تالیفات

 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

Anxiety and depression in rheumatoid arthritis: an epidemiologic survey and investigation of clinical correlates in Iranian population

Authers: Ahmad‑Reza Jamshidi1 · Arash Tehrani Banihashemi1, 2 · Pedram Paragomi1 · Maryam Hasanzadeh1 · Mozhgan Barghamdi1 · Shima Ghoroghi1

Abstract: Psychiatric disorders occur in a considerable proportion of patients with rheumatoid arthritis (RA). This study was conducted in order to evaluate the prevalence of anxiety and depression in Iranian RA patients. In the cross sectional study, 414 RA patients were enrolled prospectively during a period of 6 months from RA clinic of Rheumatology Research Center. Beck’s and Cattell’s inventories were applied to investigate depression and anxiety in RA patients. RA activity was measured by Disease Activity Score and patients’ ... سال انتشار: 2016
 

Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study

Authers: Arash TEHRANI-BANIHASHEMI, 1, 2 Fereydoun DAVATCHI, 1 Ahmad-Reza JAMSHIDI, 1 Tahereh FAEZI, 1 Pedram PARAGOMI1 and Mozhgan BARGHAMDI

Abstract: Aim: To estimate the prevalence of osteoarthritis (OA) of different joints in rural areas of Iran. Methods: From five villages of Tuyserkan County, 1565 individuals were randomly selected and were interviewed to complete the Community Oriented Programme for Control of the Rheumatic Diseases (COPCORD) Core Questionnaire. Among these cases 1192 cases with rheumatic complaints were examined by a rheumatologist and laboratory and radiology tests were performed if necessary for the diagnosis. Definition of OA ... سال انتشار: 2014
 

Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)

Authers: Sasan Fallahi (MD) *1, 2 Ahmad Reza Jamshidi (MD) 2 Farhad Gharibdoost (MD) 2 Mahdi Mahmoudi (PhD) 2 Pedram Paragomi (MD) 2 Mohammad Hossein Nicknam (MD, PhD) 3 Elham Farhadi (MSc) 3 Mostafa Qorbani (PhD) 4

Abstract: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-sectional study from Iranian AS association, Iran Rheumatology Center and Rheumatology Clinic of ... سال انتشار: 2012
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

The prevalence of symptomatic hand osteoarthritis in Tehran: Community-oriented program for Control of Rheumatic Diseases- COPCORD

Authers: Dahaghin S, Jamshidi A.R, Tehrani Banihashemi A, Gholami J., Forouzanfar M.H, Akhlaghi M, Khabazi A.R, Noorolahzadeh E, Barghamdi M, Arabzadeh B, Davatchi F

Abstract: Osteoarthritis is the most common form of arthritis in the world. This study presents the evidence on the prevalence of symptomatic hand osteoarthritis in urban community. To add to the evidence on the prevalence of symptomatic hand osteoarthritis in urban community. Methods: Inhabitants (age≥15 yrs) in 22 randomly selected districts (Tehran) participated in a Community-Oriented Program for Control of Rheumatic Diseases (COPCORD) evaluating major rheumatic disorders, including osteoarthritis. Eventually, 10, 291 inhabitants completed a Questionnaire (75% response-rate). ... سال انتشار: 2009
 

For Peer Review Only Squatting, sitting on the floor, or cycling: are life-long daily activities risk factors for clinical knee osteoarthritis?

Authers: Dahaghin S. MD, PhD, Tehrani-Banihashemi SA. MD, MPH, Faezi, ST. MD, Jamshidi AR. MD, Prof Davatchi F, MD

Abstract: Objective: To evaluate the association between occupation, sport, life-long daily activities, and knee osteoarthritis. Method: We randomly recruited 480 subjects with knee osteoarthritis who had participated in an earlier community-based study (Tehran-COPCORD, stage-I); they were compared with 490 controls (case-control study). A questionnaire was used to record all occupations/sports, plus details of the following daily activities: standing, walking on flat ground, walking up/downhill, sitting on the floor, sitting on a chair, squatting, knee-bending, cycling, climbing stairs, and ... سال انتشار: 2009
 

The Comparison of Serum Zinc Level in Behcet Patients and Healthy Controls

Authers: Kamal Esalatmanesh MD, Ahmadreza Jamshidi MD, Farhad Shahram MD, Fereydoun Davatchi MD, Zahra Soleimani MD, Shohreh Movahedi MD*****, , Mansour Salesi MD, Mansoor Karimifar MD

Abstract: Zinc was suggested as an antioxidant and immunomodulator trace element in parallel with other trace elements and antioxidant enzymes. Recently selenium deficiency was indicated in Behcet disease. In this study, we evaluated the correlation of serum zinc level and Behcet disease. Background: In a cross-sectional, descriptive study serum level of zinc was measured in 49 cases satisfying International Study Group criteria and 51 controls. Serum zinc level was measured by atomic absorption spectrometry and compared the mean of serum ... سال انتشار: 2009
 

Effect of ethnic origin (Caucasians versus Turks) on the prevalence of rheumatic diseases: a WHO-ILAR COPCORD urban study in Iran

Authers: Fereydoun Davatchi،Ahmad-Reza Jamshidi،Arash Tehrani Banihashemi،Jaleh Gholami،Mohammad Hossein Forouzanfar،Massoomeh Akhlaghi،Mojgan Barghamdi،Elham Noorolahzadeh،Ali-Reza Khabazi،Mansour Salesi،Amir-Hossein Salari،Mansoor Karimifar،Kamal Essalat-Manesh

Abstract: The objective of this study was to compare the prevalence of musculoskeletal complaints and rheumatic disorders in Caucasians and Turks in an identical environment. Subjects were selected randomly for an interview from Tehran’s 22 districts. The Community Oriented Program for Control of Rheumatic Diseases questionnaire was filled in, positive cases were examined, and if needed, laboratory or X-ray tests were performed. A total of 4,096 houses were visited, and 10,291 persons were interviewed. They were 71.4% Caucasians and 23.1% ... سال انتشار: 2009
 

WHO-ILAR COPCORD Study (Stage 1, Urban Study) in Iran

Authers: FEREYDOUN DAVATCHI, AHMAD-REZA JAMSHIDI, ARASH TEHRANI BANIHASHEMI, JALEH GHOLAMI, MOHAMMAD HOSSEIN FOROUZANFAR, MASSOOMEH AKHLAGHI, MOJGAN BARGHAMDI, ELHAM NOOROLAHZADEH،ALI-REZA KHABAZI،MANSOOR SALESI،AMIR-HOSSEIN SALARI،MANSOOR KARIMIFAR،KAMAL ESSALAT-MANESH،MEHRZAD HAJIALILOO،MOHSEN SOROOSH

Abstract: To find the prevalence of musculoskeletal complaints and rheumatic disorders in Iran. Methods. Tehran, with one-ninth of the population of Iran and of mixed ethnic origins, was selected as the field. Subjects were randomly selected from the 22 districts. Interviews were conducted once a week, on the weekend. The 3 phases of stage 1 were done on the same day, in parallel, like the fast-track Community Oriented Program for Control of Rheumatic Diseases (COPCORD). Results. ... سال انتشار: 2008
 

The Prevalence of Oral Aphthosis in a Normal Population in Iran: A WHO-ILAR COPCORD Study

Authers: Fereydoun Davatchi MD•*, ،Arash Tehrani-Banihashemi MD*, ،Ahmad-Reza Jamshidi MD*, ،Cheyda Chams-Davatchi MD*, ،Jaleh Gholami MD*, ،Maziar Moradi MD*, ،Massoomeh Akhlaghi MD*, ،Mohammad Hossein Forouzanfar MD*, ،Elham Noorolahzadeh،Mojgan Barghamdi،Farideh Samadi،Mehrzad Hadj-Aliloo MD،Koorosh Ghaznavi MD

Abstract: This study was conducted to determine the prevalence of oral aphthosis in a normal population in Iran, using the data of the WHO-ILAR COPCORD study in Iran. We conducted this study in Tehran, the capital of Iran which was selected as the COPCORD study field. In 22 districts of Tehran, 50 clusters were randomly selected. Of the selected houses, 4,096 households were visited and 10,291 persons were interviewed (response rate of 75%). Out of ... سال انتشار: 2008