تالیفات

Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors  

Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors

مولف: Maryam Akhtari1 & Seyed Jalal Zargar1 & Mahdi Mahmoudi2 & Mahdi Vojdanian2 & Alireza Rezaeimanesh3 & Ahmadreza Jamshidi2

خلاصه: Macrophages play an important role in the ankylosing spondylitis (AS) auto-inflammatory responses and fibrocartilage destruction. Adenosine is a key modulator of inflammatory conditions. The various effects of adenosine are mediated by its interaction with adenosine receptors (AR). In this study, we investigated the mRNA expression ofA1, A2A, A2B, andA3 adenosine receptors, ectonucleoside triphosphate diphosphohydrolase-1 (CD39), and ecto-5′-nucleotidase (CD73) in the monocyte-derived macrophages from AS patients in comparison to healthy controls. We also explored the ... سال انتشار: 2018
 

Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

مولف: Raheleh ASSARI, 1, 2 Yahya AGHIGHI, 3 Vahid ZIAEE, 1, 2 Maryam SADR, 4 Farzaneh RAHMANI, 5 Arezou REZAEI, 5 Zeinab SADR, 4 Mohammad Hassan MORADINEJAD, 2 Seyed Reza RAEESKARAMI6 and Nima REZAEI

خلاصه: Aim: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-a polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. Methods: Fifty-five patients with KD who were randomly selected from referrals to the main pediatric hospital were enrolled in this ... سال انتشار: 2017
 

PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis

مولف: Mahdi Mahmoudi1, 2, Alireza Rezaiemanesh1, 3, Sara Harsini4, 5, Arash Salmaninejad6, Shiva Poursani1, Tayyeb Bahrami7, Vahid Ziaee8, 9, and Nima Rezaei3, 5, 6

خلاصه: Abstract- Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients ... سال انتشار: 2017
 

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Mahdi Mahmoudi1, Shayan Mostafaei1, Alireza Rezaeimanesh3, Massoomeh Akhlaghi1, and Farhad Shahram1

خلاصه: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients ... سال انتشار: 2017
 

Lack of Association between STAT4 Single Nucleotide Polymorphisms and Iranian Juvenile Rheumatoid Arthritis Patients

مولف: Saeed Aslani, Mahdi Mahmoudi, Arash Salmaninejad, Shiva Poursani, Vahid Ziaee & Nima Rezaei

خلاصه: Juvenile rheumatoid arthritis (JRA) is a common chronic systemic autoimmune disease in children. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene are suspected to have associationwith the risk of autoimmune diseases. Previous investigations have indicated that the STAT4 rs7574865 T allele was significantly associated with rheumatoid arthritis. In this study, we aimed to evaluate the association of STAT4 SNPs with JRA in Iranian population. T allele of STAT4 rs7574865 SNPwas less ... سال انتشار: 2017
 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
 

Association Study of MECP2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients from Iran

مولف: Mahdi Mahmoudi, Saeed Aslani, Elham Hamzeh, Vahid Ziaee, Shiva Poursani, Mohammad Hossein Nicknam & Nima Rezaei

خلاصه: Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a multigenic autoimmune disorder. Polymorphisms of MECP2 gene have been reported to increase the risk of adult-onset SLE. In this study, we aimed to analyze if MECP2 gene polymorphisms could impress the proneness to JSLE in Iranian population. Material and Methods: Polymorphisms of MECP2 gene were genotyped in 50 Iranian JSLE patients and 426 matched healthy controls employing the real-time PCR allelic discrimination technique. Results: None of the alleles and ... سال انتشار: 2017
 

Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients

مولف: Arash Salmaninejad1, 2, Mahdi Mahmoudi1, 3, Saeed Aslani1, 3, Shiva Poursani1, Vahid Ziaee4, 5, Nima Rezaei6, 7, 8

خلاصه: SUMMARY: Salmaninejad A, Mahmoudi M, Aslani S, Poursani S, Ziaee V, Rezaei N. Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients. Turk J Pediatr 2017; 59: 144-149. Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to have relationship with the risk of ... سال انتشار: 2017
 

Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis

مولف: Danyal Imani1, Ramazan Rezaei1, Bahman Razi2, Shahab Alizadeh3, and Mahdi Mahmoudi4, 5

خلاصه: Abstract- Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with Graves' disease. Medline, EMBASE, and Web of Science databases were searched to identify all eligible studies published before August 2016. Odds ratios (ORs) and their corresponding 95% confidence intervals ... سال انتشار: 2017
 

Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis

Authers: Vahid Ziaee1, 2 & Arezou Rezaei3 & Sara Harsini3, 4 & Marzieh Maddah2 & Samaneh Zoghi4, 5 & Maryam Sadr6 & Mohammad Hassan Moradinejad2 & Nima Rezaei 3, 4, 5

Abstract: As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at positions -1098, -590, and -33, as well as IL-4RA gene at position +1902 were genotyped ... سال انتشار: 2016
 

HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

Authers: Shamsolmoulouk Najafi1, Mahsa Mohammadzadeh2, Alireza Zare Bidoki3, 4, Ghasem Meighani5, Saeed Aslani6, 7, Mahdi Mahmoudi6, and Nima Rezaei7, 8, 9

Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

EAssociation of Interleukin-2, but notInterferon-Gamma, single nucleotide polymorphismswith juvenile idiopathic arthritisM.

Authers: Maddaha, S. Harsinib, A. Rezaeib, M. Sadrc, S. Zoghid, M.H. Moradinejada, V. Ziaeea, e, N. Rezaei

Abstract: Cytokines, including interleukin-2 (IL-2) and interferon-gamma (IFN-), seem toplay a role in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study wasto investigate the associations of IL-2 and IFN- single nucleotide polymorphisms (SNPs) withsusceptibility to JIA in an Iranian population.Methods: Genomic DNA of 54 Iranian patients with JIA and 139 healthy unrelated controls weretyped for IL-2 (G/T at −330 and +166) as well as IFN- gene (A/T ... سال انتشار: 2016
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... سال انتشار: 2014
 

Systemic sclerosis: comparison of efficacy of oral cyclophosphamide and azathioprine on skin score and pulmonary involvement—a retrospective study

Authers: Hadi Poormoghim · Nader Rezaei · Zeinab Sheidaie · Ali Reza Almasi · Maziar Moradi‑Lakeh · Simin Almasi · Elham Andalib

Abstract: Abstract T he aim of this study was to evaluate efficacy of azathioprine (AZA) and cyclophosphamide (CYC) as a therapeutic regimen for interstitial lung disease associated with systemic sclerosis (SSc). Thirty-six selected patients included in this retrospective cohort and received one of the two drugs; the first group consists of 15 patients who were treated with AZA (1.5–2 mg/kg/day) and the second group with 21 patients received oral CYC (up to 2 mg/kg/day). Both groups received additional low ... سال انتشار: 2014
 

Association Between the Interleukin 6 Genotype at Position –174 and Atopic Dermatitis

Authers: M Gharagozlou, 1 E Farhadi, 2, 4 M Khaledi, 5 N Behniafard, 1 S Sotoudeh, 1 R Salari, 2 B Darabi, 1 SM Fathi, 1 M Mahmoudi, 6 A Aghamohammadi, 1, 7 AA Amirzargar, 2, 3 N Rezaei1, 2, 3, 7

Abstract: Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the fi rst time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease. Methods: This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions –174 and nt565 in 89 Iranian children with AD and 139 healthy controls. Results: ... سال انتشار: 2013
 

TNF-alpha single nucleotide polymorphisms in atopic dermatitis

Authers: Nasrin Behniafard1, Mohammad Gharagozlou1, Elham Farhadi2, 3, Mojdeh Khaledi4, Soheila Sotoudeh1, Behzad Darabi1, Seid Mohammad Fathi1, Zahra Gholizadeh Moghaddam1, Mahdi Mahmoudi5, Asghar Aghamohammadi1, 6, Ali Akbar Amirzargar2, Nima Rezaei1, 2, 6

Abstract: Tumor necrosis factor-alpha (TNF-) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF- gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was ... سال انتشار: 2013
 

TNF-alpha single nucleotide polymorphisms in atopic dermatitis

Authers: Nasrin Behniafard, Mohammad Gharagozlou1, Elham Farhadi2, 3, Mojdeh Khaledi4, Soheila Sotoudeh1, Behzad Darabi1, Seid Mohammad Fathi1, Zahra Gholizadeh Moghaddam1, Mahdi Mahmoudi5, Asghar Aghamohammadi1, 6, Ali Akbar Amirzargar2, Nima Rezaei1, 2, 6

Abstract: Tumor necrosis factor-alpha (TNF-) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF- gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was ... سال انتشار: 2012
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, , Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Association of CTLA4 Gene Polymorphism in Iranian Patients with Ankylosing Spondylitis

Authers: Esfandiar Azizi, Ahmad Massoud, Ali Akbar Amirzargar, Mahdi Mahmoudi, Narjes Soleimanifar, Nima Rezaei, Ahmad Reza Jamshidi, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Introduction Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a costimulatory molecule expressed by activated T cells. This study was performed to investigate the allele and genotype frequencies of CTLA4 gene polymorphisms in Iranian patients with ankylosing spondylitis (AS). Methods One hundred and fifty-seven patients with AS and 103 controls were included in this study. Polymorphisms of CTLA4 gene at positions +49 (in exon 1), −318, and −1,147 (in the promoter region) were studied on the genomic DNA using PCR restriction ... سال انتشار: 2010
 

Study of Programmed Cell Death 1 (PDCD1) Gene 2 Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, , Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Abstract—Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 ... سال انتشار: 2010
 

HLA-B27 subtypes and tumor necrosis factor α promoter region polymorphism in Iranian patients with ankylosing spondylitis

Authers: Mohammad Hossein Nicknam, Mahdi Mahmoudi, Ali Akbar Amirzargar1, Ahmad Reza Jamshidi, Nima Rezaei, Behrouz Nikbin

Abstract: Background. HLA-B27 is an MHC class I molecule that is strongly associated with ankylosing spondylitis (AS). TNF-α, as an important cytokine in inflammatory joint disease, might have a role in the process of AS. This study was performed to determine HLA-B27 subtypes among Iranian patients with AS, and to investigate TNF-α gene polymorphisms in the patient groups. Methods. Ninety seven AS patients (74 HLAB27- positive and 23 HLA-B27-negative) and 137 healthy normal subjects (2 ... سال انتشار: 2009