تالیفات

 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydon Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi-Abdollahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

Longitudinal Study of Chlorambucil in Ocular Abstract Manifestations of Behçet’s Disease

Authers: Fereydoune Davatchi, Hormoz Chams, Farhad Shahram, Abdol-Hadi Nadji, Cheyda Chams-Davatchi, Bahar Sadeghi Abdillahi, Masoumeh Akhlaghi, Tahereh Faeizi, Ahmad-Reza Jamshidi, Mahmood Akbarian, Farhad Gharibdoost

Abstract: Cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of Behçet’s Disease (BD). The purpose of this study was to evaluate eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. Methods: Chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. Prednisolone was concomitantly given as 0.5 mg per kilogram of body weight. Prednisolone was tapered ... سال انتشار: 2009
 

HLA-B51 IN BEHÇET’S DISEASE

Authers: F. Davatchi*, , F. Shahram, , A. Nadji, , S. Soroosh, , A. R. Jamshidi, , C. Chams, , H. Chams, , M Akbarian, , F. Gharibdoost, , M. Akhlaghi, , B. Sadeghi Abdollahi, N. Ziaie

Abstract: There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet’s disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no ... سال انتشار: 2008
 

RECENT EPIDEMIOLOGICAL DATA ON BEHCET’S DISEASE IN IRAN, THE 2001 SUYRVEY.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The latest nationwide survey on Behcet’s disease (BD) in Iran was carried out in 2001. We present here its data, and compare it with the previous two surveys in 1991 (on 1882 patients) and 1996 (on 3153 patients). Patients & methods: The data of patients in the BD registry before the end of the year 2001 were collected on a standard protocol comprising 100 clinical and paraclinical items. A ... سال انتشار: 2002
 

ASSOCIATION OF HLA-B51 WITH CLINICAL EXPRESSION OF BEHCET’S DISEASE, ANALYSIS OF 201 IRANIAN PATIENTS.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, K. Bahar, F. Gharibdoost, C. Chams

Abstract: Introduction: Despite the strong association between HLA-B51 and Behcet’s disease (BD), the clinical significance of this genetic marker has not been fully elucidated. The aim of this study was to find out the association of HLA-B51 with various manifestations of BD, and to compare it to those of HLA-B5. Patients & methods: All newly diagnosed BD patients in a 9-month period from April 2001 to January 2002 were studied. They ... سال انتشار: 2002
 

AZATHIOPRINE AND LOW DOSE PULSE CYCLOPHOSPHAMIDE IN SEVERE OCULAR LESIONS OF BEHCET’S DISEASE, A PRELIMINARY REPORT.

Authers: F. Shahram, F. Davatchi, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Combination of cytotoxic drugs was suggested to decrease the rate of non-responders in severe ocular lesions of Behcet’s disease (BD). We present here our preliminary data with low dose pulse Cyclophosphamide (LDP) and Azathioprine (AZA) in the treatment of posterior uveitis (PU) and/or retinal vasculitis (RV) of BD. Patients & methods: Twelve BD patients with PU and RV were selected. They all received LDP as 0.5 g/m2 body surface/month ... سال انتشار: 2002
 

TONSILLECTOMY AND BEHCET’S DISEASE.

Authers: M. Jalessi, F. Shahram, A. Safavi, F. Davatchi, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost.

Abstract: Introduction: Increasing development of some diseases such as Behcet’s disease (BD) was reported after tonsillectomy. This study was designed to find the association between tonsillectomy/adenoidectomy (T/A) and subsequent development of BD. Patients & methods: In a prospective control study, 128 patients with BD and 139 controls from the orthopedic clinic (age and sex matched) were studied regarding previous T/A. A complete ENT clinical examination was performed for all of them. ... سال انتشار: 2002
 

URINE ABNORMALITIES IN BEHCET’S DISEASE, STUDY OF 4704 CASES.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost, C. Chams.

Abstract: Introduction: Despite the multisystem nature of Behcet’s disease (BD), renal involvement is rare in this disease. The aim of this study was to find the prevalence and characteristics of urine abnormalities and renal involvement of BD in Iran. Patients & methods: In a cohort of 4704 patients with BD, urinalysis was performed to screen patients with urine abnormalities. Different manifestations of the disease, including 100 clinical and paraclinical parameters, were ... سال انتشار: 2002
 

BEHCET’S DISEASE. ANALYSIS OF 4660 CASES.

Authers: F. Davatchi, C. Chams, F. Shahram, F. H. Chams, A. Nadji, M. Akbarian, F. Gharibdoost

Abstract: Behcet’s Disease (BD) is a multisystemic disease with a peculiar distribution in the world. The disease is specially seen in the countries bordering the ancient SILK ROAD specially Japan, China, Korea, Iran, and Turkey. The majority of reports on BD are on hospital based patients. Others are either local based patients or epidemilogical studies on a small area. The only two nationwide analysis of BD is from Japan and ... سال انتشار: 2002
 

THE COMPARISON OF ANKYLOSING SPONDYLITIS IN BEHCET'S DISEASE AND NORMAL POPULATION: A CONTROL STUDY.

Authers: A. Nadji, F. Davatchi, F. Shahram, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: We previously reported that ankylosing spondylitis (AS) was associated with Behcet's disease (BD) in Iranian patients. This study was designed to evaluate the features of AS in BD (ASBD) and compare them with the AS in normal population (ASN). Materials and Methods: Among 4700 BD patients, 73 ASBD were found and were compared with a cohort of 180 ASN. Seventy out of 73 ASBD met the European Spondyloarthropathy Study Group ... سال انتشار: 2002
 

THE INFLUENCE OF THE DELAY IN AGGRESSIVE TREATMENT ON THE VISON AND ITS OUTCOME IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.R. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: The natural course of eye lesions is well known, leading to sever loss of vision or blindness. The cumulative nature of eye lesions during successive attacks, leads to gradual loss of visual acuity (VA). The aim of this study was to evaluate the effect of the delay in aggressive treatment on the VA and its long-term outcome. Materials and Methods: All Behcet’s patients of the treatment registry (1009 ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A.R. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

HIGH DOSE METHOTREXATE FOR OCULAR LESIONS OF BEHCET’S DISEASE. PRELIMINARY SHORT-TERM RESULTS ON 23 PATIENTS.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Jamshidi, A. Nadji, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: methotrexate in weekly low dose pulse of 7.5 mg has long proved its efficacy in the treatment of ocular lesions. During the 1998 ACR congress where we presented our data on 262 patients it was suggested the high dose of 15 mg. This is the short-term result of that study. Materials and Methods: MTX was used as 15 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. The visual ... سال انتشار: 2002
 

The Impact of the Treatment Delay on the Outcome of Vision in Ocular Lesions of Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ... سال انتشار: 2002
 

THE INFLUENCE OF PATHERGY TEST ON THE ACCURACY OF DIFFERENT DIAGNOSIS CRITERIA FOR BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, A. Nadji, A. Jamshidi, C. Chams, H. Chams, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ... سال انتشار: 2002
 

THE INFLUENCE OF SEX ON THE FREQUENCY OF CLINICAL SYMPTOMS IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: It is known from long date that some manifestations are seen more frequently in men than women and in some of them the difference may be statistically significant. The aim of this study was to address that issue and to find if a statistical difference was of any clinical relevance or significance Materials and Methods: All patients of the BD registry (4717 at January 20, 2002) entered the ... سال انتشار: 2002
 

Clinical Manifestattion Of Behcet’s Disease.

Authers: A. Jamshidi, F. Shahram, A. Nadji, H. Chams, M. Akbarian, F. Gharibdoost, C. Chams, F. Davatchi

Abstract: Objectives: Behcet's disease (BD) is a multi-system disease. We present here the various clinical aspects of BD based on the data of 4586 Iranian patients. The male to female ratio was 1.17/l. The mean age at the onset of the disease was 26 yr (SD:9.6, CI:0.3). The mean disease duration was 9 yr (SD:7), and the mean follow up time was 3 yr (SD:3.8). As the first manifestation of the ... سال انتشار: 2001
 

EXPERIENCE IN IRAN WITH SPECIAL REFERENCE TO BEHCETS DISEASE (BD).

Authers: F. Davatchi, F. Shahram, C. Chams, H. Chams, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Pattern of Rheumatic Diseases in Iran: They have the same frequency and the same pattern as in Western countries. A study from 1993 demonstrated a prevalence of 32.6% among adults (31.4% in the USA, Cunningham 1984). Inflammatory disorders counted for 11% of all rheumatic diseases. The ratio of RA to AS was 8/1 (7/1 in USA), and SLE to Scleroderma 3.5/1 (3.6/1 in USA). Psoriatic arthritis and Reiter's syndrome were ... سال انتشار: 2001
 

­LARGE VESSEL MANIFESTATIONS OF BEHCET’S DISEASE,REPORT OF 377 CASES.

Authers: F. Shahram, A. Nadji, M. Akbarian, A. Jamshidi, F. Gharibdoost, F. Davatchi

Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET'S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A. Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ... سال انتشار: 2001
 

LONG-TERM OUTCOME OF VISION IN BEHCET’S DISEASE.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, A.Jamshidi, C. Chams, M. Akbarian, F. Gharibdoost

Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ... سال انتشار: 2001
 

Behcet's Disease in Afghan immigrants of Iran; Report of 12 cases.

Authers: F. Shahram. F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Behcet's Disease (BD) is mainly seen in the countries along the Silk Rout. Among Asian countries, there is no data from Afghanistan on the clinical features of BD. Near 2 million Afghan immigrants live in Iran. This is a report on the clinical features of the disease in them with a comparison to the Iranian patients. Patients & Methods: All Afghan patients with BD referred to our BD unit ... سال انتشار: 2000
 

OUTCOME MEASUREMENT OF TYPE IV SYSTEMIC LUPUS NEPHRITIS BY CLASSIFICATION AND REGRATION TREE (CART).

Authers: S. Soroosh, M. Akbarian, F. Davatchi, F. Shahram, A. Nadji, F. Gharibdoost, A. Jamshidi

Abstract: The prognosis of Systemic Lupus Erythematosus depends partly on renal involvement. Lupus nephritis has evolved from a frequently terminal process such as type IV lupus nephritis according to WHO classification to one in which a fairly normal quality of life and good outcome are possible. The aim of this study was to try to predict the short-term outcome of type IV lupus nephritis by looking at the disease variables before ... سال انتشار: 2000
 

On going epidemiological survey on Behcet's Disease in Iran; Tendency toward milder forms of the disease.

Authers: F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, M. Akbarian, F. Gharibdoost

Abstract: Introduction: Iran is among the countries with high prevalence of Behcet's Disease (BD). The epidemiological survey on different aspects of the disease has been continuously carrying out since 1975 in our center. The aim of this study was to find if the characteristics of the disease are changing through the time. Patients & Methods: In a cohort of 4130 patients with BD, registered at our BD unit during the past 25 ... سال انتشار: 2000
 

Long-term outcome of ocular manifestations in Behcet's Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, A. Nadji, M. Akbarian, C. Chams, F. Gharibdoost, A. Jamshidi, F. Romooz.

Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ... سال انتشار: 2000
 

COMPARISON OF POLYMYOSITIS TO POLYMYOSITIS-SCLERODERMA OVERLAP SYNDROME.

Authers: A. Jamshidi, A. Nadji, F. Gharibdoost, M. Akbarian, F. Shahram, and F.Davatchi

Abstract: Purpose: Polymyositis (PM) is an inflammatory muscle disease, which has more overlap with scleroderma than other connective tissue diseases. The aim of this study is to compare the clinical, paraclinical and therapeutic response of polymyositis with polymyositis-scleroderma overlap syndrome. Methods: During the past 10 years we had 16 overlap syndromes and 40 primary polymyositis. All patients were classified by the American college of Rheumatology classification criteria. Ninety-seven items were checked in ... سال انتشار: 2000
 

Azathioprine for The Treatment of Ophthalmological Lesions of Behcet’s Disease.

Authers: F. Davatchi, F. Shahram, H. Chams, M. Akbarian, A. Nadji, C. Chams, F. Gharibdoost, A. Jamshidi, S. Soroosh

Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) are the main morbidity factor in Behcet’s Disease (BD). They usually progress toward severe loss of vision or blindness. They need aggressive treatment with cytotoxic drugs. Azathioprine was demonstrated, in a double blind control study, to be effective in Behcet’s Disease. The aim of this study was to evaluate the efficacy of Azathioprine in ocular lesions of BD, and to compare ... سال انتشار: 1998
 

Comparison of Juvenile wth Adult Behcet’s Disease.

Authers: N. Shafaei, F. Shahram, F. Davatch, A. Nadji, M. Akbarian, F. Gharibdoost, S. Soroosh

Abstract: Introduction: Behcet’s disease (BD) is not rare in children. Its clinical picture differs from adults. The purpose of this study was 1-To find the characteristics of juvenile BD (JBD). 2-To compare JBD with the adult from (ABD) of the disease. Materials & Methods: In a cohort of 3729 patients with BD, different manifestations of the disease, including 100 clinical and paraclinical data, were analyzed. Patients were divided in two groups. 1- ... سال انتشار: 1998
 

Familial Oral Aphthosis in General Population As Compared To Behcet’s Disease.

Authers: C. Chams, F. Davatchi, F. Shahram, M. Akbarian, A. Nadji, F. Gharibdoost, H. Chams, A. Jamshidi.

Abstract: Introduction: Oral aphthosis (OA) is seen in 96% of patient with Behcet’s Disease (BB) OA is said to be rather frequent in the general population. It was therefore interesting to determine whether OA in the general population had also a genetic background as it is for BD. It was also interesting to determine if the genetic background was similar in both conditions (BD and OA in the general population). Therefore, ... سال انتشار: 1998