تالیفات

 

Downregulation of Aquaporin3 in Systemic Sclerosis Dermal Fibroblasts

مولف: Bahman Yousefi1, 2, Mahdi Mahmoudi1, Abdolfattah Sarafnejad2, Elham Karimizadeh1, Elham Farhadi3, Ahmad Reza Jamshidi1, Hoda Kavosi1, Saeed Aslani1, and Farhad Gharibdoost1

خلاصه: Skin dryness and thickening are hallmarks of systemic sclerosis (SSc) disease. Aquaporins (AQPs) are plasma membrane proteins that transport glycerol and water, resulting in water retention and skin hydration. Expression of AQPs has been evaluated in human normal skin. However, expression of these proteins in SSc dermal fibroblasts has not yet been reported. The aim of this study was to assess the expression profile of AQPs in dermal fibroblasts of ... سال انتشار: 2017
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

مولف: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

خلاصه: Juvenile idiopathic arthritis (JIA) which consists of a heterogeneous group of chronic disorders (e.g., oligoarthritis, polyarthritis, and systemic arthritis) is an autoimmune, noninfectious inflammation of joints’ synovial membrane and connective tissues that lastsmore than 6 weeks [1, 2].The disorder has been identified all over the world in nearly all races and ethnicities with an average prevalence rate of 1 to 2 per 1,000 children [3]. Some children may experience JIA symptoms for only a few months while others ... سال انتشار: 2017
 

Association Study of MECP2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients from Iran

مولف: Mahdi Mahmoudi, Saeed Aslani, Elham Hamzeh, Vahid Ziaee, Shiva Poursani, Mohammad Hossein Nicknam & Nima Rezaei

خلاصه: Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a multigenic autoimmune disorder. Polymorphisms of MECP2 gene have been reported to increase the risk of adult-onset SLE. In this study, we aimed to analyze if MECP2 gene polymorphisms could impress the proneness to JSLE in Iranian population. Material and Methods: Polymorphisms of MECP2 gene were genotyped in 50 Iranian JSLE patients and 426 matched healthy controls employing the real-time PCR allelic discrimination technique. Results: None of the alleles and ... سال انتشار: 2017
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder

Authers: Amir Hossein Memari, 1 Elham Chamanara, 2 Vahid Ziaee, 3, 4 Ramin Kordi, 1, 5 and Seyed-Reza Raeeskarami4, 6

Abstract: Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA.Atotal of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range ... سال انتشار: 2016
 

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis

Authers: Mahdi Mahmoudi1, Ahmad Reza Jamshidi1, Jafar Karami1, 2, Alireza Mohseni3, Ali Akbar Amirzargar2, 4, Elham Farhadi5, Nooshin Ahmadzadeh1, and Mohammad Hossein Nicknam2, 4

Abstract: Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy ... سال انتشار: 2016
 

Gender differences in Iranian patients with ankylosing spondylitis

Authers: Abtin Shahlaee & Mahdi Mahmoudi & Mohammad Hossein Nicknam & Elham Farhadi & Sasan Fallahi & Ahmad Reza Jamshidi

Abstract: Abstract Inequalities in features and severity of ankylosing spondylitis (AS) have been noticed between men and women, suggesting a possible influence of gender on disease phenotypes. Comparing disease features and characterization of gender differences in clinical features and medications could help elucidate the potential influence of gender on the severity of AS in patients. This study aims to assess the influence of gender on disease patterns in Iranian patients with AS. Three hundred and twenty patients diagnosed with ... سال انتشار: 2015
 

c-Abl silencing reduced the inhibitory effects of TGF-b1 on apoptosis in systemic sclerosis dermal fibroblasts

مولف: Elham Karimizadeh1 • Farhad Gharibdoost2 • Nasrin Motamed1 • Saeideh Jafarinejad-Farsangi1 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

خلاصه: It is generally accepted that the apoptosis of myofibroblasts is a crucial event in the normal wound healing. Delay in myofibroblasts apoptosis results in fibrotic diseases such as systemic sclerosis (SSc). Transforming growth factor-b1 (TGF-b1) is an important cytokine to induce fibroblasts differentiation into myofibroblasts. Cellular Abelson (c-Abl) is known as a TGF-b1- modulating molecule in fibrosis. The role of c-Abl, TGFb1, and their interaction in SSc myofibroblasts apoptosis has not yet been fully explored. The aim of this ... سال انتشار: 2015
 

RAC1 single nucleotide polymor-phisms in Crohn’s disease

Authers: Mohammad TaheraNasser Ebrahimi DaryaniaMona HedayatbMohammad EslamianaElham Farhadic, dMahdi MahmoudieSamira ShirzadfMohammd Kazem Nouri TaromlouaMeghedi ChaharmahaligMohammad Hossein NicknamcMohammad BashashatihNima

Abstract: diseaseRac1 is a regulator for cellular motility, proliferation andtransformation. A recent showed that mutations of RAC1gene are associated with higher risk of inflammatory boweldisease (IBD). These mutations increase the expression ofRac1 protein and intriguingly, loss of Rac1 expression resultsin protection from colitis [1,2].Thus we conducted a case-control study on 67 patientswith Crohn’s disease (CD) and 78 healthy individuals toidentify whether there is any association between CD andsingle nucleotide polymorphisms (SNPs) ... سال انتشار: 2014
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... سال انتشار: 2014
 

Systemic sclerosis: comparison of efficacy of oral cyclophosphamide and azathioprine on skin score and pulmonary involvement—a retrospective study

Authers: Hadi Poormoghim · Nader Rezaei · Zeinab Sheidaie · Ali Reza Almasi · Maziar Moradi‑Lakeh · Simin Almasi · Elham Andalib

Abstract: Abstract T he aim of this study was to evaluate efficacy of azathioprine (AZA) and cyclophosphamide (CYC) as a therapeutic regimen for interstitial lung disease associated with systemic sclerosis (SSc). Thirty-six selected patients included in this retrospective cohort and received one of the two drugs; the first group consists of 15 patients who were treated with AZA (1.5–2 mg/kg/day) and the second group with 21 patients received oral CYC (up to 2 mg/kg/day). Both groups received additional low ... سال انتشار: 2014
 

Attenuation of fibrosis with selective inhibition of c-Abl by siRNA in systemic sclerosis dermal fibroblasts

Authers: Elham Karimizadeh • Nasrin Motamed • Mahdi Mahmoudi • Saeideh Jafarinejad-Farsangi • Ahmadreza Jamshidi • Habibeh Faridani • Farhad Gharibdoost

Abstract: Cellular abelson (c-Abl), a non-receptor tyrosine kinase, is an important molecule in the pathogenesis of systemic sclerosis. There have been reports of beneficial effects of pharmacological tyrosine kinase inhibitors, such as imatinib mesylate, on fibrosis. However, these inhibitors affect multiple tyrosine kinases including c-Abl, c-kit, and platelet-derived growth factor receptor. The effects of selective inhibition of c-Abl using small interfering RNA (siRNA) on dermal fibrosis have not yet been explored. The aim of this study is to evaluate whether ... سال انتشار: 2014
 

Systemic sclerosis: demographic, clinical and serological features in 100 Iranian patients

Authers: Hadi Poormoghim • Alireza Salek Moghadam • Maziar Moradi-Lakeh • Mehrzad Jafarzadeh • Behnam Asadifar • Mohsen Ghelman • Elham Andalib

Abstract: To evaluate demographic, clinical and laboratory features associated with scleroderma-specific autoantibodies. Sera of 100 patients with systemic sclerosis (SSc) were analyzed by an indirect immunofluorescence technique with HEp-2 cells as a substrate. Specific ANA such as anticentromere antibodies (ACA), anti-topoisomerase (TOPO), anti-RNA polymerase III (Pol 3), anti-U3-RNP (U3-RNP), anti-Th/To (Th/To) and anti-PM/Scl (PM/Scl) were detected by line immunoassay and anti-U1-RNP (U1-RNP) by ELISA. Frequency of clinical features associated with a specific antibody group was reported cumulatively over the follow-up period. Frequency ... سال انتشار: 2013
 

Effect of HLA-B*27 and its Subtypes on Clinical Manifestations and Severity of Ankylosing Spondylitis in Iranian Patients

Authers: Sasan Fallahi1, 2, Mahdi Mahmoudi2, Mohammad Hossein Nicknam3, 5, Farhad Gharibdoost2, Elham Farhadi4, Azad Saei5, Keramat Nourijelyani6, Nooshin Ahmadzadeh2, and Ahmad Reza Jamshidi2

Abstract: The aim of this study was to assess the role of HLA-B*27 and it’s subtypes in determining severity and clinical manifestations of ankylosing spondylitis (AS). A total of 163 AS patients were assessed for clinical manifestations and severity using structured questionnaires. HLA-B*27 screening and B*27 sub-typing were performed by PCR. One hundred twenty two patients (74.8%) were B*27 positive. The male to female ratio, peripheral arthritis, steroid use, intense dorsal kyphosis and ... سال انتشار: 2013
 

TNF-alpha single nucleotide polymorphisms in atopic dermatitis

Authers: Nasrin Behniafard1, Mohammad Gharagozlou1, Elham Farhadi2, 3, Mojdeh Khaledi4, Soheila Sotoudeh1, Behzad Darabi1, Seid Mohammad Fathi1, Zahra Gholizadeh Moghaddam1, Mahdi Mahmoudi5, Asghar Aghamohammadi1, 6, Ali Akbar Amirzargar2, Nima Rezaei1, 2, 6

Abstract: Tumor necrosis factor-alpha (TNF-) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF- gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was ... سال انتشار: 2013
 

Katayoon Bidad • Sasan Fallahi • Mahdi Mahmoudi • Ahmadreza Jamshidi • Elham Farhadi • Alipasha Meysamie • Mohammad Hossein Nicknam

Authers: Katayoon Bidad • Sasan Fallahi • Mahdi Mahmoudi • Ahmadreza Jamshidi • Elham Farhadi • Alipasha Meysamie • Mohammad Hossein Nicknam

Abstract: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) are widely used instruments in assessment of patients suffering from ankylosing spondylitis (AS). The Patient Acceptable Symptom State (PASS) is regarded as a target for patients’ well-being. The aim of this study was to translate and adapt BASDAI, BASFI and PASS into the Iranian official language, Farsi, and evaluate their reliability and validity. Ninety patients with AS were included in this study. The ... سال انتشار: 2012
 

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

Authers: Mahdi Mahmoudi1, 2, 3, Ahmad Reza Jamshidi2, Ali Akbar Amirzargar1, 3, Elham Farhadi1, Keramat Nourijelyani4, Sasan Fallahi2, 5, Mona Oraei3, Sahar Noori4, and Mohammad Hossein Nicknam1, 3

Abstract: Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population. The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran. Using Real Time PCR allelic discrimination method, we genotyped four SNPs ... سال انتشار: 2012
 

Clinical Manifestations of the Female Athlete Triad among Some Iranian Athletes

Authers: SHAFIEH MOVASEGHI1, HALEH DADGOSTAR2, SAEIDEH DAHAGHIN1, NARGES CHIMEH3, TALIA ALENABI4, ELHAM DADGOSTAR4, and FEREYDON DAVATCHI1

Abstract: MOVASEGHI, S., H. DADGOSTAR, S. DAHAGHIN, N. CHIMEH, T. ALENABI, E. DADGOSTAR, and F. DAVATCHI. Clinical Manifestations of the Female Athlete Triad among Some Iranian Athletes. Med. Sci. Sports Exerc., Vol. 44, No. 5, pp. 958–965, 2012. Purpose: The study’s purpose was to evaluate clinical manifestations of the female athlete triad among some elite Iranian athletes. Methods: This cross-sectional study was conducted in three phases: 1) screening for menstrual irregularity (oligomenorrhea/amenorrhea) and/or stress fracture ... سال انتشار: 2012
 

Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)

Authers: Sasan Fallahi (MD) *1, 2 Ahmad Reza Jamshidi (MD) 2 Farhad Gharibdoost (MD) 2 Mahdi Mahmoudi (PhD) 2 Pedram Paragomi (MD) 2 Mohammad Hossein Nicknam (MD, PhD) 3 Elham Farhadi (MSc) 3 Mostafa Qorbani (PhD) 4

Abstract: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-sectional study from Iranian AS association, Iran Rheumatology Center and Rheumatology Clinic of ... سال انتشار: 2012
 

TNF-alpha single nucleotide polymorphisms in atopic dermatitis

Authers: Nasrin Behniafard, Mohammad Gharagozlou1, Elham Farhadi2, 3, Mojdeh Khaledi4, Soheila Sotoudeh1, Behzad Darabi1, Seid Mohammad Fathi1, Zahra Gholizadeh Moghaddam1, Mahdi Mahmoudi5, Asghar Aghamohammadi1, 6, Ali Akbar Amirzargar2, Nima Rezaei1, 2, 6

Abstract: Tumor necrosis factor-alpha (TNF-) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF- gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was ... سال انتشار: 2012
 

Evaluation of the Iranian versions of the bath ankylosing spondylitis disease activity index (BASDAI), the bath ankylosing spondylitis functional index (BASFI) and the patient acceptable symptom state (PASS) in patients with ankylosing spondylitis

Authers: Katayoon Bidad, Sasan Fallahi, Mahdi Mahmoudi, Ahmadreza Jamshidi, Elham Farhadi, Alipasha Meysamie, Mohammad Hossein Nicknam

Abstract: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) are widely used instruments in assessment of patients suffering from ankylosing spondylitis (AS). The Patient Acceptable Symptom State (PASS) is regarded as a target for patients’ well-being. The aim of this study was to translate and adapt BASDAI, BASFI and PASS into the Iranian official language, Farsi, and evaluate their reliability and validity. Ninety patients with AS were included in this study. The ... سال انتشار: 2011
 

A WHO-ILAR COPCORD STUDY (Stage 1, rural study) IN IRAN

Authers: Davatchi, Fereydoun;, Tehran Banihashemi, Arash;, Gholami, Jaleh;, faezi, seyedeh tahereh;, Forouzanfar, Mohammad Hossein;, Salesi, Mansour, Karimifar, mansour, Essalat-Manesh, Kamal, Barghamdi, Mojgan, Noorolahzadeh, Elham, Dahaghin, Saideh

Abstract: Objective: To study the prevalence of musculoskeletal complaints and disorders in a rural area in Iran. Materials and Methods: Interviews were conducted in randomly selected subjects from 5 villages in Tuyserkan County, North Western part of Iran. The 3 phases of stage 1 COPCORD (Community Oriented Program for Control Of Rheumatic Diseases) were done during the same day. Results: A total of 614 houses was visited, 1565 persons interviewed and 1192 persons examined. Musculoskeletal complaints ... سال انتشار: 2009
 

The prevalence of musculoskeletal complaints in a rural area in Iran: a WHO-ILAR COPCORD study (stage 1, rural study) in Iran

Authers: Fereydoun Davatchi, Arash Tehrani Banihashemi, Jaleh Gholami, Seyedeh Tahereh Faezi, Mohammad Hossein Forouzanfar, Mansour Salesi, Mansour Karimifar, Kamal Essalatmanesh, Mojgan Barghamdi, Elham Noorolahzadeh, Saideh Dahaghin, Johannes J. Rasker

Abstract: The objective of this study is to study the prevalence of musculoskeletal complaints and disorders in a rural area in Iran. Interviews were conducted in randomly selected subjects from five villages in Tuyserkan County, northwestern part of Iran. The three phases of stage 1 Community Oriented Program for Control of Rheumatic Diseases were done during the same day. A total of 614 houses was visited, 1,565 persons interviewed, and 1,192 persons examined. Musculoskeletal complaints during the past 7 days ... سال انتشار: 2009
 

Effect of ethnic origin (Caucasians versus Turks) on the prevalence of rheumatic diseases: a WHO-ILAR COPCORD urban study in Iran

Authers: Fereydoun Davatchi،Ahmad-Reza Jamshidi،Arash Tehrani Banihashemi،Jaleh Gholami،Mohammad Hossein Forouzanfar،Massoomeh Akhlaghi،Mojgan Barghamdi،Elham Noorolahzadeh،Ali-Reza Khabazi،Mansour Salesi،Amir-Hossein Salari،Mansoor Karimifar،Kamal Essalat-Manesh

Abstract: The objective of this study was to compare the prevalence of musculoskeletal complaints and rheumatic disorders in Caucasians and Turks in an identical environment. Subjects were selected randomly for an interview from Tehran’s 22 districts. The Community Oriented Program for Control of Rheumatic Diseases questionnaire was filled in, positive cases were examined, and if needed, laboratory or X-ray tests were performed. A total of 4,096 houses were visited, and 10,291 persons were interviewed. They were 71.4% Caucasians and 23.1% ... سال انتشار: 2009
 

WHO-ILAR COPCORD Study (Stage 1, Urban Study) in Iran

Authers: FEREYDOUN DAVATCHI, AHMAD-REZA JAMSHIDI, ARASH TEHRANI BANIHASHEMI, JALEH GHOLAMI, MOHAMMAD HOSSEIN FOROUZANFAR, MASSOOMEH AKHLAGHI, MOJGAN BARGHAMDI, ELHAM NOOROLAHZADEH،ALI-REZA KHABAZI،MANSOOR SALESI،AMIR-HOSSEIN SALARI،MANSOOR KARIMIFAR،KAMAL ESSALAT-MANESH،MEHRZAD HAJIALILOO،MOHSEN SOROOSH

Abstract: To find the prevalence of musculoskeletal complaints and rheumatic disorders in Iran. Methods. Tehran, with one-ninth of the population of Iran and of mixed ethnic origins, was selected as the field. Subjects were randomly selected from the 22 districts. Interviews were conducted once a week, on the weekend. The 3 phases of stage 1 were done on the same day, in parallel, like the fast-track Community Oriented Program for Control of Rheumatic Diseases (COPCORD). Results. ... سال انتشار: 2008
 

The Prevalence of Oral Aphthosis in a Normal Population in Iran: A WHO-ILAR COPCORD Study

Authers: Fereydoun Davatchi MD•*, ،Arash Tehrani-Banihashemi MD*, ،Ahmad-Reza Jamshidi MD*, ،Cheyda Chams-Davatchi MD*, ،Jaleh Gholami MD*, ،Maziar Moradi MD*, ،Massoomeh Akhlaghi MD*, ،Mohammad Hossein Forouzanfar MD*, ،Elham Noorolahzadeh،Mojgan Barghamdi،Farideh Samadi،Mehrzad Hadj-Aliloo MD،Koorosh Ghaznavi MD

Abstract: This study was conducted to determine the prevalence of oral aphthosis in a normal population in Iran, using the data of the WHO-ILAR COPCORD study in Iran. We conducted this study in Tehran, the capital of Iran which was selected as the COPCORD study field. In 22 districts of Tehran, 50 clusters were randomly selected. Of the selected houses, 4,096 households were visited and 10,291 persons were interviewed (response rate of 75%). Out of ... سال انتشار: 2008