تالیفات

 

Association Study of IL10 and IL23R–IL12RB2 in Iranian Patients With Behc¸et’s Disease

Authers: Joana M. Xavier, 1 Farhad Shahram, 2 Fereydoun Davatchi, 2 Alexandra Rosa, 3 Jorge Crespo, 4 Bahar Sadeghi Abdollahi, 2 Abdolhadi Nadji, 2 Gorete Jesus, 5 Filipe Barcelos, 6 Jose´ Vaz Patto, 6 Niloofar Mojarad Shafiee, 2 Fahmida Ghaderibarim, 2 and Sofia A. Oliveira1

Abstract: Independent replication of the findings from genome-wide association studies (GWAS) remains the gold standard for results validation. Our aim was to test the association of Behc¸et’s disease (BD) with the interleukin-10 gene (IL10) and the IL-23 receptor–IL-12 receptor 2 (IL23R–IL12RB2) locus, each of which has been previously identified as a risk factor for BD in 2 different GWAS. Methods. Six haplotype-tagging single-nucleotide polymorphisms (SNPs) in IL10 and 42 in IL23R–IL12RB2 were genotyped in 973 Iranian patients with BD and 637 non-BD ... سال انتشار: 2012
 

Isolated Hematuria in SLE Patients and its Association with Proteinuria, Urinary Cast and SLE Disease Activity

Authers: M. Akbarian, H. Soleymani, F. Gharibdoost, A. Nadji, A.R. Jamshidi, , F. Shahram, M. Akhlaghi, S. Khosravi, S. Almasi, Fereydoun Davatchi

Abstract: Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of ... سال انتشار: 2009
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-α and TNF receptor system in systemic lupus erythematosus

Authers: M. KARIMIFAR, , F. GHARIBDOOST, , M. AKBARIAN, , A. P. MEYSAMIE, , SH. KHOSRAVI, , Mozh. KARIMIFAR, , F. SHAHRAM, A. NADJI, A. R. JAMSHIDI, , M. AKHLAGHI, , B. YAZDANI1, F. DAVATCHI1

Abstract: Objective: There are some clues that measurement of triglyceride (TG) and high-density lipoprotein (HDL) and their correlation with tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor type 1 and type 2 (sTNFR1, sTNFR2) in serum could be valuable in the assessment of disease activity of systemic lupus erythematosus (SLE) patients. Methods: In this cross-sectional study, fasting blood samples were obtained from 86 SLE patients referred to the Rheumatology Research Center of Tehran University in Shariati ... سال انتشار: 2007
 

Heat shock protein 70 level of synovial fluid in rheumatoid arthritis versus osteoarthritis: a comparative study

Authers: Gharibdoost F., Samadi F., Taghipoor R., Akbarian M., Shahram F., Nadji A., Jamshidi A R, Davatchi F.

Abstract: Background: Heat-shock proteins are part of a strictly controlled biological system that allows organisms to respond to environmental stresses. Different proinflammatory cytokines are present in the synovial tissue of rheumatoid arthritis patients. Such tissues respond to stress and induce heat-shock proteins. In addition, synovial cells are exposed to mechanical stress caused by joint motion. The effects of mechanical stress on the metabolism of the synovial cells may be substantial, even pathogenic. Heat-shock proteins are often implicated ... سال انتشار: 2007
 

Bone mass density in the normal population of Iran

Authers: M. AKBARIAN, F. DAVATCHI, A. SALIMZADEH, F. SHAHRAM, F. GHARIBDOUST, A. NADJI, M. PAJOUHI, A. JAMSHIDI

Abstract: Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators of the bone mass and thus useful predictors of fracture risk. Dual energy X-ray absorptiometry (DEXA) is the easiest, yet the most precise and non-invasive technique. The need for a population-specific normative BMD data is vital in preventing mislabelling or misdiagnosis of osteopenia or even osteoporosis. Aim: This study was performed to determine the lumbar vertebral and the proximal ... سال انتشار: 2005
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

ASSOCIATION OF HLA-B51 WITH CLINICAL EXPRESSION OF BEHCET’S DISEASE, ANALYSIS OF 201 IRANIAN PATIENTS.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, F. Gharibdoost, C. Chams

Abstract: Introduction: Despite the strong association between HLA-B51 and Behcet’s disease (BD), the clinical significance of this genetic marker has not been fully elucidated. The aim of this study was to find out the association of HLA-B51 with various manifestations of BD, and to compare it to those of HLA-B5. Patients & methods: All newly diagnosed BD patients in a 9-month period from April 2001 to January 2002 were studied. They ... سال انتشار: 2002
 

HLA-B51 FREQUENCY IN IRANIAN PATIENTS WITH BEHCET’S DISEASE.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, M. Akbarian, C. Chams

Abstract: Introduction: HLA-B51, a split antigen of HLA-B5, has generally been associated with Behcet’s disease (BD) in different countries notably those along the Silk route. The aim of this study was to determine the frequency of HLA-B51 in Iranian patients with BD, and to compare it with the control patients. Patients & methods: In a prospective study, 599 consecutive new patients referred to the BD clinic, in a 9-month period from ... سال انتشار: 2002
 

CHRONOLOGY OF CLINICAL MANIFESTATIONS IN BEHCET’S DISEASE, ANALYSIS OF 3542 CASES.

Authers: F. Shahram, K. Assadi, F. Davatchi, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian

Abstract: Introduction: Manifestations of Behcet’s disease (BD) appear one after another during the course of the disease. Some involvements such as mucous lesions seem to appear early, and others such as gastrointestinal (GI) and neurological (CNS) involvement many years later. This study was planned to find out the chronology of different manifestations of BD. Patients & methods: In a retrospective study, files of all BD patients diagnosed since 1989 were reviewed ... سال انتشار: 2002
 

AZATHIOPRINE AND LOW DOSE PULSE CYCLOPHOSPHAMIDE IN SEVERE OCULAR LESIONS OF BEHCET’S DISEASE, A PRELIMINARY REPORT.

Authers: F. Shahram, F. Davatchi, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Combination of cytotoxic drugs was suggested to decrease the rate of non-responders in severe ocular lesions of Behcet’s disease (BD). We present here our preliminary data with low dose pulse Cyclophosphamide (LDP) and Azathioprine (AZA) in the treatment of posterior uveitis (PU) and/or retinal vasculitis (RV) of BD. Patients & methods: Twelve BD patients with PU and RV were selected. They all received LDP as 0.5 g/m2 body surface/month ... سال انتشار: 2002
 

TONSILLECTOMY AND BEHCET’S DISEASE.

Authers: M. Jalessi, F. Shahram, A. Safavi, F. Davatchi, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost.

Abstract: Introduction: Increasing development of some diseases such as Behcet’s disease (BD) was reported after tonsillectomy. This study was designed to find the association between tonsillectomy/adenoidectomy (T/A) and subsequent development of BD. Patients & methods: In a prospective control study, 128 patients with BD and 139 controls from the orthopedic clinic (age and sex matched) were studied regarding previous T/A. A complete ENT clinical examination was performed for all of them. ... سال انتشار: 2002
 

URINE ABNORMALITIES IN BEHCET’S DISEASE, STUDY OF 4704 CASES.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost, C. Chams.

Abstract: Introduction: Despite the multisystem nature of Behcet’s disease (BD), renal involvement is rare in this disease. The aim of this study was to find the prevalence and characteristics of urine abnormalities and renal involvement of BD in Iran. Patients & methods: In a cohort of 4704 patients with BD, urinalysis was performed to screen patients with urine abnormalities. Different manifestations of the disease, including 100 clinical and paraclinical parameters, were ... سال انتشار: 2002
 

THE COMPARISON OF ANKYLOSING SPONDYLITIS IN BEHCET'S DISEASE AND NORMAL POPULATION: A CONTROL STUDY.

Authers: A. Nadji, F. Davatchi, F. Shahram, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: We previously reported that ankylosing spondylitis (AS) was associated with Behcet's disease (BD) in Iranian patients. This study was designed to evaluate the features of AS in BD (ASBD) and compare them with the AS in normal population (ASN). Materials and Methods: Among 4700 BD patients, 73 ASBD were found and were compared with a cohort of 180 ASN. Seventy out of 73 ASBD met the European Spondyloarthropathy Study Group ... سال انتشار: 2002
 

COMPARISON OF ORAL APHTHAE IN BEHCET DISEASE AND IDIOPATHIC RECURRENT APHTHOUS STOMATITIS.

Authers: C. Chams-Davatchi, M. Shizarpour, F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi

Abstract: Background: The purpose of this study was to evaluate the difference between oral aphthae in Behcet’s Disease (BD) and recurrent aphthous stomatitis (RAS). Methods: In a prospective study 56 cases of BD and 133 RAS were evaluated consecutively. Sex, age of onset, frequency of aphthous lesions, their duration and their mean number at each attack, pathergy test, HLA-B5, HLA-B51 and HLA-B27 were evaluated in both groups. Comparison was made by Student ... سال انتشار: 2002
 

EVALUATION OF THE MORTALITY IN SLE, ANALYSIS OF 165 PATIENTS.

Authers: A. Hadjiabbassi, M. Akbarian, S. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A.R. Jamshidi, F. Davatchi

Abstract: Objective: SLE is an autoimmune disease. The mortality rate and causes are different in the various countries. The present study is done to find out the causes of mortality in the SLE patients in Iran. Methods: This study was retrospective according to medical records of patients who were referred to Rheumatology polyclinic, admitted in Rheumatology ward, ICU, Gynecology and Nephrology wards of Shariati hospital during 10 years, from 1991-2001. Results: Of 2021 ... سال انتشار: 2002
 

EXTENSIVE PYODERMA GANGRENOSUM LIKE LESION IN TWO CASES OF BEHCET’S DISEASE, RESPONDING ONLY TO CYCLOSPORIN.

Authers: C. Chams-Davatchi, M. Shizarpour, F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi

Abstract: Introduction: Pyoderma gangrenosum (PG) like lesion is a Behcet’s disease (BD) skin lesion, which is seen very exceptionally. We report here 2 cases with unusual severe and extensive skin lesions, having an intensive hypersensitivity to needle injection, inducing new lesions. Cases report: The first case is a 42 years old man with a history of 5 years recurrent bipolar aphthosis, skin pustulosis, ocular lesions, and articular involvement. After ... سال انتشار: 2002
 

THE INFLUENCE OF THE DELAY IN AGGRESSIVE TREATMENT ON THE VISON AND ITS OUTCOME IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The natural course of eye lesions is well known, leading to sever loss of vision or blindness. The cumulative nature of eye lesions during successive attacks, leads to gradual loss of visual acuity (VA). The aim of this study was to evaluate the effect of the delay in aggressive treatment on the VA and its long-term outcome. Materials and Methods: All Behcet’s patients of the treatment registry (1009 ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

LATE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS IN IRAN.

Authers: M. Akbarian, M. Valizadeh, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objectives: The aim of this study is to analyze the clinical features, laboratory findings and type of treatments in late onset SLE (after 50 years) in Iranian patients and compare them with the early onset. Methods: Records of 1419 SLE patients who attended our lupus unit, between 1975 and 1999 were reviewed. Nineteen Patients with late onset disease were identified. For comparison, 47 patients with disease onset before the age of ... سال انتشار: 2002
 

MUCO-CUTANEOUS LESIONS OF BEHÇET’S DISEASE, 10 YEARS EXPIRIENCE ON 4605 PATIENTS.

Authers: C. ChamsDavatchi, F. Davatchi, F. Shahram, A. Nadji, H. Chams, A. Jamshidi

Abstract: Background: Our purpose was to show different aspects of the muco-cutaneous lesions of Behcet’s disease (BD). Although they are not specific, they constitute the major symptoms in all sets of diagnosis criteria for BD. Methods: Description of muco-cutaneous lesions seen during 12 years follow up in 4605 patients. Results: 1- Mucous-membrane lesions: Recurrent oral aphthosis (OA) is the most important and frequent lesion of BD. It resembles the other OA of other ... سال انتشار: 2002
 

The Impact of the Treatment Delay on the Outcome of Vision in Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ... سال انتشار: 2002
 

THE INFLUENCE OF PATHERGY TEST ON THE ACCURACY OF DIFFERENT DIAGNOSIS CRITERIA FOR BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

THE ORAL AND RADIOLOGICAL MANIFESTATIONS OF SYSTEMIC SCLEROSIS IN IRANIAN PATIENTS.

Authers: F. Gharibdoost, R. Nadjafizadeh, M. Akbarian, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi.

Abstract: Objective: Oral involvement is one of the most important manifestations in systemic sclerosis. We studied clinical and radiological presentations of patients with systemic sclerosis in IRAN. Methods: This study is a prospective case series on forty patients with systemic sclerosis (29 limited & 11 diffuse form) according to ACR (American College of Rheumatology) criteria, referred to Rheumatology Research Center from 2000-2001. For every patient, 41 data surveyed. Results: The mean age of ... سال انتشار: 2002
 

EXPERIENCE IN IRAN WITH SPECIAL REFERENCE TO BEHCETS DISEASE (BD).

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Pattern of Rheumatic Diseases in Iran: They have the same frequency and the same pattern as in Western countries. A study from 1993 demonstrated a prevalence of 32.6% among adults (31.4% in the USA, Cunningham 1984). Inflammatory disorders counted for 11% of all rheumatic diseases. The ratio of RA to AS was 8/1 (7/1 in USA), and SLE to Scleroderma 3.5/1 (3.6/1 in USA). Psoriatic arthritis and Reiter's syndrome were ... سال انتشار: 2001
 

­LARGE VESSEL MANIFESTATIONS OF BEHCET’S DISEASE,REPORT OF 377 CASES.

Authers: F. Shahram, A. Nadji, M. Akbarian, A. Jamshidi, F. Gharibdoost, F. Davatchi

Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET'S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ... سال انتشار: 2001