD, Hojjatollah Farahani2, PhD, Mojgan Tabatabaee Jamarani1, MSc, Seyedeh Tahereh Faezi3, MD, Kamran Moradi3, MD & Pedram Paragomi3, MD

Abstract: Purpose: The purpose of this study was to evaluate the effects of applying continuous care model (CCM) on the knowledge level and health-related quality of life (HRQoL) of systemic lupus erythematosus (SLE) patients and their perceptions of family awareness about the disease. Design: Continuous care model was implemented for 3 months on 34 SLE patients, in a pretest–posttest quasi-experimental design. Methods: Two sets of questionnaires were designed for knowledge assessment. HRQoL was assessed by SF-36 questionnaires. Analysis ... سال انتشار: 2017
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

مولف: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

خلاصه: Juvenile idiopathic arthritis (JIA) which consists of a heterogeneous group of chronic disorders (e.g., oligoarthritis, polyarthritis, and systemic arthritis) is an autoimmune, noninfectious inflammation of joints’ synovial membrane and connective tissues that lastsmore than 6 weeks [1, 2].The disorder has been identified all over the world in nearly all races and ethnicities with an average prevalence rate of 1 to 2 per 1,000 children [3]. Some children may experience JIA symptoms for only a few months while others ... سال انتشار: 2017
 

Behcet’s Disease: Epidemiology, Clinical Manifestations, and Diagnosis

مولف: Fereydoun Davatchi, Cheyda Chams-davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi & Mariam Masoumi

خلاصه: Introduction: Behcet’s Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

مولف: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

خلاصه: 299-308. Editorial It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). The ISG criteria were created by ... سال انتشار: 2017
 

Association Study of MECP2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients from Iran

مولف: Mahdi Mahmoudi, Saeed Aslani, Elham Hamzeh, Vahid Ziaee, Shiva Poursani, Mohammad Hossein Nicknam & Nima Rezaei

خلاصه: Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a multigenic autoimmune disorder. Polymorphisms of MECP2 gene have been reported to increase the risk of adult-onset SLE. In this study, we aimed to analyze if MECP2 gene polymorphisms could impress the proneness to JSLE in Iranian population. Material and Methods: Polymorphisms of MECP2 gene were genotyped in 50 Iranian JSLE patients and 426 matched healthy controls employing the real-time PCR allelic discrimination technique. Results: None of the alleles and ... سال انتشار: 2017
 

Association analysisofRAC1sin- gle nucleotidepolymorphismswith ulcerativecolitis

مولف: Mohammad Tahera Nasser EbrahimiDaryania Mona Hedayatb, c Mohammad Eslamiana

خلاصه: number ofpossiblecandidategeneshavebeenidentifiedto play acausativeroleinconferringageneticsusceptibilityto UC, resultinginimmunedysregulation.Recently,Muiseetal. reported anovelgeneticassociationbetweenRAC1withUC, a findingsupportedbyhumangeneticandfunctionalstud- ies andanimalmodelsofcolitis [3]. Administrationofthe RAC1 inhibitorNSC23766,aswellasconditionaldisruption of RAC1 [3], decreasedDSS-inducedneutrophilrecruitment and tissuedamageinthecolon.InhibitionofRAC1wasshown to abolishCXCchemokine-inducedneutrophilchemotaxis and up-regulationofMac-1invitro.Inadditiontoitsessen- tial roleinmodulatingimmuneandinflammatoryresponses, RAC1 playsanessentialroleinwoundhealingandepithe- lial celladhesion/migration/differentiation,whichinvolves Rho GTPase-mediatedcytoskeletonremodelinganddisso- lution andreassemblyofcellularjunctions [4]. Moreover, inflammation- andpathogen-inducedRAC1inactivationpro- motes apoptosisandcontributestomicrobialinfectionand barrier dysfunction. In thepresentstudy,three RAC1 gene variants,previously reported toconfersusceptibilitytoUC [3], werestudies in anIranianpatientpopulation.Ourresultsindicatedthat the allelicfrequenciesoftheseSNPswerenotsignifican- tly differentinUCpatientscomparedtocontrols,which was similartowhatwepreviouslyreportedinpatientswith CD [13]. Thiscanbeinpartexplainedbyheterogeneityof the studiedpopulations,suggestingaroleforepigenetic factors inthecomplexinterplaybetweengenesandenvi- ronment amongdifferentethnicpopulations.Italsoshould be emphasizedthatUCisacomplexdisease,inwhichmul- tiple factorscanaffectdiseasebehaviororseverity.Thus, different studydesigns,controlpopulations,andincomplete phenotype descriptioncouldpotentiallyresultindifferent outcomes. GivenitshigherprevalenceinEuropeandNorth America comparedtotheMiddleEasternregions,itcouldbe hypothesized that RAC1 gene variantsmightbeassociated with UCamongpatientsofEuropeanancestry,althoughit needs furtherinvestigations. In conclusion,ourstudydidnotshowanyassociation between thestudiedRAC1SNPsandUCinIranianpatients, similar towhatwefoundinCD.WhetherRAC1,thoughnota predictive geneticbiomarkerbasedontheassessedSNPsin the presentstudy,isamajorplayerinthepathogenesisof UC inourpatientpopulationneedsfurtherinvestigations. Considering ethnicitydifferencesstudyingimmunemodu- lating genesindifferentpopulationswouldshedlightonthe molecular pathogenesisofUC.Thiswilllaythefoundation for improvedpersonalizedmedicineinUCbasedonpharma- cogenetic approachesandtargetedgenetherapy.Further studies ondifferentpopulationswithlargersamplesizes are requiredtoidentifytheexactroleofRAC1andother contributing genesinUC. سال انتشار: 2017
Ankylosing spondylitis M-CSF-derived macrophages are undergoing unfolded protein response (UPR) and express higher levels of interleukin-23  

Ankylosing spondylitis M-CSF-derived macrophages are undergoing unfolded protein response (UPR) and express higher levels of interleukin-23

مولف: Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Ahmad Reza Jamshidi & Mohammad Hossein Nicknam

خلاصه: Objective: Interleukin (IL)-23/IL-17 pathway involves in the pathogenesis of ankylosing spondylitis (AS). The exact mechanism implicated in overexpression of IL-23 and activation of the IL-23/IL-17 axis is not clear. The aim of the study was to clarify whether macrophages of AS patients undergo unfolded protein response (UPR) and secret increased IL-23. Methods: Peripheral blood monocyte isolated from 10 HLA-B27þ patients and five HLA-B27þ normal subjects were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for seven ... سال انتشار: 2017
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications

Authers: Mahdi Mahmoudi1*, Saeed Aslani1*, Mohammad Hossein Nicknam2, Jafar Karami1, and Ahmad Reza Jamshidi1

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2016
 

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

Authers: Mohammad Sahebalzamani1, PhD, Hojjatollah Farahani2, PhD, Mojgan Tabatabaee Jamarani1, MSc, Seyedeh Tahereh Faezi3, MD, Kamran Moradi3, MD & Pedram Paragomi3, MD

Abstract: Purpose: The purpose of this study was to evaluate the effects of applying continuous care model (CCM) on the knowledge level and health-related quality of life (HRQoL) of systemic lupus erythematosus (SLE) patients and their perceptions of family awareness about the disease. Design: Continuous care model was implemented for 3 months on 34 SLE patients, in a pretest–posttest quasi-experimental design. Methods: Two sets of questionnaires were designed for knowledge assessment. HRQoL was assessed by SF-36 questionnaires. Analysis ... سال انتشار: 2016
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Consensus classification criteria for paediatric Behçet’s disease from a prospective observational cohort: PEDBD

Authers: Isabelle Koné-Paut, 1 Fahrad Shahram, 2 Martha Darce-Bello, 1 Luca Cantarini, 3 Rolando Cimaz, 4 Marco Gattorno, 5 Jordi Anton, 6 Michael Hofer, 7 Bouchra Chkirate, 8 Kenza Bouayed, 9 Ilknur Tugal-Tutkun, 10 Jasmin Kuemmerle-Deschner, 11 Hélène Agostini,

Abstract: We aimed to describe the main features of Behçet’s disease (BD) in children in the largest prospective cohort to date and to propose a classification. Methods An international expert consensus group was formed to define a data set of minimal symptoms for the inclusion of patients. Patients were entered prospectively during 66 months. Experts classified patients on a consensus basis. The concordance of two international classifications was analysed in confirmed patients with BD. Comparisons of subgroups of patients helped define consensus ... سال انتشار: 2015