تالیفات

 

New insights toward the pathogenesis of ankylosing ; genetic variations and epigenetic modifications

مولف: Mahdi Mahmoudi, Saeed Aslani, Mohammad Hossein Nicknam, Jafar Karami & Ahmad Reza Jamshidi

خلاصه: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2017
 

Epigenetic involvement in etiopathogenesis and implications in treatment of systemic lupus erythematous

مولف: Arron Munggela Foma1 • Saeed Aslani1, 2 • Jafar Karami2, 3 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

خلاصه: Abstract Background Recent researches in the field of genetics have extended our knowledge through the discovery of genetic factors associated with autoimmune diseases (AID). Genetics by itself, however, cannot elucidate all the uncertainties encountered in the etiopathology of AID. On the other hand, incomplete harmony in the prevalence of AID in identical twins suggests that non-genetic factors may play an important role in determining the disease susceptibility. Besides, epigenetics, which is defined by changes in gene expression without a corresponding change ... سال انتشار: 2017
 

STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

Authers: Zeinab Alizadeh a, b, Ali Farazmand b, Maassoomeh Akhlaghi a, *, Ahmad Reza Jamshidi a, Abtin Shahlaee a, Jafar Karami a, Elmira Shamsian a, Mahdi Mahmoudi

Abstract: The gene encoding signal transducer and activator of transcription 4 (STAT4) has been documented to be associated with rheumatoid arthritis (RA) in several populations. The aim of this study was to determine the association of the STAT4 gene polymorphism (rs7574865) with RA in the Iranian population. Methods: This study included 612 Iranian RA patients and 389 healthy control subjects. For all samples, DNA was genotyped for STAT4 G>T (rs7574865) polymorphism using the MGB TaqMan Allelic Discrimination ... سال انتشار: 2016
 

New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications

Authers: Mahdi Mahmoudi1*, Saeed Aslani1*, Mohammad Hossein Nicknam2, Jafar Karami1, and Ahmad Reza Jamshidi1

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted ... سال انتشار: 2016
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016