تالیفات

 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... سال انتشار: 2016
 

Association of STAT4 rs7574865 with Susceptibility to Systemic Lupus Erythematosus in Iranian Population

Authers: Sedigheh Mirkazemi, 1 Mahmoud Akbarian, 2 Ahmad Reza Jamshidi, 2 Reza Mansouri, 3 Shima Ghoroghi, 2 Yahya Salimi, 4 Zahra Tahmasebi, 2 and Mahdi Mahmoudi2, 5

Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and ... سال انتشار: 2013