تالیفات

 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

Rituximab as first choice for patients with refractory rheumatoid arthritis: cost‑effectiveness analysis in Iran based on a systematic review and meta‑analysis

Authers: Saeed Ahmadiani1 · Shekoufeh Nikfar1, 5 · Somayeh Karimi2 · Ahmad Reza Jamshidi3 · Ali Akbari‑Sari4 · Abbas Kebriaeezadeh1

Abstract: Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease which affects joints and can lead to deformity of proximal organs due to erosion [1]. Prevalence of RA is ranging from 0.3 to 2.1 % in different societies [2]. As reported before, 0.33 % of urban population and 0.19 % of rural population are affected with RA in Iran [3]. With over 77 million population [4], it can be estimated that about 42,000 people in rural area and over ... سال انتشار: 2016
 

Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis

Authers: Vahid Ziaee1, 2 & Arezou Rezaei3 & Sara Harsini3, 4 & Marzieh Maddah2 & Samaneh Zoghi4, 5 & Maryam Sadr6 & Mohammad Hassan Moradinejad2 & Nima Rezaei 3, 4, 5

Abstract: As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at positions -1098, -590, and -33, as well as IL-4RA gene at position +1902 were genotyped ... سال انتشار: 2016
 

بررسی و تعیین اثرات متقابل مهم پلیمورفیسم هاي تک نوکلئوتیدي ژنهاي سایتوکاینهاي التهابی و ضد التهابی در ابتلا به بیماري لوپوس آریتماتوز سیستمیک با استفاده از رویکرد شناسه گزینی منطقی

مولف: سعید مهرآور 1، کرامت نوري جلیانی 2، کمال اعظم 3*، عباس رحیمی فروشانی 2، مهدي محمودي 4، علیاکبر امیرزرگر 5، ربابه قدسی قاسم آبادي

خلاصه: زمینه و هدف: با وجود اینکه تاکنون مطالعات گستردهاي برروي تاثیر پلیمورفیسمهاي تک نوکئوتیدي ها) بر روي بیماریهاي SNP) ها با هم در بروز بیماریها خصوصاً بیماریهاي مرتبط با ژنتیک از یکسو SNP مختلف صورت گرفته است ولی لزوم بررسی اثرات متقابل این و تعداد زیاد این متغیرها و ضعف مدلهاي کلاسیک آماري در لحاظ کردن آنها از سویی دیگر لزوم بکارگیري روشهاي نوین آماري در تعیین این اثرات متقابل را نشان می ... سال انتشار: 2014
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

Authers: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

Abstract: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2016
 

HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

Authers: Shamsolmoulouk Najafi1, Mahsa Mohammadzadeh2, Alireza Zare Bidoki3, 4, Ghasem Meighani5, Saeed Aslani6, 7, Mahdi Mahmoudi6, and Nima Rezaei7, 8, 9

Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus

Authers: Sahar Mortezagholi1, Zohreh Babaloo1, Parisa Rahimzadeh2, Mojgan Ghaedi2, Hayedeh Namdari3, Shirin Assar4, Maryam Azimi Mohamadabadi5, and Eisa Salehi5

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood ... سال انتشار: 2016
 

Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis

Authers: Parisa Momenzadeh1, 2 · Mahdi Mahmoudi2, 6 · Maani Beigy2, 3 · Masoud Garshasbi4 · Mahdi Vodjdanian2 · Ali Farazmand1, 5, 7 · Ahmad Reza Jamshidi2

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin, while both genetic and environmental factors have been demonstrated to be etiologically involved. Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis. This case–control study was performed on 349 unrelated AS patients and 469 age- and gender-matched healthy controls, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

در فیبروبلاست هاي پوست بیماران Apaf- و 1 Fas بررسی میزان بیان ژن هاي مبتلا به اسکلروز سیستمیک

مولف: مجید عابد خجسته 1، فرشته آل صاحب فصول 1، مهدي محمودي 2، محمد باقر محمودي 3، شایان مصطفایی 4، مزدك گنجعلی خانی حاکمی 1، فرهاد * غریب دوست

خلاصه: زمینه و هدف : در اسکلروز سیستمیک ، فیبروبلاست ها در برابر آپوپتوز مقاوم شده و با ترشح مداوم کلاژن و ماتر یکس خارج سلو لی، موجب تشک یل فیبروز در بافت ها م ی شوند. لازم است علل ثانو یه بروز بیمار ي، از جمله عدم پاسخ فیبروبلاست هاي فعال شده به آپوپتوز به عنوان عامل اصل ی در ایجاد و استقرار بیماري، مورد توجه قرار گی رد. مطالعه که به ترتیب ... سال انتشار: 1395
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Consensus classification criteria for paediatric Behçet’s disease from a prospective observational cohort: PEDBD

Authers: Isabelle Koné-Paut, 1 Fahrad Shahram, 2 Martha Darce-Bello, 1 Luca Cantarini, 3 Rolando Cimaz, 4 Marco Gattorno, 5 Jordi Anton, 6 Michael Hofer, 7 Bouchra Chkirate, 8 Kenza Bouayed, 9 Ilknur Tugal-Tutkun, 10 Jasmin Kuemmerle-Deschner, 11 Hélène Agostini,

Abstract: We aimed to describe the main features of Behçet’s disease (BD) in children in the largest prospective cohort to date and to propose a classification. Methods An international expert consensus group was formed to define a data set of minimal symptoms for the inclusion of patients. Patients were entered prospectively during 66 months. Experts classified patients on a consensus basis. The concordance of two international classifications was analysed in confirmed patients with BD. Comparisons of subgroups of patients helped define consensus ... سال انتشار: 2015
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016
 

Nicolau Syndrome in 29 Months Boy: Another Report of Iran

Authers: Mojtaba Fazel1, Parvin Akbar Asbagh2, Azadeh Afshin3*, Mamak Shariat4, Mahmoud Fazel5, Massumeh Akhlaghi5

Abstract: Nicolau syndrome (NS) is a very rare complication of intramuscular injections that leads to some degree of necrosis in skin, subcutaneous fat and muscles. The type of injected Drugs and wrong injection methods are the main factors for this iatrogenic syndrome. Here we report a 29 months boy, one of the Iranian children affected NS following the wrong intramuscular injection of Benzathine Penicillin. But he came back home without any major complication because of ... سال انتشار: 2015
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

Spectrum of Mutations of Familial Mediterranean Fever Gene in Iranian Population

Authers: Tayebeh Sabokbar1, 2, Ali Malayeri2, Cyrus Azimi2, Seyyed Reza Raeeskarami3, 4, Vahid Ziaee3, 4, Yahya Aghighi3, 4, Abbas Shakoori2, 5

Abstract: Familial Mediterranean fever is a genetic disease that is caused by the MEFV gene. Our study was based on clinical manifestations of recurrent attacks of fever and inflammation and distribution of MEFV mutations in an Iranian patient using a comprehensive mutation detection method. Methods: Eighty-five clinically diagnosed FMF patients from university hospitals who were referred to the Department of Genetics for molecular diagnosis of FMF. Results: Mutations in one allele and in both ... سال انتشار: 2014
 

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

Authers: Mina Doudkani-Fard1, Vahid Ziaee2, Mohamad-Hassan Moradinejad3 Mojtaba Sedaghat4, Mohammad-Taghi Haghi-Ashtiani5, Zahra Ahmadinejad6

Abstract: Background: Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis (RA). Evaluation of ... سال انتشار: 2014
 

Relationship between bone density and abdominal visceral fat in premenopausal overweight and obese Iranian women aged 30–50 years

Authers: Ahmad SALIMZADEH, 1 Maryam ABOLHASANI, 2, 3 Moslem SEDAGHATTALAB4 and Maryam MOGHADASI1

Abstract: Aim: The presence of a direct relationship between body mass index (BMI) and bone mineral density (BMD) is frequently reported. However, data on the relationship between visceral fat and bone density varies, with positive, negative or no relationship having been reported. This study aims to examine the relationship between abdominal visceral fat and BMD. Methods: A cross sectional study was carried out on 95 premenopausal, overweight and obese women aged 30– 50 years referred to ... سال انتشار: 2014
 

Behcet’s disease

Authers: Fereydoun DAVATCHI1, 2, 3, 4

Abstract: neurological manifestations and positive pathergy tests each get one point. Oral aphthosis, genital aphthosis and ocular lesions each get two points. To be classified/ diagnosed as BD, a patient has to get four points (or more). Behcet’s disease manifestations are self-limiting, but recurrent. Some heal without a sequelae, but others are the main cause of morbidity, such as ophthalmological manifestations which may cause blindness if not aggressively treated. Some may cause mortality, as in some of the vascular, neurological, cardiac ... سال انتشار: 2014
 

IL10 low-frequency variants in Behcet’s disease patients

Authers: Mafalda MATOS, 1, 2 Joana M. XAVIER, 1, 2 Patrıcia ABRANTES, 1, 2 In^es SOUSA, 1, 2 Nadia REI, 1, 2 Fereydoun DAVATCHI, 3 Farhad SHAHRAM, 3 Gorete JESUS, 4 Filipe BARCELOS, 5 Joana VEDES, 6 Manuel SALGADO, 7

Abstract: Aim: To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behcet’s disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility. Methods: To identify IL10 low-frequency variants, a discovery group of 50 Portuguese BD ... سال انتشار: 2014
 

Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor Isotypes in Iranian Patients with Rheumatoid Arthritis: Evaluation of Clinical Value and Association with Disease Activity

Authers: Yadollah Shakiba1, Susan Koopah1, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, Ahmad Masoud1, Amir Kiani3, Mohammad Hossein Niknam1, Bahareh Nazari1, and Behrouz Nikbin1, 4

Abstract: In this study we determined the frequency, sensitivity and specificity of anti cyclic citrullinated peptides (anti-CCP) IgG antibody, total rheumatoid factor (RF-T), and RF isotypes in Iranian patients with rheumatoid arthritis (RA) and their association with age, clinical and serological parameters. Anti-CCP and RF-T and RF isotypes level were measured in 418 patients and 399 healthy controls by enzyme-linked immunosurbant assay (ELISA). Additionally, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ... سال انتشار: 2014
 

The perspectives of iranian physicians and patients towards patient decision aids: a qualitative study

Authers: Hamideh Rashidian1, 2, Saharnaz Nedjat2, 3*, Reza Majdzadeh2, 3, Jaleh Gholami3, Leila Haghjou3, Bahar Sadeghi Abdollahi4, Fereydoun Davatchi4 and Arash Rashidian3, 5

Abstract: Patient preference is one of the main components of clinical decision making, therefore leading to the development of patient decision aids. The goal of this study was to describe physicians’ and patients’ viewpoints on the barriers and limitations of using patient decision aids in Iran, their proposed solutions, and, the benefits of using these tools. Methods: This qualitative study was conducted in 2011 in Iran by holding in-depth interviews with 14 physicians and 8 arthritis ... سال انتشار: 2013
 

Association of STAT4 rs7574865 with Susceptibility to Systemic Lupus Erythematosus in Iranian Population

Authers: Sedigheh Mirkazemi, 1 Mahmoud Akbarian, 2 Ahmad Reza Jamshidi, 2 Reza Mansouri, 3 Shima Ghoroghi, 2 Yahya Salimi, 4 Zahra Tahmasebi, 2 and Mahdi Mahmoudi2, 5

Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and ... سال انتشار: 2013
 

The International Criteria for Behcet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria

Authers: F. Davatchi, 1, *, † S. Assaad-Khalil, 2, † K.T. Calamia, 3, † J.E. Crook, 4, † B. Sadeghi-Abdollahi, 1, † M. Schirmer, 5, † T. Tzellos, 6, † C.C. Zouboulis, 6, 7, 8, *, † M. Akhlagi, 1 A. Al-Dalaan, 9 Z.S. Alekberova, 10 A.A. Ali, ،A.R. Jamshidi،A. Nadji،F. Shahram،H. Shams،N. Ziaei1

Abstract: Behcet’s disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test. Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD-mimicking diseases or presenting at least one major BD sign. These were randomly divided into ... سال انتشار: 2013
 

Effect of HLA-B*27 and its Subtypes on Clinical Manifestations and Severity of Ankylosing Spondylitis in Iranian Patients

Authers: Sasan Fallahi1, 2, Mahdi Mahmoudi2, Mohammad Hossein Nicknam3, 5, Farhad Gharibdoost2, Elham Farhadi4, Azad Saei5, Keramat Nourijelyani6, Nooshin Ahmadzadeh2, and Ahmad Reza Jamshidi2

Abstract: The aim of this study was to assess the role of HLA-B*27 and it’s subtypes in determining severity and clinical manifestations of ankylosing spondylitis (AS). A total of 163 AS patients were assessed for clinical manifestations and severity using structured questionnaires. HLA-B*27 screening and B*27 sub-typing were performed by PCR. One hundred twenty two patients (74.8%) were B*27 positive. The male to female ratio, peripheral arthritis, steroid use, intense dorsal kyphosis and ... سال انتشار: 2013
 

Scientometric analysis and mapping of scientific articles on Behcet’s disease

Authers: Farhad SHAHRAM, 1 Ahmad-Reza JAMSHIDI, 1 Armin HIRBOD-MOBARAKEH, 2, 3 Gholamreza HABIBI, 4 Amir MARDANI4 and Marjan GHAEMI4

Abstract: Behcet’s disease (BD) is a systemic vasculitis disease with oral and genital aphthous ulceration, uveitis, skin manifestations, arthritis and neurological involvement. Many investigators have published articles on BD in the last two decades since introduction of diagnosis criteria by the International Study Group for Behcet’s Disease in 1990. However, there is no scientometric analysis available for this increasing amount of literature. Methods: A scientometric analysis method was used to achieve a view of scientific articles ... سال انتشار: 2013