تالیفات

 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Mahdi Mahmoudi1, Shayan Mostafaei1, Alireza Rezaeimanesh3, Massoomeh Akhlaghi1, and Farhad Shahram1

خلاصه: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients ... سال انتشار: 2017
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

IL10 low-frequency variants in Behcet’s disease patients

Authers: Mafalda MATOS, 1, 2 Joana M. XAVIER, 1, 2 Patrıcia ABRANTES, 1, 2 In^es SOUSA, 1, 2 Nadia REI, 1, 2 Fereydoun DAVATCHI, 3 Farhad SHAHRAM, 3 Gorete JESUS, 4 Filipe BARCELOS, 5 Joana VEDES, 6 Manuel SALGADO, 7

Abstract: Aim: To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behcet’s disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility. Methods: To identify IL10 low-frequency variants, a discovery group of 50 Portuguese BD ... سال انتشار: 2014
 

Causes of Blindness in Ocular Behçet’s Disease Comparing the End-Blinding Results in Two Genders

Authers: Hormoz Chams, MD1 • Hassan Behboudi, MD2 • Fariba Ghassemi, MD3 Fereydoun Davatchi, MD4 • Farhad Shahram, MD4 • Sheyda Chams-Davatchi, MD5

Abstract: To investigate and compare the causes of blindness in ocular Behçet’s disease (BD) in men and women Methods: In a retrospective, descriptive investigation from 1976 to 2008, 6,021 BD cases were registered in our BD Unit of Shariati Hospital of Tehran University of Medical Sciences (TUMS). At the last visit, 187 patients (124 men and 63 women) were blind (vision=1/10 or less) at least in one eye and with at least ... سال انتشار: 2012