تالیفات

 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016
 

Effect of All-transretinoic Acid on Th17 and T Regulatory Cell Subsets in Patients with Ankylosing Spondylitis

Authers: KATAYOON BIDAD, EISA SALEHI, AHMADREZA JAMSHIDI, ALI AKBAR SABOOR-YARAGHI, MONA ORAEI, ALIPASHA MEYSAMIE, MAHDI MAHMOUDI, and MOHAMMAD HOSSEIN NICKNAM

Abstract: We compared Th17 and T regulatory cells in patients with ankylosing spondylitis (AS) and in healthy controls. The effect of all-transretinoic acid (ATRA) was studied on cultured CD4+ T cells of patients with AS compared to controls. Methods. Eighteen patients with AS and 18 age- and sex-matched healthy controls were included. CD4+ T cells were separated and cultured in conditions of anti-CD3 and anti-CD28 stimulation with and without ATRA. Intracellular and secreted cytokines, transcription factors, ... سال انتشار: 2013
 

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

Authers: Mahdi Mahmoudi1, 2, 3, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, 3, Elham Farhadi1, Keramat Nourijelyani4, Sasan Fallahi2, 5, Mona Oraei3, Sahar Noori4, and Mohammad Hossein Nicknam1, 3

Abstract: Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population. The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran. Using Real Time PCR allelic discrimination method, we genotyped four SNPs ... سال انتشار: 2012
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, , Ahmad Reza Jamshidi, Nima Rezaei, Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, A) in ... سال انتشار: 2011
 

Association of CTLA4 Gene Polymorphism in Iranian Patients with Ankylosing Spondylitis

Authers: Esfandiar Azizi, Ahmad Massoud, Ali Akbar Amirzargar, Mahdi Mahmoudi, Narjes Soleimanifar, Nima Rezaei, Ahmad Reza Jamshidi, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Introduction Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a costimulatory molecule expressed by activated T cells. This study was performed to investigate the allele and genotype frequencies of CTLA4 gene polymorphisms in Iranian patients with ankylosing spondylitis (AS). Methods One hundred and fifty-seven patients with AS and 103 controls were included in this study. Polymorphisms of CTLA4 gene at positions +49 (in exon 1), −318, and −1,147 (in the promoter region) were studied on the genomic DNA using PCR restriction ... سال انتشار: 2010
 

Study of Programmed Cell Death 1 (PDCD1) Gene 2 Polymorphims in Iranian Patients with Ankylosing Spondylitis

Authers: Narjes Soleimanifar, Ali Akbar Amirzargar, Mahdi Mahmoudi, Ali Akbar Pourfathollah, Esfandiar Azizi, Ahmad Reza Jamshidi, Nima Rezaei, , Mohammad Taher Tahoori, Katayoon Bidad, Behrouz Nikbin, Mohammad Hossein Nicknam

Abstract: Abstract—Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis in which the genetic–environmental factors seem to be involved in the pathogenesis of the disease. This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to AS. In this study, 161 Iranian patients with AS and 208 normal controls were enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 ... سال انتشار: 2010