تالیفات

The effects of team-based learning on learning outcomes in a course of rheumatology  

The effects of team-based learning on learning outcomes in a course of rheumatology

مولف: SEYEDEH TAHEREH FAEZI1, KAMRAN MORADI1, 2, ALI GHAFAR RAHIMI AMIN3, MASSOOMEH AKHLAGHI1, FATEMEH KESHMIRI4*

خلاصه: Introduction: We evaluated the effects of implementing Team- Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n=84) participating in a course of ... سال انتشار: 2018
Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
 

Association analysisofRAC1sin- gle nucleotidepolymorphismswith ulcerativecolitis

مولف: Mohammad Tahera Nasser EbrahimiDaryania Mona Hedayatb, c Mohammad Eslamiana

خلاصه: number ofpossiblecandidategeneshavebeenidentifiedto play acausativeroleinconferringageneticsusceptibilityto UC, resultinginimmunedysregulation.Recently,Muiseetal. reported anovelgeneticassociationbetweenRAC1withUC, a findingsupportedbyhumangeneticandfunctionalstud- ies andanimalmodelsofcolitis [3]. Administrationofthe RAC1 inhibitorNSC23766,aswellasconditionaldisruption of RAC1 [3], decreasedDSS-inducedneutrophilrecruitment and tissuedamageinthecolon.InhibitionofRAC1wasshown to abolishCXCchemokine-inducedneutrophilchemotaxis and up-regulationofMac-1invitro.Inadditiontoitsessen- tial roleinmodulatingimmuneandinflammatoryresponses, RAC1 playsanessentialroleinwoundhealingandepithe- lial celladhesion/migration/differentiation,whichinvolves Rho GTPase-mediatedcytoskeletonremodelinganddisso- lution andreassemblyofcellularjunctions [4]. Moreover, inflammation- andpathogen-inducedRAC1inactivationpro- motes apoptosisandcontributestomicrobialinfectionand barrier dysfunction. In thepresentstudy,three RAC1 gene variants,previously reported toconfersusceptibilitytoUC [3], werestudies in anIranianpatientpopulation.Ourresultsindicatedthat the allelicfrequenciesoftheseSNPswerenotsignifican- tly differentinUCpatientscomparedtocontrols,which was similartowhatwepreviouslyreportedinpatientswith CD [13]. Thiscanbeinpartexplainedbyheterogeneityof the studiedpopulations,suggestingaroleforepigenetic factors inthecomplexinterplaybetweengenesandenvi- ronment amongdifferentethnicpopulations.Italsoshould be emphasizedthatUCisacomplexdisease,inwhichmul- tiple factorscanaffectdiseasebehaviororseverity.Thus, different studydesigns,controlpopulations,andincomplete phenotype descriptioncouldpotentiallyresultindifferent outcomes. GivenitshigherprevalenceinEuropeandNorth America comparedtotheMiddleEasternregions,itcouldbe hypothesized that RAC1 gene variantsmightbeassociated with UCamongpatientsofEuropeanancestry,althoughit needs furtherinvestigations. In conclusion,ourstudydidnotshowanyassociation between thestudiedRAC1SNPsandUCinIranianpatients, similar towhatwefoundinCD.WhetherRAC1,thoughnota predictive geneticbiomarkerbasedontheassessedSNPsin the presentstudy,isamajorplayerinthepathogenesisof UC inourpatientpopulationneedsfurtherinvestigations. Considering ethnicitydifferencesstudyingimmunemodu- lating genesindifferentpopulationswouldshedlightonthe molecular pathogenesisofUC.Thiswilllaythefoundation for improvedpersonalizedmedicineinUCbasedonpharma- cogenetic approachesandtargetedgenetherapy.Further studies ondifferentpopulationswithlargersamplesizes are requiredtoidentifytheexactroleofRAC1andother contributing genesinUC. سال انتشار: 2017
 

WHO-ILAR COPCORD study (stage 1, urban study) in Sanandaj, Iran

Authers: Nasrin Moghimi & Fereydoun Davatchi & Ezat Rahimi & Afshin Saidi & Naser Rashadmanesh & Solmaz Moghimi & Hoshyar Ghafori & Peiman Zandi & Negin Ahmadi & Hamed Ghafori & Mohsen Moghimi & Marjan hajiheshmati

Abstract: This study aims to conduct an urban Community Oriented Program for Control Of Rheumatic Diseases (COPCORD) study in Sanandaj (Kurdistan, Iran). Sanandaj with a population of 311,446 (2006 census), Caucasian of Kurdish subgroup, was selected as the field. Sanandaj was divided into 100 clusters and subjects were randomly selected from them (50 subjects from each cluster). The COPCORD study started on July 2011 and ended on June 2012. Of the households, 1,631 was visited and 5,830 persons were interviewed. ... سال انتشار: 2015
 

RAC1 single nucleotide polymor-phisms in Crohn’s disease

Authers: Mohammad TaheraNasser Ebrahimi DaryaniaMona HedayatbMohammad EslamianaElham Farhadic, dMahdi MahmoudieSamira ShirzadfMohammd Kazem Nouri TaromlouaMeghedi ChaharmahaligMohammad Hossein NicknamcMohammad BashashatihNima

Abstract: diseaseRac1 is a regulator for cellular motility, proliferation andtransformation. A recent showed that mutations of RAC1gene are associated with higher risk of inflammatory boweldisease (IBD). These mutations increase the expression ofRac1 protein and intriguingly, loss of Rac1 expression resultsin protection from colitis [1,2].Thus we conducted a case-control study on 67 patientswith Crohn’s disease (CD) and 78 healthy individuals toidentify whether there is any association between CD andsingle nucleotide polymorphisms (SNPs) ... سال انتشار: 2014
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... سال انتشار: 2014
 

Multiple Imputation to Deal with Missing Clinical Data in Rheumatologic Surveys: an Application in the WHO-ILAR COPCORD Study in Iran

Authers: M Mirmohammadkhani1, A Rahimi Foroushani1, F Davatchi2, 3, K Mohammad1, A Jamshidi2, 3, A Tehrani Banihashemi1, 3, *K Holakouie Naieni 1,

Abstract: The aim of the article is demonstrating an application of multiple imputation (MI) for handling missing clinical data in the setting of rheumatologic surveys using data derived from 10291 people participating in the first phase of the Community Oriented Program for Control of Rheumatic Disorders (COPCORD) in Iran. Methods: Five data subsets were produced from the original data set. Certain demographics were selected as complete variables. In each subset, we created a univariate pattern ... سال انتشار: 2012
 

Translation and measuring the reliability of the Stanford Health Assessment Questionnaire (HAQ) in Iranian patients with rheumatoid arthritis

Authers: Rastmanesh R1, Faryar A2; Eghbali M, Shaabani Y1, Mazinani E, Ebrahimi AA, Jamshidi AR

Abstract: Evaluation of functional disability by using proper instruments, like Stanford Health Assessment Questionnaire (HAQ) in patients with rheumatoid arthritis (RA), is necessary not only for quality of life assessment, but also as a useful marker for disease activity. Stanford HAQ has been translated into many languages. The present study seeks to measure reliability of the Persian version of the Stanford HAQ. Persian version of the Stanford HAQ (PE-HAQ) with culturally necessary modifications of the arising, ... سال انتشار: 2009
 

Evaluation of the effect of Acetazolamide on Cystoid Macular Edema in Patients with Behcet’s disease.

Authers: A.R. Lashay, A. Rahimi, H. Chams, F. Davatchi, F. Shahram

Abstract: To study the effect of acetazolamide on Cystoid Macular Edema (CME) in patients with Behcet's disease, twenty three patients (46 eyes) who had chronic, but controlled uveitis associated cystoid macular edema were randomized into a double masked, cross - over trial comparing acetazolamide (250mg bid) versus placebo. Eighteen patients (36 eyes) completed the trial (11 males, 7 females). Although acetazolamide trial led to slightly better results in decreaing CME angiographically, over ... سال انتشار: 2000