تالیفات

 

Effects of intravenous Semelil (ANGIPARSTM) on diabetic foot ulcers healing: A multicenter clinical trial

Authers: Larijani B, Heshmat R, Bahrami A, Delshad H, 5Ranjbar Omrani G, Mohammad K, Heidarpour R, Mohajeri Tehrani MR, Kamali K, Farhadi M, Gharibdoust F, , Madani SH

Abstract: Some diabetic foot ulcers, which are notoriously difficult to cure, are one of the most common health problems in diabetic patients .There are several surgical and medical options which already have been introduced for treatment of diabetic foot ulcers, so some patient will require amputation. The purpose of this study was to evaluate the efficacy of intravenous Semelil (ANGIPARSTM), a naive herbal extract to accelerate healing of diabetic foot ulcers. A multi-centric randomized controlled trial ... سال انتشار: 2008
 

Effect of ANGIPARS™, a new herbal drug on diabetic foot ulcer: A phase 2 clinical study

Authers: Masoompour SM, , 2Bagheri MH, , 3Borhani Haghighi A, , 4Novitsky YA, , Sadeghi B, Gharibdoust F, Larijani B, 1Ranjbar Omrani G

Abstract: Diabetes foot ulcers are a major predictor of future lower-extremity amputation in patients with diabetes. The animal studies have indicated that treatment with a new herbal extract named ANGIPARS™ improves healing of chronic ulcers. The main objective of the study was to evaluate the safety and healing rates of diabetic foot ulcers in patients treated with ANGIPARS™. Ten diabetic patients (7 males and 3 females) were eligible for enrollment in this single arm before-after clinical trial. ... سال انتشار: 2008
 

Clinical application of oral form of ANGIPARS™ and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

Authers: 1Bahrami A, , 2Kamali K, , 1Ali-Asgharzadeh A, , 3Hosseini P, , Heshmat R, , Khorram Khorshid HR, , Gharibdoust F, , 6Madani SH, , 3Larijani B

Abstract: ANGIPARS™ is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARS™ and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities. Twenty one patients with diabetic foot ulcers were divided into 3 ... سال انتشار: 2008
 

Assessment of maximum tolerated dose of a new herbal drug, Semelil (ANGIPARSTM) in patients with diabetic foot ulcer: A Phase I clinical trial

Authers: Heshmat R, , 1Mohammad K, , 2Mohajeri Tehrani MR, 2Tabatabaie Malazy O, Keshtkar AA, Gharibdoust F, , 2Larijani B

Abstract: Background and the purpose of the study: In many cases of diabetic foot ulcer (DFU) management, wound healing is incomplete, and wound closure and epithelial junctional integrity are rarely achieved. Our aim was to evaluate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of Semelil (ANGIPARSTM), a new herbal compound for wound treatment in a Phase I clinical trial. Methods: In this open label study, six male diabetic patients with a mean age of ... سال انتشار: 2008
 

Effects of levothyroxine suppressive therapy on bone mineral density in premenopausal women

Authers: B. Larijani* MD،F. Gharibdoost MD،M. Pajouhi* MD،A. Sadjadi MD،S. Aghakhani MD،R. Eshraghian§ PhD،S. M. Akrami– MD PhD،G. Maalouf** MD

Abstract: SUMMARY Background: Levothyroxine (L-T4) is widely prescribed for treating thyroid disorders, but its effect on bone mineral density (BMD), is being debated. Objectives: We studied the effect of supraphysiologic doses of L-T4 on BMD in a group of premenopausal women. Patients and methods: We included 50 women (mean age = 36Æ8 ± 7Æ6 years) receiving L-T4 for at least 1 year for treating their benign cold thyroid nodules. Serum T3, T4, thyroid-stimulating hormone (TSH), parathyroid hormone (PTH), calcium, and phosphate and urine calcium ... سال انتشار: 2004
 

Effects of Suppressive Therapy with Levothyroxine on Bone Density.

Authers: B. Larijanie, F. Gharibdoost, M. Pajoohi, M. Bastanhagh, A. Sajadi, M. Shirzad, F. Davatchi

Abstract: Increased thyroid hormones level is associated with diminished bone density. It has been clarified that thyroid hormones by sirculating bone resorption lead to decrease in bone density. Thyroid hormone in many cases as in Non - Toxic Grotre & in supplement therapy in hypothyroidism is used as a drug & it is possible that suppressive therapy with T4 causes subclinical - hyperthyroidism. Studies done in west has shown different results ... سال انتشار: 1996