تالیفات

The effects of team-based learning on learning outcomes in a course of rheumatology  

The effects of team-based learning on learning outcomes in a course of rheumatology

مولف: SEYEDEH TAHEREH FAEZI1, KAMRAN MORADI1, 2, ALI GHAFAR RAHIMI AMIN3, MASSOOMEH AKHLAGHI1, FATEMEH KESHMIRI4*

خلاصه: Introduction: We evaluated the effects of implementing Team- Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n=84) participating in a course of ... سال انتشار: 2018
Relapsing Polychondritis and Hematuria: A Case Report  

Relapsing Polychondritis and Hematuria: A Case Report

مولف: Mojtaba Fazel1, Zeinab Kavyani2, Masoome Sadat Sadeghzadeh1, Maassoumeh Akhlaghi3

خلاصه: Relapsing polychondritis (RP) is very rare inflammatory disorder characterized by episodic, progressive, and destructive courses affecting cartilages. Renal involvement also is very rare presenting sign in these patients. It has seldom been described in children. We describe an 11-yearold girl with RP and complaint of frequent episodes of hematuria, and dysuria with fever and periorbital edema that auricular cartilage involvement appeared after renal involvement. Renal involvement in the setting of RP is سال انتشار: 2018
Paediatric Behçet’s disease in Iran: report of 204 cases  

Paediatric Behçet’s disease in Iran: report of 204 cases

مولف: F. Shahram1, A. Nadji1, M. Akhlaghi1, S.T. Faezi1, C. Chams-Davatchi1, 2, H. Shams1, 3, S. Z. Ghodsi1, 2, F. Davatchi1

خلاصه: ABSTRACT Objectives. This study proposed to report the characteristics of paediatric Behçet’s disease (PED-BD) in a cohort of patients from Iran’s registry and compare them with different reports throughout the world. Methods. From a cohort of 7504 Iranian patients with Behçet’s disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. سال انتشار: 2018
 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

مولف: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI

خلاصه: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2017
 

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Mahdi Mahmoudi1, Shayan Mostafaei1, Alireza Rezaeimanesh3, Massoomeh Akhlaghi1, and Farhad Shahram1

خلاصه: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients ... سال انتشار: 2017
 

High-dose intravenous steroid pulse therapy in ocular involvement of Behcet’s disease: a pilot double-blind control study

مولف: Mastaneh MOHAMMADI, 1 Farhad SHAHRAM, 1 Hormoz SHAMS, 1, 2 Massoomeh AKHLAGHI, 1 Farimah ASHOFTEH1 and Fereydoun DAVATCHI1

خلاصه: Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet’s disease (BD). Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index ... سال انتشار: 2017
 

Behcet’s Disease: Epidemiology, Clinical Manifestations, and Diagnosis

مولف: Fereydoun Davatchi, Cheyda Chams-davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi & Mariam Masoumi

خلاصه: Introduction: Behcet’s Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

مولف: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

خلاصه: 299-308. Editorial It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). The ISG criteria were created by ... سال انتشار: 2017
 

STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

Authers: Zeinab Alizadeh a, b, Ali Farazmand b, Maassoomeh Akhlaghi a, *, Ahmad Reza Jamshidi a, Abtin Shahlaee a, Jafar Karami a, Elmira Shamsian a, Mahdi Mahmoudi

Abstract: The gene encoding signal transducer and activator of transcription 4 (STAT4) has been documented to be associated with rheumatoid arthritis (RA) in several populations. The aim of this study was to determine the association of the STAT4 gene polymorphism (rs7574865) with RA in the Iranian population. Methods: This study included 612 Iranian RA patients and 389 healthy control subjects. For all samples, DNA was genotyped for STAT4 G>T (rs7574865) polymorphism using the MGB TaqMan Allelic Discrimination ... سال انتشار: 2016
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

Authers: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

Abstract: It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). ... سال انتشار: 2016
 

Adult Behcet’s disease in Iran: analysis of 6075 patients

Authers: Fereydoun DAVATCHI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Bahar SADEGHI ABDOLLAHI, Farimah ASHOFTEH, Zahra GHODSI, Negin MOHTASHAM and Farhad SHAHRAM

Abstract: This is an analysis of adult Behcet’s disease (BD) in Iran, from the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%). Patients: Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet’s Disease (ICBD). Adult BDs were patients who had their first ... سال انتشار: 2016
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... سال انتشار: 2015
 

Nicolau Syndrome in 29 Months Boy: Another Report of Iran

Authers: Mojtaba Fazel1, Parvin Akbar Asbagh2, Azadeh Afshin3*, Mamak Shariat4, Mahmoud Fazel5, Massumeh Akhlaghi5

Abstract: Nicolau syndrome (NS) is a very rare complication of intramuscular injections that leads to some degree of necrosis in skin, subcutaneous fat and muscles. The type of injected Drugs and wrong injection methods are the main factors for this iatrogenic syndrome. Here we report a 29 months boy, one of the Iranian children affected NS following the wrong intramuscular injection of Benzathine Penicillin. But he came back home without any major complication because of ... سال انتشار: 2015
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

Authers: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI2

Abstract: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2015
 

Vitamin D deficiency in patients with Behcet’s disease

Authers: Seyedeh Tahereh Faezi*, Narges Ansari, Pedram Paragomi, Maassoumeh Akhlaghi, Majid Ghanavat and Fereydoun Davatchi

Abstract: Background: Behcet’s disease is an autoimmune, recurrent and multisystem disease. Vitamin D has immunomodulator role in immune system. So that vitamin D deficiency was reported in some autoimmune diseases. Behcet’s disease as a Silk Road disease is common in Iran. The aim of this study was to detect the serum level of 25(OH) vitamin D in Behcet’s patients and control group. Methods: In this case–control study, 112 Behcet’s patients as cases group and 112 ... سال انتشار: 2014
 

The relationship between plasma homocysteine level and HLA-B51 in patients with Behcet’s disease: a case-control study

Authers: Soraya SHADMANFAR, 1, 2 Farhad SHAHRAM, 2 Abdolhadi NADJI, 2 Maassoumeh AKHLAGHI, 2 Seyedeh T. FAEZI, 2 Bahar SADEGHI-ABDOLLAHI, 2 Alireza FARIDAR, 2 Nima MADANCHI3 and Fereydoun DAVATCHI2

Abstract: Background: Various coagulation disorders have been reported to explain hypercoagulability state in Behcet’s disease (BD). A possible negative association between human leukocyte antigen (HLA)-B51 and increased homocysteine level has been suggested in a previous report from Iranian patients with BD. The aim of this study was to find any possible relationship between plasma homocysteine levels and HLA-B51. Methods: In a case-control study, BD patients (fulfilling the new International Criteria for BD) and controls (who had ... سال انتشار: 2014
 

Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients

Authers: Masoumeh Kheirandish , Seyedeh Tahereh Faezi , Pedram Paragomi , Maassoumeh Akhlaghi , Farhad Gharibdoost , Ashraf Shahali , Mahboubeh Ebrahimpour Fini, and Mahmood Akbarian

Abstract: Objectives . We aimed to evaluate the prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE) and explore their association with demographic and clinical features. Methods. In this cross-sectional study, 166 SLE patients in rheumatology center of Shariati hospital, Tehran University of Medical Sciences were enrolled. SLE disease activity index (SLEDAI) and Beck and Cattell inventories for evaluation of depression and anxiety were completed for each patient. Results. The mean age of patients was ... سال انتشار: 2014
 

Genital aphthosis in Behçet’s disease: Is it associated with less eye involvement?

Authers: Seyedeh Tahereh Faezi · Cheyda Chams‑Davatchi · S. Zahra Ghodsi · Farhad Shahram · Abdolhadi Nadji · Massoomeh Akhlaghi · Kamran Moradi · Pedram Paragomi · Golnaz Ghazizadeh Esslami · Bahar Sadeghi Abdollahi · Farimah Ashofteh · Fereydoun Davatchi

Abstract: Behçet’s disease (BD) is a multisystem disease classified among the vasculitides with various clinical features. Genital aphthosis (GA) is one of the major manifestations of BD. The aim of this study was to evaluate the characteristics of BD patients with GA. A cross-sectional sample of BD patients registered in 37 years was selected. We determined clinical and laboratory features of BD patients with GA (GA cases) and compared them with the patients who never developed GA (non-GA cases). The ... سال انتشار: 2014
 

Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet’s disease: longitudinal study of up to 10 years

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Farimah ASHOFTEH and Negin MOHTASHAM

Abstract: Aim: Ocular lesions of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Retinal vasculitis is the most aggressive lesion of ocular manifestations and predicts a worse systemic outcome. We present here the outcome with a combination of pulse cyclophosphamide, azathioprine and prednisolone, on long-term usage, up to 10 years, on 295 patients (18 493 eye-months of ... سال انتشار: 2014
 

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Authers: Seyedeh Tahereh FAEZI, Mahdieh HOSSEINI ALMODARRESI, Mahmood AKBARIAN, Farhad GHARIBDOOST, Masoumeh AKHLAGHI, Ahamadreza JAMSHIDI, Farhad SHAHRAM, Abdolhadi NADJI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Pedram PARAGOMI and Fereydoun DAVATCHI

Abstract: Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports. Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients ... سال انتشار: 2014
 

Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet’s disease

Authers: Fereydoun Davatchi • Bahar Sadeghi Abdollahi • Cheyda Chams-Davatchi • Farhad Shahram • Zahra Ghodsi • Abdolhadi Nadji • Massoomeh Akhlaghi • Tahereh Faezi • Hormoz Shams • Roghieh Larimi • Farima Ashofteh

Abstract: The only diagnostic test that currently exists for Behcet’s disease (BD) is the pathergy test. A positive pathergy test (PPT) is an important component of many of the 16 sets of classification/diagnosis criteria used to diagnose BD. The aim of this study was to determine the importance of a PTT in the performance of the diagnosis/ classification criteria for BD. Patients and methods All patients listed in the BD registry of the Rheumatology Research Center, Tehran (6,727) and 4,648 ... سال انتشار: 2013
 

Clinical features of Behcet ’ s disease in patients without oral aphthosis

Authers: Seyedeh Tahereh Faezi 1 , Pedram Paragomi 1 , Farhad Shahram 1 , Hormoz Shams 2 , Cheida Shams-Davatchi 3 , Zahra Ghodsi 3 , Abdolhadi Nadji 1 , Maassoumeh Akhlaghi 1 , and Fereydoun Davatchi 1

Abstract: In current study we evaluated clinical features of Behcet ’ s Disease (BD) in patients without oral aphthosis (NOA cases). Methods. In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer ’ s exact test. Results. Among 6821 BD patients, 175 patients (2.56%) ... سال انتشار: 2013
 

Methotrexate in ocular manifestations of Behcet’s disease: a longitudinal study up to 15 years

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Tahereh FAEZI, Massoomeh AKHLAGHI and Farimah ASHOFTEH

Abstract: Ocular manifestations of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Methotrexate is the least toxic, used mainly for posterior uveitis. We present here the outcome of eye lesions with methotrexate and prednisolone, in a longitudinal study of up to 15 years, on 682 patients (5447 eye-years of follow-up). Patients and methods: Methotrexate was started at ... سال انتشار: 2013
 

Evaluation of apoptosis-related gene Fas (CD95) and FasL (CD178) polymorphisms in Iranian rheumatoid arthritis patients

Authers: Adel Mohammadzadeh • Ali Akbar Pourfathollah • Mohammad Taher Tahoori • Saeed Daneshmandi • Ladan Langroudi • Masoumeh Akhlaghi

Abstract: Apoptosis signals are essential for establishing homeostasis and adequate immune response. Dysregulation of apoptosis-related genes in the immune system, which could be due to gene polymorphisms, conduct to autoimmune diseases including rheumatoid arthritis. In the current study, the apoptosis-related gene Fas_-670A[G, FasL_ 844C[T, and FasLIVS2nt_124A[G polymorphisms were genotyped in 120 Iranian patients with rheumatoid arthritis (RA) and 112 unrelated healthy controls using PCR–RFLP method. Among the 120 RA patients being heterozygous in the promoter region of Fas_-670A/G (OR 1.42,CI 0.92- 1.52, ... سال انتشار: 2012
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI and Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2012
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2011