تالیفات

 

M2000 (b-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

مولف: S. Aletaha*, L. Haddad†, M. Roozbehkia*, R. Bigdeli‡, §, V. Asgary*, M. Mahmoudi¶ & A. Mirshafiey*

خلاصه: To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As b- D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signalling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, ... سال انتشار: 2017
 

Validity and reliability of the Persian version of Behçet’s disease quality-of-life (BD-QoL) questionnaire: a cross-cultural adaptation

Authers: Mahdi Vojdanian, Seyedeh Tahereh Faezi, Alan Tennant, Ann W. Morgan, Pedram Paragomi, Mostafa Qorbani, Maryam Mattaji, et al.

Abstract: The Leeds Behçet’s disease quality-of-life (BDQoL) questionnaire is a specific and valid measure which is applied in English-speaking patients. We conducted Persian adaptation of BD-QoL questionnaire. Between June and December 2012, 220 Iranian patients fulfilling International Study Group criteria for the diagnosis of BD attending the rheumatology clinics at Tehran University of Medical Sciences were enrolled. Bilingual translators undertook the forward translation and cross-cultural adaptation of the BD-QoL questionnaire. Back-translation was conducted, and this version was sent to the designer ... سال انتشار: 2014
 

EVALUATION OF IL1- AND TNF- SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION

Authers: A. R. Rostamian*, , A. H. Naji, , F. Gharibdoost, , A. Khalvat, L., Jafari-Saraf, K. Saeedfar

Abstract: Abstract- Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-& (Interleukin 1&) and TNF- & (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-& and TNF- & in ... سال انتشار: 2007
 

SACROILIITIS IN BEHCET'S DISEASE, A RADIOLOGIC STUDY.

Authers: A. Nadji, F. Shahram, M. Shabani, A. Jamshidi, L. Shenavar, F. Davatchi

Abstract: Introduction: The association of Behcet's disease (BD) and ankylosing spondylitis (AS) is still a controversial subject. As the presence of sacroiliac joint (SIJ) involvement is an essential criterion in the diagnosis of AS, we decided to determine the prevalence of SIJ involvement in BD and compare it with control group. Materials & Methods: We selected randomly 199 BD patients and 168 non-­BD cases (CG), in a 12 month period (between April ... سال انتشار: 2001
 

Clinical Features of Behcet’s Disease in Children: A Collaborative Study of 86 cases.

Authers: I. Kone’-Paut, S. Yurdakul, S. Bahabri, N. Shafae, S. Ozen, H. Ozdogan, JL. Bernard

Abstract: We collected retrospectively clinical informations about a large series of 86 patients up to 16y of age, from 4 countries: Turquey (43), France (22), Saudi Arabia (11). Iran (10). All cases were first reviewed then 53 of them were selected according to the criteria of the International study group for BD. Statistical analysis: X2 square test and two tailed Fisher exact test. Descriptive data: males 45, females 41, sex ratio ... سال انتشار: 1996