تالیفات

 

M2000 (b-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

مولف: S. Aletaha*, L. Haddad†, M. Roozbehkia*, R. Bigdeli‡, §, V. Asgary*, M. Mahmoudi¶ & A. Mirshafiey*

خلاصه: To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As b- D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signalling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, ... سال انتشار: 2017
 

HerbalmedicineIMODsuppressesLPS-inducedproductionofproinflammatorycytokinesinhumandendriticcells

Authers: Saeedeh Mirzaee1†, AgataDrewniak1†, RaminSarrami-Forooshani1, TanjaM.Kaptein1, FarhadGharibdoost2 and TeunisB.H.Geijtenbeek1*

Abstract: Traditional medicines thatstimulateormodulatetheimmunesystemcanbeusedasinnovativeapproachestotreatimmunologicaldiseases.TheherbalmedicineIMODhasbeenshowntostronglymodulateimmuneresponsesinseveralanimalstudiesaswellasinclinicaltrials.However,littleisknownaboutthemechanismsofIMODtomodulateimmunity.HerewehaveinvestigatedwhetherIMODmodulatestheimmunologicalfunctionofhumandendriticcells(DCs).IMODalonedidnotinduceDCmaturationnorproductionofcytokines.Notably,IMODdecreasedtheproductionofpro-inflammatorycytokinesIL-6,IL-12p70,andTNFαbyLPS-activatedDCsatbothmRNAandproteinlevelsinadosedependentmanner.Incontrast,treatmentwithIMODdidnotaffectLPSinduced-productionoftheanti-inflammatorycytokineIL-10.Furthermore,IMODinhibitedTcellactivation/proliferationbyLPS-treatedDCsandskewedT-cellsresponsestowardtheThelpertype2polarization.ThesedatastronglyindicatethatIMODhasapotentimmunomodulatoryabilitythataffectsTLRsignalingandtherebymodulatesDCfunction.InsightintotheimmunomodulatoryeffectofherbalmedicineIMODmayprovideinnovativestrategiestoaffecttheimmunesystemandtohelpcombatvarousdiseases. Keywords:IMOD,immune-modulation,LPS,pro-inflammatorycytokines,dendriticcells سال انتشار: 2015
 

The International Criteria for Behcet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria

Authers: F. Davatchi, 1, *, † S. Assaad-Khalil, 2, † K.T. Calamia, 3, † J.E. Crook, 4, † B. Sadeghi-Abdollahi, 1, † M. Schirmer, 5, † T. Tzellos, 6, † C.C. Zouboulis, 6, 7, 8, *, † M. Akhlagi, 1 A. Al-Dalaan, 9 Z.S. Alekberova, 10 A.A. Ali, ،A.R. Jamshidi،A. Nadji،F. Shahram،H. Shams،N. Ziaei1

Abstract: Behcet’s disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test. Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD-mimicking diseases or presenting at least one major BD sign. These were randomly divided into ... سال انتشار: 2013
 

Randomized double blind trial of prednisolone and azathioprine, vs. prednisolone and placebo, in the treatment of pemphigus vulgaris

Authers: C. Chams-Davatchi, †, * A. Mortazavizadeh, † M. Daneshpazhooh, † F. Davatchi, ‡ K. Balighi, † N. Esmaili, † M. Akhyani, † Z. Hallaji, † H. seirafi, † H. Mortazavi†

Abstract: The classic treatment for pemphigus vulgaris is prednisolone. Immunosuppressive drugs can be used in association. Objective To compare the efficacy of Azathioprine in reducing the Disease Activity Index (DAI). Patients and methods A double blind randomized controlled study was conducted on 56 new patients, assigned to two therapeutic groups: (i) prednisolone plus placebo; (ii) prednisolone plus Azathioprine. Patients were checked regularly for 1 year. ‘Complete remission’ was defined as healing of all lesions after 12 ... سال انتشار: 2012
 

Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging

Authers: Samane Ghanbari1†, Mahsa Yonessi1†, Azadeh Mohammadirad2†, Mahdi Gholami2, Maryam Baeeri2, Hamid Reza Khorram-Khorshid3, Farhad Gharibdoost4 and Mohammad Abdollahi2*

Abstract: The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose ... سال انتشار: 2012