تالیفات

 

Overlap of Ankylosing Spondylitis and Systemic Lupus Erythematosus: A case report

Authers: MahmoodAkbaryan1 and Zahra Soltani2*

Abstract: Ankylosing spondylitis is a typical, very heritable incendiary joint inflammation, influencing principally the spine and pelvis. Inflammatory arthritis in ankylosing spondylitis causes pain and stiffness and progressively leads to new bone formation and ankylosis (fusion) of affected joints. Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous autoimmune disease that most often afflicts women in their child-bearing years. It is characterized by circulating self-reactive antibodies that deposit in tissues, including skin, kidneys, ... سال انتشار: 2016
 

A RARE CYCLOPHOSPHAMIDE -ASSOCIATED LIVER TOXICITY IN A PATIENT WITH PAN-LIKE VASCULITIS: A CASE REPORT AND LITERATURE REVIEW

Authers: MAHMOOD AKBARYAN1, ZAHRA SOLTANI2

Abstract: Cyclophosphamide is an alkylating agent belongs to oxazaphosphorines. It can be prescribed both oral and intravenous and also in a wide ranges of dosage. However various reported side effects of the drug are the main reason to restrict the uses. Cyclophosphamide can be metabolized in the liver mostly by cytochrome p450 enzymes into to form 4-hydroxycyclophosphamide that has the chemotherapeutic characteristic. By metabolizing the parent molecule cytotoxic molecules can be derived such as acrolein which is ... سال انتشار: 2016