تالیفات

 

Alpha 1-antitrypsin activity is markedly decreased in Wegener’s granulomatosis

Authers: Ali Mota • Abbas Sahebghadam Lotfi • Ahmad-Reza Jamshidi • Saeed Najavand

Abstract: Abstract Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners’ granulomatosis. A1AT deficiency correlated with ANCA-associated vasculitis. This study explores the trypsin inhibitory capacity (TIC), specific activity, and phenotypic deficiency of A1AT in Wegener’s granulomatosis. Twenty-seven WG patients were studied. ANCA was tested by IIF and ELISA. Serum a1-anti-trypsin levels were quantified inWG patients and healthy controls by immunoturbidimetric ... سال انتشار: 2014
 

Alpha 1-antitrypsin activity is markedly decreased in Wegener’s granulomatosis

Authers: Ali Mota • Abbas Sahebghadam Lotfi • Ahmad-Reza Jamshidi • Saeed Najavand

Abstract: Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners’ granulomatosis. A1AT deficiency correlated with ANCA-associated vasculitis. This study explores the trypsin inhibitory capacity (TIC), specific activity, and phenotypic deficiency of A1AT in Wegener’s granulomatosis. Twenty-seven WG patients were studied. ANCA was tested by IIF and ELISA. Serum a1-anti-trypsin levels were quantified in WG patients and healthy controls by immunoturbidimetric ... سال انتشار: 2013