تالیفات

The effects of team-based learning on learning outcomes in a course of rheumatology  

The effects of team-based learning on learning outcomes in a course of rheumatology

مولف: SEYEDEH TAHEREH FAEZI1, KAMRAN MORADI1, 2, ALI GHAFAR RAHIMI AMIN3, MASSOOMEH AKHLAGHI1, FATEMEH KESHMIRI4*

خلاصه: Introduction: We evaluated the effects of implementing Team- Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n=84) participating in a course of ... سال انتشار: 2018
Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients  

Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients

مولف: Zafari P.1, 2, Mostafaei Sh.3, Iranshahi N.1, 2, Jalili S.4, Taghadosi M., PhD5

خلاصه: Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of vitamin D plasma level with Foxp3 gene expression in the patients with RA. Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of ... سال انتشار: 2018
Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis  

Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis

مولف: Mohsen Moghoofei1 | Seyed Hamidreza Monavari2 | Shayan Mostafaei3, 4 | Shima Hadifar5, 6 | Amir Ghasemi7 | Farhad Babaei1 | Hoda Kavosi4 | Ahmad Tavakoli2 | Davod Javanmard2 | Maryam Esghaei2 | Nilofar Khodabandehlou8

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle- East’ and ‘Meta-analysis’. The ... سال انتشار: 2018
microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients  

microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

مولف: Mohsen Moghoofei1, Farah Bokharaei-Salim1, 2, Maryam Esghaei1, Hossein Keyvani1, Maryam Honardoost3, Shayan Mostafaei4, 5, Amir Ghasemi6, Ahmad Tavakoli1, Davod Javanmard1, Farhad Babaei7, Saba Garshasbi2 & Seyed Hamidreza Monavari*,

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with ... سال انتشار: 2018
 

Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

مولف: Raheleh ASSARI, 1, 2 Yahya AGHIGHI, 3 Vahid ZIAEE, 1, 2 Maryam SADR, 4 Farzaneh RAHMANI, 5 Arezou REZAEI, 5 Zeinab SADR, 4 Mohammad Hassan MORADINEJAD, 2 Seyed Reza RAEESKARAMI6 and Nima REZAEI

خلاصه: Aim: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-a polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. Methods: Fifty-five patients with KD who were randomly selected from referrals to the main pediatric hospital were enrolled in this ... سال انتشار: 2017
 

Prevalence of respiratory viruses in Iranian patients with idiopathic pulmonary fibrosis

مولف: Hossein Keyvani, 1 Mohsen Moghoofei, 2 Farah Bokharaei-Salim, 1, 3 Shayan Mostafaei, 4 Seyed-Ali Javad Mousavi, 5 Seyed Hamidreza Monavari1 and Maryam Esghaei1, *

خلاصه: Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal ... سال انتشار: 2017
 

Prevalence of Influenza A Infection in the Middle-East: A Systematic Review and Meta-analysis

مولف: Mohsen Moghoofei1, Seyed Hamidreza Monavari2, Shayan Mostafaei3, 4, Shima Hadifar5, 6, Amir Ghasemi7, Farhad Babaei1, Hoda Kavosi5, Ahmad Tavakoli2 , Davod Javanmard2, Maryam Esghaei2*, Nilofar Khodabandehlou8*

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were “Influenza”, “Subtype”, “Seroprevalence”, “Incidence”, “Seroepidemiology”, “H1N1”, “H3N2”, “H5N1”, “H9N2”, “Middle-East”, and “Metaanalysis”. The reported ... سال انتشار: 2017
 

Prevalence of hepatitis B surface antigen among hemodialysis patients from Middle Eastern countries: a systematic review and meta-analysis

مولف: Ahmad Tavakoli1, 2, Mohsen Moghoofei3, 4, Shayan Mostafaei5, 6, Hadi Ghaffari2, Seyed Hamidreza Monavari2 & Seyed Moayed Alavian*,

خلاصه: Aim: The aim of this study was to determine the overall prevalence of hepatitis B surface antigen (HBsAg) among hemodialysis patients reported from the Eastern Mediterranean Regional Office of the WHO (EMRO) countries and the Middle East. Methods: Several databases such as PubMed, ISI Web of Science, MEDLINE and Scopus were searched for publications reporting HBsAg prevalence among hemodialysis patients up to December 2016. Results: From all the samples, the pooled prevalence of HBsAg was ... سال انتشار: 2017
 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis

مولف: Mahdi Mahmoudi1, 2, Alireza Rezaiemanesh1, 3, Sara Harsini4, 5, Arash Salmaninejad6, Shiva Poursani1, Tayyeb Bahrami7, Vahid Ziaee8, 9, and Nima Rezaei3, 5, 6

خلاصه: Abstract- Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients ... سال انتشار: 2017
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

مولف: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

خلاصه: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2017
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

مولف: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

خلاصه: Juvenile idiopathic arthritis (JIA) which consists of a heterogeneous group of chronic disorders (e.g., oligoarthritis, polyarthritis, and systemic arthritis) is an autoimmune, noninfectious inflammation of joints’ synovial membrane and connective tissues that lastsmore than 6 weeks [1, 2].The disorder has been identified all over the world in nearly all races and ethnicities with an average prevalence rate of 1 to 2 per 1,000 children [3]. Some children may experience JIA symptoms for only a few months while others ... سال انتشار: 2017
 

Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients

مولف: Arash Salmaninejad1, 2, Mahdi Mahmoudi1, 3, Saeed Aslani1, 3, Shiva Poursani1, Vahid Ziaee4, 5, Nima Rezaei6, 7, 8

خلاصه: SUMMARY: Salmaninejad A, Mahmoudi M, Aslani S, Poursani S, Ziaee V, Rezaei N. Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients. Turk J Pediatr 2017; 59: 144-149. Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to have relationship with the risk of ... سال انتشار: 2017
 

Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis

مولف: Danyal Imani1, Ramazan Rezaei1, Bahman Razi2, Shahab Alizadeh3, and Mahdi Mahmoudi4, 5

خلاصه: Abstract- Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with Graves' disease. Medline, EMBASE, and Web of Science databases were searched to identify all eligible studies published before August 2016. Odds ratios (ORs) and their corresponding 95% confidence intervals ... سال انتشار: 2017
 

A Multidisciplinary Workplace Intervention for Chronic Low Back Pain among Nursing Assistants in Iran

Authers: Sarallah Shojaei1, 2, Sedigheh Sadat Tavafian1, Ahmad Reza Jamshidi3, Joan Wagner4

Abstract: Study Design: Interventional research with a 6-month follow-up period. Purpose: We aimed to establish the effectiveness of a multidisciplinary workplace intervention on reduction of work-related low back pain (WRLBP), using ergonomic posture training coupled with an educational program based on social cognitive theory. Overview of Literature: WRLBP is a major occupational problem among healthcare workers, who are often required to lift heavy loads. Patient handling is a particular requirement of nurse aides, and has ... سال انتشار: 2017
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

Rituximab as first choice for patients with refractory rheumatoid arthritis: cost‑effectiveness analysis in Iran based on a systematic review and meta‑analysis

Authers: Saeed Ahmadiani1 · Shekoufeh Nikfar1, 5 · Somayeh Karimi2 · Ahmad Reza Jamshidi3 · Ali Akbari‑Sari4 · Abbas Kebriaeezadeh1

Abstract: Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease which affects joints and can lead to deformity of proximal organs due to erosion [1]. Prevalence of RA is ranging from 0.3 to 2.1 % in different societies [2]. As reported before, 0.33 % of urban population and 0.19 % of rural population are affected with RA in Iran [3]. With over 77 million population [4], it can be estimated that about 42,000 people in rural area and over ... سال انتشار: 2016
 

Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis

Authers: Vahid Ziaee1, 2 & Arezou Rezaei3 & Sara Harsini3, 4 & Marzieh Maddah2 & Samaneh Zoghi4, 5 & Maryam Sadr6 & Mohammad Hassan Moradinejad2 & Nima Rezaei 3, 4, 5

Abstract: As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at positions -1098, -590, and -33, as well as IL-4RA gene at position +1902 were genotyped ... سال انتشار: 2016
 

بررسی و تعیین اثرات متقابل مهم پلیمورفیسم هاي تک نوکلئوتیدي ژنهاي سایتوکاینهاي التهابی و ضد التهابی در ابتلا به بیماري لوپوس آریتماتوز سیستمیک با استفاده از رویکرد شناسه گزینی منطقی

مولف: سعید مهرآور 1، کرامت نوري جلیانی 2، کمال اعظم 3*، عباس رحیمی فروشانی 2، مهدي محمودي 4، علیاکبر امیرزرگر 5، ربابه قدسی قاسم آبادي

خلاصه: زمینه و هدف: با وجود اینکه تاکنون مطالعات گستردهاي برروي تاثیر پلیمورفیسمهاي تک نوکئوتیدي ها) بر روي بیماریهاي SNP) ها با هم در بروز بیماریها خصوصاً بیماریهاي مرتبط با ژنتیک از یکسو SNP مختلف صورت گرفته است ولی لزوم بررسی اثرات متقابل این و تعداد زیاد این متغیرها و ضعف مدلهاي کلاسیک آماري در لحاظ کردن آنها از سویی دیگر لزوم بکارگیري روشهاي نوین آماري در تعیین این اثرات متقابل را نشان می ... سال انتشار: 2014
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

Authers: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

Abstract: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2016
 

HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

Authers: Shamsolmoulouk Najafi1, Mahsa Mohammadzadeh2, Alireza Zare Bidoki3, 4, Ghasem Meighani5, Saeed Aslani6, 7, Mahdi Mahmoudi6, and Nima Rezaei7, 8, 9

Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus

Authers: Sahar Mortezagholi1, Zohreh Babaloo1, Parisa Rahimzadeh2, Mojgan Ghaedi2, Hayedeh Namdari3, Shirin Assar4, Maryam Azimi Mohamadabadi5, and Eisa Salehi5

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood ... سال انتشار: 2016
 

Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis

Authers: Parisa Momenzadeh1, 2 · Mahdi Mahmoudi2, 6 · Maani Beigy2, 3 · Masoud Garshasbi4 · Mahdi Vodjdanian2 · Ali Farazmand1, 5, 7 · Ahmad Reza Jamshidi2

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin, while both genetic and environmental factors have been demonstrated to be etiologically involved. Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis. This case–control study was performed on 349 unrelated AS patients and 469 age- and gender-matched healthy controls, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

در فیبروبلاست هاي پوست بیماران Apaf- و 1 Fas بررسی میزان بیان ژن هاي مبتلا به اسکلروز سیستمیک

مولف: مجید عابد خجسته 1، فرشته آل صاحب فصول 1، مهدي محمودي 2، محمد باقر محمودي 3، شایان مصطفایی 4، مزدك گنجعلی خانی حاکمی 1، فرهاد * غریب دوست

خلاصه: زمینه و هدف : در اسکلروز سیستمیک ، فیبروبلاست ها در برابر آپوپتوز مقاوم شده و با ترشح مداوم کلاژن و ماتر یکس خارج سلو لی، موجب تشک یل فیبروز در بافت ها م ی شوند. لازم است علل ثانو یه بروز بیمار ي، از جمله عدم پاسخ فیبروبلاست هاي فعال شده به آپوپتوز به عنوان عامل اصل ی در ایجاد و استقرار بیماري، مورد توجه قرار گی رد. مطالعه که به ترتیب ... سال انتشار: 1395
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016