تالیفات

 

c-Abl silencing reduced the inhibitory effects of TGF-b1 on apoptosis in systemic sclerosis dermal fibroblasts

مولف: Elham Karimizadeh1 • Farhad Gharibdoost2 • Nasrin Motamed1 • Saeideh Jafarinejad-Farsangi1 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

خلاصه: It is generally accepted that the apoptosis of myofibroblasts is a crucial event in the normal wound healing. Delay in myofibroblasts apoptosis results in fibrotic diseases such as systemic sclerosis (SSc). Transforming growth factor-b1 (TGF-b1) is an important cytokine to induce fibroblasts differentiation into myofibroblasts. Cellular Abelson (c-Abl) is known as a TGF-b1- modulating molecule in fibrosis. The role of c-Abl, TGFb1, and their interaction in SSc myofibroblasts apoptosis has not yet been fully explored. The aim of this ... سال انتشار: 2015
 

Attenuation of fibrosis with selective inhibition of c-Abl by siRNA in systemic sclerosis dermal fibroblasts

Authers: Elham Karimizadeh • Nasrin Motamed • Mahdi Mahmoudi • Saeideh Jafarinejad-Farsangi • Ahmadreza Jamshidi • Habibeh Faridani • Farhad Gharibdoost

Abstract: Cellular abelson (c-Abl), a non-receptor tyrosine kinase, is an important molecule in the pathogenesis of systemic sclerosis. There have been reports of beneficial effects of pharmacological tyrosine kinase inhibitors, such as imatinib mesylate, on fibrosis. However, these inhibitors affect multiple tyrosine kinases including c-Abl, c-kit, and platelet-derived growth factor receptor. The effects of selective inhibition of c-Abl using small interfering RNA (siRNA) on dermal fibrosis have not yet been explored. The aim of this study is to evaluate whether ... سال انتشار: 2014
 

Alpha 1-antitrypsin activity is markedly decreased in Wegener’s granulomatosis

Authers: Ali Mota • Abbas Sahebghadam Lotfi • Ahmad-Reza Jamshidi • Saeed Najavand

Abstract: Abstract Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners’ granulomatosis. A1AT deficiency correlated with ANCA-associated vasculitis. This study explores the trypsin inhibitory capacity (TIC), specific activity, and phenotypic deficiency of A1AT in Wegener’s granulomatosis. Twenty-seven WG patients were studied. ANCA was tested by IIF and ELISA. Serum a1-anti-trypsin levels were quantified inWG patients and healthy controls by immunoturbidimetric ... سال انتشار: 2014
 

Alpha 1-antitrypsin activity is markedly decreased in Wegener’s granulomatosis

Authers: Ali Mota • Abbas Sahebghadam Lotfi • Ahmad-Reza Jamshidi • Saeed Najavand

Abstract: Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners’ granulomatosis. A1AT deficiency correlated with ANCA-associated vasculitis. This study explores the trypsin inhibitory capacity (TIC), specific activity, and phenotypic deficiency of A1AT in Wegener’s granulomatosis. Twenty-seven WG patients were studied. ANCA was tested by IIF and ELISA. Serum a1-anti-trypsin levels were quantified in WG patients and healthy controls by immunoturbidimetric ... سال انتشار: 2013
 

Analysis Of Microsatellite Polymorphism Around The HLA-B Locus In Iranian Patients With Behcet's Disease.

Authers: N. Mizuki, K. Yabuki, M. Ota, Y. Katsuyama, H. Ando, E. Nomura, K. Funakoshi, F. Davatchi, H. Chams, B. Nikbin, A.A. Ghaderi, S. Ohno, H. Inoko H

Abstract: We have previously suggested that in a Japanese population the susceptible locus for Behcet's disease (BD) is HLA-B51 itself. To confirm this finding in another population, we performed HLA class I typing using the PCR-SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA-B gene using automated sequencer and subsequent automated fragment detection by fluorescent-based technology with the DNA samples of 84 Iranian patients with BD ... سال انتشار: 2002