تالیفات

 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydon Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi-Abdollahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydoune Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi Abdillahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

CHRONOLOGY OF CLINICAL MANIFESTATIONS IN BEHCET’S DISEASE, ANALYSIS OF 3542 CASES.

Authers: F. Shahram, K. Assadi, F. Davatchi, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian

Abstract: Introduction: Manifestations of Behcet’s disease (BD) appear one after another during the course of the disease. Some involvements such as mucous lesions seem to appear early, and others such as gastrointestinal (GI) and neurological (CNS) involvement many years later. This study was planned to find out the chronology of different manifestations of BD. Patients & methods: In a retrospective study, files of all BD patients diagnosed since 1989 were reviewed ... سال انتشار: 2002
 

AZATHIOPRINE AND LOW DOSE PULSE CYCLOPHOSPHAMIDE IN SEVERE OCULAR LESIONS OF BEHCET’S DISEASE, A PRELIMINARY REPORT.

Authers: F. Shahram, F. Davatchi, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Combination of cytotoxic drugs was suggested to decrease the rate of non-responders in severe ocular lesions of Behcet’s disease (BD). We present here our preliminary data with low dose pulse Cyclophosphamide (LDP) and Azathioprine (AZA) in the treatment of posterior uveitis (PU) and/or retinal vasculitis (RV) of BD. Patients & methods: Twelve BD patients with PU and RV were selected. They all received LDP as 0.5 g/m2 body surface/month ... سال انتشار: 2002
 

BEHCET’S DISEASE. ANALYSIS OF 4660 CASES.

Authers: F. Davatchi, C. Chams, F. Shahram, F. H. Chams, A. Nadji, M. Akbarian, F. Gharibdoost

Abstract: Behcet’s Disease (BD) is a multisystemic disease with a peculiar distribution in the world. The disease is specially seen in the countries bordering the ancient SILK ROAD specially Japan, China, Korea, Iran, and Turkey. The majority of reports on BD are on hospital based patients. Others are either local based patients or epidemilogical studies on a small area. The only two nationwide analysis of BD is from Japan and ... سال انتشار: 2002
 

THE COMPARISON OF ANKYLOSING SPONDYLITIS IN BEHCET'S DISEASE AND NORMAL POPULATION: A CONTROL STUDY.

Authers: A. Nadji, F. Davatchi, F. Shahram, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: We previously reported that ankylosing spondylitis (AS) was associated with Behcet's disease (BD) in Iranian patients. This study was designed to evaluate the features of AS in BD (ASBD) and compare them with the AS in normal population (ASN). Materials and Methods: Among 4700 BD patients, 73 ASBD were found and were compared with a cohort of 180 ASN. Seventy out of 73 ASBD met the European Spondyloarthropathy Study Group ... سال انتشار: 2002
 

THE INFLUENCE OF THE DELAY IN AGGRESSIVE TREATMENT ON THE VISON AND ITS OUTCOME IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The natural course of eye lesions is well known, leading to sever loss of vision or blindness. The cumulative nature of eye lesions during successive attacks, leads to gradual loss of visual acuity (VA). The aim of this study was to evaluate the effect of the delay in aggressive treatment on the VA and its long-term outcome. Materials and Methods: All Behcet’s patients of the treatment registry (1009 ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

HIGH DOSE METHOTREXATE FOR OCULAR LESIONS OF BEHCET’S DISEASE. PRELIMINARY SHORT-TERM RESULTS ON 23 PATIENTS.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Jamshidi, A. Nadji, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: methotrexate in weekly low dose pulse of 7.5 mg has long proved its efficacy in the treatment of ocular lesions. During the 1998 ACR congress where we presented our data on 262 patients it was suggested the high dose of 15 mg. This is the short-term result of that study. Materials and Methods: MTX was used as 15 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. The visual ... سال انتشار: 2002
 

The Impact of the Treatment Delay on the Outcome of Vision in Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ... سال انتشار: 2002
 

THE INFLUENCE OF PATHERGY TEST ON THE ACCURACY OF DIFFERENT DIAGNOSIS CRITERIA FOR BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

Clinical Manifestattion Of Behcet’s Disease.

Authers: A. Jamshidi, F. Shahram, A. Nadji, H. Chams, M. Akbarian, F. Gharibdoost, C. Chams, F. Davatchi

Abstract: Objectives: Behcet's disease (BD) is a multi-system disease. We present here the various clinical aspects of BD based on the data of 4586 Iranian patients. The male to female ratio was 1.17/l. The mean age at the onset of the disease was 26 yr (SD:9.6, CI:0.3). The mean disease duration was 9 yr (SD:7), and the mean follow up time was 3 yr (SD:3.8). As the first manifestation of the ... سال انتشار: 2001
 

EXPERIENCE IN IRAN WITH SPECIAL REFERENCE TO BEHCETS DISEASE (BD).

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Pattern of Rheumatic Diseases in Iran: They have the same frequency and the same pattern as in Western countries. A study from 1993 demonstrated a prevalence of 32.6% among adults (31.4% in the USA, Cunningham 1984). Inflammatory disorders counted for 11% of all rheumatic diseases. The ratio of RA to AS was 8/1 (7/1 in USA), and SLE to Scleroderma 3.5/1 (3.6/1 in USA). Psoriatic arthritis and Reiter's syndrome were ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET'S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ... سال انتشار: 2001
 

Intermediate Term Results Of Combination Therapy With Low Dose Pulse Cyclophosphamide And Methotrexate In Ocular Lesions Of Behcet’s Disease.

Authers: F. Shahram, H. Chams, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian

Abstract: Introduction: In a preliminary report to the 8th International Congress on Behcet’s Disease (BD) in 1998, we showed the efficacy of combination therapy with low dose pulse Cyclophosphamide (LDP) and Methotrexate (MTX) in posterior uveitis (PU) and retinal vasculitis (RV) of BD. We present here our experience with more patients and a longer follow up. Patients & Methods: BD Patients who were on the association of LDP and MTX due ... سال انتشار: 2000
 

Pulse Cyclophosphamide for Ocular Lesions of Behcet's Disease: double blind crossover study.

Authers: F. Davatchi, H. Chams, F. Shahram, M. Akbarian

Abstract: Introduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are thought to be effective, but no control study has yet been done to show their efficacy. This study was designed to evaluate the short-term efficacy of pulse cyclophosphamide (PCP) in a randomized double blind control study. Materials & methods: PCP was used as lg per square meter of body ... سال انتشار: 2000
 

Long-term outcome of ocular manifestations in Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, M. Akbarian, C. Chams, F. Gharibdoost, A. Jamshidi, F. Romooz.

Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ... سال انتشار: 2000
 

Mid-term Results of Azathiopriae to Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, H. Chams, F. Shahram, A. Nadji, A. Jamshidi, M. Akbarian, F Gharibdoust

Abstract: lntroduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are necessary for the treatment. A short-term study with azathioprine (AZA) was presented to the 8th lnternational Conference on Behcet's Disease. The aim of this study is to present the results for a longer period of time. Materials & methods: Patients (32) who received more than 9 months of treatment ... سال انتشار: 2000
 

OUTCOME MEASUREMENT OF OCULAR LESIONS IN BEHCETS DISEASE.

Authers: S. Soroosh, F. Davatchi, F. Shahram, H. Chams, M. Akbarian, F. Gharibdoost, A. Nadji, C. Chams

Abstract: Introduction: The ocular lesions of Behcet's disease (BD) progress usually toward severe loss of vision or blindness, and therefore need aggressive treatment. However, even such a treatment is not always successful. We used classification and regression tree (cart) method to see if some factors could predict the result of the future treatment. Methods: Eight hundreds and thirty patients who fulfilled the Iran criteria for BD were selected for this study. They ... سال انتشار: 2000
 

Pulse Cyclophosphamide (PCP) for Ocular Lesions Of Behcet’s Disease: Double Blind Crossover Study.

Authers: F. Davatchi, F. Shahram, H. Chams, M. Akbarian

Abstract: Introduction: Ocular lesions of Behcet’s Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Although cytotoxic drugs are thought to be the main therapeutic arsenal, no control study has yet been done to demonstrate their efficacy. This study was designed t evaluate the short-term efficacy of pulse cyclophosphamide in a randomized double blind control study. Materials & Methods: PCP was used as Ig per square meter ... سال انتشار: 1999
 

Azathioprine for The Treatment of Ophthalmological Lesions of Behcet’s Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, M. Akbarian, A. Nadji, C. Chams, F. Gharibdoost, A. Jamshidi, S. Soroosh

Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) are the main morbidity factor in Behcet’s Disease (BD). They usually progress toward severe loss of vision or blindness. They need aggressive treatment with cytotoxic drugs. Azathioprine was demonstrated, in a double blind control study, to be effective in Behcet’s Disease. The aim of this study was to evaluate the efficacy of Azathioprine in ocular lesions of BD, and to compare ... سال انتشار: 1998
 

Combination Therapy with Low Dose Pulse Cyclophosphamide and Methotrexate in Ocular Lesions of Behcet’s Disease.

Authers: F. Shahram, H. Chams, F. Davatchi, A. Nadji, M. Akbarian

Abstract: Introduction: Cytotoxic drugs are all effective in the treatment of ocular lesions of Behcet’s disease (BD). However, with all methods there are some patients that their eye lesions will progress despite the treatment. This study was designed to find whether a combination therapy with 2 of these drugs could have better effect in reducing the rate of non-responders. Materials & Methods: Twenty eight patients diagnosed as BD (according to the Iran ... سال انتشار: 1998
 

Epidemiology of Behcet's disease in Iran.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost, A. Nadji, A. Jamshidi, S. Soroosh

Abstract: Introduction: The geographical distribution of Behcet's Disease (B.D) is thought to be due to the predisposing factor(s) spread along the Silk Route. It is widely accepted that the predisposing factor(s) is of genetic origin. However the rarity of BD among Hawaiian's Japanese immigrants may be in favor of environmental factors. Iran is situated in the middle of the Silk Route. Caucasians account for 75.4%, Turks (from Mongoloid ethnic origin) for ... سال انتشار: 1998
 

Familial Study in Behcet's Disease, Analysis of 1242 Patients.

Authers: F. Shahram, C. Chams, F. Davatchi, A. Nadji, M. Akbarian. A. Jamshidi

Abstract: Introduction: The etiology of Behcet's disease (BD) is unknown, but like other autoimmune disorders both environmental and genetic factors contribute to its pathophysiology. The familial form of BD is in favor of a genetic predisposition. This study was designed to evaluate the prevalence of the familial form and their possible effect on the disease expression in Iranian patients. Materials & Methods: We studied prospectively 1242 consecutive patients with ... سال انتشار: 1998
 

Methotrexate in the Treatment of Ocular Lesions of Behcet’s Disease in Children.

Authers: N. Shafaie, F. Shahram, H. Chams, F. Davatchi, A. Nadji, M. Akbarian

Abstract: Introduction: Different methods of treatment were employed in ocular lesions of Behcet’s disease (BD) in adults. Most of them are not permitted in children due to their potential toxicity. Methotrexate (MTX) has gained wide acceptance for the treatment of childhood rheumatic diseases. On the other hand, we showed in several reports the efficacy of MTX in the treatment of ocular lesions of BD. This study was designed to show the ... سال انتشار: 1998