تالیفات

 

Downregulation of Autophagy-Related Genes in Macrophages From Patients With Behcet’s Disease

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Farhad Shahram1*, Shayan Mostafaei1, Maassoomeh Akhlaghi1, Soheila Sobhani1, Mahdi Mahmoudi1*

خلاصه: Objective: Overwhelming inflammatory chemokines and cytokines characterize the immunological profile and inflammatory settings of Behcet disease (BD). The connection between autophagy-related genes (ATGs) and various perspectives of innate and adaptive immunobiology such as antigen presentation, immune tolerance, lymphocyte development and differentiation, cytokine signaling, and inflammation have been implicated. The aim of this study was to evaluate the mRNA expression profile of ATGs in macrophages of patients with BD. Materials and Methods: ... سال انتشار: 2018
 

Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

مولف: Mohammadtaghi Palizgir, 1 Mahdi Mahmoudi, 1 Mostafa Qorbani, 2 Shirin Djalalinia, 3 Shayan Mostafaei, 4 and Farhad Shahram1, *

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA ... سال انتشار: 2017
 

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA

مولف: Mohammad Taghi Palizgir1, Maryam Akhtari1, 2, Mahdi Mahmoudi1, Shayan Mostafaei1, Alireza Rezaeimanesh3, Massoomeh Akhlaghi1, and Farhad Shahram1

خلاصه: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients ... سال انتشار: 2017
 

High-dose intravenous steroid pulse therapy in ocular involvement of Behcet’s disease: a pilot double-blind control study

مولف: Mastaneh MOHAMMADI, 1 Farhad SHAHRAM, 1 Hormoz SHAMS, 1, 2 Massoomeh AKHLAGHI, 1 Farimah ASHOFTEH1 and Fereydoun DAVATCHI1

خلاصه: Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet’s disease (BD). Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index ... سال انتشار: 2017
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Headache in Behcet’s disease: types and characteristics

Authers: Maryam Moghaddassi1, Mansoureh Togha2, 3*, Farhad Shahram1, Hamed Hanif4, Sahar Dadkhah5, Soodeh Razeghi Jahromi6 and Mohammad Mozafari2

Abstract: Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet’s disease is relatively high in Iran, this study was carried out to ... سال انتشار: 2016
 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

Osteoporosis in Patients with Pemphigus Vulgaris before Steroid Therapy

Authers: S. Zahra Ghodsi1, 2, Farhad Shahram2, Maryam Daneshpazhooh1, Azam Saadatfar1, and Cheyda Chams-Davatchi1,

Abstract: Pemphigus Vulgaris (PV) is often complicated by osteoporosis. Although corticosteroid therapy undoubtedly plays a causative role, inflammation associated with PV may also contribute to osteoporosis. This study was designed to determine the prevalence of osteoporosis in patients with PV before corticosteroid therapy and to compare these findings with those reported previously in healthy volunteers. Newly diagnosed patients with PV who had not received systemic corticosteroids were enrolled. Bone mineral density (BMD) was measured both in ... سال انتشار: 2014
 

Iron deficiency state in resistant oral aphthosis of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: Aim: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics ... سال انتشار: 2014
 

Scientometric analysis and mapping of scientific articles on Behcet’s disease

Authers: Farhad SHAHRAM, 1 Ahmad-Reza JAMSHIDI, 1 Armin HIRBOD-MOBARAKEH, 2, 3 Gholamreza HABIBI, 4 Amir MARDANI4 and Marjan GHAEMI4

Abstract: Behcet’s disease (BD) is a systemic vasculitis disease with oral and genital aphthous ulceration, uveitis, skin manifestations, arthritis and neurological involvement. Many investigators have published articles on BD in the last two decades since introduction of diagnosis criteria by the International Study Group for Behcet’s Disease in 1990. However, there is no scientometric analysis available for this increasing amount of literature. Methods: A scientometric analysis method was used to achieve a view of scientific articles ... سال انتشار: 2013
 

Clinical features of Behcet ’ s disease in patients without oral aphthosis

Authers: Seyedeh Tahereh Faezi 1 , Pedram Paragomi 1 , Farhad Shahram 1 , Hormoz Shams 2 , Cheida Shams-Davatchi 3 , Zahra Ghodsi 3 , Abdolhadi Nadji 1 , Maassoumeh Akhlaghi 1 , and Fereydoun Davatchi 1

Abstract: In current study we evaluated clinical features of Behcet ’ s Disease (BD) in patients without oral aphthosis (NOA cases). Methods. In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer ’ s exact test. Results. Among 6821 BD patients, 175 patients (2.56%) ... سال انتشار: 2013
 

Iron deficiency state in resistant oral aphthous of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics of ... سال انتشار: 2013
 

Mesenchymal stem cell therapy unable to rescue the vision from advanced Behcet’s disease retinal vasculitis: report of three patients

Authers: Fereydoun DAVATCHI, 1 Behrooz NIKBIN, 2 Hormoz SHAMS, 1 Bahar SADEGHI ABDOLLAHI, 1 Mandana MOHYEDDIN2 and Farhad SHAHRAM1

Abstract: Retinal vasculitis (RV) is the most aggressive lesion of ocular manifestations of Behcet’s disease, seen in 32.1% of patients. Although visual acuity (VA) improves with early and aggressive treatment, in the long run it is seen in only 48% of patients. Mesenchymal stem cell (MSC) transplantation (MSCT) can theoretically reverse the RV process. Patients and Methods: Three patients with advanced RV and very low VA were selected. Eyes selected for MSCT were legally blind (no ... سال انتشار: 2013
 

Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behc¸et’sDisease

Authers: Rachel Black, 1 Sue Lester, 1 Emma Dunstan, 1 Farhad Shahram, 2 Abdolhadi Nadji, 2 Noushin Bayat, 2, 3 Kayvan Saeedfar, 2, 4 Naghmeh Ziaei, 2 Catherine Hill, 1, 5 Maureen Rischmueller, 1, 5 and Fereydoun Davatchi2

Abstract: Behc¸et’s disease (BD) is an immune-mediated systemic vasculitis associated with HLAB51. Other gene associations are likely and may provide further insight into the pathogenesis of this disease. Fc-gamma receptors play an important role in regulating immune function. Copy number variation (CNV) of the Fc-gamma receptor 3B (FCGR3B) gene is associated with other inflammatory conditions and may also play a role in BD. The aim of this study was to determine whether CNV of ... سال انتشار: 2012
 

Association Study of IL10 and IL23R–IL12RB2 in Iranian Patients With Behc¸et’s Disease

Authers: Joana M. Xavier, 1 Farhad Shahram, 2 Fereydoun Davatchi, 2 Alexandra Rosa, 3 Jorge Crespo, 4 Bahar Sadeghi Abdollahi, 2 Abdolhadi Nadji, 2 Gorete Jesus, 5 Filipe Barcelos, 6 Jose´ Vaz Patto, 6 Niloofar Mojarad Shafiee, 2 Fahmida Ghaderibarim, 2 and Sofia A. Oliveira1

Abstract: Independent replication of the findings from genome-wide association studies (GWAS) remains the gold standard for results validation. Our aim was to test the association of Behc¸et’s disease (BD) with the interleukin-10 gene (IL10) and the IL-23 receptor–IL-12 receptor 2 (IL23R–IL12RB2) locus, each of which has been previously identified as a risk factor for BD in 2 different GWAS. Methods. Six haplotype-tagging single-nucleotide polymorphisms (SNPs) in IL10 and 42 in IL23R–IL12RB2 were genotyped in 973 Iranian patients with BD and 637 non-BD ... سال انتشار: 2012
 

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

Authers: Fereydoun DAVATCHI, Bahar SADEGHI ABDOLLAHI, Mandana MOHYEDDIN, Farhad SHAHRAM1, Behrooz NIKBIN

Abstract: Background: Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells (MSCs) due to their multi-lineage potential, immunosuppressive activities, limited immunogenicity and relative ease of growth in culture, have attracted attentions for clinical use. Aim: The aim of ... سال انتشار: 2011
 

Plasma Homocysteine Level in Patients with Behcet’s Disease with or without Thrombosis

Authers: Farhad Shahram MD, Alireza Faridar MD1, Mohammad Ghaffari Hamedani MD, Abdolhadi Nadji MD1, Nassim Naderi MD, Niloofar Mojarad Shaee BS, Johannes J. Rasker MD, Fereydoun Davatchi MD

Abstract: Aim: To nd the possible role of plasma homocysteine level as a contributing factor in venous and arterial thrombosis in patients with Behcet’s disease (BD). Methods: In a case control study, two groups of BD patients were included: 47 with thrombosis and 49 without thrombosis. All patients fullled the International Study Group Criteria for BD and the conrming diagnostic procedures for vascular thrombosis were either Doppler sonography or angiography. Forty-nine controls were selected by ... سال انتشار: 2010
 

Effect of conjugated linoleic acid, vitamin E and their combination on lipid profi les and blood pressure of Iranian adults with active rheumatoid arthritis

Authers: Naheed Aryaeian1, Farhad Shahram2, Mahmoud Djalali1, Mohammad R Eshragian, Abolghasem Djazayeri, Abdolfatah Sarrafnejad, Nasim Naderi, Maryam Chamari, Fariha Fatehi, Mahnaz Zarei

Abstract: Abstract: The aim of this study was to assess the impact of conjugated linoleic acids (CLAs), vitamin E, and combination of these nutrients on serum lipid profi les and blood pressure (BP) in patients with active rheumatoid arthritis (RA). In a randomized, double-blind, placebo-controlled trial, 87 patients with active RA were divided into four groups receiving one of the following daily supplements for three months: Group C: CLAs 2.5 g equivalent to 2 g ... سال انتشار: 2009