تالیفات

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran  

Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran

مولف: Shima Hadifara, b, 1, Leila Shamkhalia, b, 1, Mansour Kargarpour Kamakolia, b, Shayan Mostafaeic, d, Sharareh Khanipoura, Noormohamad Mansoorie, Abolfazl Fateha, b, Seyed Davar Siadata, b, Farzam Vaziria, b, ⁎

خلاصه: Objectives: Evaluation of the genetic diversity of Mycobacterium tuberculosis (M.tb) and determining if the association between a specific genotype and the site of infection is crucial. Accordingly, the current study aimed at comparing predominant M.tb genotypes in pulmonary (PTB) and extrapulmonary tuberculosis (EPTB) isolates circulating in the capital of Iran. Methods: The genetic diversity of culture-confirmed PTB and EPTB isolates were evaluated by Spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive-unit–variable-number tandem-repeat) typing methods. Genotyping data were analyzed ... سال انتشار: 2019
Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis  

Prevalence of influenza A infection in the Middle-East: A systematic review and meta-analysis

مولف: Mohsen Moghoofei1 | Seyed Hamidreza Monavari2 | Shayan Mostafaei3, 4 | Shima Hadifar5, 6 | Amir Ghasemi7 | Farhad Babaei1 | Hoda Kavosi4 | Ahmad Tavakoli2 | Davod Javanmard2 | Maryam Esghaei2 | Nilofar Khodabandehlou8

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle- East’ and ‘Meta-analysis’. The ... سال انتشار: 2018
microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients  

microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

مولف: Mohsen Moghoofei1, Farah Bokharaei-Salim1, 2, Maryam Esghaei1, Hossein Keyvani1, Maryam Honardoost3, Shayan Mostafaei4, 5, Amir Ghasemi6, Ahmad Tavakoli1, Davod Javanmard1, Farhad Babaei7, Saba Garshasbi2 & Seyed Hamidreza Monavari*,

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with ... سال انتشار: 2018
Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer  

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2018
 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Curcumin reduces the expression of interleukin 1b and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet's disease

مولف: Mohammad Taghi Palizgira, Maryam Akhtaria, b, Mahdi Mahmoudia , Shayan Mostafaeia, Alireza Rezaiemaneshc and Farhad Shahrama

خلاصه: Objective: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. Methods: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for ... سال انتشار: 2018
 

Cochlea CT radiomics predicts chemoradiotherapy induced sensorineural hearing loss in head and neck cancer patients: A machine learning and multi-variable modelling study

مولف: Hamid Abdollahia, Shayan Mostafaeib, Susan Cheraghic, d, Isaac Shirie, f, Seied Rabi Mahdavia, d, ⁎, Anoshirvan Kazemnejadb, ⁎

خلاصه: Objectives: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. Material and methods: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection ... سال انتشار: 2018
Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients  

Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients

مولف: Parisa Zafari, Kheirollah Yari, Shayan Mostafaei, Nasrin Iranshahi, Shirin Assar, Adel Fekri & Mahdi Taghadosi

خلاصه: The control of auto-reactive cells is defective in rheumatoid arthritis (RA). Regulatory T (Treg) cells which play a key role in the modulation of immune responses have an impaired function in RA. Foxp3 is a master regulator of Treg cells which its expression is سال انتشار: 2018
 

Worldwide prevalence of viral infection in AECOPD patients: A metaanalysis

مولف: Habib Jafarinejada, Mohsen Moghoofeib, Shayan Mostafaeic, Jafar Salimiand, Sadegh Azimzadeh Jamalkandid, ∗, Ali Ahmadia, ∗∗

خلاصه: Background and objective: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. Methods: PubMed database was systematically searched for population-based prevalence studies (1930–2017). Fixed and random effects models were used for estimation of summary effect-sizes. ... سال انتشار: 2017
 

Prevalence of respiratory viruses in Iranian patients with idiopathic pulmonary fibrosis

مولف: Hossein Keyvani, 1 Mohsen Moghoofei, 2 Farah Bokharaei-Salim, 1, 3 Shayan Mostafaei, 4 Seyed-Ali Javad Mousavi, 5 Seyed Hamidreza Monavari1 and Maryam Esghaei1, *

خلاصه: Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal ... سال انتشار: 2017
 

Prevalence of Influenza A Infection in the Middle-East: A Systematic Review and Meta-analysis

مولف: Mohsen Moghoofei1, Seyed Hamidreza Monavari2, Shayan Mostafaei3, 4, Shima Hadifar5, 6, Amir Ghasemi7, Farhad Babaei1, Hoda Kavosi5, Ahmad Tavakoli2 , Davod Javanmard2, Maryam Esghaei2*, Nilofar Khodabandehlou8*

خلاصه: Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were “Influenza”, “Subtype”, “Seroprevalence”, “Incidence”, “Seroepidemiology”, “H1N1”, “H3N2”, “H5N1”, “H9N2”, “Middle-East”, and “Metaanalysis”. The reported ... سال انتشار: 2017
 

Prevalence of hepatitis B surface antigen among hemodialysis patients from Middle Eastern countries: a systematic review and meta-analysis

مولف: Ahmad Tavakoli1, 2, Mohsen Moghoofei3, 4, Shayan Mostafaei5, 6, Hadi Ghaffari2, Seyed Hamidreza Monavari2 & Seyed Moayed Alavian*,

خلاصه: Aim: The aim of this study was to determine the overall prevalence of hepatitis B surface antigen (HBsAg) among hemodialysis patients reported from the Eastern Mediterranean Regional Office of the WHO (EMRO) countries and the Middle East. Methods: Several databases such as PubMed, ISI Web of Science, MEDLINE and Scopus were searched for publications reporting HBsAg prevalence among hemodialysis patients up to December 2016. Results: From all the samples, the pooled prevalence of HBsAg was ... سال انتشار: 2017
 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

Molecular investigation of virulence factors of Brucella melitensis and Brucella abortus strains isolated from clinical and non-clinical samples

مولف: Reza Mirnejad a, Faramarz Masjedian Jazi b, Shayan Mostafaei c, d, Mansour Sedighi

خلاصه: Brucella is zoonotic pathogen that induces abortion and sterility in domestic mammals and chronic infections in humans called Malta fever. It is a facultative intracellular potential pathogen with high infectivity. The virulence of Brucella is dependent upon its potential virulence factors such as enzymes and cell envelope associated virulence genes. The aim of this study was to investigate the Brucella virulence factors among strains isolated from humans and animals in different parts of Iran. ... سال انتشار: 2017
 

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Mahdi Mahmoudi1, Shayan Mostafaei1, Alireza Rezaeimanesh3, Massoomeh Akhlaghi1, and Farhad Shahram1

خلاصه: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients ... سال انتشار: 2017
 

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

مولف: Ramazan REZAEI, 1, 2 Mahdi MAHMOUDI, 1 Farhad GHARIBDOOST, 1 Hoda KAVOSI, 1 Navid DASHTI, 1, 2 Vahideh IMENI, 1 Ahmadreza JAMSHIDI, 1 Saeed ASLANI, 1 Shayan MOSTAFAEI1 and Mohammad VODJGANI2

خلاصه: Objective: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. Methods: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs, complementary DNA (cDNA) was synthesized. Afterwards, quantitative analysis of ... سال انتشار: 2017
 

Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer

مولف: Mokhtar Zarea, Shayan Mostafaeib, Ali Ahmadic, Sadegh Azimzadeh Jamalkandid, Atefeh Abedinie, Zahra Esfahani-Monfarede, Ruhollah Dorostkarf, ∗, Mojtaba Saadatia, ∗∗

خلاصه: Lung cancer, the leading cause of cancer mortality, needs urgent development of newly qualified diagnostic and therapeutic biomarkers. Recently, Human Endogenous Retroviruses (HERVs) have been introduced for cancer diagnosis. In this case-control study, we have collected blood samples from 60 lung cancer patients and 20 healthy controls. Quantitative gene expression analysis of various HERV env genes, including HERV-R, HERV-H, HERV-K, and HERV-P was performed by real-time PCR. Results indicate that expression of all four ... سال انتشار: 2017
 

Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis

مولف: Fatemeh Abbasi1, Reza Mansouri1, Farhad Gharibdoost2, Saeed Aslani2, Shayan Mostafaei2, Hoda Kavosi2, Shiva Poursani2, Soheila Sobhani2, and Mahdi Mahmoudi2

خلاصه: CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex, and ethnic -matched healthy individuals. Genotyping of rs2056626 ... سال انتشار: 2017