تالیفات

 

The association of pathergy reaction and active clinical presentations of Behçet’s disease

مولف: Shirin Assar1, Bahar Sadeghi2, Fereydoun Davatchi2, Seyyedeh Zahra Ghodsi2, Abdolhadi Nadji2, Farhad Shahram2, Farimah Ashofte2, Seyyedeh Roghieh Larimi2, Masoud Sadeghi3

خلاصه: Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet’s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR. Materials and methods: This was ... سال انتشار: 2017
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

مولف: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI

خلاصه: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2017
 

High-dose intravenous steroid pulse therapy in ocular involvement of Behcet’s disease: a pilot double-blind control study

مولف: Mastaneh MOHAMMADI, 1 Farhad SHAHRAM, 1 Hormoz SHAMS, 1, 2 Massoomeh AKHLAGHI, 1 Farimah ASHOFTEH1 and Fereydoun DAVATCHI1

خلاصه: Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet’s disease (BD). Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index ... سال انتشار: 2017
 

Behcet’s Disease: Epidemiology, Clinical Manifestations, and Diagnosis

مولف: Fereydoun Davatchi, Cheyda Chams-davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi & Mariam Masoumi

خلاصه: Introduction: Behcet’s Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral ... سال انتشار: 2017
 

Adult Behcet’s disease in Iran: analysis of 6075 patients

Authers: Fereydoun DAVATCHI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Bahar SADEGHI ABDOLLAHI, Farimah ASHOFTEH, Zahra GHODSI, Negin MOHTASHAM and Farhad SHAHRAM

Abstract: This is an analysis of adult Behcet’s disease (BD) in Iran, from the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%). Patients: Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet’s Disease (ICBD). Adult BDs were patients who had their first ... سال انتشار: 2016
 

25 Years Old Women With Inflammatory Low Back Pain

Authers: Zahra Soltani and Fereydoun Davatchi

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological type of malignant lymphomas (approximately 30% of cases). DLBCL is highly curable through chemotherapy. Rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy as the most frequent of care for first - DLBCL therapy, improves long-term survival of patients effectively. Case report: A young female (25 years old) complained about pain in her right back for two years. She was suffering from backache with ... سال انتشار: 2016
 

WHO-ILAR COPCORD study (stage 1, urban study) in Sanandaj, Iran

Authers: Nasrin Moghimi & Fereydoun Davatchi & Ezat Rahimi & Afshin Saidi & Naser Rashadmanesh & Solmaz Moghimi & Hoshyar Ghafori & Peiman Zandi & Negin Ahmadi & Hamed Ghafori & Mohsen Moghimi & Marjan hajiheshmati

Abstract: This study aims to conduct an urban Community Oriented Program for Control Of Rheumatic Diseases (COPCORD) study in Sanandaj (Kurdistan, Iran). Sanandaj with a population of 311,446 (2006 census), Caucasian of Kurdish subgroup, was selected as the field. Sanandaj was divided into 100 clusters and subjects were randomly selected from them (50 subjects from each cluster). The COPCORD study started on July 2011 and ended on June 2012. Of the households, 1,631 was visited and 5,830 persons were interviewed. ... سال انتشار: 2015
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... سال انتشار: 2015
 

Prospective study of articular manifestations in Behcet’s disease: five-year report

Authers: Alimohammad FATEMI, 1, 2 Farhad SHAHRAM, 2 Massoomeh AKHLAGHI, 2 Abbas SMILEY, 3 Abdolhadi NADJI2 and Fereydoun DAVATCHI2

Abstract: Aim: To evaluate different aspects of articular involvements (prevalence, types, relation to extra-articular manifestations, etc.) in Iranian patients with Behcet’s disease (BD). Methods: In a prospective study, all patients with BD attending an outpatient BD clinic were enrolled. The type of articular involvements (peripheral or axial), involved joints, duration of attacks and their relation to extraarticular manifestations, human leukocyte antigen (HLA)-B5 and HLA-B27 were evaluated. Data analysis was done by using descriptive statistical indices such ... سال انتشار: 2015
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

Vitamin D deficiency in patients with Behcet’s disease

Authers: Seyedeh Tahereh Faezi*, Narges Ansari, Pedram Paragomi, Maassoumeh Akhlaghi, Majid Ghanavat and Fereydoun Davatchi

Abstract: Background: Behcet’s disease is an autoimmune, recurrent and multisystem disease. Vitamin D has immunomodulator role in immune system. So that vitamin D deficiency was reported in some autoimmune diseases. Behcet’s disease as a Silk Road disease is common in Iran. The aim of this study was to detect the serum level of 25(OH) vitamin D in Behcet’s patients and control group. Methods: In this case–control study, 112 Behcet’s patients as cases group and 112 ... سال انتشار: 2014
 

The relationship between plasma homocysteine level and HLA-B51 in patients with Behcet’s disease: a case-control study

Authers: Soraya SHADMANFAR, 1, 2 Farhad SHAHRAM, 2 Abdolhadi NADJI, 2 Maassoumeh AKHLAGHI, 2 Seyedeh T. FAEZI, 2 Bahar SADEGHI-ABDOLLAHI, 2 Alireza FARIDAR, 2 Nima MADANCHI3 and Fereydoun DAVATCHI2

Abstract: Background: Various coagulation disorders have been reported to explain hypercoagulability state in Behcet’s disease (BD). A possible negative association between human leukocyte antigen (HLA)-B51 and increased homocysteine level has been suggested in a previous report from Iranian patients with BD. The aim of this study was to find any possible relationship between plasma homocysteine levels and HLA-B51. Methods: In a case-control study, BD patients (fulfilling the new International Criteria for BD) and controls (who had ... سال انتشار: 2014
 

Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study

Authers: Arash TEHRANI-BANIHASHEMI, 1, 2 Fereydoun DAVATCHI, 1 Ahmad-Reza JAMSHIDI, 1 Tahereh FAEZI, 1 Pedram PARAGOMI1 and Mozhgan BARGHAMDI

Abstract: Aim: To estimate the prevalence of osteoarthritis (OA) of different joints in rural areas of Iran. Methods: From five villages of Tuyserkan County, 1565 individuals were randomly selected and were interviewed to complete the Community Oriented Programme for Control of the Rheumatic Diseases (COPCORD) Core Questionnaire. Among these cases 1192 cases with rheumatic complaints were examined by a rheumatologist and laboratory and radiology tests were performed if necessary for the diagnosis. Definition of OA ... سال انتشار: 2014
 

Genital aphthosis in Behçet’s disease: Is it associated with less eye involvement?

Authers: Seyedeh Tahereh Faezi · Cheyda Chams‑Davatchi · S. Zahra Ghodsi · Farhad Shahram · Abdolhadi Nadji · Massoomeh Akhlaghi · Kamran Moradi · Pedram Paragomi · Golnaz Ghazizadeh Esslami · Bahar Sadeghi Abdollahi · Farimah Ashofteh · Fereydoun Davatchi

Abstract: Behçet’s disease (BD) is a multisystem disease classified among the vasculitides with various clinical features. Genital aphthosis (GA) is one of the major manifestations of BD. The aim of this study was to evaluate the characteristics of BD patients with GA. A cross-sectional sample of BD patients registered in 37 years was selected. We determined clinical and laboratory features of BD patients with GA (GA cases) and compared them with the patients who never developed GA (non-GA cases). The ... سال انتشار: 2014
 

Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet’s disease: longitudinal study of up to 10 years

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Farimah ASHOFTEH and Negin MOHTASHAM

Abstract: Aim: Ocular lesions of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Retinal vasculitis is the most aggressive lesion of ocular manifestations and predicts a worse systemic outcome. We present here the outcome with a combination of pulse cyclophosphamide, azathioprine and prednisolone, on long-term usage, up to 10 years, on 295 patients (18 493 eye-months of ... سال انتشار: 2014
 

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Authers: Seyedeh Tahereh FAEZI, Mahdieh HOSSEINI ALMODARRESI, Mahmood AKBARIAN, Farhad GHARIBDOOST, Masoumeh AKHLAGHI, Ahamadreza JAMSHIDI, Farhad SHAHRAM, Abdolhadi NADJI, Nahid SHAFAIE, Maryam AKHLAGHKHAH, Pedram PARAGOMI and Fereydoun DAVATCHI

Abstract: Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports. Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients ... سال انتشار: 2014
 

Behcet’s disease

Authers: Fereydoun DAVATCHI1, 2, 3, 4

Abstract: neurological manifestations and positive pathergy tests each get one point. Oral aphthosis, genital aphthosis and ocular lesions each get two points. To be classified/ diagnosed as BD, a patient has to get four points (or more). Behcet’s disease manifestations are self-limiting, but recurrent. Some heal without a sequelae, but others are the main cause of morbidity, such as ophthalmological manifestations which may cause blindness if not aggressively treated. Some may cause mortality, as in some of the vascular, neurological, cardiac ... سال انتشار: 2014
 

IL10 low-frequency variants in Behcet’s disease patients

Authers: Mafalda MATOS, 1, 2 Joana M. XAVIER, 1, 2 Patrıcia ABRANTES, 1, 2 In^es SOUSA, 1, 2 Nadia REI, 1, 2 Fereydoun DAVATCHI, 3 Farhad SHAHRAM, 3 Gorete JESUS, 4 Filipe BARCELOS, 5 Joana VEDES, 6 Manuel SALGADO, 7

Abstract: Aim: To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behcet’s disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility. Methods: To identify IL10 low-frequency variants, a discovery group of 50 Portuguese BD ... سال انتشار: 2014
 

Iron deficiency state in resistant oral aphthosis of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: Aim: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics ... سال انتشار: 2014
 

The perspectives of iranian physicians and patients towards patient decision aids: a qualitative study

Authers: Hamideh Rashidian1, 2, Saharnaz Nedjat2, 3*, Reza Majdzadeh2, 3, Jaleh Gholami3, Leila Haghjou3, Bahar Sadeghi Abdollahi4, Fereydoun Davatchi4 and Arash Rashidian3, 5

Abstract: Patient preference is one of the main components of clinical decision making, therefore leading to the development of patient decision aids. The goal of this study was to describe physicians’ and patients’ viewpoints on the barriers and limitations of using patient decision aids in Iran, their proposed solutions, and, the benefits of using these tools. Methods: This qualitative study was conducted in 2011 in Iran by holding in-depth interviews with 14 physicians and 8 arthritis ... سال انتشار: 2013
 

Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet’s disease

Authers: Fereydoun Davatchi • Bahar Sadeghi Abdollahi • Cheyda Chams-Davatchi • Farhad Shahram • Zahra Ghodsi • Abdolhadi Nadji • Massoomeh Akhlaghi • Tahereh Faezi • Hormoz Shams • Roghieh Larimi • Farima Ashofteh

Abstract: The only diagnostic test that currently exists for Behcet’s disease (BD) is the pathergy test. A positive pathergy test (PPT) is an important component of many of the 16 sets of classification/diagnosis criteria used to diagnose BD. The aim of this study was to determine the importance of a PTT in the performance of the diagnosis/ classification criteria for BD. Patients and methods All patients listed in the BD registry of the Rheumatology Research Center, Tehran (6,727) and 4,648 ... سال انتشار: 2013
 

Gene expression profiling and association studies implicate the neuregulin signaling pathway in Behçet's disease susceptibility

Authers: Joana M. Xavier & Tiago Krug & Fereydoun Davatchi & Farhad Shahram & Benedita V. Fonseca & Gorete Jesus & Filipe Barcelos & Joana Vedes & Manuel Salgado & Bahar Sadeghi Abdollahi & Abdolhadi Nadji & Maria Francisca Moraes-Fontes & Niloofar Mojarad Shafiee

Abstract: Behçet's disease (BD) is a complex disease with genetic and environmental risk factors implicated in its etiology; however, its pathophysiology is poorly understood. To decipher BD's genetic underpinnings, we combined gene expression profiling with pathway analysis and association studies. We compared the gene expression profiles in peripheral blood mononuclear cells (PBMCs) of 15 patients and 14 matched controls using Affymetrix microarrays and found that the neuregulin signaling pathway was over-represented among the differentially expressed genes. The Epiregulin (EREG), Amphiregulin (AREG), ... سال انتشار: 2013
 

Clinical features of Behcet ’ s disease in patients without oral aphthosis

Authers: Seyedeh Tahereh Faezi 1 , Pedram Paragomi 1 , Farhad Shahram 1 , Hormoz Shams 2 , Cheida Shams-Davatchi 3 , Zahra Ghodsi 3 , Abdolhadi Nadji 1 , Maassoumeh Akhlaghi 1 , and Fereydoun Davatchi 1

Abstract: In current study we evaluated clinical features of Behcet ’ s Disease (BD) in patients without oral aphthosis (NOA cases). Methods. In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer ’ s exact test. Results. Among 6821 BD patients, 175 patients (2.56%) ... سال انتشار: 2013
 

Iron deficiency state in resistant oral aphthous of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics of ... سال انتشار: 2013
 

Mesenchymal stem cell therapy unable to rescue the vision from advanced Behcet’s disease retinal vasculitis: report of three patients

Authers: Fereydoun DAVATCHI, 1 Behrooz NIKBIN, 2 Hormoz SHAMS, 1 Bahar SADEGHI ABDOLLAHI, 1 Mandana MOHYEDDIN2 and Farhad SHAHRAM1

Abstract: Retinal vasculitis (RV) is the most aggressive lesion of ocular manifestations of Behcet’s disease, seen in 32.1% of patients. Although visual acuity (VA) improves with early and aggressive treatment, in the long run it is seen in only 48% of patients. Mesenchymal stem cell (MSC) transplantation (MSCT) can theoretically reverse the RV process. Patients and Methods: Three patients with advanced RV and very low VA were selected. Eyes selected for MSCT were legally blind (no ... سال انتشار: 2013
 

Methotrexate in ocular manifestations of Behcet’s disease: a longitudinal study up to 15 years

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Tahereh FAEZI, Massoomeh AKHLAGHI and Farimah ASHOFTEH

Abstract: Ocular manifestations of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Methotrexate is the least toxic, used mainly for posterior uveitis. We present here the outcome of eye lesions with methotrexate and prednisolone, in a longitudinal study of up to 15 years, on 682 patients (5447 eye-years of follow-up). Patients and methods: Methotrexate was started at ... سال انتشار: 2013
 

The efficacy of Back School on chronic low back pain of workers of a pharmaceutical company in a Tehran Suburb. COPCORD stage II study

Authers: Bahar SADEGHI-ABDOLLAHI, Anita ESHAGHI, Siavash Nejad HOSSEINI, Mojgan GHAHREMANI and Fereydoun DAVATCHI

Abstract: Low back pain (LBP) is the second most frequent reason for seeking medical advice. Various treatments are proposed from no intervention, to analgesics, rest, exercises, local interventions and surgical procedures. Results and outcomes are differently reported. Back School (BS), a combination of patient education and physical exercises, seems to have good results. The aim of this study was to check the effect of BS in factory workers. Patients and Methods: All (70) workers were interviewed ... سال انتشار: 2012
 

Quality-of-Life Measurement in Blistering Diseases

Authers: Deshan F. Sebaratnam, MBBS (Hons)a, b, 1, John W. Frew, MBBS (Hons), MMed (Clin Epi)a, b, 1, Fereydoun Davatchi, MDc, Dédée F. Murrell, MA, BMBCh, FAAD, MD, FACDd, *

Abstract: Quality of life (QOL) has been defined as “the individual’s perception of their position in life, in the context of the cultural and value systems in which they live and in relation to their goals, expectations, standards and concerns.”1 It is an abstract multidimensional construct reflecting the physical, psychological, and social aspects of an individual’s condition complementing the concept of health as “a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.”2 ... سال انتشار: 2012
 

Performance of the 2010 rheumatoid arthritis classification criteria

Authers: Fereydoun DAVATCHI, 1 Iraj SALEHI ABARI, 1 Soosan SOROOSH, 2 Mohsen SOROOSH2 and Bahar SADEGHI ABDOLLAHI1

Abstract: Rheumatoid arthritis (RA) needs early treatment to improve clinical outcome by reducing joint damage, radiographic progression and disability. The aim of this study was to evaluate the 2010 Rheumatoid Arthritis Classification Criteria for its ability to classify RA patients, in their early stages, not exceeding 12 months of disease progression. Methods: Rheumatoid arthritis (RA) patients were selected from August to December 2010, among those coming for their follow-up. The inclusion criteria were patients with not ... سال انتشار: 2012
 

Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behc¸et’sDisease

Authers: Rachel Black, 1 Sue Lester, 1 Emma Dunstan, 1 Farhad Shahram, 2 Abdolhadi Nadji, 2 Noushin Bayat, 2, 3 Kayvan Saeedfar, 2, 4 Naghmeh Ziaei, 2 Catherine Hill, 1, 5 Maureen Rischmueller, 1, 5 and Fereydoun Davatchi2

Abstract: Behc¸et’s disease (BD) is an immune-mediated systemic vasculitis associated with HLAB51. Other gene associations are likely and may provide further insight into the pathogenesis of this disease. Fc-gamma receptors play an important role in regulating immune function. Copy number variation (CNV) of the Fc-gamma receptor 3B (FCGR3B) gene is associated with other inflammatory conditions and may also play a role in BD. The aim of this study was to determine whether CNV of ... سال انتشار: 2012