تالیفات

The effects of team-based learning on learning outcomes in a course of rheumatology  

The effects of team-based learning on learning outcomes in a course of rheumatology

مولف: SEYEDEH TAHEREH FAEZI1, KAMRAN MORADI1, 2, ALI GHAFAR RAHIMI AMIN3, MASSOOMEH AKHLAGHI1, FATEMEH KESHMIRI4*

خلاصه: Introduction: We evaluated the effects of implementing Team- Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n=84) participating in a course of ... سال انتشار: 2018
microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients  

microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

مولف: Mohsen Moghoofei1, Farah Bokharaei-Salim1, 2, Maryam Esghaei1, Hossein Keyvani1, Maryam Honardoost3, Shayan Mostafaei4, 5, Amir Ghasemi6, Ahmad Tavakoli1, Davod Javanmard1, Farhad Babaei7, Saba Garshasbi2 & Seyed Hamidreza Monavari*,

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with ... سال انتشار: 2018
 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Prevalence of respiratory viruses in Iranian patients with idiopathic pulmonary fibrosis

مولف: Hossein Keyvani, 1 Mohsen Moghoofei, 2 Farah Bokharaei-Salim, 1, 3 Shayan Mostafaei, 4 Seyed-Ali Javad Mousavi, 5 Seyed Hamidreza Monavari1 and Maryam Esghaei1, *

خلاصه: Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal ... سال انتشار: 2017
 

Prevalence of Influenza A Infection in the Middle-East: A Systematic Review and Meta-analysis

مولف: Mohsen Moghoofei1, Seyed Hamidreza Monavari2, Shayan Mostafaei3, 4, Shima Hadifar5, 6, Amir Ghasemi7, Farhad Babaei1, Hoda Kavosi5, Ahmad Tavakoli2 , Davod Javanmard2, Maryam Esghaei2*, Nilofar Khodabandehlou8*

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were “Influenza”, “Subtype”, “Seroprevalence”, “Incidence”, “Seroepidemiology”, “H1N1”, “H3N2”, “H5N1”, “H9N2”, “Middle-East”, and “Metaanalysis”. The reported ... سال انتشار: 2017
 

Prevalence of hepatitis B surface antigen among hemodialysis patients from Middle Eastern countries: a systematic review and meta-analysis

مولف: Ahmad Tavakoli1, 2, Mohsen Moghoofei3, 4, Shayan Mostafaei5, 6, Hadi Ghaffari2, Seyed Hamidreza Monavari2 & Seyed Moayed Alavian*,

خلاصه: Aim: The aim of this study was to determine the overall prevalence of hepatitis B surface antigen (HBsAg) among hemodialysis patients reported from the Eastern Mediterranean Regional Office of the WHO (EMRO) countries and the Middle East. Methods: Several databases such as PubMed, ISI Web of Science, MEDLINE and Scopus were searched for publications reporting HBsAg prevalence among hemodialysis patients up to December 2016. Results: From all the samples, the pooled prevalence of HBsAg was ... سال انتشار: 2017
 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

M2000 (b-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

مولف: S. Aletaha*, L. Haddad†, M. Roozbehkia*, R. Bigdeli‡, §, V. Asgary*, M. Mahmoudi¶ & A. Mirshafiey*

خلاصه: To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As b- D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signalling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, ... سال انتشار: 2017
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

مولف: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

خلاصه: 299-308. Editorial It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). The ISG criteria were created by ... سال انتشار: 2017
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

Authers: Zeinab Alizadeh a, b, Ali Farazmand b, Maassoomeh Akhlaghi a, *, Ahmad Reza Jamshidi a, Abtin Shahlaee a, Jafar Karami a, Elmira Shamsian a, Mahdi Mahmoudi

Abstract: The gene encoding signal transducer and activator of transcription 4 (STAT4) has been documented to be associated with rheumatoid arthritis (RA) in several populations. The aim of this study was to determine the association of the STAT4 gene polymorphism (rs7574865) with RA in the Iranian population. Methods: This study included 612 Iranian RA patients and 389 healthy control subjects. For all samples, DNA was genotyped for STAT4 G>T (rs7574865) polymorphism using the MGB TaqMan Allelic Discrimination ... سال انتشار: 2016
 

Overlap of Ankylosing Spondylitis and Systemic Lupus Erythematosus: A case report

Authers: MahmoodAkbaryan1 and Zahra Soltani2*

Abstract: Ankylosing spondylitis is a typical, very heritable incendiary joint inflammation, influencing principally the spine and pelvis. Inflammatory arthritis in ankylosing spondylitis causes pain and stiffness and progressively leads to new bone formation and ankylosis (fusion) of affected joints. Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous autoimmune disease that most often afflicts women in their child-bearing years. It is characterized by circulating self-reactive antibodies that deposit in tissues, including skin, kidneys, ... سال انتشار: 2016
 

Novel Echocardiographic Indices for Assessing the Left Main Coronary Artery in Children With Kawasaki Disease

Authers: Elaheh Malakan Rad, 1, 2, * Iran Malekzadeh, 1, 2 Vahid Ziaee, 1, 2, 3 Raheleh Rajabi, 2 and Zohreh Shahabi2

Abstract: Kawasaki disease (KD) is the most common cause of acquired myocardial infarction in children. Coronary artery involvement is the most serious feature of this vasculitis syndrome. Timely diagnosis of coronary artery involvement is of utmost importance since it can prevent long-term morbidity and mortality. The current methods for the diagnosis of coronary artery dilation in KD are inconsistent and are also not capable of detecting all the abnormal coronary arteries or the so-called ... سال انتشار: 2016
 

New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications

Authers: Mahdi Mahmoudi1*, Saeed Aslani1*, Mohammad Hossein Nicknam2, Jafar Karami1, and Ahmad Reza Jamshidi1

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2016
 

بررسی و تعیین اثرات متقابل مهم پلیمورفیسم هاي تک نوکلئوتیدي ژنهاي سایتوکاینهاي التهابی و ضد التهابی در ابتلا به بیماري لوپوس آریتماتوز سیستمیک با استفاده از رویکرد شناسه گزینی منطقی

مولف: سعید مهرآور 1، کرامت نوري جلیانی 2، کمال اعظم 3*، عباس رحیمی فروشانی 2، مهدي محمودي 4، علیاکبر امیرزرگر 5، ربابه قدسی قاسم آبادي

خلاصه: زمینه و هدف: با وجود اینکه تاکنون مطالعات گستردهاي برروي تاثیر پلیمورفیسمهاي تک نوکئوتیدي ها) بر روي بیماریهاي SNP) ها با هم در بروز بیماریها خصوصاً بیماریهاي مرتبط با ژنتیک از یکسو SNP مختلف صورت گرفته است ولی لزوم بررسی اثرات متقابل این و تعداد زیاد این متغیرها و ضعف مدلهاي کلاسیک آماري در لحاظ کردن آنها از سویی دیگر لزوم بکارگیري روشهاي نوین آماري در تعیین این اثرات متقابل را نشان می ... سال انتشار: 2014
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

در فیبروبلاست هاي پوست بیماران Apaf- و 1 Fas بررسی میزان بیان ژن هاي مبتلا به اسکلروز سیستمیک

مولف: مجید عابد خجسته 1، فرشته آل صاحب فصول 1، مهدي محمودي 2، محمد باقر محمودي 3، شایان مصطفایی 4، مزدك گنجعلی خانی حاکمی 1، فرهاد * غریب دوست

خلاصه: زمینه و هدف : در اسکلروز سیستمیک ، فیبروبلاست ها در برابر آپوپتوز مقاوم شده و با ترشح مداوم کلاژن و ماتر یکس خارج سلو لی، موجب تشک یل فیبروز در بافت ها م ی شوند. لازم است علل ثانو یه بروز بیمار ي، از جمله عدم پاسخ فیبروبلاست هاي فعال شده به آپوپتوز به عنوان عامل اصل ی در ایجاد و استقرار بیماري، مورد توجه قرار گی رد. مطالعه که به ترتیب ... سال انتشار: 1395
 

Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment

Authers: Marjan Vakili, 1 Vahid Ziaee, 2, 3, * Mohammad Hassan Moradinejad, 1, 3 Seyed Reza Raeeskarami, 3 Farzad Kompani, 1, 3 and Tayebeh Rahamooz1

Abstract: Various indices have been raised as predictors of activity and severity of juvenile idiopathic arthritis. Objectives: This study was conducted to investigate the changes of platelet indices in acute phase and two months after treatment in these patients. Patients and Methods: In a cohort study, platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were evaluated in children referred to children’s medical center, Tehran due to juvenile idiopathic arthritis from ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Which Criteria to use for the Diagnosis of Behcet’s Disease: International Study Group (ISG) Criteria or International Criteria for Behcet’s Disease (ICBD)?

Authers: Davatchi F*, Sadeghi Abdollahi B, Shahram F, Nadji A, Chams-Davatchi C, Faezi T, Shams H, Akhlaghi M, Ghodsi Z, Ashofteh F, Mohtasham N, Kavosi H and Masoumi M

Abstract: It is interesting to note that Behcet’s Disease (BD) is one of those diseases which had an early diagnostic criteria (9 years after its official recognition, with the Curth criteria in 1946), having one of the largest number of classification/diagnosis criteria (17 sets, in 70 years, till 2016), among them only 2 real International Criteria (ISG and ICBD), and having one of the largest international participation (27 countries for ICBD). ... سال انتشار: 2016
 

Nicolau Syndrome in 29 Months Boy: Another Report of Iran

Authers: Mojtaba Fazel1, Parvin Akbar Asbagh2, Azadeh Afshin3*, Mamak Shariat4, Mahmoud Fazel5, Massumeh Akhlaghi5

Abstract: Nicolau syndrome (NS) is a very rare complication of intramuscular injections that leads to some degree of necrosis in skin, subcutaneous fat and muscles. The type of injected Drugs and wrong injection methods are the main factors for this iatrogenic syndrome. Here we report a 29 months boy, one of the Iranian children affected NS following the wrong intramuscular injection of Benzathine Penicillin. But he came back home without any major complication because of ... سال انتشار: 2015
 

HerbalmedicineIMODsuppressesLPS-inducedproductionofproinflammatorycytokinesinhumandendriticcells

Authers: Saeedeh Mirzaee1†, AgataDrewniak1†, RaminSarrami-Forooshani1, TanjaM.Kaptein1, FarhadGharibdoost2 and TeunisB.H.Geijtenbeek1*

Abstract: Traditional medicines thatstimulateormodulatetheimmunesystemcanbeusedasinnovativeapproachestotreatimmunologicaldiseases.TheherbalmedicineIMODhasbeenshowntostronglymodulateimmuneresponsesinseveralanimalstudiesaswellasinclinicaltrials.However,littleisknownaboutthemechanismsofIMODtomodulateimmunity.HerewehaveinvestigatedwhetherIMODmodulatestheimmunologicalfunctionofhumandendriticcells(DCs).IMODalonedidnotinduceDCmaturationnorproductionofcytokines.Notably,IMODdecreasedtheproductionofpro-inflammatorycytokinesIL-6,IL-12p70,andTNFαbyLPS-activatedDCsatbothmRNAandproteinlevelsinadosedependentmanner.Incontrast,treatmentwithIMODdidnotaffectLPSinduced-productionoftheanti-inflammatorycytokineIL-10.Furthermore,IMODinhibitedTcellactivation/proliferationbyLPS-treatedDCsandskewedT-cellsresponsestowardtheThelpertype2polarization.ThesedatastronglyindicatethatIMODhasapotentimmunomodulatoryabilitythataffectsTLRsignalingandtherebymodulatesDCfunction.InsightintotheimmunomodulatoryeffectofherbalmedicineIMODmayprovideinnovativestrategiestoaffecttheimmunesystemandtohelpcombatvarousdiseases. Keywords:IMOD,immune-modulation,LPS,pro-inflammatorycytokines,dendriticcells سال انتشار: 2015
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

Vitamin D deficiency in patients with Behcet’s disease

Authers: Seyedeh Tahereh Faezi*, Narges Ansari, Pedram Paragomi, Maassoumeh Akhlaghi, Majid Ghanavat and Fereydoun Davatchi

Abstract: Background: Behcet’s disease is an autoimmune, recurrent and multisystem disease. Vitamin D has immunomodulator role in immune system. So that vitamin D deficiency was reported in some autoimmune diseases. Behcet’s disease as a Silk Road disease is common in Iran. The aim of this study was to detect the serum level of 25(OH) vitamin D in Behcet’s patients and control group. Methods: In this case–control study, 112 Behcet’s patients as cases group and 112 ... سال انتشار: 2014
 

Are clinical measures influenced by various ethnic origins in Iranian patients with ankylosing spondylitis? A pilot study

Authers: Sasan Fallahi (MD) * 1, 2 Ahmad Reza Jamshidi (MD) 2 Mahdi Mahmoudi (MD) 2 Mostafa Qorbani (MD)

Abstract: Abstract Background: Ankylosing spondylitis (AS) may manifest with heterogeneous patterns according to ethnic origins. The purpose of this study was to describe the influence of various Iranian ethnic origins on clinical measures in patients with AS. Methods: 0ne hundred sixty-three AS patients diagnosed by modified New York 1984 criteria were enrolled consecutively. The patients were classified into Fars, Turk, Kord, Lor and other ethnic origins. Several clinical measures were described and compared ... سال انتشار: 2014
 

The perspectives of iranian physicians and patients towards patient decision aids: a qualitative study

Authers: Hamideh Rashidian1, 2, Saharnaz Nedjat2, 3*, Reza Majdzadeh2, 3, Jaleh Gholami3, Leila Haghjou3, Bahar Sadeghi Abdollahi4, Fereydoun Davatchi4 and Arash Rashidian3, 5

Abstract: Patient preference is one of the main components of clinical decision making, therefore leading to the development of patient decision aids. The goal of this study was to describe physicians’ and patients’ viewpoints on the barriers and limitations of using patient decision aids in Iran, their proposed solutions, and, the benefits of using these tools. Methods: This qualitative study was conducted in 2011 in Iran by holding in-depth interviews with 14 physicians and 8 arthritis ... سال انتشار: 2013