تالیفات

 

Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

مولف: Raheleh ASSARI, 1, 2 Yahya AGHIGHI, 3 Vahid ZIAEE, 1, 2 Maryam SADR, 4 Farzaneh RAHMANI, 5 Arezou REZAEI, 5 Zeinab SADR, 4 Mohammad Hassan MORADINEJAD, 2 Seyed Reza RAEESKARAMI6 and Nima REZAEI

خلاصه: Aim: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-a polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. Methods: Fifty-five patients with KD who were randomly selected from referrals to the main pediatric hospital were enrolled in this ... سال انتشار: 2017
 

PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis

مولف: Mahdi Mahmoudi1, 2, Alireza Rezaiemanesh1, 3, Sara Harsini4, 5, Arash Salmaninejad6, Shiva Poursani1, Tayyeb Bahrami7, Vahid Ziaee8, 9, and Nima Rezaei3, 5, 6

خلاصه: Abstract- Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients ... سال انتشار: 2017
 

Lack of Association between STAT4 Single Nucleotide Polymorphisms and Iranian Juvenile Rheumatoid Arthritis Patients

مولف: Saeed Aslani, Mahdi Mahmoudi, Arash Salmaninejad, Shiva Poursani, Vahid Ziaee & Nima Rezaei

خلاصه: Juvenile rheumatoid arthritis (JRA) is a common chronic systemic autoimmune disease in children. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene are suspected to have associationwith the risk of autoimmune diseases. Previous investigations have indicated that the STAT4 rs7574865 T allele was significantly associated with rheumatoid arthritis. In this study, we aimed to evaluate the association of STAT4 SNPs with JRA in Iranian population. T allele of STAT4 rs7574865 SNPwas less ... سال انتشار: 2017
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

مولف: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

خلاصه: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2017
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

مولف: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

خلاصه: Juvenile idiopathic arthritis (JIA) which consists of a heterogeneous group of chronic disorders (e.g., oligoarthritis, polyarthritis, and systemic arthritis) is an autoimmune, noninfectious inflammation of joints’ synovial membrane and connective tissues that lastsmore than 6 weeks [1, 2].The disorder has been identified all over the world in nearly all races and ethnicities with an average prevalence rate of 1 to 2 per 1,000 children [3]. Some children may experience JIA symptoms for only a few months while others ... سال انتشار: 2017
 

Association Study of MECP2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients from Iran

مولف: Mahdi Mahmoudi, Saeed Aslani, Elham Hamzeh, Vahid Ziaee, Shiva Poursani, Mohammad Hossein Nicknam & Nima Rezaei

خلاصه: Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a multigenic autoimmune disorder. Polymorphisms of MECP2 gene have been reported to increase the risk of adult-onset SLE. In this study, we aimed to analyze if MECP2 gene polymorphisms could impress the proneness to JSLE in Iranian population. Material and Methods: Polymorphisms of MECP2 gene were genotyped in 50 Iranian JSLE patients and 426 matched healthy controls employing the real-time PCR allelic discrimination technique. Results: None of the alleles and ... سال انتشار: 2017
 

Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients

مولف: Arash Salmaninejad1, 2, Mahdi Mahmoudi1, 3, Saeed Aslani1, 3, Shiva Poursani1, Vahid Ziaee4, 5, Nima Rezaei6, 7, 8

خلاصه: SUMMARY: Salmaninejad A, Mahmoudi M, Aslani S, Poursani S, Ziaee V, Rezaei N. Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients. Turk J Pediatr 2017; 59: 144-149. Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to have relationship with the risk of ... سال انتشار: 2017
 

Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis

Authers: Vahid Ziaee1, 2 & Arezou Rezaei3 & Sara Harsini3, 4 & Marzieh Maddah2 & Samaneh Zoghi4, 5 & Maryam Sadr6 & Mohammad Hassan Moradinejad2 & Nima Rezaei 3, 4, 5

Abstract: As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at positions -1098, -590, and -33, as well as IL-4RA gene at position +1902 were genotyped ... سال انتشار: 2016
 

Novel Echocardiographic Indices for Assessing the Left Main Coronary Artery in Children With Kawasaki Disease

Authers: Elaheh Malakan Rad, 1, 2, * Iran Malekzadeh, 1, 2 Vahid Ziaee, 1, 2, 3 Raheleh Rajabi, 2 and Zohreh Shahabi2

Abstract: Kawasaki disease (KD) is the most common cause of acquired myocardial infarction in children. Coronary artery involvement is the most serious feature of this vasculitis syndrome. Timely diagnosis of coronary artery involvement is of utmost importance since it can prevent long-term morbidity and mortality. The current methods for the diagnosis of coronary artery dilation in KD are inconsistent and are also not capable of detecting all the abnormal coronary arteries or the so-called ... سال انتشار: 2016
 

Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ ANTXR2 Gene

Authers: Leila Youssefian1, 2#, Hassan Vahidnezhad1, 3#, Yahya Aghighi4#, Vahid Ziaee4, 5#, Sirous Zeinali3, 6, Maryam Abiri2, 3 and Jouni Uitto1

Abstract: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Cytokines in Systemic Lupus Erythematosus: Their Role in Pathogenesis of Disease and Possible Therapeutic Opportunities

Authers: Leili Tahernia, 1 Shideh Namazi, 2 Nima Rezaei, 2, 3, 4, * and Vahid Ziaee5, 6

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, ... سال انتشار: 2016
 

Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment

Authers: Marjan Vakili, 1 Vahid Ziaee, 2, 3, * Mohammad Hassan Moradinejad, 1, 3 Seyed Reza Raeeskarami, 3 Farzad Kompani, 1, 3 and Tayebeh Rahamooz1

Abstract: Various indices have been raised as predictors of activity and severity of juvenile idiopathic arthritis. Objectives: This study was conducted to investigate the changes of platelet indices in acute phase and two months after treatment in these patients. Patients and Methods: In a cohort study, platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were evaluated in children referred to children’s medical center, Tehran due to juvenile idiopathic arthritis from ... سال انتشار: 2016
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Spectrum of Mutations of Familial Mediterranean Fever Gene in Iranian Population

Authers: Tayebeh Sabokbar1, 2, Ali Malayeri2, Cyrus Azimi2, Seyyed Reza Raeeskarami3, 4, Vahid Ziaee3, 4, Yahya Aghighi3, 4, Abbas Shakoori2, 5

Abstract: Familial Mediterranean fever is a genetic disease that is caused by the MEFV gene. Our study was based on clinical manifestations of recurrent attacks of fever and inflammation and distribution of MEFV mutations in an Iranian patient using a comprehensive mutation detection method. Methods: Eighty-five clinically diagnosed FMF patients from university hospitals who were referred to the Department of Genetics for molecular diagnosis of FMF. Results: Mutations in one allele and in both ... سال انتشار: 2014
 

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

Authers: Mina Doudkani-Fard1, Vahid Ziaee2, Mohamad-Hassan Moradinejad3 Mojtaba Sedaghat4, Mohammad-Taghi Haghi-Ashtiani5, Zahra Ahmadinejad6

Abstract: Background: Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis (RA). Evaluation of ... سال انتشار: 2014