تالیفات

 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
Ankylosing spondylitis M-CSF-derived macrophages are undergoing unfolded protein response (UPR) and express higher levels of interleukin-23  

Ankylosing spondylitis M-CSF-derived macrophages are undergoing unfolded protein response (UPR) and express higher levels of interleukin-23

مولف: Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Ahmad Reza Jamshidi & Mohammad Hossein Nicknam

خلاصه: Objective: Interleukin (IL)-23/IL-17 pathway involves in the pathogenesis of ankylosing spondylitis (AS). The exact mechanism implicated in overexpression of IL-23 and activation of the IL-23/IL-17 axis is not clear. The aim of the study was to clarify whether macrophages of AS patients undergo unfolded protein response (UPR) and secret increased IL-23. Methods: Peripheral blood monocyte isolated from 10 HLA-B27þ patients and five HLA-B27þ normal subjects were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for seven ... سال انتشار: 2017
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

Authers: Shamsolmoulouk Najafi1, Mahsa Mohammadzadeh2, Alireza Zare Bidoki3, 4, Ghasem Meighani5, Saeed Aslani6, 7, Mahdi Mahmoudi6, and Nima Rezaei7, 8, 9

Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment

Authers: Marjan Vakili, 1 Vahid Ziaee, 2, 3, * Mohammad Hassan Moradinejad, 1, 3 Seyed Reza Raeeskarami, 3 Farzad Kompani, 1, 3 and Tayebeh Rahamooz1

Abstract: Various indices have been raised as predictors of activity and severity of juvenile idiopathic arthritis. Objectives: This study was conducted to investigate the changes of platelet indices in acute phase and two months after treatment in these patients. Patients and Methods: In a cohort study, platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were evaluated in children referred to children’s medical center, Tehran due to juvenile idiopathic arthritis from ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

Treatment of low back pain: randomized clinical trial comparing a multidisciplinary group-based rehabilitation program with oral drug treatment up to 12 months

Authers: Sedigheh Sadat TAVAFIAN, 1 Ahmad Reza JAMSHIDI2 and Kazem MOHAMMAD3

Abstract: Background: This study aimed to examine the effects of a multidisciplinary treatment program on health-related quality of life of Iranian patients living with chronic low back, at 12 months follow-up. Methods: This study is an extended follow-up of an original randomized, controlled trial with registration number NCT00600197. In the present study 87 patients in an intervention group and 91 patients in a control group were assessed at 12 months follow-up. The intervention was a ... سال انتشار: 2014
 

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

Authers: Mina Doudkani-Fard1, Vahid Ziaee2, Mohamad-Hassan Moradinejad3 Mojtaba Sedaghat4, Mohammad-Taghi Haghi-Ashtiani5, Zahra Ahmadinejad6

Abstract: Background: Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis (RA). Evaluation of ... سال انتشار: 2014
 

RAC1 single nucleotide polymor-phisms in Crohn’s disease

Authers: Mohammad TaheraNasser Ebrahimi DaryaniaMona HedayatbMohammad EslamianaElham Farhadic, dMahdi MahmoudieSamira ShirzadfMohammd Kazem Nouri TaromlouaMeghedi ChaharmahaligMohammad Hossein NicknamcMohammad BashashatihNima

Abstract: diseaseRac1 is a regulator for cellular motility, proliferation andtransformation. A recent showed that mutations of RAC1gene are associated with higher risk of inflammatory boweldisease (IBD). These mutations increase the expression ofRac1 protein and intriguingly, loss of Rac1 expression resultsin protection from colitis [1,2].Thus we conducted a case-control study on 67 patientswith Crohn’s disease (CD) and 78 healthy individuals toidentify whether there is any association between CD andsingle nucleotide polymorphisms (SNPs) ... سال انتشار: 2014
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... سال انتشار: 2014
 

Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor Isotypes in Iranian Patients with Rheumatoid Arthritis: Evaluation of Clinical Value and Association with Disease Activity

Authers: Yadollah Shakiba1, Susan Koopah1, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, Ahmad Masoud1, Amir Kiani3, Mohammad Hossein Niknam1, Bahareh Nazari1, and Behrouz Nikbin1, 4

Abstract: In this study we determined the frequency, sensitivity and specificity of anti cyclic citrullinated peptides (anti-CCP) IgG antibody, total rheumatoid factor (RF-T), and RF isotypes in Iranian patients with rheumatoid arthritis (RA) and their association with age, clinical and serological parameters. Anti-CCP and RF-T and RF isotypes level were measured in 418 patients and 399 healthy controls by enzyme-linked immunosurbant assay (ELISA). Additionally, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ... سال انتشار: 2014
 

Effect of All-transretinoic Acid on Th17 and T Regulatory Cell Subsets in Patients with Ankylosing Spondylitis

Authers: KATAYOON BIDAD, EISA SALEHI, AHMADREZA JAMSHIDI, ALI AKBAR SABOOR-YARAGHI, MONA ORAEI, ALIPASHA MEYSAMIE, MAHDI MAHMOUDI, and MOHAMMAD HOSSEIN NICKNAM

Abstract: We compared Th17 and T regulatory cells in patients with ankylosing spondylitis (AS) and in healthy controls. The effect of all-transretinoic acid (ATRA) was studied on cultured CD4+ T cells of patients with AS compared to controls. Methods. Eighteen patients with AS and 18 age- and sex-matched healthy controls were included. CD4+ T cells were separated and cultured in conditions of anti-CD3 and anti-CD28 stimulation with and without ATRA. Intracellular and secreted cytokines, transcription factors, ... سال انتشار: 2013
 

Association Between the Interleukin 6 Genotype at Position –174 and Atopic Dermatitis

Authers: M Gharagozlou, 1 E Farhadi, 2, 4 M Khaledi, 5 N Behniafard, 1 S Sotoudeh, 1 R Salari, 2 B Darabi, 1 SM Fathi, 1 M Mahmoudi, 6 A Aghamohammadi, 1, 7 AA Amirzargar, 2, 3 N Rezaei1, 2, 3, 7

Abstract: Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the fi rst time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease. Methods: This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions –174 and nt565 in 89 Iranian children with AD and 139 healthy controls. Results: ... سال انتشار: 2013
 

TNF-alpha single nucleotide polymorphisms in atopic dermatitis

Authers: Nasrin Behniafard1, Mohammad Gharagozlou1, Elham Farhadi2, 3, Mojdeh Khaledi4, Soheila Sotoudeh1, Behzad Darabi1, Seid Mohammad Fathi1, Zahra Gholizadeh Moghaddam1, Mahdi Mahmoudi5, Asghar Aghamohammadi1, 6, Ali Akbar Amirzargar2, Nima Rezaei1, 2, 6

Abstract: Tumor necrosis factor-alpha (TNF-) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF- gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was ... سال انتشار: 2013
 

The Effects of Isolated Hip Abductor and External Rotator Muscle Strengthening on Pain, Health Status, and Hip Strength in Females With Patellofemoral Pain: A Randomized Controlled Trial

Authers: KHALIL KHAYAMBASHI, PT, PhD1 • ZEYNAB MOHAMMADKHANI, MS2 • KOUROSH GHAZNAVI, MD3, MARK A. LYLE, PT, OCS4 • CHRISTOPHER M. POWERS, PT, PhD5

Abstract: TTSTUDY DESIGN: Randomized controlled trial. TTOBJECTIVES: To examine the effectiveness of isolated hip abductor and external rotator strengthening on pain, health status, and hip strength in females with patellofemoral pain (PFP). TTBACKGROUND: Altered hip kinematics resulting from hip muscle weakness has been proposed as a contributing factor in the development of PFP. To date, no study has examined clinical outcomes associated with isolated hip muscle strengthening in those with PFP. TTMETHODS: Twenty-eight females with ... سال انتشار: 2012
 

Multiple Imputation to Deal with Missing Clinical Data in Rheumatologic Surveys: an Application in the WHO-ILAR COPCORD Study in Iran

Authers: M Mirmohammadkhani1, A Rahimi Foroushani1, F Davatchi2, 3, K Mohammad1, A Jamshidi2, 3, A Tehrani Banihashemi1, 3, *K Holakouie Naieni 1,

Abstract: The aim of the article is demonstrating an application of multiple imputation (MI) for handling missing clinical data in the setting of rheumatologic surveys using data derived from 10291 people participating in the first phase of the Community Oriented Program for Control of Rheumatic Disorders (COPCORD) in Iran. Methods: Five data subsets were produced from the original data set. Certain demographics were selected as complete variables. In each subset, we created a univariate pattern ... سال انتشار: 2012
 

Random Forests Analysis: A modern statistical method for screening in high-dimensional studies and its application in a population-based genetic association study

Authers: Sahar Noori1, Keramat Nourijelyani 2*, Kazem Mohammad3, Mohammad Hossein Niknam4, Mahdi Mahmoudi5, Laris Andonian6, and Arash Akaberi7

Abstract: Technology advances in this century, especially, in molecular generics yields high volume, high dimensional data. This creates many unprecedented challenges for statisticians who are responsible for analysis of such data. Although logistic regression method is quite popular in association analysis in medical researches but it has some serious limitations in handling high dimensional data. In present study, our goal is introduce a modern model-free statistical method called random forest that we believe is able to overcome difficulties ... سال انتشار: 2012
 

Katayoon Bidad • Sasan Fallahi • Mahdi Mahmoudi • Ahmadreza Jamshidi • Elham Farhadi • Alipasha Meysamie • Mohammad Hossein Nicknam

Authers: Katayoon Bidad • Sasan Fallahi • Mahdi Mahmoudi • Ahmadreza Jamshidi • Elham Farhadi • Alipasha Meysamie • Mohammad Hossein Nicknam

Abstract: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) are widely used instruments in assessment of patients suffering from ankylosing spondylitis (AS). The Patient Acceptable Symptom State (PASS) is regarded as a target for patients’ well-being. The aim of this study was to translate and adapt BASDAI, BASFI and PASS into the Iranian official language, Farsi, and evaluate their reliability and validity. Ninety patients with AS were included in this study. The ... سال انتشار: 2012
 

Evaluation of apoptosis-related gene Fas (CD95) and FasL (CD178) polymorphisms in Iranian rheumatoid arthritis patients

Authers: Adel Mohammadzadeh • Ali Akbar Pourfathollah • Mohammad Taher Tahoori • Saeed Daneshmandi • Ladan Langroudi • Masoumeh Akhlaghi

Abstract: Apoptosis signals are essential for establishing homeostasis and adequate immune response. Dysregulation of apoptosis-related genes in the immune system, which could be due to gene polymorphisms, conduct to autoimmune diseases including rheumatoid arthritis. In the current study, the apoptosis-related gene Fas_-670A[G, FasL_ 844C[T, and FasLIVS2nt_124A[G polymorphisms were genotyped in 120 Iranian patients with rheumatoid arthritis (RA) and 112 unrelated healthy controls using PCR–RFLP method. Among the 120 RA patients being heterozygous in the promoter region of Fas_-670A/G (OR 1.42,CI 0.92- 1.52, ... سال انتشار: 2012
 

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

Authers: Mahdi Mahmoudi1, 2, 3, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, 3, Elham Farhadi1, Keramat Nourijelyani4, Sasan Fallahi2, 5, Mona Oraei3, Sahar Noori4, and Mohammad Hossein Nicknam1, 3

Abstract: Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population. The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran. Using Real Time PCR allelic discrimination method, we genotyped four SNPs ... سال انتشار: 2012
 

Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging

Authers: Samane Ghanbari1†, Mahsa Yonessi1†, Azadeh Mohammadirad2†, Mahdi Gholami2, Maryam Baeeri2, Hamid Reza Khorram-Khorshid3, Farhad Gharibdoost4 and Mohammad Abdollahi2*

Abstract: The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose ... سال انتشار: 2012
 

Early diagnosis of rheumatoid arthritis: an introduction to the newly designed Iran Criteria for Rheumatoid Arthritis

Authers: Iraj Salehi · Shabnam Khazaeli · Mohammad Khak

Abstract: More than 14 years of clinical practice in rheumatology led the author to discover the prognostic role of anti-citrullinated protein antibody (ACPA) as well as the erosions found by MRI, in detecting the RA patients resulting in establishing a new set of criteria by revising the 1987 ACR classiWcation—Iran Criteria for Rheumatoid Arthritis. Medical records of 243 patients at the outpatient Rheumatology Clinic of the author (private sector) were reviewed for the data on the criteria of the ... سال انتشار: 2012