تالیفات

 

Evaluation of TLR9 expression on PBMCs and CpG ODN-TLR9 ligation on IFN-α production in SLE patients

مولف: Sahar Mortezagholi, Zohreh Babaloo, Parisa Rahimzadeh, Haideh Namdari, Mojgan Ghaedi, Farhad Gharibdoost, Reza Mirzaei, Katayoon Bidad & Eisa Salehi

خلاصه: ABSTRACT Context: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in the pathogenesis of SLE. Objective: In this study, the level of TLR9 expression on peripheral blood mononuclear cells (PBMCs) was analyzed. The levels of produced IFN-a were also measured in supernatant of PBMCs from SLE patients and healthy controls after stimulation with CpG ODN2216 which is a ... سال انتشار: 2017
 

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus

Authers: Sahar Mortezagholi1, Zohreh Babaloo1, Parisa Rahimzadeh2, Mojgan Ghaedi2, Hayedeh Namdari3, Shirin Assar4, Maryam Azimi Mohamadabadi5, and Eisa Salehi5

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood ... سال انتشار: 2016
 

Effect of All-transretinoic Acid on Th17 and T Regulatory Cell Subsets in Patients with Ankylosing Spondylitis

Authers: KATAYOON BIDAD, EISA SALEHI, AHMADREZA JAMSHIDI, ALI AKBAR SABOOR-YARAGHI, MONA ORAEI, ALIPASHA MEYSAMIE, MAHDI MAHMOUDI, and MOHAMMAD HOSSEIN NICKNAM

Abstract: We compared Th17 and T regulatory cells in patients with ankylosing spondylitis (AS) and in healthy controls. The effect of all-transretinoic acid (ATRA) was studied on cultured CD4+ T cells of patients with AS compared to controls. Methods. Eighteen patients with AS and 18 age- and sex-matched healthy controls were included. CD4+ T cells were separated and cultured in conditions of anti-CD3 and anti-CD28 stimulation with and without ATRA. Intracellular and secreted cytokines, transcription factors, ... سال انتشار: 2013
 

Performance of the 2010 rheumatoid arthritis classification criteria

Authers: Fereydoun DAVATCHI, 1 Iraj SALEHI ABARI, 1 Soosan SOROOSH, 2 Mohsen SOROOSH2 and Bahar SADEGHI ABDOLLAHI1

Abstract: Rheumatoid arthritis (RA) needs early treatment to improve clinical outcome by reducing joint damage, radiographic progression and disability. The aim of this study was to evaluate the 2010 Rheumatoid Arthritis Classification Criteria for its ability to classify RA patients, in their early stages, not exceeding 12 months of disease progression. Methods: Rheumatoid arthritis (RA) patients were selected from August to December 2010, among those coming for their follow-up. The inclusion criteria were patients with not ... سال انتشار: 2012
 

Early diagnosis of rheumatoid arthritis: an introduction to the newly designed Iran Criteria for Rheumatoid Arthritis

Authers: Iraj Salehi · Shabnam Khazaeli · Mohammad Khak

Abstract: More than 14 years of clinical practice in rheumatology led the author to discover the prognostic role of anti-citrullinated protein antibody (ACPA) as well as the erosions found by MRI, in detecting the RA patients resulting in establishing a new set of criteria by revising the 1987 ACR classiWcation—Iran Criteria for Rheumatoid Arthritis. Medical records of 243 patients at the outpatient Rheumatology Clinic of the author (private sector) were reviewed for the data on the criteria of the ... سال انتشار: 2012
 

Assessments of Pulmonary Involvement in Patients with Systemic Sclerosis

Authers: Keivan Gohari Moghadam MD, Farhad Gharibdoost MD, Gilda Parastandechehr MD, Pirooz Salehian MD

Abstract: The lungs are affected in 70 – 90% of cases diagnosed with systemic sclerosis. Pulmonary involvement is associated with increased morbidity and mortality. Materials and Methods: Fifty-ve cases of systemic sclerosis underwent plethysmography, diffusion lung capacity for carbon monoxide (DLCO) measurement, high resolution computed tomography scanning, and bronchoalveolar lavage (BAL) to evaluate their diagnostic roles in grading the severity of lung involvement and their relationships to each other. Results: The indices of DLCO% (measured DLCO ... سال انتشار: 2011
 

Bone density in patients with chondromalacia patella

Authers: Iraj Salehi, Shabnam Khazaeli, Parta Hatami, Mahdi Malekpour

Abstract: Chondromalacia of the patella is the most common cause of anterior knee pain in young women. The etiology of the disease is not well-understood but the initial lesion is a disorganization of collagenous structures. Since the disease is proposed to be due to generalized constitutional disturbance, we postulated that bony structures could also be involved. To investigate this hypothesis we measured the bone density of 286 patients with the diagnosis of chondromalacia of the patella during a 4-year ... سال انتشار: 2010
 

High prevalence of low bone density in young Iranian healthy individuals

Authers: Iraj Salehi, Shabnam Khazaeli, Seyed Reza Najafizadeh, Haleh Ashraf, Mahdi Malekpour

Abstract: With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem, more particularly in the Middle East region. Bone mineral density (BMD) of the hip, lumbar spine, and forearm was measured by dual X-ray absorptiometry (Lunar) in 2085 (25% men, 75% women) healthy Iranian subjects aged 20–88 yr. The prevalence of osteoporosis and osteopenia in at least one measured site in subjects aged 50 yr and older were 36.1% and 43.9% in women, and 24.5% and ... سال انتشار: 2009
 

RELATIONSHIP BETWEEN KNEE MALALIGNMENT AND QANGLE WITH AGE AT ONSET OF DISEASE IN 260 CHONDROMALACIA PATELLA PATIENTS

Authers: I. SALEHI, R. JAMALI, S. KHAZAELI, A. JAMSHIDI, M.AKBARIAN, F. GHARIBDOOST, F. DAVATCHI

Abstract: Background: Chondromalacia patella is the most common cause of mechanical knee pain in young women. Q angle and knee alignment are important clinical parameters for biomechanics of the patellofemoral joint. Objective: To identifY the prevalence of knee malalignment and to find out if there is a correlation between knee mal alignment and Q angle with age at onset of disease. Methods: All patients under 40 years old complaining of mechanical knee pain with positive shrug sign ... سال انتشار: 2005
 

CLINICAL AND LABORATORY MANIFESTATIONS OF THROMBOCYTOPENIA IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Authers: I. Salehi., M. Akbarian., F. Shahram., F.Gharibdoost., A. Nadji., A. Jamshidi, F. Davatchi

Abstract: In systemic lupus eryThematosus (SLE) various antibodies are produced against cells including platelets and result in thrombocytopenia. !n the literature, the incidence of thrombocytopenia varied from 7% to 52%, in seven series of SLE patients with a mean cumulative percentage of 14.5% (1-5 ). SLE patients referred to the Lupus Unit of the Rheumatology Research Center. Tehran University for Medical Sciences. (Shariati Hospital) during the period of 1975 to 1977 ... سال انتشار: 1997