تالیفات

 

Downregulation of Aquaporin3 in Systemic Sclerosis Dermal Fibroblasts

مولف: Bahman Yousefi1, 2, Mahdi Mahmoudi1, Abdolfattah Sarafnejad2, Elham Karimizadeh1, Elham Farhadi3, Ahmad Reza Jamshidi1, Hoda Kavosi1, Saeed Aslani1, and Farhad Gharibdoost1

خلاصه: Skin dryness and thickening are hallmarks of systemic sclerosis (SSc) disease. Aquaporins (AQPs) are plasma membrane proteins that transport glycerol and water, resulting in water retention and skin hydration. Expression of AQPs has been evaluated in human normal skin. However, expression of these proteins in SSc dermal fibroblasts has not yet been reported. The aim of this study was to assess the expression profile of AQPs in dermal fibroblasts of ... سال انتشار: 2017
 

Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Authers: Saeideh Jafarinejad-Farsangi1, PhD, Ali Farazmand1, PhD, Farhad Gharibdoost2, MD, Elham Karimizadeh1, PhD, Farshid Noorbakhsh3, PhD, Habibeh Faridani2, MD, Mahdi Mahmoudi2, PhD, and Ahmad Reza Jamshidi2, MD

Abstract: Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. Methods The effects of miR-21 on expression of Bcl-2 and Bax, two apoptotic genes, in dermal fibroblasts of SSc patients were evaluated using real-time polymerase chain reaction and Western blot analysis. Apoptotic ... سال انتشار: 2016
 

c-Abl silencing reduced the inhibitory effects of TGF-b1 on apoptosis in systemic sclerosis dermal fibroblasts

مولف: Elham Karimizadeh1 • Farhad Gharibdoost2 • Nasrin Motamed1 • Saeideh Jafarinejad-Farsangi1 • Ahmadreza Jamshidi2 • Mahdi Mahmoudi

خلاصه: It is generally accepted that the apoptosis of myofibroblasts is a crucial event in the normal wound healing. Delay in myofibroblasts apoptosis results in fibrotic diseases such as systemic sclerosis (SSc). Transforming growth factor-b1 (TGF-b1) is an important cytokine to induce fibroblasts differentiation into myofibroblasts. Cellular Abelson (c-Abl) is known as a TGF-b1- modulating molecule in fibrosis. The role of c-Abl, TGFb1, and their interaction in SSc myofibroblasts apoptosis has not yet been fully explored. The aim of this ... سال انتشار: 2015