تالیفات

 

Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor Isotypes in Iranian Patients with Rheumatoid Arthritis: Evaluation of Clinical Value and Association with Disease Activity

Authers: Yadollah Shakiba1, Susan Koopah1, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, Ahmad Masoud1, Amir Kiani3, Mohammad Hossein Niknam1, Bahareh Nazari1, and Behrouz Nikbin1, 4

Abstract: In this study we determined the frequency, sensitivity and specificity of anti cyclic citrullinated peptides (anti-CCP) IgG antibody, total rheumatoid factor (RF-T), and RF isotypes in Iranian patients with rheumatoid arthritis (RA) and their association with age, clinical and serological parameters. Anti-CCP and RF-T and RF isotypes level were measured in 418 patients and 399 healthy controls by enzyme-linked immunosurbant assay (ELISA). Additionally, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ... سال انتشار: 2014
 

Mesenchymal stem cell therapy unable to rescue the vision from advanced Behcet’s disease retinal vasculitis: report of three patients

Authers: Fereydoun DAVATCHI, 1 Behrooz NIKBIN, 2 Hormoz SHAMS, 1 Bahar SADEGHI ABDOLLAHI, 1 Mandana MOHYEDDIN2 and Farhad SHAHRAM1

Abstract: Retinal vasculitis (RV) is the most aggressive lesion of ocular manifestations of Behcet’s disease, seen in 32.1% of patients. Although visual acuity (VA) improves with early and aggressive treatment, in the long run it is seen in only 48% of patients. Mesenchymal stem cell (MSC) transplantation (MSCT) can theoretically reverse the RV process. Patients and Methods: Three patients with advanced RV and very low VA were selected. Eyes selected for MSCT were legally blind (no ... سال انتشار: 2013
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, , Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Mandana MOHYEDDIN, Farhad SHAHRAM1, Behrooz NIKBIN

Abstract: Background: Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells (MSCs) due to their multi-lineage potential, immunosuppressive activities, limited immunogenicity and relative ease of growth in culture, have attracted attentions for clinical use. Aim: The aim of ... سال انتشار: 2011
 

Mesenchymal Stem Cell Therapy for Knee Osteoarthritis. Preliminary Report of Four Patients

Authers: Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Mandana Mohyeddin, Farhad Shahram*, , Behrooz Nikbin

Abstract: Osteoarthritis is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells due to their multi-lineage potential, immunosuppressive activities, limited immunogenicity, and relative ease of growth in culture have attracted attentions for clinical use. The aim of this study was to look ... سال انتشار: 2010
 

Association of CTLA4 Gene Polymorphism in Iranian Patients with Ankylosing Spondylitis

Authers: Esfandiar Azizi, Ahmad Massoud, Ali Akbar Amirzargar, Mahdi Mahmoudi, Narjes Soleimanifar, Nima Rezaei, Ahmad Reza Jamshidi, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Introduction Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a costimulatory molecule expressed by activated T cells. This study was performed to investigate the allele and genotype frequencies of CTLA4 gene polymorphisms in Iranian patients with ankylosing spondylitis (AS). Methods One hundred and fifty-seven patients with AS and 103 controls were included in this study. Polymorphisms of CTLA4 gene at positions +49 (in exon 1), −318, and −1,147 (in the promoter region) were studied on the genomic DNA using PCR restriction ... سال انتشار: 2010
 

Study of Programmed Cell Death 1 (PDCD1) Gene 2 Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, , Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Abstract—Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 ... سال انتشار: 2010
 

HLA-B27 subtypes and tumor necrosis factor α promoter region polymorphism in Iranian patients with ankylosing spondylitis

Authers: Mohammad Hossein Nicknam, Mahdi Mahmoudi, Ali Akbar Amirzargar1, Ahmad Reza Jamshidi, Nima Rezaei, Behrouz Nikbin

Abstract: Background. HLA-B27 is an MHC class I molecule that is strongly associated with ankylosing spondylitis (AS). TNF-α, as an important cytokine in inflammatory joint disease, might have a role in the process of AS. This study was performed to determine HLA-B27 subtypes among Iranian patients with AS, and to investigate TNF-α gene polymorphisms in the patient groups. Methods. Ninety seven AS patients (74 HLAB27- positive and 23 HLA-B27-negative) and 137 healthy normal subjects (2 ... سال انتشار: 2009
 

Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis

Authers: Mohamad Hossein Nicknam1, , Mahdi Mahmoudi, , Ali Akbar Amirzargar, , Mazdak Ganjalikhani Hakemi, , Farideh Khosravi, , Ahmad Reza Jamshidi, , Aref Amirkhani, , Bita Ansaripour, , Zahra Pourpak, , Mostafa Moin, , Behrooz Nikbin

Abstract: The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important to know whether certain subtypes show any preferential association with AS. Because there is ... سال انتشار: 2008
 

Analysis Of Microsatellite Polymorphism Around The HLA-B Locus In Iranian Patients With Behcet's Disease.

Authers: N. Mizuki, K. Yabuki, M. Ota, Y. Katsuyama, H. Ando, E. Nomura, K. Funakoshi, F. Davatchi, H. Chams, B. Nikbin, A.A. Ghaderi, S. Ohno, H. Inoko H

Abstract: We have previously suggested that in a Japanese population the susceptible locus for Behcet's disease (BD) is HLA-B51 itself. To confirm this finding in another population, we performed HLA class I typing using the PCR-SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA-B gene using automated sequencer and subsequent automated fragment detection by fluorescent-based technology with the DNA samples of 84 Iranian patients with BD ... سال انتشار: 2002
 

Pathergy test (PT): sensitivity and selectivity in 544 patients with Behcet's Disease (BD) and in 174 controls.

Authers: P. Mansoori, C. Chams, F. Davatchi, M. Akbarian, M. R. Hatef, F. Shahram, H. Chams, B. Nikbin

Abstract: PT was performed by 2 methodes: 1- Needle prick. 2-- Intra dermal injection of normal salin. 83 % of BD patients presented a positive PT. Control subjects were composed of 101 healthy person, 46 Rheumatoid Arthritis, 5 Ankylosing Spondylitis, 18 Systemic Lupus Erythematosus (SLE). 3 Sclerodermia, and 1 permatomyositis. Among them 16% presented a positive PT. Only 3% had a positive PT with both needle prick and normal salin method. ... سال انتشار: 1988
 

Immunogenetic basis of resistance to ocular involvement in Behcet's Disease (BD).

Authers: B. Nikbin, F. Khossravi, F. Davatchi, H. Chams, C. Chams

Abstract: In a separate report we demonstrated that B5 cluster antigens acts as a leading factor for ocular injuries. The question is why in some patients, these antigens does not produce the same lesions. This may be due to a genetic factor(s) which determine resistance to ocular lesions. Two HLA antigens attracted our attention as possible factors. One from the class I (CW4), and the other from the class II (DQW1). DQW1 ... سال انتشار: 1988
 

HLA-B5 cluster in non ocular type of Behcet's Disease (BD).

Authers: F. Khossravi, A. Sarafnejad, B. Nikbin, M. Akbarian, F. Shahram, M. R. Hatef

Abstract: We have reported a 100% association of ocular type of BD with B5 cluster antigens. The HLA results of non ocular type shows respectively 30% and 40% of association with B5 and B5 cluster antigens. These results indicate that B5 cluster antigens are decreased in non ocular patients compared to 62% of normal population. Considering the etiologic fraction for B5 cluster in ocular type patients which was at its maximum ... سال انتشار: 1988
 

HLA-B5 in Behcet's Disease, relationship to symptoms, analysis of 543 cases.

Authers: M. Akbarian, F. Davatchi, B. Nikbin, H. Chams, C. Chams, M.R. Hatef, F. Shahram, Z. Aalami-Harandi, P. Mansoori

Abstract: Behcet's Disease (BD) has been found to be related to the first class HLA antigens, the B5. In Iran, B5 is present in 64% of BD patients versus 34% in normal population. The relative risk is 3.33. Uveitis has been demonstrated to be related to the presence of B5. in our study the posterior uveitis was present in 59% of patients with B5 versus 48% without it (p سال انتشار: 1988
 

Histocompatibility antigens (HLA) in rheumatic diseases in Iran

Authers: F. Davatchi،B. Nikbin

Abstract: One hundred and sixty-six patients with different forms of rheumatic diseases were tissue typed for 26 antigens of the A and B locus of the HLA system, using a modified KN cytotoxicity test. Among 25 patients with confirmed ankylosing spondylitis, 23 had HLA B27 (92 per cent), compared to 2.5 per cent in the normal controls. This confirms the strong association of HLA B27 with ankylosing spondylitis. Eight patients had ... سال انتشار: 1977