تالیفات

Paediatric Behçet’s disease in Iran: report of 204 cases  

Paediatric Behçet’s disease in Iran: report of 204 cases

مولف: F. Shahram1, A. Nadji1, M. Akhlaghi1, S.T. Faezi1, C. Chams-Davatchi1, 2, H. Shams1, 3, S. Z. Ghodsi1, 2, F. Davatchi1

خلاصه: ABSTRACT Objectives. This study proposed to report the characteristics of paediatric Behçet’s disease (PED-BD) in a cohort of patients from Iran’s registry and compare them with different reports throughout the world. Methods. From a cohort of 7504 Iranian patients with Behçet’s disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. سال انتشار: 2018
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

مولف: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

خلاصه: 299-308. Editorial It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). The ISG criteria were created by ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

Authers: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

Abstract: It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). ... سال انتشار: 2016
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... سال انتشار: 2015
 

Osteoporosis in Patients with Pemphigus Vulgaris before Steroid Therapy

Authers: S. Zahra Ghodsi1, 2, Farhad Shahram2, Maryam Daneshpazhooh1, Azam Saadatfar1, and Cheyda Chams-Davatchi1,

Abstract: Pemphigus Vulgaris (PV) is often complicated by osteoporosis. Although corticosteroid therapy undoubtedly plays a causative role, inflammation associated with PV may also contribute to osteoporosis. This study was designed to determine the prevalence of osteoporosis in patients with PV before corticosteroid therapy and to compare these findings with those reported previously in healthy volunteers. Newly diagnosed patients with PV who had not received systemic corticosteroids were enrolled. Bone mineral density (BMD) was measured both in ... سال انتشار: 2014
 

Genital aphthosis in Behçet’s disease: Is it associated with less eye involvement?

Authers: Seyedeh Tahereh Faezi · Cheyda Chams‑Davatchi · S. Zahra Ghodsi · Farhad Shahram · Abdolhadi Nadji · Massoomeh Akhlaghi · Kamran Moradi · Pedram Paragomi · Golnaz Ghazizadeh Esslami · Bahar Sadeghi Abdollahi · Farimah Ashofteh · Fereydoun Davatchi

Abstract: Behçet’s disease (BD) is a multisystem disease classified among the vasculitides with various clinical features. Genital aphthosis (GA) is one of the major manifestations of BD. The aim of this study was to evaluate the characteristics of BD patients with GA. A cross-sectional sample of BD patients registered in 37 years was selected. We determined clinical and laboratory features of BD patients with GA (GA cases) and compared them with the patients who never developed GA (non-GA cases). The ... سال انتشار: 2014
 

Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet’s disease: longitudinal study of up to 10 years

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Farimah ASHOFTEH and Negin MOHTASHAM

Abstract: Aim: Ocular lesions of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Retinal vasculitis is the most aggressive lesion of ocular manifestations and predicts a worse systemic outcome. We present here the outcome with a combination of pulse cyclophosphamide, azathioprine and prednisolone, on long-term usage, up to 10 years, on 295 patients (18 493 eye-months of ... سال انتشار: 2014
 

Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet’s disease

Authers: Fereydoun Davatchi • Bahar Sadeghi Abdollahi • Cheyda Chams-Davatchi • Farhad Shahram • Zahra Ghodsi • Abdolhadi Nadji • Massoomeh Akhlaghi • Tahereh Faezi • Hormoz Shams • Roghieh Larimi • Farima Ashofteh

Abstract: The only diagnostic test that currently exists for Behcet’s disease (BD) is the pathergy test. A positive pathergy test (PPT) is an important component of many of the 16 sets of classification/diagnosis criteria used to diagnose BD. The aim of this study was to determine the importance of a PTT in the performance of the diagnosis/ classification criteria for BD. Patients and methods All patients listed in the BD registry of the Rheumatology Research Center, Tehran (6,727) and 4,648 ... سال انتشار: 2013
 

Methotrexate in ocular manifestations of Behcet’s disease: a longitudinal study up to 15 years

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Tahereh FAEZI, Massoomeh AKHLAGHI and Farimah ASHOFTEH

Abstract: Ocular manifestations of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Methotrexate is the least toxic, used mainly for posterior uveitis. We present here the outcome of eye lesions with methotrexate and prednisolone, in a longitudinal study of up to 15 years, on 682 patients (5447 eye-years of follow-up). Patients and methods: Methotrexate was started at ... سال انتشار: 2013
 

Causes of Blindness in Ocular Behçet’s Disease Comparing the End-Blinding Results in Two Genders

Authers: Hormoz Chams, MD1 • Hassan Behboudi, MD2 • Fariba Ghassemi, MD3 Fereydoun Davatchi, MD4 • Farhad Shahram, MD4 • Sheyda Chams-Davatchi, MD5

Abstract: To investigate and compare the causes of blindness in ocular Behçet’s disease (BD) in men and women Methods: In a retrospective, descriptive investigation from 1976 to 2008, 6,021 BD cases were registered in our BD Unit of Shariati Hospital of Tehran University of Medical Sciences (TUMS). At the last visit, 187 patients (124 men and 63 women) were blind (vision=1/10 or less) at least in one eye and with at least ... سال انتشار: 2012
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI and Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2012
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2011
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI, Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2011
 

Validation of the International Criteria for Behc¸et’s disease (ICBD) in Iran

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Nasim NADERI, Massoomeh AKHLAGHI, Tahereh FAEZI, Alireza FARIDAR

Abstract: To evaluate the performance of the new International Criteria for Behc¸et’s Disease (ICBD) in Iran. The ICBD was created in 2006 to replace the International Study Group (ISG) criteria (created in 1990). In this study, 14 existing diagnosis/classification criteria (Curth, Hewitt, Mason and Barnes, Japan original, Hubault and Hamza, O’Duffy, Cheng and Zhang, Dilsen, Japan revised, International Study Group, Iran traditional, Iran Classification Tree, revised Dilsen, Korea), were evaluated and compared to ICBD by ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

Rituximab in intractable ocular lesions of Behcet’s disease; randomized single-blind control study (pilot study)

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Mozhgan REZAIPOOR, Bahar SADEGHI-ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Massoomeh AKHLAGHI, Tahereh FAEZI, Nasim NADERI

Abstract: Ocular lesions, the main morbidity of Behcet’s disease (BD), are the most difficult to treat. The aim of this study was to evaluate the efficacy of rituximab. Methods: Inclusion criteria were retinal vasculitis and edema, resistant to cytotoxic drugs. Twenty patients were randomized to a rituximab group (RG) or cytotoxic combination therapy group (CCTG). Rituximab was given in two 1000-mg courses (15-day interval). Subjects received methotrexate (15 mg/weekly) with prednisolone (0.5 mg/kg per day). The ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

How to deal with Behcet’s disease in daily practice

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Massoomeh AKHLAGHI, Tahereh FAEZI, SADEGHI ABDOLLAHI

Abstract: Introduction: Behcet’s Disease (BD) is classified as a vasculitis, and progresses via attacks and remissions. BD is mainly seen around the Silk Road. The picture varies in different reports. For clinical descriptions, the data from the international cohort of patients (27 countries), will be used. Clinical manifestations: Mucous membrane manifestations were oral aphthosis seen in 98.1%, and genital aphthosis in 76.9% of patients. Skin manifestations were seen in 71.9% (pseudofolliculitis in 53.6% and erythema nodosum ... سال انتشار: 2010
 

Risk Factors of Blindness in Behcet’s Disease

Authers: Hormoz Chams, MD1, Fereydoun Davatchi, Amir Hossein Mahmoudi, Farhad Shahram, Cheyda Chams, Saeideh Dahaghein

Abstract: Purpose: To investigate long-term ocular manifestations of ocular Behcet’s disease (BD), and the causes for blindness Methods: In August 2008, at Shariati hospital of Tehran (Behcet unit) all files of the ocular BD patients from 1976 to 2008 who were legally blind (Visual acuity=20/200 or less) at least in one eye at the last visit and had at least three years of follow-up were reviewed and the desired informations were extracted. ... سال انتشار: 2010
 

Behcet’s disease: from east to west

Authers: Fereydoun Davatchi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahereh Faezi, Zahra Ghodsi, Alireza Faridar, Farima Ashofteh, Bahar Sadeghi Abdollahi

Abstract: Behcet's disease (BD) is classified among vasculitides. There are actually five nationwide surveys of BD: Iran, Japan, China, Korea, and Germany. Among case series, four are on more than 200 cases (Turkey, Morocco, Tunisia, and UK). BD was classically seen around the Silk Route. Now, it is seen everywhere. The male to female ratios were, respectively (in nationwide surveys), 1.19, 0.98, 1.34, 0.63, and 1.40 to 1. The mean age at onset was 26.2, 35.7, 33.8, 29, and ... سال انتشار: 2010
 

Behcet’s disease in Iran: analysis of 6500 cases

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Massoomeh AKHLAGHI, Tahereh FAEZI, Zahra GHODSI, Roghieh LARIMI, Farima ASHOFTEH, Bahar SADEGHI ABDOLLAHI

Abstract: To identify the clinical picture of Behcet’s disease in a large cohort of patients (6500) in Iran, over a period of 35 years, and compare them with other large series from around the world. Methods: Patients with Behcet’s disease from all over Iran were seen in the Behcet’s Disease Research Unit by a multidisciplinary team (rheumatologists, dermatologists, and ophthalmologists). Diagnosis was based on ‘expert opinion’. Data were collected on a standardized data sheet (105 ... سال انتشار: 2010
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydon Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi-Abdollahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Colchicine versus placebo in Behc¸et’s disease: randomized, double-blind, controlled crossover trial

Authers: Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Arash Tehrani Banihashemi, Farhad Shahram, Abdolhadi Nadji, Hormoz Shams, Cheyda Chams-Davatchi

Abstract: The effect of colchicine was evaluated in a large cohort of Behc¸et’s disease (BD) patients and compared to placebo. In a randomized, double-blind, controlled crossover trial, 169 patients without major organ involvement were selected consecutively. They fulfilled the International Criteria for Behc¸et’s Disease. Patients were randomly assigned to colchicine or placebo. At 4 months, they were swapped over (colchicine to placebo, placebo to colchicine) for another 4 months. The primary outcome was the overall disease activity index, the IBDDAM. ... سال انتشار: 2009
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydoune Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi Abdillahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

The Prevalence of Oral Aphthosis in a Normal Population in Iran: A WHO-ILAR COPCORD Study

Authers: Fereydoun Davatchi MD•*, ،Arash Tehrani-Banihashemi MD*, ،Ahmad-Reza Jamshidi MD*, ،Cheyda Chams-Davatchi MD*, ،Jaleh Gholami MD*, ،Maziar Moradi MD*, ،Massoomeh Akhlaghi MD*, ،Mohammad Hossein Forouzanfar MD*, ،Elham Noorolahzadeh،Mojgan Barghamdi،Farideh Samadi،Mehrzad Hadj-Aliloo MD،Koorosh Ghaznavi MD

Abstract: This study was conducted to determine the prevalence of oral aphthosis in a normal population in Iran, using the data of the WHO-ILAR COPCORD study in Iran. We conducted this study in Tehran, the capital of Iran which was selected as the COPCORD study field. In 22 districts of Tehran, 50 clusters were randomly selected. Of the selected houses, 4,096 households were visited and 10,291 persons were interviewed (response rate of 75%). Out of ... سال انتشار: 2008
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

Analysis Of Microsatellite Polymorphism Around The HLA-B Locus In Iranian Patients With Behcet's Disease.

Authers: N. Mizuki, K. Yabuki, M. Ota, Y. Katsuyama, H. Ando, E. Nomura, K. Funakoshi, F. Davatchi, H. Chams, B. Nikbin, A.A. Ghaderi, S. Ohno, H. Inoko H

Abstract: We have previously suggested that in a Japanese population the susceptible locus for Behcet's disease (BD) is HLA-B51 itself. To confirm this finding in another population, we performed HLA class I typing using the PCR-SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA-B gene using automated sequencer and subsequent automated fragment detection by fluorescent-based technology with the DNA samples of 84 Iranian patients with BD ... سال انتشار: 2002
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

ASSOCIATION OF HLA-B51 WITH CLINICAL EXPRESSION OF BEHCET’S DISEASE, ANALYSIS OF 201 IRANIAN PATIENTS.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, F. Gharibdoost, C. Chams

Abstract: Introduction: Despite the strong association between HLA-B51 and Behcet’s disease (BD), the clinical significance of this genetic marker has not been fully elucidated. The aim of this study was to find out the association of HLA-B51 with various manifestations of BD, and to compare it to those of HLA-B5. Patients & methods: All newly diagnosed BD patients in a 9-month period from April 2001 to January 2002 were studied. They ... سال انتشار: 2002
 

HLA-B51 FREQUENCY IN IRANIAN PATIENTS WITH BEHCET’S DISEASE.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, M. Akbarian, C. Chams

Abstract: Introduction: HLA-B51, a split antigen of HLA-B5, has generally been associated with Behcet’s disease (BD) in different countries notably those along the Silk route. The aim of this study was to determine the frequency of HLA-B51 in Iranian patients with BD, and to compare it with the control patients. Patients & methods: In a prospective study, 599 consecutive new patients referred to the BD clinic, in a 9-month period from ... سال انتشار: 2002