تالیفات

 

M2000 (b-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

مولف: S. Aletaha*, L. Haddad†, M. Roozbehkia*, R. Bigdeli‡, §, V. Asgary*, M. Mahmoudi¶ & A. Mirshafiey*

خلاصه: To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As b- D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signalling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, ... سال انتشار: 2017
 

Effects of levothyroxine suppressive therapy on bone mineral density in premenopausal women

Authers: B. Larijani* MD،F. Gharibdoost MD،M. Pajouhi* MD،A. Sadjadi MD،S. Aghakhani MD،R. Eshraghian§ PhD،S. M. Akrami– MD PhD،G. Maalouf** MD

Abstract: SUMMARY Background: Levothyroxine (L-T4) is widely prescribed for treating thyroid disorders, but its effect on bone mineral density (BMD), is being debated. Objectives: We studied the effect of supraphysiologic doses of L-T4 on BMD in a group of premenopausal women. Patients and methods: We included 50 women (mean age = 36Æ8 ± 7Æ6 years) receiving L-T4 for at least 1 year for treating their benign cold thyroid nodules. Serum T3, T4, thyroid-stimulating hormone (TSH), parathyroid hormone (PTH), calcium, and phosphate and urine calcium ... سال انتشار: 2004