تالیفات

 

High-dose intravenous steroid pulse therapy in ocular involvement of Behcet’s disease: a pilot double-blind control study

مولف: Mastaneh MOHAMMADI, 1 Farhad SHAHRAM, 1 Hormoz SHAMS, 1, 2 Massoomeh AKHLAGHI, 1 Farimah ASHOFTEH1 and Fereydoun DAVATCHI1

خلاصه: Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet’s disease (BD). Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index ... سال انتشار: 2017
 

Behcet’s Disease: Epidemiology, Clinical Manifestations, and Diagnosis

مولف: Fereydoun Davatchi, Cheyda Chams-davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi & Mariam Masoumi

خلاصه: Introduction: Behcet’s Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral ... سال انتشار: 2017
 

Adult Behcet’s disease in Iran: analysis of 6075 patients

Authers: Fereydoun DAVATCHI, Cheyda CHAMS-DAVATCHI, Hormoz SHAMS, Abdolhadi NADJI, Tahereh FAEZI, Massoomeh AKHLAGHI, Bahar SADEGHI ABDOLLAHI, Farimah ASHOFTEH, Zahra GHODSI, Negin MOHTASHAM and Farhad SHAHRAM

Abstract: This is an analysis of adult Behcet’s disease (BD) in Iran, from the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%). Patients: Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet’s Disease (ICBD). Adult BDs were patients who had their first ... سال انتشار: 2016
 

Validation of the revised International Criteria for Behcet’s Disease (ICBD) in Iran

Authers: Fereydoun Davatchi & Bahar Sadeghi Abdollahi & Cheyda Chams-Davatchi & Farhad Shahram & Abdolhadi Nadji & Hormoz Shams & Tahereh Faezi & Massoomeh Akhlaghi & Farimah Ashofteh & Maryam Mataji & Kamran Moradi & Negin Mohtasham

Abstract: The first internationally agreed criteria for Behcet’s disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet’s Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet’s Disease (rICBD) in Iran. In this study, the ISG ... سال انتشار: 2015
 

Genital aphthosis in Behçet’s disease: Is it associated with less eye involvement?

Authers: Seyedeh Tahereh Faezi · Cheyda Chams‑Davatchi · S. Zahra Ghodsi · Farhad Shahram · Abdolhadi Nadji · Massoomeh Akhlaghi · Kamran Moradi · Pedram Paragomi · Golnaz Ghazizadeh Esslami · Bahar Sadeghi Abdollahi · Farimah Ashofteh · Fereydoun Davatchi

Abstract: Behçet’s disease (BD) is a multisystem disease classified among the vasculitides with various clinical features. Genital aphthosis (GA) is one of the major manifestations of BD. The aim of this study was to evaluate the characteristics of BD patients with GA. A cross-sectional sample of BD patients registered in 37 years was selected. We determined clinical and laboratory features of BD patients with GA (GA cases) and compared them with the patients who never developed GA (non-GA cases). The ... سال انتشار: 2014
 

Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet’s disease: longitudinal study of up to 10 years

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Tahereh FAEZI, Massoomeh AKHLAGHI, Zahra GHODSI, Farimah ASHOFTEH and Negin MOHTASHAM

Abstract: Aim: Ocular lesions of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Retinal vasculitis is the most aggressive lesion of ocular manifestations and predicts a worse systemic outcome. We present here the outcome with a combination of pulse cyclophosphamide, azathioprine and prednisolone, on long-term usage, up to 10 years, on 295 patients (18 493 eye-months of ... سال انتشار: 2014
 

Methotrexate in ocular manifestations of Behcet’s disease: a longitudinal study up to 15 years

Authers: Fereydoun DAVATCHI, Hormoz SHAMS, Farhad SHAHRAM, Abdolhadi NADJI, Cheyda CHAMS-DAVATCHI, Bahar SADEGHI ABDOLLAHI, Tahereh FAEZI, Massoomeh AKHLAGHI and Farimah ASHOFTEH

Abstract: Ocular manifestations of Behcet’s disease (BD) need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents and the first line treatment. Methotrexate is the least toxic, used mainly for posterior uveitis. We present here the outcome of eye lesions with methotrexate and prednisolone, in a longitudinal study of up to 15 years, on 682 patients (5447 eye-years of follow-up). Patients and methods: Methotrexate was started at ... سال انتشار: 2013