تالیفات

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran  

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran

مولف: Shima Hadifara, b, 1, Leila Shamkhalia, b, 1, Mansour Kargarpour Kamakolia, b, Shayan Mostafaeic, d, Sharareh Khanipoura, Noormohamad Mansoorie, Abolfazl Fateha, b, Seyed Davar Siadata, b, Farzam Vaziria, b, ⁎

خلاصه: Objectives: Evaluation of the genetic diversity of Mycobacterium tuberculosis (M.tb) and determining if the association between a specific genotype and the site of infection is crucial. Accordingly, the current study aimed at comparing predominant M.tb genotypes in pulmonary (PTB) and extrapulmonary tuberculosis (EPTB) isolates circulating in the capital of Iran. Methods: The genetic diversity of culture-confirmed PTB and EPTB isolates were evaluated by Spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive-unit–variable-number tandem-repeat) typing methods. Genotyping data were analyzed ... سال انتشار: 2019
Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
Relapsing Polychondritis and Hematuria: A Case Report  

Relapsing Polychondritis and Hematuria: A Case Report

مولف: Mojtaba Fazel1, Zeinab Kavyani2, Masoome Sadat Sadeghzadeh1, Maassoumeh Akhlaghi3

خلاصه: Relapsing polychondritis (RP) is very rare inflammatory disorder characterized by episodic, progressive, and destructive courses affecting cartilages. Renal involvement also is very rare presenting sign in these patients. It has seldom been described in children. We describe an 11-yearold girl with RP and complaint of frequent episodes of hematuria, and dysuria with fever and periorbital edema that auricular cartilage involvement appeared after renal involvement. Renal involvement in the setting of RP is سال انتشار: 2018
Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis  

Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis

مولف: Mohsen Moghoofei1 | Seyed Hamidreza Monavari2 | Shayan Mostafaei3, 4 | Shima Hadifar5, 6 | Amir Ghasemi7 | Farhad Babaei1 | Hoda Kavosi4 | Ahmad Tavakoli2 | Davod Javanmard2 | Maryam Esghaei2 | Nilofar Khodabandehlou8

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle- East’ and ‘Meta-analysis’. The ... سال انتشار: 2018
microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients  

microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

مولف: Mohsen Moghoofei1, Farah Bokharaei-Salim1, 2, Maryam Esghaei1, Hossein Keyvani1, Maryam Honardoost3, Shayan Mostafaei4, 5, Amir Ghasemi6, Ahmad Tavakoli1, Davod Javanmard1, Farhad Babaei7, Saba Garshasbi2 & Seyed Hamidreza Monavari*,

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with ... سال انتشار: 2018
Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer  

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2018
 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Curcumin reduces the expression of interleukin 1b and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease

مولف: Mohammad Taghi Palizgira, Maryam Akhtaria, b, Mahdi Mahmoudia , Shayan Mostafaeia, Alireza Rezaiemaneshc and Farhad Shahrama

خلاصه: Objective: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. Methods: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for ... سال انتشار: 2018
 

Cochlea CT radiomics predicts chemoradiotherapy induced sensorineural hearing loss in head and neck cancer patients: A machine learning and multi-variable modelling study

مولف: Hamid Abdollahia, Shayan Mostafaeib, Susan Cheraghic, d, Isaac Shirie, f, Seied Rabi Mahdavia, d, ⁎, Anoshirvan Kazemnejadb, ⁎

خلاصه: Objectives: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. Material and methods: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection ... سال انتشار: 2018
 

Worldwide prevalence of viral infection in AECOPD patients: A metaanalysis

مولف: Habib Jafarinejada, Mohsen Moghoofeib, Shayan Mostafaeic, Jafar Salimiand, Sadegh Azimzadeh Jamalkandid, ∗, Ali Ahmadia, ∗∗

خلاصه: Background and objective: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. Methods: PubMed database was systematically searched for population-based prevalence studies (1930–2017). Fixed and random effects models were used for estimation of summary effect-sizes. ... سال انتشار: 2017
 

Treatment of low back pain: First extended follow up of an original trial (NCT00600197) comparing a multidisciplinary group-based rehabilitation program with oral drug treatment alone up to 24 months

مولف: Sedigheh Sadat TAVAFIAN, 1 Ahmad Reza JAMSHIDI2 and Barbara SHAY

خلاصه: multidisciplinary rehabilitation program which was continued by monthly motivational consultation. Data on measures of Short Form 36 (SF-36), Quebec Disability Scale (QDS) and Ronald Morris Disability (RDQ) were collected at 12-, 18- and 24-month follow-ups and analyzed through repeated measures analysis of variance. Results: The patients who responded (n = 165) and who did not respond (n = 32) to the questionnaires were the same in terms of all baseline data except for physical ... سال انتشار: 2017
 

The association of pathergy reaction and active clinical presentations of Behçet’s disease

مولف: Shirin Assar1, Bahar Sadeghi2, Fereydoun Davatchi2, Seyyedeh Zahra Ghodsi2, Abdolhadi Nadji2, Farhad Shahram2, Farimah Ashofte2, Seyyedeh Roghieh Larimi2, Masoud Sadeghi3

خلاصه: Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet’s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR. Materials and methods: This was ... سال انتشار: 2017
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

مولف: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI

خلاصه: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2017
 

Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients

مولف: J Karami1, M Mahmoudi2, A Amirzargar1, M Gharshasbi3, A Jamshidi2, S Aslani1, 2 and MH Nicknam1

خلاصه: Methylation of DNA is one of the important regulatory mechanisms of gene transcription. B-cell chronic lymphocytic leukemia/ lymphoma 11B (BCL11B) plays a key role in the development, proliferation, differentiation, and survival of T cells. The aim of this study was to evaluate promoter methylation of BCL11B gene and its mRNA level in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis (AS) patients in relation to healthy controls and evaluate their correlation with diseases ... سال انتشار: 2017
 

Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

مولف: Raheleh ASSARI, 1, 2 Yahya AGHIGHI, 3 Vahid ZIAEE, 1, 2 Maryam SADR, 4 Farzaneh RAHMANI, 5 Arezou REZAEI, 5 Zeinab SADR, 4 Mohammad Hassan MORADINEJAD, 2 Seyed Reza RAEESKARAMI6 and Nima REZAEI

خلاصه: Aim: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-a polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. Methods: Fifty-five patients with KD who were randomly selected from referrals to the main pediatric hospital were enrolled in this ... سال انتشار: 2017
 

Prevalence of respiratory viruses in Iranian patients with idiopathic pulmonary fibrosis

مولف: Hossein Keyvani, 1 Mohsen Moghoofei, 2 Farah Bokharaei-Salim, 1, 3 Shayan Mostafaei, 4 Seyed-Ali Javad Mousavi, 5 Seyed Hamidreza Monavari1 and Maryam Esghaei1, *

خلاصه: Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal ... سال انتشار: 2017
 

Prevalence of Influenza A Infection in the Middle-East: A Systematic Review and Meta-analysis

مولف: Mohsen Moghoofei1, Seyed Hamidreza Monavari2, Shayan Mostafaei3, 4, Shima Hadifar5, 6, Amir Ghasemi7, Farhad Babaei1, Hoda Kavosi5, Ahmad Tavakoli2 , Davod Javanmard2, Maryam Esghaei2*, Nilofar Khodabandehlou8*

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were “Influenza”, “Subtype”, “Seroprevalence”, “Incidence”, “Seroepidemiology”, “H1N1”, “H3N2”, “H5N1”, “H9N2”, “Middle-East”, and “Metaanalysis”. The reported ... سال انتشار: 2017
 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis

مولف: Mahdi Mahmoudi1, 2, Alireza Rezaiemanesh1, 3, Sara Harsini4, 5, Arash Salmaninejad6, Shiva Poursani1, Tayyeb Bahrami7, Vahid Ziaee8, 9, and Nima Rezaei3, 5, 6

خلاصه: Abstract- Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients ... سال انتشار: 2017
 

Molecular investigation of virulence factors of Brucella melitensis and Brucella abortus strains isolated from clinical and non-clinical samples

مولف: Reza Mirnejad a, Faramarz Masjedian Jazi b, Shayan Mostafaei c, d, Mansour Sedighi

خلاصه: Brucella is zoonotic pathogen that induces abortion and sterility in domestic mammals and chronic infections in humans called Malta fever. It is a facultative intracellular potential pathogen with high infectivity. The virulence of Brucella is dependent upon its potential virulence factors such as enzymes and cell envelope associated virulence genes. The aim of this study was to investigate the Brucella virulence factors among strains isolated from humans and animals in different parts of Iran. ... سال انتشار: 2017
 

M2000 (b-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

مولف: S. Aletaha*, L. Haddad†, M. Roozbehkia*, R. Bigdeli‡, §, V. Asgary*, M. Mahmoudi¶ & A. Mirshafiey*

خلاصه: To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As b- D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signalling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, ... سال انتشار: 2017
 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

مولف: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

خلاصه: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2017
 

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2017