تالیفات

 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
 

ANTI-NEUTROPHIL CYTOPLASMIC AUTOANTIBCIDY IN S.L.E.

Authers: M. Vodjgani, M. Akbarian, F. Nassiri, F. Kochakian

Abstract: Anti-neutrophil cytoplasrnic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed virtually unnoticed until an association was found between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and in considering potential pathogenic role of ANCA in vascular inflammation. The gold standard method for ANCA detection rests with indirect immunofluorescence (IIF) microscopy. ... سال انتشار: 1995