تالیفات

 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... سال انتشار: 2016
 

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Authers: Seyedeh Tahereh FAEZI, Mahdieh HOSSEINI ALMODARRESI, Mahmood AKBARIAN, Farhad GHARIBDOOST, Masoumeh AKHLAGHI, Ahamadreza JAMSHIDI, Farhad SHAHRAM, Abdolhadi NADJI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Pedram PARAGOMI and Fereydoun DAVATCHI

Abstract: Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports. Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients ... سال انتشار: 2014
 

Association of STAT4 rs7574865 with Susceptibility to Systemic Lupus Erythematosus in Iranian Population

Authers: Sedigheh Mirkazemi, 1 Mahmoud Akbarian, 2 Ahmad Reza Jamshidi, 2 Reza Mansouri, 3 Shima Ghoroghi, 2 Yahya Salimi, 4 Zahra Tahmasebi, 2 and Mahdi Mahmoudi2, 5

Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and ... سال انتشار: 2013
 

Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: Zahra Tahmasebi • Mahmoud Akbarian • Sedigheh Mirkazemi • Abtin Shahlaee • Zahra Alizadeh • Ali Akbar Amirzargar • Ahmad Reza Jamshidi • Shima Ghoroghi • Shiva Poursani • Keramat Nourijelyani • Mahdi Mahmoudi

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology with a complex pathogenesis involving multiple genetic and environmental contributions. Single-nucleotide polymorphisms (SNPs) in cytokine genes are associated with higher or lower cytokine activity, which can alter the susceptibility to certain diseases or their clinical outcomes. We investigated SNPs of the IL-1 family in Iranian SLE patients and normal individuals. We obtained blood samples from 207 SLE patients and 213 healthy controls. Cytokine genotyping was performed by polymerase ... سال انتشار: 2013
 

Clinical and preclinical manifestation of systemic lupus erythmatous

Authers: M. Ebrahimpur Fini, MD, T. Faezi, MD, M. Akbarian, MD, M. Akhlaghi, MD, M. Kheiyrandish, MD, A. Shahali, MD, F. Gharibdoust, MD, F. Shahram, MD, A.H. Naji, MD, A.R. Jamshidi, MD, F. Davachi, MD

Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male ... سال انتشار: 2011
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

Systemic lupus erythematosus in Iran: a study of 2280 patients over 33 years

Authers: Mahmood AKBARIAN, Seyedeh Tahereh FAEZI, Farhad GHARIBDOOST, Farhad SHAHRAM, Abdolhadi NADJI, Ahmad Reza JAMSHIDI, Maasoumeh AKHLAGHI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Fereydoun DAVATCHI

Abstract: Systemic lupus erythematosus (SLE) as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. The aim of this study was to show the manifestations of SLE in Iranian patients. Methods: The study was on manifestations of SLE according to the database of the Rheumatology Research Center (RRC), Tehran, Iran, on registered patients during the period of 1976 to ... سال انتشار: 2010
 

Isolated Hematuria in SLE Patients and its Association with Proteinuria, Urinary Cast and SLE Disease Activity

Authers: M. Akbarian, H. Soleymani, F. Gharibdoost, A. Nadji, A.R. Jamshidi, , F. Shahram, M. Akhlaghi, S. Khosravi, S. Almasi, Fereydoun Davatchi

Abstract: Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of ... سال انتشار: 2009
 

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center

Authers: Mahmood Akbarian, Farhad Gharibdoost, Mehrzad Hadjaliloo, Abdolhadi Nadji, Ahmad Reza Jamshidi, Farhad Shahram, Masoomeh Akhlaghi, Shahrzad Khosravi, Simin Almasi, Fereydoun Davatchi

Abstract: At present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsDNA antibodies), erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP), or cytokines such as IL-2/IL-2 receptor, IL-6 and IL-10 are used as indirect serological markers with variable degrees of significance. To date, no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury ... سال انتشار: 2009
 

Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-α and TNF receptor system in systemic lupus erythematosus

Authers: M. KARIMIFAR, , F. GHARIBDOOST, , M. AKBARIAN, , A. P. MEYSAMIE, , SH. KHOSRAVI, , Mozh. KARIMIFAR, , F. SHAHRAM, A. NADJI, A. R. JAMSHIDI, , M. AKHLAGHI, , B. YAZDANI1, F. DAVATCHI1

Abstract: Objective: There are some clues that measurement of triglyceride (TG) and high-density lipoprotein (HDL) and their correlation with tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor type 1 and type 2 (sTNFR1, sTNFR2) in serum could be valuable in the assessment of disease activity of systemic lupus erythematosus (SLE) patients. Methods: In this cross-sectional study, fasting blood samples were obtained from 86 SLE patients referred to the Rheumatology Research Center of Tehran University in Shariati ... سال انتشار: 2007
 

Heat shock protein 70 level of synovial fluid in rheumatoid arthritis versus osteoarthritis: a comparative study

Authers: Gharibdoost F., Samadi F., Taghipoor R., Akbarian M., Shahram F., Nadji A., Jamshidi A R, Davatchi F.

Abstract: Background: Heat-shock proteins are part of a strictly controlled biological system that allows organisms to respond to environmental stresses. Different proinflammatory cytokines are present in the synovial tissue of rheumatoid arthritis patients. Such tissues respond to stress and induce heat-shock proteins. In addition, synovial cells are exposed to mechanical stress caused by joint motion. The effects of mechanical stress on the metabolism of the synovial cells may be substantial, even pathogenic. Heat-shock proteins are often implicated ... سال انتشار: 2007
 

Bone mass density in the normal population of Iran

Authers: M. AKBARIAN, F. DAVATCHI, A. SALIMZADEH, F. SHAHRAM, F. GHARIBDOUST, A. NADJI, M. PAJOUHI, A. JAMSHIDI

Abstract: Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators of the bone mass and thus useful predictors of fracture risk. Dual energy X-ray absorptiometry (DEXA) is the easiest, yet the most precise and non-invasive technique. The need for a population-specific normative BMD data is vital in preventing mislabelling or misdiagnosis of osteopenia or even osteoporosis. Aim: This study was performed to determine the lumbar vertebral and the proximal ... سال انتشار: 2005
 

EVALUATION OF THE MORTALITY IN SLE, ANALYSIS OF 165 PATIENTS.

Authers: A. Hadjiabbassi, M. Akbarian, S. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A.R. Jamshidi, F. Davatchi

Abstract: Objective: SLE is an autoimmune disease. The mortality rate and causes are different in the various countries. The present study is done to find out the causes of mortality in the SLE patients in Iran. Methods: This study was retrospective according to medical records of patients who were referred to Rheumatology polyclinic, admitted in Rheumatology ward, ICU, Gynecology and Nephrology wards of Shariati hospital during 10 years, from 1991-2001. Results: Of 2021 ... سال انتشار: 2002
 

LATE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS IN IRAN.

Authers: M. Akbarian, M. Valizadeh, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objectives: The aim of this study is to analyze the clinical features, laboratory findings and type of treatments in late onset SLE (after 50 years) in Iranian patients and compare them with the early onset. Methods: Records of 1419 SLE patients who attended our lupus unit, between 1975 and 1999 were reviewed. Nineteen Patients with late onset disease were identified. For comparison, 47 patients with disease onset before the age of ... سال انتشار: 2002
 

THE ORAL AND RADIOLOGICAL MANIFESTATIONS OF SYSTEMIC SCLEROSIS IN IRANIAN PATIENTS.

Authers: F. Gharibdoost, R. Nadjafizadeh, M. Akbarian, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi.

Abstract: Objective: Oral involvement is one of the most important manifestations in systemic sclerosis. We studied clinical and radiological presentations of patients with systemic sclerosis in IRAN. Methods: This study is a prospective case series on forty patients with systemic sclerosis (29 limited & 11 diffuse form) according to ACR (American College of Rheumatology) criteria, referred to Rheumatology Research Center from 2000-2001. For every patient, 41 data surveyed. Results: The mean age of ... سال انتشار: 2002
 

­LARGE VESSEL MANIFESTATIONS OF BEHCET’S DISEASE,REPORT OF 377 CASES.

Authers: F. Shahram, A. Nadji, M. Akbarian, A. Jamshidi, F. Gharibdoost, F. Davatchi

Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ... سال انتشار: 2001
 

OUTCOME MEASUREMENT OF TYPE IV SYSTEMIC LUPUS NEPHRITIS BY CLASSIFICATION AND REGRATION TREE (CART).

Authers: S. Soroosh, M. Akbarian, F. Davatchi, F. Shahram, A. Nadji, F. Gharibdoost, A. Jamshidi

Abstract: The prognosis of Systemic Lupus Erythematosus depends partly on renal involvement. Lupus nephritis has evolved from a frequently terminal process such as type IV lupus nephritis according to WHO classification to one in which a fairly normal quality of life and good outcome are possible. The aim of this study was to try to predict the short-term outcome of type IV lupus nephritis by looking at the disease variables before ... سال انتشار: 2000
 

CLASSIFICATION TREE AS PREDICTOR OF TYPE IV WHO KIDNEY INVOLVEMENT, USING CLINICAL AND LABORATORY TESTS, IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).

Authers: A. Hadjabbassi. M. Akbarian, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Purpose: To use clinical and laboratory tests instead of kidney biopsy for the diagnosis of type IV WHO renal involvement in SLE. Methods: Patients with SLE were divided in two groups according to their kidney biopsy: type IV WHO (110 patients) and other forms (98 patients). Each group was further divided in two groups: the learning sample and the validation ample. The classification and regression tree method was used for the ... سال انتشار: 2000
 

Long-term outcome of ocular manifestations in Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, M. Akbarian, C. Chams, F. Gharibdoost, A. Jamshidi, F. Romooz.

Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ... سال انتشار: 2000
 

Clinical features in Systemic Sclerosis in early and late phases. Analysis of 53 patients.

Authers: F. Gharibdoost, R. Najafizadeh, A. Khalvat, M. Akbarian, F. Shahram. A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objective: Systemic sclerosis is a generalized disorder of connective tissue disease. This study surveyed the clinical manifestations of systemic sclerosis in early (6 years) phases of limited and diffuse variants. Methods: Nineteen patients with diffuse and thirty-four cases with limited form of disease were selected consecutively from 1992 to 1998. Sixty-five clinical data were evaluated and then analyzed by MC-Nemar chi square test between two forms in both phases. Results: (1) There were ... سال انتشار: 1999
 

CONVULSION AND ITS RELATION TO ANTI-DNA ANTIBODY LEVELS IN SYSTEMIC LUPUS ERYTHEMATOSUS.

Authers: F. Gharibdoost, M. Akbarian, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: The neuropsychiatric manifestations of systemic lupus erythematosus are frequent. One of the most serious presentations is convulsion. This study was carried out to evaluate the relation between convulsion and anti-DNA antibody levels. An analytic, retrospective case-controlled study was carried out, with reference to 1001 recorded cases of systemic SLE lupus erythematosus in Lupus Unit, Rheumatology Center, Shariati Hospital, Tehran University of Medical Sciences. The frequency Of convulsion was 13.3%. There ... سال انتشار: 1999
 

PREGNANCY OUTCOME IN SYSTEMIC LUPUS ERYTHEMATOSUS.

Authers: M. Akbarian, F. Pouryousef, F. Shahram, F. Gharibdoust, A. Nadji, A.R. Jamshidi, F. Davatchi.

Abstract: Objective: To assess the course of maternal disease and outcome of preg­nancy in patients with systemic lupus erythematosus (SLE). Patients and Methods: One hundred SLE patients who carried out 128 pregnancies were studied retrospectively. These patients were followed in lupus unit every one to two months by the rheumatologist and obstetrician team throughout pregnancy. Some patients were given prophylactic low-dose Prednisolone. Lupus flares were treated by increasing Prednisolone doses. Patients who ... سال انتشار: 1999
 

Azathioprine for The Treatment of Ophthalmological Lesions of Behcet’s Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, M. Akbarian, A. Nadji, C. Chams, F. Gharibdoost, A. Jamshidi, S. Soroosh

Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) are the main morbidity factor in Behcet’s Disease (BD). They usually progress toward severe loss of vision or blindness. They need aggressive treatment with cytotoxic drugs. Azathioprine was demonstrated, in a double blind control study, to be effective in Behcet’s Disease. The aim of this study was to evaluate the efficacy of Azathioprine in ocular lesions of BD, and to compare ... سال انتشار: 1998
 

Bone Mass Density in Normal Iranian Population.

Authers: M. Akbarian, F. Davatchi, A. Salimzadeh, F. Shahram, F. Gharibdoost, A. Nadji, M. Pajouhi, A. Jamshidi

Abstract: The bone mass density (BMD) may vary in different countries due to different genetic and environmental factors. This study was performed to determine the BMD of the normal population in Iran. Subjects were selected randomly from different social workers classes in Tehran (from the lowest to the highest). For each decade and sexes, 20 normal subjects were selected (140 men and 140 women). BMD was measured with a Hologic 1000 ... سال انتشار: 1998
 

OVERLAP IN CONNECTIVE TISSUE DISEASES EVALUATION OF 119 CASES.

Authers: S.G. Soroosh, F. Shahram, M. Akbarian, F. Gharibdoost, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: The overlap syndrome is a vague entity in the group of connective tissue diseases. It is unclear whether it is fortuitous association of two or more connective tissue diseases (CTD), or a distinct disease. The early description of this syndrome was "a collection symptoms of CTD and the existence of anti - nRNP antibody". Many studies however, show that the anti - nRNP antibody is not specific for diagnosis. The ... سال انتشار: 1998
 

Epidemiology of Behcet's disease in Iran.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost, A. Nadji, A. Jamshidi, S. Soroosh

Abstract: Introduction: The geographical distribution of Behcet's Disease (B.D) is thought to be due to the predisposing factor(s) spread along the Silk Route. It is widely accepted that the predisposing factor(s) is of genetic origin. However the rarity of BD among Hawaiian's Japanese immigrants may be in favor of environmental factors. Iran is situated in the middle of the Silk Route. Caucasians account for 75.4%, Turks (from Mongoloid ethnic origin) for ... سال انتشار: 1998
 

Familial Oral Aphthosis in General Population As Compared To Behcet’s Disease.

Authers: C. Chams, F. Davatchi, F. Shahram, M. Akbarian, A. Nadji, F. Gharibdoost, H. Chams, A. Jamshidi.

Abstract: Introduction: Oral aphthosis (OA) is seen in 96% of patient with Behcet’s Disease (BB) OA is said to be rather frequent in the general population. It was therefore interesting to determine whether OA in the general population had also a genetic background as it is for BD. It was also interesting to determine if the genetic background was similar in both conditions (BD and OA in the general population). Therefore, ... سال انتشار: 1998
 

Familial Study in Behcet's Disease, Analysis of 1242 Patients.

Authers: F. Shahram, C. Chams, F. Davatchi, A. Nadji, M. Akbarian. A. Jamshidi

Abstract: Introduction: The etiology of Behcet's disease (BD) is unknown, but like other autoimmune disorders both environmental and genetic factors contribute to its pathophysiology. The familial form of BD is in favor of a genetic predisposition. This study was designed to evaluate the prevalence of the familial form and their possible effect on the disease expression in Iranian patients. Materials & Methods: We studied prospectively 1242 consecutive patients with ... سال انتشار: 1998
 

Juvenile Behcet's Disease: Diagnosed Before Or After Childhood?

Authers: F. Shahram, N. Shafaie, F. Davatchi, A. Nadji, M. Akbarian, A. Jamshidi

Abstract: Introduction: Behcet's disease (BD) is underdiagnosed in children. It is mainly due to the wide range manifestations of the disease, the low specificity of the symptoms, and the unfamiliarity of most physicians with childhood BD. These patients are not included in the juvenile group and may be a cause of controversy in the description of BD in children. The aim of this study was to find if the characteristics of ... سال انتشار: 1998
 

METHOTREXATE FOR OCULAR LESIONS OF BEHCET'S DISEASE. COHORT STUDY ON 262 PATIENTS.

Authers: F. Davatchi, F. Shahram, H. Chams. M. Akbarian, A. Nadji. F. Gharibdoost, C. Chams. A. Jamshidi, S. Soroosh

Abstract: INTRODUCTION: Ocular lesions of Behcet's Disease (BD) progress usually toward severe loss of vision or blindness, if not aggressively treated. Cytotoxic drugs are the main therapeutic arsenals used for it: Low dose methotrexate (MTX) by its safety and its efficacy is one of the best therapeutic choices. MATERIALS &METHODS: MTX was used as 7.5 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. Upon the suppression of the inflammatory reaction, prednisolone ... سال انتشار: 1998