تالیفات

 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

Rituximab as first choice for patients with refractory rheumatoid arthritis: cost‑effectiveness analysis in Iran based on a systematic review and meta‑analysis

Authers: Saeed Ahmadiani1 · Shekoufeh Nikfar1, 5 · Somayeh Karimi2 · Ahmad Reza Jamshidi3 · Ali Akbari‑Sari4 · Abbas Kebriaeezadeh1

Abstract: Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease which affects joints and can lead to deformity of proximal organs due to erosion [1]. Prevalence of RA is ranging from 0.3 to 2.1 % in different societies [2]. As reported before, 0.33 % of urban population and 0.19 % of rural population are affected with RA in Iran [3]. With over 77 million population [4], it can be estimated that about 42,000 people in rural area and over ... سال انتشار: 2016
 

Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis

Authers: Vahid Ziaee1, 2 & Arezou Rezaei3 & Sara Harsini3, 4 & Marzieh Maddah2 & Samaneh Zoghi4, 5 & Maryam Sadr6 & Mohammad Hassan Moradinejad2 & Nima Rezaei 3, 4, 5

Abstract: As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at positions -1098, -590, and -33, as well as IL-4RA gene at position +1902 were genotyped ... سال انتشار: 2016
 

Novel Echocardiographic Indices for Assessing the Left Main Coronary Artery in Children With Kawasaki Disease

Authers: Elaheh Malakan Rad, 1, 2, * Iran Malekzadeh, 1, 2 Vahid Ziaee, 1, 2, 3 Raheleh Rajabi, 2 and Zohreh Shahabi2

Abstract: Kawasaki disease (KD) is the most common cause of acquired myocardial infarction in children. Coronary artery involvement is the most serious feature of this vasculitis syndrome. Timely diagnosis of coronary artery involvement is of utmost importance since it can prevent long-term morbidity and mortality. The current methods for the diagnosis of coronary artery dilation in KD are inconsistent and are also not capable of detecting all the abnormal coronary arteries or the so-called ... سال انتشار: 2016
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

بررسی و تعیین اثرات متقابل مهم پلیمورفیسم هاي تک نوکلئوتیدي ژنهاي سایتوکاینهاي التهابی و ضد التهابی در ابتلا به بیماري لوپوس آریتماتوز سیستمیک با استفاده از رویکرد شناسه گزینی منطقی

مولف: سعید مهرآور 1، کرامت نوري جلیانی 2، کمال اعظم 3*، عباس رحیمی فروشانی 2، مهدي محمودي 4، علیاکبر امیرزرگر 5، ربابه قدسی قاسم آبادي

خلاصه: زمینه و هدف: با وجود اینکه تاکنون مطالعات گستردهاي برروي تاثیر پلیمورفیسمهاي تک نوکئوتیدي ها) بر روي بیماریهاي SNP) ها با هم در بروز بیماریها خصوصاً بیماریهاي مرتبط با ژنتیک از یکسو SNP مختلف صورت گرفته است ولی لزوم بررسی اثرات متقابل این و تعداد زیاد این متغیرها و ضعف مدلهاي کلاسیک آماري در لحاظ کردن آنها از سویی دیگر لزوم بکارگیري روشهاي نوین آماري در تعیین این اثرات متقابل را نشان می ... سال انتشار: 2014
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

Authers: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

Abstract: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2016
 

HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

Authers: Shamsolmoulouk Najafi1, Mahsa Mohammadzadeh2, Alireza Zare Bidoki3, 4, Ghasem Meighani5, Saeed Aslani6, 7, Mahdi Mahmoudi6, and Nima Rezaei7, 8, 9

Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus

Authers: Sahar Mortezagholi1, Zohreh Babaloo1, Parisa Rahimzadeh2, Mojgan Ghaedi2, Hayedeh Namdari3, Shirin Assar4, Maryam Azimi Mohamadabadi5, and Eisa Salehi5

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood ... سال انتشار: 2016
 

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

Authers: Mohammad Sahebalzamani1, PhD, Hojjatollah Farahani2, PhD, Mojgan Tabatabaee Jamarani1, MSc, Seyedeh Tahereh Faezi3, MD, Kamran Moradi3, MD & Pedram Paragomi3, MD

Abstract: Purpose: The purpose of this study was to evaluate the effects of applying continuous care model (CCM) on the knowledge level and health-related quality of life (HRQoL) of systemic lupus erythematosus (SLE) patients and their perceptions of family awareness about the disease. Design: Continuous care model was implemented for 3 months on 34 SLE patients, in a pretest–posttest quasi-experimental design. Methods: Two sets of questionnaires were designed for knowledge assessment. HRQoL was assessed by SF-36 questionnaires. Analysis ... سال انتشار: 2016
 

Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis

Authers: Parisa Momenzadeh1, 2 · Mahdi Mahmoudi2, 6 · Maani Beigy2, 3 · Masoud Garshasbi4 · Mahdi Vodjdanian2 · Ali Farazmand1, 5, 7 · Ahmad Reza Jamshidi2

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin, while both genetic and environmental factors have been demonstrated to be etiologically involved. Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis. This case–control study was performed on 349 unrelated AS patients and 469 age- and gender-matched healthy controls, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

در فیبروبلاست هاي پوست بیماران Apaf- و 1 Fas بررسی میزان بیان ژن هاي مبتلا به اسکلروز سیستمیک

مولف: مجید عابد خجسته 1، فرشته آل صاحب فصول 1، مهدي محمودي 2، محمد باقر محمودي 3، شایان مصطفایی 4، مزدك گنجعلی خانی حاکمی 1، فرهاد * غریب دوست

خلاصه: زمینه و هدف : در اسکلروز سیستمیک ، فیبروبلاست ها در برابر آپوپتوز مقاوم شده و با ترشح مداوم کلاژن و ماتر یکس خارج سلو لی، موجب تشک یل فیبروز در بافت ها م ی شوند. لازم است علل ثانو یه بروز بیمار ي، از جمله عدم پاسخ فیبروبلاست هاي فعال شده به آپوپتوز به عنوان عامل اصل ی در ایجاد و استقرار بیماري، مورد توجه قرار گی رد. مطالعه که به ترتیب ... سال انتشار: 1395
 

Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment

Authers: Marjan Vakili, 1 Vahid Ziaee, 2, 3, * Mohammad Hassan Moradinejad, 1, 3 Seyed Reza Raeeskarami, 3 Farzad Kompani, 1, 3 and Tayebeh Rahamooz1

Abstract: Various indices have been raised as predictors of activity and severity of juvenile idiopathic arthritis. Objectives: This study was conducted to investigate the changes of platelet indices in acute phase and two months after treatment in these patients. Patients and Methods: In a cohort study, platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were evaluated in children referred to children’s medical center, Tehran due to juvenile idiopathic arthritis from ... سال انتشار: 2016
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Consensus classification criteria for paediatric Behçet’s disease from a prospective observational cohort: PEDBD

Authers: Isabelle Koné-Paut, 1 Fahrad Shahram, 2 Martha Darce-Bello, 1 Luca Cantarini, 3 Rolando Cimaz, 4 Marco Gattorno, 5 Jordi Anton, 6 Michael Hofer, 7 Bouchra Chkirate, 8 Kenza Bouayed, 9 Ilknur Tugal-Tutkun, 10 Jasmin Kuemmerle-Deschner, 11 Hélène Agostini,

Abstract: We aimed to describe the main features of Behçet’s disease (BD) in children in the largest prospective cohort to date and to propose a classification. Methods An international expert consensus group was formed to define a data set of minimal symptoms for the inclusion of patients. Patients were entered prospectively during 66 months. Experts classified patients on a consensus basis. The concordance of two international classifications was analysed in confirmed patients with BD. Comparisons of subgroups of patients helped define consensus ... سال انتشار: 2015
 

Association study of AFF1 gene polymorphism (rs340630) with Iranian systemic lupus erythematosus patients

Authers: Arabi E1, 3, Garshasbi M2, Jamshidi AR1, Khalesi R2, Ahmadzadeh N1, Akbarian M1, Mahmoudi M1

Abstract: Aim: To investigate whether AFF1 polymorphism was associated with susceptibility and clinical features of SLE in Iranian patients. Methods: A total of 320 patients with SLE and 330 age, sex and ethnically matched healthy control subjects were enrolled in the present study. Both cases and healthy controls were genotyped for rs340630 polymorphism located inside the AFF1using Amplification Refractory Mutation System-PCR (ARMS-PCR). In order to investigate the association of this SNP with clinical features of SLE, clinical manifestations of the patients ... سال انتشار: 2016
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016
 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... سال انتشار: 2016
 

A Multidisciplinary Work-Related Low Back Pain Predictor Questionnaire: Psychometric Evaluation of Iranian Patient-Care Workers

Authers: Shojaei Sarallah1, Tavafian Sedigheh Sadat1, Ahmad Reza Jamshidi2, Wagner Joan3

Abstract: Study Design: Psychometric evaluation design. Purpose: Psychometric evaluation of a multidisciplinary work-related low back pain predictor questionnaire (MWRLBPPQ) of Iranians patient-care workers based on the social cognitive theory. Overview of Literature: Healthcare is one of the professions in which work-related musculoskeletal disorders are prevalent. The chronic low back pain experienced by patient caregivers can negatively impact their professional performance, and patient handling in a hospital is the main cause of low back ... سال انتشار: 2016
 

Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013

Authers: Mosharafeh Chaleshgar Kordasiabi1, Maassoumeh Akhlaghi2, Mohammad Hossein Baghianimoghadam1, Mohammad Ali Morowatisharifabad1, Mohsen Askarishahi1, Behnaz Enjezab3 & Zeinab Pajouhi2

Abstract: Rheumatoid Arthritis (RA) is a systemic, autoimmune and inflammatory disease with an unknown etiology that is associated with progressive joint degeneration, limitation of physical activity and disability. The aim of the study was to evaluate self-management behaviors and their associated factors in RA patients. Material and Method: This cross-sectional study was performed in 2013 on185 patients in Tehran, Iran selected through convenient sampling. The collected data included demographic variables, disease related variables, Arthritis Impact Measurement Scale ... سال انتشار: 2016
 

Nicolau Syndrome in 29 Months Boy: Another Report of Iran

Authers: Mojtaba Fazel1, Parvin Akbar Asbagh2, Azadeh Afshin3*, Mamak Shariat4, Mahmoud Fazel5, Massumeh Akhlaghi5

Abstract: Nicolau syndrome (NS) is a very rare complication of intramuscular injections that leads to some degree of necrosis in skin, subcutaneous fat and muscles. The type of injected Drugs and wrong injection methods are the main factors for this iatrogenic syndrome. Here we report a 29 months boy, one of the Iranian children affected NS following the wrong intramuscular injection of Benzathine Penicillin. But he came back home without any major complication because of ... سال انتشار: 2015
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

Authers: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI2

Abstract: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2015
 

ملاس يگدنز كبس ذاختا رد روحم يروئت يشزومآ همانرب ريثأتينيلاب ييامزآراك هعلاطم كي :وناز زورترآ هب نايلاتبم رد

مولف: 217-209 :1393 زییاپ ،3 هرامش ،32 هرود ،ناريا يملاسا يروهمج يكشزپ ماظن نامزاس يملع هلجم

خلاصه: یتلکسا ینلاضع متسیس هدننک ناوتان تلالاتخا نیرتلوادتم زا وناز یگدییاس :هنیمز ملاس يگدنز كبس ذاحتا .دوش یم لاتبم دارفا یمسج ییاناوتان و درد بجوم هک تسا نيرت مهم وناز زورترا يتظفاحم ياهراتفر هب نا�سر بيسآ ياهراتفر رييغت هلزنم هب يشزومآ همانرب ريثأت يسررب هعلاطم نيا زا فده .تسا لكشم نيا زا يريگ�شيپ هار.تسا وناز زورترآ هب نايلاتبم رد ملاس يگدنز كبس ذاختا رد روحم يروئت لاتبم ناراميب زا رفن 168 ... سال انتشار: 2015
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015