تالیفات

 

Evaluation of TLR9 expression on PBMCs and CpG ODN-TLR9 ligation on IFN-α production in SLE patients

مولف: Sahar Mortezagholi, Zohreh Babaloo, Parisa Rahimzadeh, Haideh Namdari, Mojgan Ghaedi, Farhad Gharibdoost, Reza Mirzaei, Katayoon Bidad & Eisa Salehi

خلاصه: ABSTRACT Context: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in the pathogenesis of SLE. Objective: In this study, the level of TLR9 expression on peripheral blood mononuclear cells (PBMCs) was analyzed. The levels of produced IFN-a were also measured in supernatant of PBMCs from SLE patients and healthy controls after stimulation with CpG ODN2216 which is a ... سال انتشار: 2017
Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus  

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

Authers: Mohammad Sahebalzamani1, PhD, Hojjatollah Farahani2, PhD, Mojgan Tabatabaee Jamarani1, MSc, Seyedeh Tahereh Faezi3, MD, Kamran Moradi3, MD & Pedram Paragomi3, MD

Abstract: Purpose: The purpose of this study was to evaluate the effects of applying continuous care model (CCM) on the knowledge level and health-related quality of life (HRQoL) of systemic lupus erythematosus (SLE) patients and their perceptions of family awareness about the disease. Design: Continuous care model was implemented for 3 months on 34 SLE patients, in a pretest–posttest quasi-experimental design. Methods: Two sets of questionnaires were designed for knowledge assessment. HRQoL was assessed by SF-36 questionnaires. Analysis ... سال انتشار: 2017
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. سال انتشار: 2015
 

Photoclinic Figure 1. Abdominal CT scan showing ascites (asterisk) and target sign (arrow) Figure 2. Abdominal CT scan showing comb sign (arrow)

Authers: Sara Sagharnia MD1, Farideh Darabi MD1, Ahmadreza Jamshidi MD•

Abstract: A 17-year-old woman with 2 weeks history of generalized crampy abdominal pain, progressive nausea/vomiting, and loose stools was admitted to the emergency department. She was a known case of systemic lupus erythematosus (SLE) with a history of associated mucocutaneous symptoms (Malar rash), nephritis (proteinuria 600 mg/24 h which wasn’t biopsied), arthritis and positive serology (positive ANA and Anti ds –DNA, with titer 2 سال انتشار: 2016
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus

Authers: Sahar Mortezagholi1, Zohreh Babaloo1, Parisa Rahimzadeh2, Mojgan Ghaedi2, Hayedeh Namdari3, Shirin Assar4, Maryam Azimi Mohamadabadi5, and Eisa Salehi5

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood ... سال انتشار: 2016
 

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

Authers: Mohammad Sahebalzamani1, PhD, Hojjatollah Farahani2, PhD, Mojgan Tabatabaee Jamarani1, MSc, Seyedeh Tahereh Faezi3, MD, Kamran Moradi3, MD & Pedram Paragomi3, MD

Abstract: Purpose: The purpose of this study was to evaluate the effects of applying continuous care model (CCM) on the knowledge level and health-related quality of life (HRQoL) of systemic lupus erythematosus (SLE) patients and their perceptions of family awareness about the disease. Design: Continuous care model was implemented for 3 months on 34 SLE patients, in a pretest–posttest quasi-experimental design. Methods: Two sets of questionnaires were designed for knowledge assessment. HRQoL was assessed by SF-36 questionnaires. Analysis ... سال انتشار: 2016
 

Cost-EffectivenessAnalysisofTocilizumabinComparisonwith Infliximab inIranianRheumatoidArthritisPatientswith Inadequate ResponsetotDMARDs:AMultistageMarkovModel

Authers: Amir Hashemi-Meshkini, PharmD1, ShekoufehNikfar, PharmD, PhD1, ElizabethGlaser, MS, MA2, Ahmadreza Jamshidi, MD3, SeyedAlirezaHosseini, PharmD, PhD1, 4, *

Abstract: To analyzethecost-effectivenessoftwocommontreat- ment strategiesinIran,comparinginfliximab plusmethotrexatewith tocilizumab plusmethotrexateinpatientswithrheumatoidarthritis with inadequateresponsetotraditionaldisease-modifyinganti- rheumatic drugs. Methods: A multistageMarkovdecisionmodel was appliedtoassesstheincrementalcost-effectivenessratio(ICER) of atocilizumab-containingregimenversusaninfliximab-containing regimen overa5-yeartimeperiod.Inthecaseofnoresponse,we assumed thatpatientsswitchedtothenexttreatment(adalimumab, rituximab, orsupportivecare)insequenceforeachstrategy.We consideredmajorcostitems,suchasdirectmedicalcostsanddirect nonmedical costs,fromapayer(patientsandthird-partypayers) perspective.Adeterministicsensitivityanalysiswasconductedto assess therobustnessofthemodelresultsovertheuncertaintyofkey parameters. Results: In thebase-caseanalysis,theICERofthe tocilizumab-containingregimenwasUS$60,800perquality-adjusted life-year ascomparedtotheinfliximab-containingregimen.In the sensitivityanalysis,changesinthepriceofthedrugsby generic substitution,inutilityscores,andindiscountratedidnot change ouroverallconclusions.Amongallinputstotheprimary study andthesensitivityanalyses,however,thepriceoftocili- zumab hadthemostimpactontheICER. Conclusions: Although tocilizumab andmethotrexateprovidealargergaininquality- adjusted life-years,theircurrentpriceisquitehighascomparedwith those ofourotherinterventions.Therefore,aregimencontaining tocilizumab isnotcost-effectiveascomparedwithaninfliximab- containingregimenforpatientswithrheumatoidarthritisinIran. Keywords: cost-effectiveness,infliximab, Iran,rheumatoidarthritis, tocilizumab. Copyright & 2015, سال انتشار: 2016
 

Anxiety and depression in rheumatoid arthritis: an epidemiologic survey and investigation of clinical correlates in Iranian population

Authers: Ahmad‑Reza Jamshidi1 · Arash Tehrani Banihashemi1, 2 · Pedram Paragomi1 · Maryam Hasanzadeh1 · Mozhgan Barghamdi1 · Shima Ghoroghi1

Abstract: Psychiatric disorders occur in a considerable proportion of patients with rheumatoid arthritis (RA). This study was conducted in order to evaluate the prevalence of anxiety and depression in Iranian RA patients. In the cross sectional study, 414 RA patients were enrolled prospectively during a period of 6 months from RA clinic of Rheumatology Research Center. Beck’s and Cattell’s inventories were applied to investigate depression and anxiety in RA patients. RA activity was measured by Disease Activity Score and patients’ ... سال انتشار: 2016
 

RAC1 single nucleotide polymor-phisms in Crohn’s disease

Authers: Mohammad TaheraNasser Ebrahimi DaryaniaMona HedayatbMohammad EslamianaElham Farhadic, dMahdi MahmoudieSamira ShirzadfMohammd Kazem Nouri TaromlouaMeghedi ChaharmahaligMohammad Hossein NicknamcMohammad BashashatihNima

Abstract: diseaseRac1 is a regulator for cellular motility, proliferation andtransformation. A recent showed that mutations of RAC1gene are associated with higher risk of inflammatory boweldisease (IBD). These mutations increase the expression ofRac1 protein and intriguingly, loss of Rac1 expression resultsin protection from colitis [1,2].Thus we conducted a case-control study on 67 patientswith Crohn’s disease (CD) and 78 healthy individuals toidentify whether there is any association between CD andsingle nucleotide polymorphisms (SNPs) ... سال انتشار: 2014
 

Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study

Authers: Arash TEHRANI-BANIHASHEMI, 1, 2 Fereydoun DAVATCHI, 1 Ahmad-Reza JAMSHIDI, 1 Tahereh FAEZI, 1 Pedram PARAGOMI1 and Mozhgan BARGHAMDI

Abstract: Aim: To estimate the prevalence of osteoarthritis (OA) of different joints in rural areas of Iran. Methods: From five villages of Tuyserkan County, 1565 individuals were randomly selected and were interviewed to complete the Community Oriented Programme for Control of the Rheumatic Diseases (COPCORD) Core Questionnaire. Among these cases 1192 cases with rheumatic complaints were examined by a rheumatologist and laboratory and radiology tests were performed if necessary for the diagnosis. Definition of OA ... سال انتشار: 2014
 

Are clinical measures influenced by various ethnic origins in Iranian patients with ankylosing spondylitis? A pilot study

Authers: Sasan Fallahi (MD) * 1, 2 Ahmad Reza Jamshidi (MD) 2 Mahdi Mahmoudi (MD) 2 Mostafa Qorbani (MD)

Abstract: Abstract Background: Ankylosing spondylitis (AS) may manifest with heterogeneous patterns according to ethnic origins. The purpose of this study was to describe the influence of various Iranian ethnic origins on clinical measures in patients with AS. Methods: 0ne hundred sixty-three AS patients diagnosed by modified New York 1984 criteria were enrolled consecutively. The patients were classified into Fars, Turk, Kord, Lor and other ethnic origins. Several clinical measures were described and compared ... سال انتشار: 2014
 

The Effects of Isolated Hip Abductor and External Rotator Muscle Strengthening on Pain, Health Status, and Hip Strength in Females With Patellofemoral Pain: A Randomized Controlled Trial

Authers: KHALIL KHAYAMBASHI, PT, PhD1 • ZEYNAB MOHAMMADKHANI, MS2 • KOUROSH GHAZNAVI, MD3, MARK A. LYLE, PT, OCS4 • CHRISTOPHER M. POWERS, PT, PhD5

Abstract: TTSTUDY DESIGN: Randomized controlled trial. TTOBJECTIVES: To examine the effectiveness of isolated hip abductor and external rotator strengthening on pain, health status, and hip strength in females with patellofemoral pain (PFP). TTBACKGROUND: Altered hip kinematics resulting from hip muscle weakness has been proposed as a contributing factor in the development of PFP. To date, no study has examined clinical outcomes associated with isolated hip muscle strengthening in those with PFP. TTMETHODS: Twenty-eight females with ... سال انتشار: 2012
 

Quality-of-Life Measurement in Blistering Diseases

Authers: Deshan F. Sebaratnam, MBBS (Hons)a, b, 1, John W. Frew, MBBS (Hons), MMed (Clin Epi)a, b, 1, Fereydoun Davatchi, MDc, Dédée F. Murrell, MA, BMBCh, FAAD, MD, FACDd, *

Abstract: Quality of life (QOL) has been defined as “the individual’s perception of their position in life, in the context of the cultural and value systems in which they live and in relation to their goals, expectations, standards and concerns.”1 It is an abstract multidimensional construct reflecting the physical, psychological, and social aspects of an individual’s condition complementing the concept of health as “a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.”2 ... سال انتشار: 2012
 

Causes of Blindness in Ocular Behçet’s Disease Comparing the End-Blinding Results in Two Genders

Authers: Hormoz Chams, MD1 • Hassan Behboudi, MD2 • Fariba Ghassemi, MD3 Fereydoun Davatchi, MD4 • Farhad Shahram, MD4 • Sheyda Chams-Davatchi, MD5

Abstract: To investigate and compare the causes of blindness in ocular Behçet’s disease (BD) in men and women Methods: In a retrospective, descriptive investigation from 1976 to 2008, 6,021 BD cases were registered in our BD Unit of Shariati Hospital of Tehran University of Medical Sciences (TUMS). At the last visit, 187 patients (124 men and 63 women) were blind (vision=1/10 or less) at least in one eye and with at least ... سال انتشار: 2012
 

Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)

Authers: Sasan Fallahi (MD) *1, 2 Ahmad Reza Jamshidi (MD) 2 Farhad Gharibdoost (MD) 2 Mahdi Mahmoudi (PhD) 2 Pedram Paragomi (MD) 2 Mohammad Hossein Nicknam (MD, PhD) 3 Elham Farhadi (MSc) 3 Mostafa Qorbani (PhD) 4

Abstract: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-sectional study from Iranian AS association, Iran Rheumatology Center and Rheumatology Clinic of ... سال انتشار: 2012
 

Assessments of Pulmonary Involvement in Patients with Systemic Sclerosis

Authers: Keivan Gohari Moghadam MD, Farhad Gharibdoost MD, Gilda Parastandechehr MD, Pirooz Salehian MD

Abstract: The lungs are affected in 70 – 90% of cases diagnosed with systemic sclerosis. Pulmonary involvement is associated with increased morbidity and mortality. Materials and Methods: Fifty-ve cases of systemic sclerosis underwent plethysmography, diffusion lung capacity for carbon monoxide (DLCO) measurement, high resolution computed tomography scanning, and bronchoalveolar lavage (BAL) to evaluate their diagnostic roles in grading the severity of lung involvement and their relationships to each other. Results: The indices of DLCO% (measured DLCO ... سال انتشار: 2011
 

Clinical and preclinical manifestation of systemic lupus erythmatous

Authers: M. Ebrahimpur Fini, MD, T. Faezi, MD, M. Akbarian, MD, M. Akhlaghi, MD, M. Kheiyrandish, MD, A. Shahali, MD, F. Gharibdoust, MD, F. Shahram, MD, A.H. Naji, MD, A.R. Jamshidi, MD, F. Davachi, MD

Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male ... سال انتشار: 2011
 

The Effects of Multidisciplinary Educational Program on Quality of Life and Disability of Patients with Chronic Low Back Pain: A Clinical Trial with 3, 6, 12 and 18 Months Follow ups

Authers: Sedigheh Sadat Tavafian MD, Ahmad Reza Jamshidi MD, Kazem Mohammad PhD

Abstract: Chronic low back pain is one of the most health problems worldwide. This study aimed to examine the effects of a designed multidisciplinary program on quality of life and disability among chronic low back pain patients up to 18 months. Methods: This study followed the participants in previous randomized controlled trial up to 18 months. Therefore, data at 18- month follow up, were collected through SF-36, Ronald –Morris Disability Questionnaire, and Quebec low back pain ... سال انتشار: 2011
 

The epidemiology of systemic lupus erythematosus in Iran: a survey on 2143 cases

Authers: Mahmood Akbarian MD, Seyedeh Tahereh Faezi MD, Farhad Gharibdoost MD, Farhad Shahram MD, Abdolhadi Nadji MD, Ahmad Reza Jamshidi MD, Masoumeh Akhlaghi MD, Nahid Shafaee MD, Maryam Akhlaghkhah MD, Fereydoun Davatchi MD

Abstract: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest series in Asia- Pacific region. The aim of this study was to show the manifestations of SLE ... سال انتشار: 2010
 

Plasma Homocysteine Level in Patients with Behcet’s Disease with or without Thrombosis

Authers: Farhad Shahram MD, Alireza Faridar MD1, Mohammad Ghaffari Hamedani MD, Abdolhadi Nadji MD1, Nassim Naderi MD, Niloofar Mojarad Shaee BS, Johannes J. Rasker MD, Fereydoun Davatchi MD

Abstract: Aim: To nd the possible role of plasma homocysteine level as a contributing factor in venous and arterial thrombosis in patients with Behcet’s disease (BD). Methods: In a case control study, two groups of BD patients were included: 47 with thrombosis and 49 without thrombosis. All patients fullled the International Study Group Criteria for BD and the conrming diagnostic procedures for vascular thrombosis were either Doppler sonography or angiography. Forty-nine controls were selected by ... سال انتشار: 2010
 

Risk Factors of Blindness in Behcet’s Disease

Authers: Hormoz Chams, MD1, Fereydoun Davatchi, Amir Hossein Mahmoudi, Farhad Shahram, Cheyda Chams, Saeideh Dahaghein

Abstract: Purpose: To investigate long-term ocular manifestations of ocular Behcet’s disease (BD), and the causes for blindness Methods: In August 2008, at Shariati hospital of Tehran (Behcet unit) all files of the ocular BD patients from 1976 to 2008 who were legally blind (Visual acuity=20/200 or less) at least in one eye at the last visit and had at least three years of follow-up were reviewed and the desired informations were extracted. ... سال انتشار: 2010
 

A WHO-ILAR COPCORD STUDY (Stage 1, rural study) IN IRAN

Authers: Davatchi, Fereydoun;, Tehran Banihashemi, Arash;, Gholami, Jaleh;, faezi, seyedeh tahereh;, Forouzanfar, Mohammad Hossein;, Salesi, Mansour, Karimifar, mansour, Essalat-Manesh, Kamal, Barghamdi, Mojgan, Noorolahzadeh, Elham, Dahaghin, Saideh

Abstract: Objective: To study the prevalence of musculoskeletal complaints and disorders in a rural area in Iran. Materials and Methods: Interviews were conducted in randomly selected subjects from 5 villages in Tuyserkan County, North Western part of Iran. The 3 phases of stage 1 COPCORD (Community Oriented Program for Control Of Rheumatic Diseases) were done during the same day. Results: A total of 614 houses was visited, 1565 persons interviewed and 1192 persons examined. Musculoskeletal complaints ... سال انتشار: 2009
 

The prevalence of symptomatic hand osteoarthritis in Tehran: Community-oriented program for Control of Rheumatic Diseases- COPCORD

Authers: Dahaghin S, Jamshidi A.R, Tehrani Banihashemi A, Gholami J., Forouzanfar M.H, Akhlaghi M, Khabazi A.R, Noorolahzadeh E, Barghamdi M, Arabzadeh B, Davatchi F

Abstract: Osteoarthritis is the most common form of arthritis in the world. This study presents the evidence on the prevalence of symptomatic hand osteoarthritis in urban community. To add to the evidence on the prevalence of symptomatic hand osteoarthritis in urban community. Methods: Inhabitants (age≥15 yrs) in 22 randomly selected districts (Tehran) participated in a Community-Oriented Program for Control of Rheumatic Diseases (COPCORD) evaluating major rheumatic disorders, including osteoarthritis. Eventually, 10, 291 inhabitants completed a Questionnaire (75% response-rate). ... سال انتشار: 2009
 

The prevalence of musculoskeletal complaints in a rural area in Iran: a WHO-ILAR COPCORD study (stage 1, rural study) in Iran

Authers: Fereydoun Davatchi, Arash Tehrani Banihashemi, Jaleh Gholami, Seyedeh Tahereh Faezi, Mohammad Hossein Forouzanfar, Mansour Salesi, Mansour Karimifar, Kamal Essalatmanesh, Mojgan Barghamdi, Elham Noorolahzadeh, Saideh Dahaghin, Johannes J. Rasker

Abstract: The objective of this study is to study the prevalence of musculoskeletal complaints and disorders in a rural area in Iran. Interviews were conducted in randomly selected subjects from five villages in Tuyserkan County, northwestern part of Iran. The three phases of stage 1 Community Oriented Program for Control of Rheumatic Diseases were done during the same day. A total of 614 houses was visited, 1,565 persons interviewed, and 1,192 persons examined. Musculoskeletal complaints during the past 7 days ... سال انتشار: 2009
 

Risk factors of knee osteoarthritis, WHO-ILAR-COPCORD study

Authers: Dahaghin S, Tehrani- Banihashemi SA, Frouzanfar MH, Barghamdi M, Norollahzadeh E, Gholami J., Faezi, ST.1, Davatchi F

Abstract: To evaluate the association between age, sex, BMI, waist/hip ratio, smoking, religion, ethnicity, education and knee osteoarthritis. Methods: Eligible subjects were randomly included from participants of Tehran COPCORD study, of whom 480 subjects with knee osteoarthritis were compared to 490 subjects without (case-control study). Using a questionnaire developed by COPCORD group (Asia & Oceania), we enquired about the risk factors of knee osteoarthritis i.e. age, sex, BMI, Waist/Hip ratio, religion, ethnicity, education and smoking. Knee osteoarthritis was ... سال انتشار: 2009
 

For Peer Review Only Squatting, sitting on the floor, or cycling: are life-long daily activities risk factors for clinical knee osteoarthritis?

Authers: Dahaghin S. MD, PhD, Tehrani-Banihashemi SA. MD, MPH, Faezi, ST. MD, Jamshidi AR. MD, Prof Davatchi F, MD

Abstract: Objective: To evaluate the association between occupation, sport, life-long daily activities, and knee osteoarthritis. Method: We randomly recruited 480 subjects with knee osteoarthritis who had participated in an earlier community-based study (Tehran-COPCORD, stage-I); they were compared with 490 controls (case-control study). A questionnaire was used to record all occupations/sports, plus details of the following daily activities: standing, walking on flat ground, walking up/downhill, sitting on the floor, sitting on a chair, squatting, knee-bending, cycling, climbing stairs, and ... سال انتشار: 2009
 

Development of Rheumatology in Tehran University of Medical Sciences

Authers: Fereydoun Davatchi MD

Abstract: Rheumatology program at Tehran University was established by Fereydoun Davatchi in 1969. Later, Reza Moghtader, Firouz Panahi, and Amir-Khan Chafizadeh joined him. The first rheumatology outpatient clinic was founded in 1970. In 1974, the first rheumatology fellowship department was established along with a small research laboratory. The department expanded gradually to become the Rheumatology Research Center (RRC) in 1981. RRC was officially recognized in 1994 by the Ministry of Health and in 2001 as the Center of Excellence for Rheumatology in ... سال انتشار: 2009
 

The Comparison of Serum Zinc Level in Behcet Patients and Healthy Controls

Authers: Kamal Esalatmanesh MD, Ahmadreza Jamshidi MD, Farhad Shahram MD, Fereydoun Davatchi MD, Zahra Soleimani MD, Shohreh Movahedi MD*****, , Mansour Salesi MD, Mansoor Karimifar MD

Abstract: Zinc was suggested as an antioxidant and immunomodulator trace element in parallel with other trace elements and antioxidant enzymes. Recently selenium deficiency was indicated in Behcet disease. In this study, we evaluated the correlation of serum zinc level and Behcet disease. Background: In a cross-sectional, descriptive study serum level of zinc was measured in 49 cases satisfying International Study Group criteria and 51 controls. Serum zinc level was measured by atomic absorption spectrometry and compared the mean of serum ... سال انتشار: 2009