تالیفات

 

Clinical and preclinical manifestation of systemic lupus erythmatous

Authers: M. Ebrahimpur Fini, MD, T. Faezi, MD, M. Akbarian, MD, M. Akhlaghi, MD, M. Kheiyrandish, MD, A. Shahali, MD, F. Gharibdoust, MD, F. Shahram, MD, A.H. Naji, MD, A.R. Jamshidi, MD, F. Davachi, MD

Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male ... سال انتشار: 2011
 

Isolated Hematuria in SLE Patients and its Association with Proteinuria, Urinary Cast and SLE Disease Activity

Authers: M. Akbarian, H. Soleymani, F. Gharibdoost, A. Nadji, A.R. Jamshidi, , F. Shahram, M. Akhlaghi, S. Khosravi, S. Almasi, Fereydoun Davatchi

Abstract: Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of ... سال انتشار: 2009
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-α and TNF receptor system in systemic lupus erythematosus

Authers: M. KARIMIFAR, , F. GHARIBDOOST, , M. AKBARIAN, , A. P. MEYSAMIE, , SH. KHOSRAVI, , Mozh. KARIMIFAR, , F. SHAHRAM, A. NADJI, A. R. JAMSHIDI, , M. AKHLAGHI, , B. YAZDANI1, F. DAVATCHI1

Abstract: Objective: There are some clues that measurement of triglyceride (TG) and high-density lipoprotein (HDL) and their correlation with tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor type 1 and type 2 (sTNFR1, sTNFR2) in serum could be valuable in the assessment of disease activity of systemic lupus erythematosus (SLE) patients. Methods: In this cross-sectional study, fasting blood samples were obtained from 86 SLE patients referred to the Rheumatology Research Center of Tehran University in Shariati ... سال انتشار: 2007
 

Heat shock protein 70 level of synovial fluid in rheumatoid arthritis versus osteoarthritis: a comparative study

Authers: Gharibdoost F., Samadi F., Taghipoor R., Akbarian M., Shahram F., Nadji A., Jamshidi A R, Davatchi F.

Abstract: Background: Heat-shock proteins are part of a strictly controlled biological system that allows organisms to respond to environmental stresses. Different proinflammatory cytokines are present in the synovial tissue of rheumatoid arthritis patients. Such tissues respond to stress and induce heat-shock proteins. In addition, synovial cells are exposed to mechanical stress caused by joint motion. The effects of mechanical stress on the metabolism of the synovial cells may be substantial, even pathogenic. Heat-shock proteins are often implicated ... سال انتشار: 2007
 

Bone mass density in the normal population of Iran

Authers: M. AKBARIAN, F. DAVATCHI, A. SALIMZADEH, F. SHAHRAM, F. GHARIBDOUST, A. NADJI, M. PAJOUHI, A. JAMSHIDI

Abstract: Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators of the bone mass and thus useful predictors of fracture risk. Dual energy X-ray absorptiometry (DEXA) is the easiest, yet the most precise and non-invasive technique. The need for a population-specific normative BMD data is vital in preventing mislabelling or misdiagnosis of osteopenia or even osteoporosis. Aim: This study was performed to determine the lumbar vertebral and the proximal ... سال انتشار: 2005
 

LATE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS IN IRAN.

Authers: M. Akbarian, M. Valizadeh, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objectives: The aim of this study is to analyze the clinical features, laboratory findings and type of treatments in late onset SLE (after 50 years) in Iranian patients and compare them with the early onset. Methods: Records of 1419 SLE patients who attended our lupus unit, between 1975 and 1999 were reviewed. Nineteen Patients with late onset disease were identified. For comparison, 47 patients with disease onset before the age of ... سال انتشار: 2002
 

Clinical features in Systemic Sclerosis in early and late phases. Analysis of 53 patients.

Authers: F. Gharibdoost, R. Najafizadeh, A. Khalvat, M. Akbarian, F. Shahram. A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Objective: Systemic sclerosis is a generalized disorder of connective tissue disease. This study surveyed the clinical manifestations of systemic sclerosis in early (6 years) phases of limited and diffuse variants. Methods: Nineteen patients with diffuse and thirty-four cases with limited form of disease were selected consecutively from 1992 to 1998. Sixty-five clinical data were evaluated and then analyzed by MC-Nemar chi square test between two forms in both phases. Results: (1) There were ... سال انتشار: 1999
 

Bone Mass Density in Normal Iranian Population.

Authers: M. Akbarian, F. Davatchi, A. Salimzadeh, F. Shahram, F. Gharibdoost, A. Nadji, M. Pajouhi, A. Jamshidi

Abstract: The bone mass density (BMD) may vary in different countries due to different genetic and environmental factors. This study was performed to determine the BMD of the normal population in Iran. Subjects were selected randomly from different social workers classes in Tehran (from the lowest to the highest). For each decade and sexes, 20 normal subjects were selected (140 men and 140 women). BMD was measured with a Hologic 1000 ... سال انتشار: 1998
 

CLINICAL AND LABORATORY MANIFESTATIONS OF THROMBOCYTOPENIA IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Authers: I. Salehi., M. Akbarian., F. Shahram., F.Gharibdoost., A. Nadji., A. Jamshidi, F. Davatchi

Abstract: In systemic lupus eryThematosus (SLE) various antibodies are produced against cells including platelets and result in thrombocytopenia. !n the literature, the incidence of thrombocytopenia varied from 7% to 52%, in seven series of SLE patients with a mean cumulative percentage of 14.5% (1-5 ). SLE patients referred to the Lupus Unit of the Rheumatology Research Center. Tehran University for Medical Sciences. (Shariati Hospital) during the period of 1975 to 1977 ... سال انتشار: 1997
 

Bone mass density (BMD) in normal Iranian population.

Authers: M. Akbarian, M. Pajouhi, A. Salimzadeh, F. Gharibdoost, F. Shahram, A. Nadji, A. Jamshidi, F. Davatchi

Abstract: Introduction: BMD varies in different countries due to different genetic and environmental factors, It is necessary to determine BMD in normal population of Iran. This study was designed by the Rheumatology Research Center to fulfill this task. It was achieved by a grant from the Deputy Ministry for Research, the Ministry of Health, Treatment and Medical Education. Materials and methods: 280 normal Iranians were selected randomly from staffs of Shariati Hospital ... سال انتشار: 1995
 

OUTCOME of PULSE CYCLOPHOSPHAMIDE (PCP) in TYPE IV SLE NEPHRITIS WITHOUT RENAL FAILURE.

Authers: M. Akbarian, F. Davatchi, F. Shahram, C. Chams, M.E. Tebbi

Abstract: Results of PCP are well known in lupus nephritis. We present here it's outcome in patients with early stage of WH0 type IV lupus nephritis. The criteria for selection was a serum creatinine inferior to 1.3 mg/ 100 ml and a minimum follow up time of 18 months. 35 patients fulfilled the selection criteria. proteinuria, hematuria, leucocyturia, cast, BUN, creatinine, and blood pressure were measured before PCP and after each one. ... سال انتشار: 1991
 

Lupus Nephritis in Iran. Analysis of 287 cases.

Authers: M. Afrousian, F.Davatchi, M.Akbarian, M.R.Hatef, F.Shahram, C.Chams

Abstract: Systemic Lupus Erythematosus (SLE) is a rather frequent disease in Iran. In the past 13 years, 449 patients with SLE attended the SLE clinic. Lupus nephritis was discovered in 278 of them. The purpose of this study is to demonstrate the caracteristics of lupus nephritis in Iran (percentage of proteinuria, hematuria, leucocyturia, casts, renal insufficiency, hypertension, and patterns of renal biopsy), to compare them to the remaining patients with SLE ... سال انتشار: 1991
 

Iran Behcet's Disease Dynamic Activity Measure (IBDDAM).

Authers: F. Davatchi, M. Akbarian, F. Shahram, M. E. Tebbi, C. Chams, H. Chams

Abstract: The evaluation of the inflammatory state of Behcet`s Disease and it's quantification is most difficult. The difficulty is due to the recurrent attacks and spontaneous remissions that charac­terizes the disease. In IBDDAM the patients is evaluated on several weeks or months. Each attack is measured separately and given an index. The ob­tained indexes are added together and the total is divided by the number of months of the evaluation period. ... سال انتشار: 1991
 

Weekly low-dose pulsed methotrexate in ocular Behcet (analysis of 41 cases).

Authers: F. Shahram, F. Davatchi, M. Akbarian, H. Chams, C. Chams, M.E. Tebbi

Abstract: Cytotoxic drugs as the only remittent agents in posterior uveitis (PU) and/or retinal vasculitis (RV) of Aehcet's disease(BD) is generally accepted today. However which cytotoxic is the least harmful and yet efficient is questionable. The safety of long term use of MTX in rheumatoid arthritis made us to use this drug in ocular Behcet. Our prelimi-nary report to the first APLAR Symposium for Treatment of Rheumatic Diseases in Korea, stowed ... سال انتشار: 1991
 

Pulse cyclophosphamide in SLE nephritis, analysis of 84 cases.

Authers: M. Akbarian, F. Davatchi, F. Shahram, C. Chams, M.E. Tebbi.

Abstract: Pulse cyclophosphamide (PCP) is a well established method for the treatment of lupus nephritis. PCP seems to produce better results with lesser side effects, than oral cytotoxic drugs. We presenthere, our experience with this method, in 84 patients. All patients had a WHO type IV histological lesion, on light microscopy, Proteinuria, hematuria, leucocyturia, casts, BUN, creatinine, and blood pressure were measured before starting PCP and after each one. The first ... سال انتشار: 1990
 

Methotrexate in ocular Behcet, preliminary report.

Authers: F. Shahram, F. Davatchi, H. Chams, M. Akbarian, C. Chams, M.E. Tebbi

Abstract: Posterior uveitis and retinal vasculitis are the most serious lesions­ of ocular Behcet. Pulse cyclophosphamide and cyclosporine A are the most efficient treatment. Oral cytotoxic drugs (cyclophosphamide, chlorambucil , and azathioprine) are less efficient. We present here our first impression on weekly pulsed methotrexate (MTX). MTX was administereted as 7.5 mg weekly in 3 divided doses, every 12 hours Prednisolone was given as 0.5 mg/kg/day. 23 patients with posterior uveitis (PU) ... سال انتشار: 1990
 

Pulse cyclophosphamide in Lupus Nephritis.

Authers: F. Davatchi, M. Akbarian, F. Shahram.

Abstract: Pulse cyclophosphamide (PCP) is a well established method for the treatment of lupus nephritis. PCP seems to produce better results, and lesser side effects, than oral cytotoxic drugs. We present here, our ex­perience with this method, in 51 patients. All patients had a WHO type IV histological lesion, on light microscopy. Proteinuria, hematuria, leuco­cyturia, casts, BUN, creatinine, and blood pressure were measured before starting PCP and after each one. The first ... سال انتشار: 1990
 

OPHTHALMOLOGICAL MANIFESTATIONS IN BEHCET'S DISEASE, COMPUTER ANALYSIS OF 1074 CASES.

Authers: F. Davatchi, H. Chams, M. Akbarian, C. Chams, F. Shahram.

Abstract: Behcet's Disease (BD) is rather frequent in Iran. Near 200 new cases are seen every year, and this rate is going up every year. Oph­thalmological manifestations are frequent (71%). Anterior uveitis (AU) is seen in 63% of patients. It is characterized by flare and cells in the anterior chamber. Hypopion, the classic lesion of the anterior chamber is transient and rarely seen in ophthalmologic examination. The AU progresses by successive ... سال انتشار: 1990
 

Pulse therapy with cyclophosphamide (PTCP) in ophthalmologic manifestations of Behcet's Disease (BD). Analysis of 67 patients.

Authers: F. Davatchi, F. Shahram, H. Chams, C. Chams, M. Akbarian, M.R. Hatef, Z. Aalami-Harandi

Abstract: Ophthalmologic manifestations of BD, especially posterior uveitis and retinal vasculitis are resistant to most treatments, leading to sever loss of vision. Cytotoxic drugs, especially chlorambucil and cyclo­phosphamide (CP) are effective in some patients. In a preliminary report to the XI EULAR Congress of Rheumatology we demonstrated the efficacy of PTCP in these lesions. PTCP was performed by perfusion of 1 g. CP per square meter of body surface in 500 ... سال انتشار: 1988
 

Pathergy test (PT): sensitivity and selectivity in 544 patients with Behcet's Disease (BD) and in 174 controls.

Authers: P. Mansoori, C. Chams, F. Davatchi, M. Akbarian, M. R. Hatef, F. Shahram, H. Chams, B. Nikbin

Abstract: PT was performed by 2 methodes: 1- Needle prick. 2-- Intra dermal injection of normal salin. 83 % of BD patients presented a positive PT. Control subjects were composed of 101 healthy person, 46 Rheumatoid Arthritis, 5 Ankylosing Spondylitis, 18 Systemic Lupus Erythematosus (SLE). 3 Sclerodermia, and 1 permatomyositis. Among them 16% presented a positive PT. Only 3% had a positive PT with both needle prick and normal salin method. ... سال انتشار: 1988
 

Pulse cyclophosphamide (PCP) in ocular manifestations of Behcet's disease.

Authers: F. Davatchi, H. Chams, F. Shahram, M. Akbarian, M.R. Hatef, C. Chams, Z. Aalami-Harandi

Abstract: Patients with sever posterior uveitis and/or retinal vasculitis, and un­responsive to oral cytatoxic drugs and/or high doses steroids, were selected for this study. Pulse cyclophosphamide (PCP) was performed by perfusion of 1 g cyclophosphalnide per square meter of body surface in 500 ml of normal saline. PCP was repeated every month after a new evaluation of the patient. 30 mg of prednisolone/day was also given. Actually 102 patients are receiving ... سال انتشار: 1988
 

HLA-B5 cluster in non ocular type of Behcet's Disease (BD).

Authers: F. Khossravi, A. Sarafnejad, B. Nikbin, M. Akbarian, F. Shahram, M. R. Hatef

Abstract: We have reported a 100% association of ocular type of BD with B5 cluster antigens. The HLA results of non ocular type shows respectively 30% and 40% of association with B5 and B5 cluster antigens. These results indicate that B5 cluster antigens are decreased in non ocular patients compared to 62% of normal population. Considering the etiologic fraction for B5 cluster in ocular type patients which was at its maximum ... سال انتشار: 1988
 

HLA-B5 in Behcet's Disease, relationship to symptoms, analysis of 543 cases.

Authers: M. Akbarian, F. Davatchi, B. Nikbin, H. Chams, C. Chams, M.R. Hatef, F. Shahram, Z. Aalami-Harandi, P. Mansoori

Abstract: Behcet's Disease (BD) has been found to be related to the first class HLA antigens, the B5. In Iran, B5 is present in 64% of BD patients versus 34% in normal population. The relative risk is 3.33. Uveitis has been demonstrated to be related to the presence of B5. in our study the posterior uveitis was present in 59% of patients with B5 versus 48% without it (p سال انتشار: 1988