تالیفات

Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors  

Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors

مولف: Maryam Akhtari1 & Seyed Jalal Zargar1 & Mahdi Mahmoudi2 & Mahdi Vojdanian2 & Alireza Rezaeimanesh3 & Ahmadreza Jamshidi2

خلاصه: Macrophages play an important role in the ankylosing spondylitis (AS) auto-inflammatory responses and fibrocartilage destruction. Adenosine is a key modulator of inflammatory conditions. The various effects of adenosine are mediated by its interaction with adenosine receptors (AR). In this study, we investigated the mRNA expression ofA1, A2A, A2B, andA3 adenosine receptors, ectonucleoside triphosphate diphosphohydrolase-1 (CD39), and ecto-5′-nucleotidase (CD73) in the monocyte-derived macrophages from AS patients in comparison to healthy controls. We also explored the ... سال انتشار: 2018
 

Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients

مولف: J Karami1, M Mahmoudi2, A Amirzargar1, M Gharshasbi3, A Jamshidi2, S Aslani1, 2 and MH Nicknam1

خلاصه: Methylation of DNA is one of the important regulatory mechanisms of gene transcription. B-cell chronic lymphocytic leukemia/ lymphoma 11B (BCL11B) plays a key role in the development, proliferation, differentiation, and survival of T cells. The aim of this study was to evaluate promoter methylation of BCL11B gene and its mRNA level in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis (AS) patients in relation to healthy controls and evaluate their correlation with diseases ... سال انتشار: 2017
 

Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis

مولف: Fatemeh Abbasi1, Reza Mansouri1, Farhad Gharibdoost2, Saeed Aslani2, Shayan Mostafaei2, Hoda Kavosi2, Shiva Poursani2, Soheila Sobhani2, and Mahdi Mahmoudi2

خلاصه: CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex, and ethnic -matched healthy individuals. Genotyping of rs2056626 ... سال انتشار: 2017
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis

Authers: Parisa Momenzadeh1, 2 · Mahdi Mahmoudi2, 6 · Maani Beigy2, 3 · Masoud Garshasbi4 · Mahdi Vodjdanian2 · Ali Farazmand1, 5, 7 · Ahmad Reza Jamshidi2

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin, while both genetic and environmental factors have been demonstrated to be etiologically involved. Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis. This case–control study was performed on 349 unrelated AS patients and 469 age- and gender-matched healthy controls, ... سال انتشار: 2016
 

Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus

Authers: M Akhtari1, A Farazmand1, M Mahmoudi2, M Akbarian2, N Ahmadzadeh2, Z Mirkazemi2, S Mostafaei3 and AR Jamshidi

Abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE. Methods: The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reactionsequence specific ... سال انتشار: 2016
 

Association of STAT4 rs7574865 with Susceptibility to Systemic Lupus Erythematosus in Iranian Population

Authers: Sedigheh Mirkazemi, 1 Mahmoud Akbarian, 2 Ahmad Reza Jamshidi, 2 Reza Mansouri, 3 Shima Ghoroghi, 2 Yahya Salimi, 4 Zahra Tahmasebi, 2 and Mahdi Mahmoudi2, 5

Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic inheritance that affecting different organs and systems. STAT4 has been newly identified as a susceptible gene in the development of SLE. According to recent studies, STAT4 has been associated with SLE in various populations. We investigated whether STAT4 single nucleotide polymorphisms (SNPs) were associated with susceptibility and clinical features of SLE in Iranian patients. The study group comprised 280 patients with SLE and ... سال انتشار: 2013
 

Effect of HLA-B*27 and its Subtypes on Clinical Manifestations and Severity of Ankylosing Spondylitis in Iranian Patients

Authers: Sasan Fallahi1, 2, Mahdi Mahmoudi2, Mohammad Hossein Nicknam3, 5, Farhad Gharibdoost2, Elham Farhadi4, Azad Saei5, Keramat Nourijelyani6, Nooshin Ahmadzadeh2, and Ahmad Reza Jamshidi2

Abstract: The aim of this study was to assess the role of HLA-B*27 and it’s subtypes in determining severity and clinical manifestations of ankylosing spondylitis (AS). A total of 163 AS patients were assessed for clinical manifestations and severity using structured questionnaires. HLA-B*27 screening and B*27 sub-typing were performed by PCR. One hundred twenty two patients (74.8%) were B*27 positive. The male to female ratio, peripheral arthritis, steroid use, intense dorsal kyphosis and ... سال انتشار: 2013