تالیفات

 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications

Authers: Mahdi Mahmoudi1*, Saeed Aslani1*, Mohammad Hossein Nicknam2, Jafar Karami1, and Ahmad Reza Jamshidi1

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2016