تالیفات

 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
 

Evaluation of TLR9 expression on PBMCs and CpG ODN-TLR9 ligation on IFN-α production in SLE patients

مولف: Sahar Mortezagholi, Zohreh Babaloo, Parisa Rahimzadeh, Haideh Namdari, Mojgan Ghaedi, Farhad Gharibdoost, Reza Mirzaei, Katayoon Bidad & Eisa Salehi

خلاصه: ABSTRACT Context: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in the pathogenesis of SLE. Objective: In this study, the level of TLR9 expression on peripheral blood mononuclear cells (PBMCs) was analyzed. The levels of produced IFN-a were also measured in supernatant of PBMCs from SLE patients and healthy controls after stimulation with CpG ODN2216 which is a ... سال انتشار: 2017
 

Downregulation of Aquaporin3 in Systemic Sclerosis Dermal Fibroblasts

مولف: Bahman Yousefi1, 2, Mahdi Mahmoudi1, Abdolfattah Sarafnejad2, Elham Karimizadeh1, Elham Farhadi3, Ahmad Reza Jamshidi1, Hoda Kavosi1, Saeed Aslani1, and Farhad Gharibdoost1

خلاصه: Skin dryness and thickening are hallmarks of systemic sclerosis (SSc) disease. Aquaporins (AQPs) are plasma membrane proteins that transport glycerol and water, resulting in water retention and skin hydration. Expression of AQPs has been evaluated in human normal skin. However, expression of these proteins in SSc dermal fibroblasts has not yet been reported. The aim of this study was to assess the expression profile of AQPs in dermal fibroblasts of ... سال انتشار: 2017
 

Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis

مولف: Fatemeh Abbasi1, Reza Mansouri1, Farhad Gharibdoost2, Saeed Aslani2, Shayan Mostafaei2, Hoda Kavosi2, Shiva Poursani2, Soheila Sobhani2, and Mahdi Mahmoudi2

خلاصه: CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex, and ethnic -matched healthy individuals. Genotyping of rs2056626 ... سال انتشار: 2017
 

Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis

مولف: Mahdi Mahmoudi1 & Faranak Fallahian2 & Soheila Sobhani1 & Shima Ghoroghi1 & Ahmadreza Jamshidi1 & Shiva Poursani 1 & Masoumeh Dolati2 & Zahra Hosseinpour1 & Farhad Gharibdoost1

خلاصه: Abstract Genetic factors have a great role in the pathogenesis of autoimmune diseases by cooperating with environmental stimuli. Killer immunoglobulin-like receptors (KIRs) are cell surface proteins on NK cells whose association with major histocompatibility complex-I regulates their killing function. The aim of this study was to provide information on the possible association between KIR and human leukocyte antigen (HLA) genes with systemic sclerosis disease in Iranian population. A total of 279 systemic sclerosis patients and 451 healthy controls were ... سال انتشار: 2017
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

HerbalmedicineIMODsuppressesLPS-inducedproductionofproinflammatorycytokinesinhumandendriticcells

Authers: Saeedeh Mirzaee1†, AgataDrewniak1†, RaminSarrami-Forooshani1, TanjaM.Kaptein1, FarhadGharibdoost2 and TeunisB.H.Geijtenbeek1*

Abstract: Traditional medicines thatstimulateormodulatetheimmunesystemcanbeusedasinnovativeapproachestotreatimmunologicaldiseases.TheherbalmedicineIMODhasbeenshowntostronglymodulateimmuneresponsesinseveralanimalstudiesaswellasinclinicaltrials.However,littleisknownaboutthemechanismsofIMODtomodulateimmunity.HerewehaveinvestigatedwhetherIMODmodulatestheimmunologicalfunctionofhumandendriticcells(DCs).IMODalonedidnotinduceDCmaturationnorproductionofcytokines.Notably,IMODdecreasedtheproductionofpro-inflammatorycytokinesIL-6,IL-12p70,andTNFαbyLPS-activatedDCsatbothmRNAandproteinlevelsinadosedependentmanner.Incontrast,treatmentwithIMODdidnotaffectLPSinduced-productionoftheanti-inflammatorycytokineIL-10.Furthermore,IMODinhibitedTcellactivation/proliferationbyLPS-treatedDCsandskewedT-cellsresponsestowardtheThelpertype2polarization.ThesedatastronglyindicatethatIMODhasapotentimmunomodulatoryabilitythataffectsTLRsignalingandtherebymodulatesDCfunction.InsightintotheimmunomodulatoryeffectofherbalmedicineIMODmayprovideinnovativestrategiestoaffecttheimmunesystemandtohelpcombatvarousdiseases. Keywords:IMOD,immune-modulation,LPS,pro-inflammatorycytokines,dendriticcells سال انتشار: 2015
 

c-Abl silencing reduced the inhibitory effects of TGF-b1 on apoptosis in systemic sclerosis dermal fibroblasts

مولف: Elham Karimizadeh1 • Farhad Gharibdoost2 • Nasrin Motamed1 • Saeideh Jafarinejad-Farsangi1 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

خلاصه: It is generally accepted that the apoptosis of myofibroblasts is a crucial event in the normal wound healing. Delay in myofibroblasts apoptosis results in fibrotic diseases such as systemic sclerosis (SSc). Transforming growth factor-b1 (TGF-b1) is an important cytokine to induce fibroblasts differentiation into myofibroblasts. Cellular Abelson (c-Abl) is known as a TGF-b1- modulating molecule in fibrosis. The role of c-Abl, TGFb1, and their interaction in SSc myofibroblasts apoptosis has not yet been fully explored. The aim of this ... سال انتشار: 2015
 

Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients

Authers: Masoumeh Kheirandish , Seyedeh Tahereh Faezi , Pedram Paragomi , Maassoumeh Akhlaghi , Farhad Gharibdoost , Ashraf Shahali , Mahboubeh Ebrahimpour Fini, and Mahmood Akbarian

Abstract: Objectives . We aimed to evaluate the prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE) and explore their association with demographic and clinical features. Methods. In this cross-sectional study, 166 SLE patients in rheumatology center of Shariati hospital, Tehran University of Medical Sciences were enrolled. SLE disease activity index (SLEDAI) and Beck and Cattell inventories for evaluation of depression and anxiety were completed for each patient. Results. The mean age of patients was ... سال انتشار: 2014
 

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Authers: Seyedeh Tahereh FAEZI, Mahdieh HOSSEINI ALMODARRESI, Mahmood AKBARIAN, Farhad GHARIBDOOST, Masoumeh AKHLAGHI, Ahamadreza JAMSHIDI, Farhad SHAHRAM, Abdolhadi NADJI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Pedram PARAGOMI and Fereydoun DAVATCHI

Abstract: Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports. Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients ... سال انتشار: 2014
 

Attenuation of fibrosis with selective inhibition of c-Abl by siRNA in systemic sclerosis dermal fibroblasts

Authers: Elham Karimizadeh • Nasrin Motamed • Mahdi Mahmoudi • Saeideh Jafarinejad-Farsangi • Ahmadreza Jamshidi • Habibeh Faridani • Farhad Gharibdoost

Abstract: Cellular abelson (c-Abl), a non-receptor tyrosine kinase, is an important molecule in the pathogenesis of systemic sclerosis. There have been reports of beneficial effects of pharmacological tyrosine kinase inhibitors, such as imatinib mesylate, on fibrosis. However, these inhibitors affect multiple tyrosine kinases including c-Abl, c-kit, and platelet-derived growth factor receptor. The effects of selective inhibition of c-Abl using small interfering RNA (siRNA) on dermal fibrosis have not yet been explored. The aim of this study is to evaluate whether ... سال انتشار: 2014
 

The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis

Authers: Sasan FALLAHI, 1, 2 Ahmad Reza JAMSHIDI, 2 Farhad GHARIBDOOST, 2 Mahdi MAHMOUDI, 2 Nooshin AHMADZADEH, 2 Mohammad Hossein NICKNAM3

Abstract: This study aims to investigate the correlation between the pack-years of smoking and disease activity, quality of life, spinal mobility, and sacroiliitis grading and ankylosing spondylitis (AS) in Iranian patients with AS. Patients and methods: A total of 160 AS patients were evaluated according to their smoking status and pack-years of smoking. The outcome measures were disease activity, quality of life, spinal mobility, and sacroiliitis grading, and these were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ... سال انتشار: 2013
 

Presentation of psoriatic arthritis in the literature: a twenty-year bibliometric evaluation

Authers: Ahmad-Reza Jamshidi • Farhad Gharibdoost • Abdolhadi Nadji • Mohammadali Nikou • Gholamreza Habibi • Amirhossein Mardani • Marjan Ghaemi

Abstract: Psoriatic arthritis is an inflammatory arthritis disabling patients with psoriasis. Bibliometric studies are tools for evaluating scientific productions in different countries, universities as well as publications related to a special topic. We aimed to perform a scientometric study to evaluate articles published under ‘‘Psoriatic arthritis’’ topic and also attempted to compare publications of different authors, countries, universities, and journals related to this topic. Study was performed on all articles published between 1989 and 2009. The ISI web of science ... سال انتشار: 2013
 

Effect of HLA-B*27 and its Subtypes on Clinical Manifestations and Severity of Ankylosing Spondylitis in Iranian Patients

Authers: Sasan Fallahi1, 2, Mahdi Mahmoudi2, Mohammad Hossein Nicknam3, 5, Farhad Gharibdoost2, Elham Farhadi4, Azad Saei5, Keramat Nourijelyani6, Nooshin Ahmadzadeh2, and Ahmad Reza Jamshidi2

Abstract: The aim of this study was to assess the role of HLA-B*27 and it’s subtypes in determining severity and clinical manifestations of ankylosing spondylitis (AS). A total of 163 AS patients were assessed for clinical manifestations and severity using structured questionnaires. HLA-B*27 screening and B*27 sub-typing were performed by PCR. One hundred twenty two patients (74.8%) were B*27 positive. The male to female ratio, peripheral arthritis, steroid use, intense dorsal kyphosis and ... سال انتشار: 2013
 

Presentation of psoriatic arthritis in the literature: a twenty-year bibliometric evaluation

Authers: Ahmad-Reza Jamshidi • Farhad Gharibdoost • Abdolhadi Nadji • Mohammadali Nikou • Gholamreza Habibi • Amirhossein Mardani • Marjan Ghaemi

Abstract: Psoriatic arthritis is an inflammatory arthritis disabling patients with psoriasis. Bibliometric studies are tools for evaluating scientific productions in different countries, universities as well as publications related to a special topic. We aimed to perform a scientometric study to evaluate articles published under ‘‘Psoriatic arthritis’’ topic and also attempted to compare publications of different authors, countries, universities, and journals related to this topic. Study was performed on all articles published between 1989 and 2009. The ISI web of science ... سال انتشار: 2012
 

Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging

Authers: Samane Ghanbari1†, Mahsa Yonessi1†, Azadeh Mohammadirad2†, Mahdi Gholami2, Maryam Baeeri2, Hamid Reza Khorram-Khorshid3, Farhad Gharibdoost4 and Mohammad Abdollahi2*

Abstract: The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose ... سال انتشار: 2012
 

Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)

Authers: Sasan Fallahi (MD) *1, 2 Ahmad Reza Jamshidi (MD) 2 Farhad Gharibdoost (MD) 2 Mahdi Mahmoudi (PhD) 2 Pedram Paragomi (MD) 2 Mohammad Hossein Nicknam (MD, PhD) 3 Elham Farhadi (MSc) 3 Mostafa Qorbani (PhD) 4

Abstract: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-sectional study from Iranian AS association, Iran Rheumatology Center and Rheumatology Clinic of ... سال انتشار: 2012
 

Assessments of Pulmonary Involvement in Patients with Systemic Sclerosis

Authers: Keivan Gohari Moghadam MD, Farhad Gharibdoost MD, Gilda Parastandechehr MD, Pirooz Salehian MD

Abstract: The lungs are affected in 70 – 90% of cases diagnosed with systemic sclerosis. Pulmonary involvement is associated with increased morbidity and mortality. Materials and Methods: Fifty-ve cases of systemic sclerosis underwent plethysmography, diffusion lung capacity for carbon monoxide (DLCO) measurement, high resolution computed tomography scanning, and bronchoalveolar lavage (BAL) to evaluate their diagnostic roles in grading the severity of lung involvement and their relationships to each other. Results: The indices of DLCO% (measured DLCO ... سال انتشار: 2011
 

Presentation of psoriatic arthritis in the literature: a twenty-year bibliometric evaluation

Authers: Ahmad-Reza Jamshidi, Farhad Gharibdoost, Abdolhadi Nadji, Mohammadali Nikou, Gholamreza Habibi, Amirhossein Mardani, Marjan Ghaemi

Abstract: Psoriatic arthritis is an inflammatory arthritis disabling patients with psoriasis. Bibliometric studies are tools for evaluating scientific productions in different countries, universities as well as publications related to a special topic. We aimed to perform a scientometric study to evaluate articles published under ‘‘Psoriatic arthritis’’ topic and also attempted to compare publications of different authors, countries, universities, and journals related to this topic. Study was performed on all articles published between 1989 and 2009. The ISI web of science ... سال انتشار: 2011
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

Systemic lupus erythematosus in Iran: a study of 2280 patients over 33 years

Authers: Mahmood AKBARIAN, Seyedeh Tahereh FAEZI, Farhad GHARIBDOOST, Farhad SHAHRAM, Abdolhadi NADJI, Ahmad Reza JAMSHIDI, Maasoumeh AKHLAGHI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Fereydoun DAVATCHI

Abstract: Systemic lupus erythematosus (SLE) as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. The aim of this study was to show the manifestations of SLE in Iranian patients. Methods: The study was on manifestations of SLE according to the database of the Rheumatology Research Center (RRC), Tehran, Iran, on registered patients during the period of 1976 to ... سال انتشار: 2010
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydon Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi-Abdollahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydoune Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi Abdillahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center

Authers: Mahmood Akbarian, Farhad Gharibdoost, Mehrzad Hadjaliloo, Abdolhadi Nadji, Ahmad Reza Jamshidi, Farhad Shahram, Masoomeh Akhlaghi, Shahrzad Khosravi, Simin Almasi, Fereydoun Davatchi

Abstract: At present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsDNA antibodies), erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP), or cytokines such as IL-2/IL-2 receptor, IL-6 and IL-10 are used as indirect serological markers with variable degrees of significance. To date, no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury ... سال انتشار: 2009