تالیفات

 

Association study of AFF1 gene polymorphism (rs340630) with Iranian systemic lupus erythematosus patients

Authers: Arabi E1, 3, Garshasbi M2, Jamshidi AR1, Khalesi R2, Ahmadzadeh N1, Akbarian M1, Mahmoudi M1

Abstract: Aim: To investigate whether AFF1 polymorphism was associated with susceptibility and clinical features of SLE in Iranian patients. Methods: A total of 320 patients with SLE and 330 age, sex and ethnically matched healthy control subjects were enrolled in the present study. Both cases and healthy controls were genotyped for rs340630 polymorphism located inside the AFF1using Amplification Refractory Mutation System-PCR (ARMS-PCR). In order to investigate the association of this SNP with clinical features of SLE, clinical manifestations of the patients ... سال انتشار: 2016
 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... سال انتشار: 2016
 

Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients

Authers: Masoumeh Kheirandish , Seyedeh Tahereh Faezi , Pedram Paragomi , Maassoumeh Akhlaghi , Farhad Gharibdoost , Ashraf Shahali , Mahboubeh Ebrahimpour Fini, and Mahmood Akbarian

Abstract: Objectives . We aimed to evaluate the prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE) and explore their association with demographic and clinical features. Methods. In this cross-sectional study, 166 SLE patients in rheumatology center of Shariati hospital, Tehran University of Medical Sciences were enrolled. SLE disease activity index (SLEDAI) and Beck and Cattell inventories for evaluation of depression and anxiety were completed for each patient. Results. The mean age of patients was ... سال انتشار: 2014
 

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Authers: Seyedeh Tahereh FAEZI, Mahdieh HOSSEINI ALMODARRESI, Mahmood AKBARIAN, Farhad GHARIBDOOST, Masoumeh AKHLAGHI, Ahamadreza JAMSHIDI, Farhad SHAHRAM, Abdolhadi NADJI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Pedram PARAGOMI and Fereydoun DAVATCHI

Abstract: Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports. Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients ... سال انتشار: 2014
 

Association of STAT4 rs7574865 with Susceptibility to Systemic Lupus Erythematosus in Iranian Population

Authers: Sedigheh Mirkazemi, 1 Mahmoud Akbarian, 2 Ahmad Reza Jamshidi, 2 Reza Mansouri, 3 Shima Ghoroghi, 2 Yahya Salimi, 4 Zahra Tahmasebi, 2 and Mahdi Mahmoudi2, 5

Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and ... سال انتشار: 2013
 

Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: Zahra Tahmasebi • Mahmoud Akbarian • Sedigheh Mirkazemi • Abtin Shahlaee • Zahra Alizadeh • Ali Akbar Amirzargar • Ahmad Reza Jamshidi • Shima Ghoroghi • Shiva Poursani • Keramat Nourijelyani • Mahdi Mahmoudi

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology with a complex pathogenesis involving multiple genetic and environmental contributions. Single-nucleotide polymorphisms (SNPs) in cytokine genes are associated with higher or lower cytokine activity, which can alter the susceptibility to certain diseases or their clinical outcomes. We investigated SNPs of the IL-1 family in Iranian SLE patients and normal individuals. We obtained blood samples from 207 SLE patients and 213 healthy controls. Cytokine genotyping was performed by polymerase ... سال انتشار: 2013
 

Clinical and preclinical manifestation of systemic lupus erythmatous

Authers: M. Ebrahimpur Fini, MD, T. Faezi, MD, M. Akbarian, MD, M. Akhlaghi, MD, M. Kheiyrandish, MD, A. Shahali, MD, F. Gharibdoust, MD, F. Shahram, MD, A.H. Naji, MD, A.R. Jamshidi, MD, F. Davachi, MD

Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male ... سال انتشار: 2011
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

Systemic lupus erythematosus in Iran: a study of 2280 patients over 33 years

Authers: Mahmood AKBARIAN, Seyedeh Tahereh FAEZI, Farhad GHARIBDOOST, Farhad SHAHRAM, Abdolhadi NADJI, Ahmad Reza JAMSHIDI, Maasoumeh AKHLAGHI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Fereydoun DAVATCHI

Abstract: Systemic lupus erythematosus (SLE) as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. The aim of this study was to show the manifestations of SLE in Iranian patients. Methods: The study was on manifestations of SLE according to the database of the Rheumatology Research Center (RRC), Tehran, Iran, on registered patients during the period of 1976 to ... سال انتشار: 2010
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydon Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi-Abdollahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Isolated Hematuria in SLE Patients and its Association with Proteinuria, Urinary Cast and SLE Disease Activity

Authers: M. Akbarian, H. Soleymani, F. Gharibdoost, A. Nadji, A.R. Jamshidi, , F. Shahram, M. Akhlaghi, S. Khosravi, S. Almasi, Fereydoun Davatchi

Abstract: Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of ... سال انتشار: 2009
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydoune Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi Abdillahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center

Authers: Mahmood Akbarian, Farhad Gharibdoost, Mehrzad Hadjaliloo, Abdolhadi Nadji, Ahmad Reza Jamshidi, Farhad Shahram, Masoomeh Akhlaghi, Shahrzad Khosravi, Simin Almasi, Fereydoun Davatchi

Abstract: At present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsDNA antibodies), erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP), or cytokines such as IL-2/IL-2 receptor, IL-6 and IL-10 are used as indirect serological markers with variable degrees of significance. To date, no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury ... سال انتشار: 2009
 

The protein–creatinine ratio in spot morning urine samples and 24-h urinary protein excretion in patients with systemic lupus erythematosus

Authers: Mansour Salesi, Mansoor Karimifar, Ziba Farajzadegan, Kamal Esalatmanesh, Shahrzad Khosravi, Parvin Fallahi, Mahmood Akbarian

Abstract: A 24-h urinary protein is a standard way to diagnose lupus nephritis. Assessment of protein–creatinine (Pr–Cr) ratio in morning spot urine is a valuable method in diabetic patients but not use in systemic lupus erythematous (SLE) patients routinely. In this study Pr–Cr ratio in spot urine was compare with 24-h urine protein; if they have valuable correlation we can use this test instead of 24- h urinary protein. The aim of this study was to evaluate the correlation ... سال انتشار: 2008
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

Correlation of systemic lupus erythematosus disease activity with classical complement (CH50) function and related protein levels

Authers: Bamdad Mehrbany K*, Akbarian M2, Salesi M, Geflati Z, Tavassoli S

Abstract: Background: The components of the classical complement pathway play an important role in the pathogenesis of systemic lupus erythematosus (SLE) and are reportedly useful biomarkers of disease activity. In this study, we evaluate disease activity, complement function (total hemolytic complement, CH50) and complement protein levels (C3, C4, C3d, C4d, SC5b-9), comparing the results of patients with active disease versus those with inactive disease. Methods: This cross-sectional study included 78 hospitalized women with SLE, 24 of whom were ... سال انتشار: 2008
 

Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-α and TNF receptor system in systemic lupus erythematosus

Authers: M. KARIMIFAR, , F. GHARIBDOOST, , M. AKBARIAN, , A. P. MEYSAMIE, , SH. KHOSRAVI, , Mozh. KARIMIFAR, , F. SHAHRAM, A. NADJI, A. R. JAMSHIDI, , M. AKHLAGHI, , B. YAZDANI1, F. DAVATCHI1

Abstract: Objective: There are some clues that measurement of triglyceride (TG) and high-density lipoprotein (HDL) and their correlation with tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor type 1 and type 2 (sTNFR1, sTNFR2) in serum could be valuable in the assessment of disease activity of systemic lupus erythematosus (SLE) patients. Methods: In this cross-sectional study, fasting blood samples were obtained from 86 SLE patients referred to the Rheumatology Research Center of Tehran University in Shariati ... سال انتشار: 2007
 

Heat shock protein 70 level of synovial fluid in rheumatoid arthritis versus osteoarthritis: a comparative study

Authers: Gharibdoost F., Samadi F., Taghipoor R., Akbarian M., Shahram F., Nadji A., Jamshidi A R, Davatchi F.

Abstract: Background: Heat-shock proteins are part of a strictly controlled biological system that allows organisms to respond to environmental stresses. Different proinflammatory cytokines are present in the synovial tissue of rheumatoid arthritis patients. Such tissues respond to stress and induce heat-shock proteins. In addition, synovial cells are exposed to mechanical stress caused by joint motion. The effects of mechanical stress on the metabolism of the synovial cells may be substantial, even pathogenic. Heat-shock proteins are often implicated ... سال انتشار: 2007
 

RELATIONSHIP BETWEEN KNEE MALALIGNMENT AND QANGLE WITH AGE AT ONSET OF DISEASE IN 260 CHONDROMALACIA PATELLA PATIENTS

Authers: I. SALEHI, R. JAMALI, S. KHAZAELI, A. JAMSHIDI, M.AKBARIAN, F. GHARIBDOOST, F. DAVATCHI

Abstract: Background: Chondromalacia patella is the most common cause of mechanical knee pain in young women. Q angle and knee alignment are important clinical parameters for biomechanics of the patellofemoral joint. Objective: To identifY the prevalence of knee malalignment and to find out if there is a correlation between knee mal alignment and Q angle with age at onset of disease. Methods: All patients under 40 years old complaining of mechanical knee pain with positive shrug sign ... سال انتشار: 2005
 

Bone mass density in the normal population of Iran

Authers: M. AKBARIAN, F. DAVATCHI, A. SALIMZADEH, F. SHAHRAM, F. GHARIBDOUST, A. NADJI, M. PAJOUHI, A. JAMSHIDI

Abstract: Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators of the bone mass and thus useful predictors of fracture risk. Dual energy X-ray absorptiometry (DEXA) is the easiest, yet the most precise and non-invasive technique. The need for a population-specific normative BMD data is vital in preventing mislabelling or misdiagnosis of osteopenia or even osteoporosis. Aim: This study was performed to determine the lumbar vertebral and the proximal ... سال انتشار: 2005
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

EVALUATION OF SERUM ALPHA-1-ANTITRYPSIN LEVELS IN 62 PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DISEASE IN TEHRAN.

Authers: K. Bamdad Mehrbany, M. Akbarian, A. Abdoly Fard

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune and chronic inflammatory disease. It is believed that the attachment of autoantibodies to autoantigens leads to inflammation and kidney disorders. Alpha- 1-antitrypsin is an acute phase protein that neu­tralizes the deleterious effects of the proteolytic enzymes. The level of alpha-1-antitrypsin raises in inflammation. This enzyme is produced from those inflammatory cells (neutrophils) infiltrating to the involved sites. The goals of this study were ... سال انتشار: 2002
 

HLA-B51 FREQUENCY IN IRANIAN PATIENTS WITH BEHCET’S DISEASE.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, M. Akbarian, C. Chams

Abstract: Introduction: HLA-B51, a split antigen of HLA-B5, has generally been associated with Behcet’s disease (BD) in different countries notably those along the Silk route. The aim of this study was to determine the frequency of HLA-B51 in Iranian patients with BD, and to compare it with the control patients. Patients & methods: In a prospective study, 599 consecutive new patients referred to the BD clinic, in a 9-month period from ... سال انتشار: 2002
 

CHRONOLOGY OF CLINICAL MANIFESTATIONS IN BEHCET’S DISEASE, ANALYSIS OF 3542 CASES.

Authers: F. Shahram, K. Assadi, F. Davatchi, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian

Abstract: Introduction: Manifestations of Behcet’s disease (BD) appear one after another during the course of the disease. Some involvements such as mucous lesions seem to appear early, and others such as gastrointestinal (GI) and neurological (CNS) involvement many years later. This study was planned to find out the chronology of different manifestations of BD. Patients & methods: In a retrospective study, files of all BD patients diagnosed since 1989 were reviewed ... سال انتشار: 2002
 

AZATHIOPRINE AND LOW DOSE PULSE CYCLOPHOSPHAMIDE IN SEVERE OCULAR LESIONS OF BEHCET’S DISEASE, A PRELIMINARY REPORT.

Authers: F. Shahram, F. Davatchi, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Combination of cytotoxic drugs was suggested to decrease the rate of non-responders in severe ocular lesions of Behcet’s disease (BD). We present here our preliminary data with low dose pulse Cyclophosphamide (LDP) and Azathioprine (AZA) in the treatment of posterior uveitis (PU) and/or retinal vasculitis (RV) of BD. Patients & methods: Twelve BD patients with PU and RV were selected. They all received LDP as 0.5 g/m2 body surface/month ... سال انتشار: 2002
 

TONSILLECTOMY AND BEHCET’S DISEASE.

Authers: M. Jalessi, F. Shahram, A. Safavi, F. Davatchi, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost.

Abstract: Introduction: Increasing development of some diseases such as Behcet’s disease (BD) was reported after tonsillectomy. This study was designed to find the association between tonsillectomy/adenoidectomy (T/A) and subsequent development of BD. Patients & methods: In a prospective control study, 128 patients with BD and 139 controls from the orthopedic clinic (age and sex matched) were studied regarding previous T/A. A complete ENT clinical examination was performed for all of them. ... سال انتشار: 2002
 

URINE ABNORMALITIES IN BEHCET’S DISEASE, STUDY OF 4704 CASES.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost, C. Chams.

Abstract: Introduction: Despite the multisystem nature of Behcet’s disease (BD), renal involvement is rare in this disease. The aim of this study was to find the prevalence and characteristics of urine abnormalities and renal involvement of BD in Iran. Patients & methods: In a cohort of 4704 patients with BD, urinalysis was performed to screen patients with urine abnormalities. Different manifestations of the disease, including 100 clinical and paraclinical parameters, were ... سال انتشار: 2002
 

BEHCET’S DISEASE. ANALYSIS OF 4660 CASES.

Authers: F. Davatchi, C. Chams, F. Shahram, F. H. Chams, A. Nadji, M. Akbarian, F. Gharibdoost

Abstract: Behcet’s Disease (BD) is a multisystemic disease with a peculiar distribution in the world. The disease is specially seen in the countries bordering the ancient SILK ROAD specially Japan, China, Korea, Iran, and Turkey. The majority of reports on BD are on hospital based patients. Others are either local based patients or epidemilogical studies on a small area. The only two nationwide analysis of BD is from Japan and ... سال انتشار: 2002
 

THE COMPARISON OF ANKYLOSING SPONDYLITIS IN BEHCET'S DISEASE AND NORMAL POPULATION: A CONTROL STUDY.

Authers: A. Nadji, F. Davatchi, F. Shahram, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: We previously reported that ankylosing spondylitis (AS) was associated with Behcet's disease (BD) in Iranian patients. This study was designed to evaluate the features of AS in BD (ASBD) and compare them with the AS in normal population (ASN). Materials and Methods: Among 4700 BD patients, 73 ASBD were found and were compared with a cohort of 180 ASN. Seventy out of 73 ASBD met the European Spondyloarthropathy Study Group ... سال انتشار: 2002
 

EVALUATION OF THE MORTALITY IN SLE, ANALYSIS OF 165 PATIENTS.

Authers: A. Hadjiabbassi, M. Akbarian, S. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A.R. Jamshidi, F. Davatchi

Abstract: Objective: SLE is an autoimmune disease. The mortality rate and causes are different in the various countries. The present study is done to find out the causes of mortality in the SLE patients in Iran. Methods: This study was retrospective according to medical records of patients who were referred to Rheumatology polyclinic, admitted in Rheumatology ward, ICU, Gynecology and Nephrology wards of Shariati hospital during 10 years, from 1991-2001. Results: Of 2021 ... سال انتشار: 2002