تالیفات

Paediatric Behçet’s disease in Iran: report of 204 cases  

Paediatric Behçet’s disease in Iran: report of 204 cases

مولف: F. Shahram1, A. Nadji1, M. Akhlaghi1, S.T. Faezi1, C. Chams-Davatchi1, 2, H. Shams1, 3, S. Z. Ghodsi1, 2, F. Davatchi1

خلاصه: ABSTRACT Objectives. This study proposed to report the characteristics of paediatric Behçet’s disease (PED-BD) in a cohort of patients from Iran’s registry and compare them with different reports throughout the world. Methods. From a cohort of 7504 Iranian patients with Behçet’s disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. سال انتشار: 2018
 

Behcet’s Disease: Epidemiology, Clinical Manifestations, and Diagnosis

مولف: Fereydoun Davatchi, Cheyda Chams-davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi & Mariam Masoumi

خلاصه: Introduction: Behcet’s Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

مولف: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

خلاصه: 299-308. Editorial It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). The ISG criteria were created by ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

Authers: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

Abstract: It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). ... سال انتشار: 2016
 

Adult Behcet’s disease in Iran: analysis of 6075 patients

Authers: Fereydoun DAVATCHI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Bahar SADEGHI ABDOLLAHI, Farimah ASHOFTEH, Zahra GHODSI, Negin MOHTASHAM and Farhad SHAHRAM

Abstract: This is an analysis of adult Behcet’s disease (BD) in Iran, from the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%). Patients: Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet’s Disease (ICBD). Adult BDs were patients who had their first ... سال انتشار: 2016
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... سال انتشار: 2015
 

Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet’s disease: longitudinal study of up to 10 years

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Farimah ASHOFTEH and Negin MOHTASHAM

Abstract: Aim: Ocular lesions of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Retinal vasculitis is the most aggressive lesion of ocular manifestations and predicts a worse systemic outcome. We present here the outcome with a combination of pulse cyclophosphamide, azathioprine and prednisolone, on long-term usage, up to 10 years, on 295 patients (18 493 eye-months of ... سال انتشار: 2014
 

Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet’s disease

Authers: Fereydoun Davatchi • Bahar Sadeghi Abdollahi • Cheyda Chams-Davatchi • Farhad Shahram • Zahra Ghodsi • Abdolhadi Nadji • Massoomeh Akhlaghi • Tahereh Faezi • Hormoz Shams • Roghieh Larimi • Farima Ashofteh

Abstract: The only diagnostic test that currently exists for Behcet’s disease (BD) is the pathergy test. A positive pathergy test (PPT) is an important component of many of the 16 sets of classification/diagnosis criteria used to diagnose BD. The aim of this study was to determine the importance of a PTT in the performance of the diagnosis/ classification criteria for BD. Patients and methods All patients listed in the BD registry of the Rheumatology Research Center, Tehran (6,727) and 4,648 ... سال انتشار: 2013
 

The International Criteria for Behcet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria

Authers: F. Davatchi, 1, *, † S. Assaad-Khalil, 2, † K.T. Calamia, 3, † J.E. Crook, 4, † B. Sadeghi-Abdollahi, 1, † M. Schirmer, 5, † T. Tzellos, 6, † C.C. Zouboulis, 6, 7, 8, *, † M. Akhlagi, 1 A. Al-Dalaan, 9 Z.S. Alekberova, 10 A.A. Ali, ،A.R. Jamshidi،A. Nadji،F. Shahram،H. Shams،N. Ziaei1

Abstract: Behcet’s disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test. Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD-mimicking diseases or presenting at least one major BD sign. These were randomly divided into ... سال انتشار: 2013
 

Clinical features of Behcet ’ s disease in patients without oral aphthosis

Authers: Seyedeh Tahereh Faezi 1 , Pedram Paragomi 1 , Farhad Shahram 1 , Hormoz Shams 2 , Cheida Shams-Davatchi 3 , Zahra Ghodsi 3 , Abdolhadi Nadji 1 , Maassoumeh Akhlaghi 1 , and Fereydoun Davatchi 1

Abstract: In current study we evaluated clinical features of Behcet ’ s Disease (BD) in patients without oral aphthosis (NOA cases). Methods. In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer ’ s exact test. Results. Among 6821 BD patients, 175 patients (2.56%) ... سال انتشار: 2013
 

Mesenchymal stem cell therapy unable to rescue the vision from advanced Behcet’s disease retinal vasculitis: report of three patients

Authers: Fereydoun DAVATCHI, 1 Behrooz NIKBIN, 2 Hormoz SHAMS, 1 Bahar SADEGHI ABDOLLAHI, 1 Mandana MOHYEDDIN2 and Farhad SHAHRAM1

Abstract: Retinal vasculitis (RV) is the most aggressive lesion of ocular manifestations of Behcet’s disease, seen in 32.1% of patients. Although visual acuity (VA) improves with early and aggressive treatment, in the long run it is seen in only 48% of patients. Mesenchymal stem cell (MSC) transplantation (MSCT) can theoretically reverse the RV process. Patients and Methods: Three patients with advanced RV and very low VA were selected. Eyes selected for MSCT were legally blind (no ... سال انتشار: 2013
 

Methotrexate in ocular manifestations of Behcet’s disease: a longitudinal study up to 15 years

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Tahereh FAEZI, Massoomeh AKHLAGHI and Farimah ASHOFTEH

Abstract: Ocular manifestations of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Methotrexate is the least toxic, used mainly for posterior uveitis. We present here the outcome of eye lesions with methotrexate and prednisolone, in a longitudinal study of up to 15 years, on 682 patients (5447 eye-years of follow-up). Patients and methods: Methotrexate was started at ... سال انتشار: 2013
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI and Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2012
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2011
 

Behcet’s disease: is there a gender influence on clinical manifestations?

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Roghieh LARIMI, Farima ASHOFTEH

Abstract: In Behcet’s disease (BD), it is customary to believe that men are more affected than women, major organs are more involved in men, and they have worse outcomes. The male-to-female ratio is reported from 5.37 to 1 (Egypt), to 0.38 to 1 (US). If in the majority of reports BD was seen more frequently in men, in some others it was more frequent in women. The aim of this study was to examine ... سال انتشار: 2011
 

Validation of the International Criteria for Behc¸et’s disease (ICBD) in Iran

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Nasim NADERI, Massoomeh AKHLAGHI, Tahereh FAEZI, Alireza FARIDAR

Abstract: To evaluate the performance of the new International Criteria for Behc¸et’s Disease (ICBD) in Iran. The ICBD was created in 2006 to replace the International Study Group (ISG) criteria (created in 1990). In this study, 14 existing diagnosis/classification criteria (Curth, Hewitt, Mason and Barnes, Japan original, Hubault and Hamza, O’Duffy, Cheng and Zhang, Dilsen, Japan revised, International Study Group, Iran traditional, Iran Classification Tree, revised Dilsen, Korea), were evaluated and compared to ICBD by ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

Rituximab in intractable ocular lesions of Behcet’s disease; randomized single-blind control study (pilot study)

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Mozhgan REZAIPOOR, Bahar SADEGHI-ABDOLLAHI, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Massoomeh AKHLAGHI, Tahereh FAEZI, Nasim NADERI

Abstract: Ocular lesions, the main morbidity of Behcet’s disease (BD), are the most difficult to treat. The aim of this study was to evaluate the efficacy of rituximab. Methods: Inclusion criteria were retinal vasculitis and edema, resistant to cytotoxic drugs. Twenty patients were randomized to a rituximab group (RG) or cytotoxic combination therapy group (CCTG). Rituximab was given in two 1000-mg courses (15-day interval). Subjects received methotrexate (15 mg/weekly) with prednisolone (0.5 mg/kg per day). The ... سال انتشار: 2010
 

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Authers: Fereydoun Davatchi, Farhad Shahram, Hormoz Shams, Abdolhadi Nadji, Cheyda Chams-Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Farima Ashofteh, Bahar Sadeghi-Abdollahi

Abstract: It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients ... سال انتشار: 2010
 

How to deal with Behcet’s disease in daily practice

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Massoomeh AKHLAGHI, Tahereh FAEZI, SADEGHI ABDOLLAHI

Abstract: Introduction: Behcet’s Disease (BD) is classified as a vasculitis, and progresses via attacks and remissions. BD is mainly seen around the Silk Road. The picture varies in different reports. For clinical descriptions, the data from the international cohort of patients (27 countries), will be used. Clinical manifestations: Mucous membrane manifestations were oral aphthosis seen in 98.1%, and genital aphthosis in 76.9% of patients. Skin manifestations were seen in 71.9% (pseudofolliculitis in 53.6% and erythema nodosum ... سال انتشار: 2010
 

Behcet’s disease: from east to west

Authers: Fereydoun Davatchi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahereh Faezi, Zahra Ghodsi, Alireza Faridar, Farima Ashofteh, Bahar Sadeghi Abdollahi

Abstract: Behcet's disease (BD) is classified among vasculitides. There are actually five nationwide surveys of BD: Iran, Japan, China, Korea, and Germany. Among case series, four are on more than 200 cases (Turkey, Morocco, Tunisia, and UK). BD was classically seen around the Silk Route. Now, it is seen everywhere. The male to female ratios were, respectively (in nationwide surveys), 1.19, 0.98, 1.34, 0.63, and 1.40 to 1. The mean age at onset was 26.2, 35.7, 33.8, 29, and ... سال انتشار: 2010
 

Behcet’s disease in Iran: analysis of 6500 cases

Authers: Fereydoun DAVATCHI, Farhad SHAHRAM, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Massoomeh AKHLAGHI, Tahereh FAEZI, Zahra GHODSI, Roghieh LARIMI, Farima ASHOFTEH, Bahar SADEGHI ABDOLLAHI

Abstract: To identify the clinical picture of Behcet’s disease in a large cohort of patients (6500) in Iran, over a period of 35 years, and compare them with other large series from around the world. Methods: Patients with Behcet’s disease from all over Iran were seen in the Behcet’s Disease Research Unit by a multidisciplinary team (rheumatologists, dermatologists, and ophthalmologists). Diagnosis was based on ‘expert opinion’. Data were collected on a standardized data sheet (105 ... سال انتشار: 2010
 

Colchicine versus placebo in Behc¸et’s disease: randomized, double-blind, controlled crossover trial

Authers: Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Arash Tehrani Banihashemi, Farhad Shahram, Abdolhadi Nadji, Hormoz Shams, Cheyda Chams-Davatchi

Abstract: The effect of colchicine was evaluated in a large cohort of Behc¸et’s disease (BD) patients and compared to placebo. In a randomized, double-blind, controlled crossover trial, 169 patients without major organ involvement were selected consecutively. They fulfilled the International Criteria for Behc¸et’s Disease. Patients were randomly assigned to colchicine or placebo. At 4 months, they were swapped over (colchicine to placebo, placebo to colchicine) for another 4 months. The primary outcome was the overall disease activity index, the IBDDAM. ... سال انتشار: 2009
 

Treatment of Ocular Lesions of Behcet’s Disease.

Authers: F. Davatchi, F. Shahram, H. Shams, A. Jamshidi

Abstract: Purpose: Cytotoxic drugs are the main therapeutic agents. A comparative study of 8 different therapeutic methods in 1220 cases is presented here. Materials & Methods: In an open, non-randomized control study, Pulse Cyclophosphamide (PCP), low dose PCP (LDP), oral cyclophosphamide ( OCP), weakly methotrexate ( MTX), chlorambucil ( CHL), cyclosporine A ( CYA), azathioprine (AZA), and combination therapy with LDP and MTX (COM) were used. Mean Duration: Ocular manifestations in months. FU: ... سال انتشار: 2001
 

Outcome measurement of ocular lesions in Behcet’s disease.

Authers: F. Davatchi, S. Soroosh, F. Shahram, H. Chams, M. Akbarian, F. Gharibdoost, A. Nadji, C. Shams

Abstract: The outcome of ocular manifestations of Behcet’s Disease remains uncertain and unpredictable despite cytotxic drugs. One of our recent studies, presented to the 1995 Korean Rheumatology Annual Meeting, showed that one third of patients were None Responders, regardless of what treatment used. This study was designed to search for factors predicting the final outcome at the beginning of the treatment. Patients having more than one year of treatment were selected ... سال انتشار: 1996